Global Information would like to present a market research report, "Competitor Analysis: Tissue Growth Factors" by La Merie Publishing.
The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercially most successful growth factors is BMP-2 from Medtronic and Pfizer (ex Wyeth) with annual sales of nearly US$ 800 mln and prospect for further growth by use in additional indications. Growth factors are used for treatment of growth failure, skin wounds and ulcers, corneal damage, oral mucositis or to stimulate bone growth. Further growth factors such as HGF, VEGF, TGF, NGF, GDF and quite a number of neurotrophic factors are under development. Apart from proteins as the classical drugs, other classes of compounds are also under development such as small molecules to stimulate growth factor receptors or antibodies to block inhibitory pathways, thereby inducing functional recovery. Furthermore, engineered peptides mimicking growth factors, cells engineered to express growth factors or simply plasmids for growth factors are under development.