Spinal Surgical Devices: Technologies and Global Markets

Spinal Surgical Devices: Technologies and Global Markets published by BCC Research in August, 2010. This report consists of 282 Pages and the price starts from US $ 4850.

Introduction

Abstract

THIS REPORT CONTAINS

• A focus on how nonfusion products, including dynamic stabilization (or motion-preservation) devices and total disc replacement (TDR) are becoming the treatments of choice, especially for younger, more-active patients
• Analysis of the global spinal devices market, with data for 2008, estimates for 2009, and projections of compound annual growth rates (CAGRs) through 2014
• A breakdown of end-user markets, including hospitals, research facilities, freestanding spinal care clinics, and outpatient centers
• An overview of the history and current state of medical spinal fusion and nonfusion devices
• Comprehensive patent analyses.

INTRODUCTION

Most people at one point or another have experienced back pain. The pain usually lasts for only a short duration and then resolves itself with little or no medical attention. For others, however, the pain is unresolving, chronic, and severe, and may involve neurological symptoms, including radiating pain or numbness down an arm or leg. For these relatively few sufferers, surgical intervention may be necessary.

As individuals age, the effects of wear and tear on the body accumulate. This is true of the spine. Degenerative changes, not a single traumatic blow, are the cause of most cases that result in spinal surgery. These degenerative changes can be evidenced radiographically in nearly all people, although only a small percentage of these changes will produce symptomatic conditions. The world' s population is aging at an unprecedented rate, and as this continues, the rate of degenerative spinal conditions is also expected to escalate.

Surgical treatment of spinal conditions has been marred in controversy. Fusion, a treatment largely abandoned by other orthopedic disciplines because of the resulting limited range of motion, is still the treatment of choice for spinal surgical intervention. Innovation in both devices and techniques in spine surgery was largely stagnant in the 1980s and early 1990s. Technological advances in both surgical approaches and spinal implants, however, are once again flourishing, making spine the fastest-growing segment of the global orthopedics market.

This growth, although driven in part by escalating procedural volume, is also the result of excitement in emerging technologies in the non-fusion, or motion-preservation, segment. Initial euphoria has been dampened both by hardware durability issues and reimbursement challenges, but hope persists that the motion preservation market will drive future expansion in the spine industry through positive patient outcomes and economic efficiencies resulting from less-invasive surgeries. Biologics is another rapidly evolving segment of spinal orthopedics that is garnering great enthusiasm. Its growth prospects are high for making current techniques more effective and possibly altering the future landscape of spine surgery with the creation of technologies that actually regenerate spinal components.

STUDY GOALS AND OBJECTIVES

The technologies in this report - implantable spinal prosthetics and hardware - are pivotal to improving the quality of life for the tens of millions worldwide who suffer from back pain and neurological deficit resulting from common spinal conditions. Advances in these devices and their implantation techniques can improve the cost benefit of treatment of spinal conditions.

The objectives of this report are to present a comprehensive analysis of the market for these orthopedic products and forecast their commercial potential through 2015.

This report will:

• Assess the prevalence of common spinal conditions and trends affecting their projected future incidence
• Examine current procedure volumes and associated expenditures, as well as projected increases in demand by technique
• Analyze the current market and forecast demand for implantable spinal surgical devices
• Describe the regulatory framework and its effect on the introduction of new devices into the spinal market both in the U.S. and abroad
• Analyze trends in patent applications and issued patents for innovations that will be altering the spinal marketplace
• Examine the drivers that will affect future utilization and rate of adoption of the implants, including demographic changes, reimbursement policy, clinical considerations, and R&D
• Identify the product manufacturers that will drive innovation, their market share, and other industry players

REASONS FOR DOING THE STUDY

The world' s population is aging at an unprecedented rate. Aging populations face increased rates of arthritic and degenerative conditions. This trend is particularly pronounced upon examination of the prevalence of back pain and underlying spinal conditions.

The convergence of the following trends represents the motivation for this report:

• The worldwide growth of the senior population will strain the capabilities of healthcare providers and the financial resources of healthcare payers.
• Patients are increasingly less likely to accept "aging pains" as they wish to maintain a more active lifestyle even with advancing age.
• Obesity, which is also increasing globally, will similarly contribute to higher rates of back pain and degenerative conditions.
• Advances in biologics, materials, imaging techniques, and the biomechanical understanding of the spine will enable treatment of spinal conditions with a focus on preservation of natural range of motion.
• To contain costs while simultaneously facing an increased procedural volume, focus is shifting toward improving instruments and techniques to reduce the invasiveness of surgery, thereby shortening hospital stays and hastening recovery.
• Increased focus is being placed on the cost benefit of surgical procedures and implants.

SCOPE OF REPORT

This report is a business analysis that has the primary purpose of examining trends in the market for spinal surgical devices, specifically arthroplasty products and implanted instrumentation hardware. The report includes sections on the following topics:

• Current prevalence of common spinal problems, trend analysis, and factors influencing future incidence
• Market analysis by surgical procedure, including annual incidence, trend analysis, and factors influencing future predicted surgical volume
• Global demand by device and projected future trends by device category
• Risk factors and other drivers that will affect the future incidence of spine surgery and related utilization of spinal surgical devices
• U.S. and international regulation of spinal devices
• Patent analysis
• Market share and information on key device manufacturers

INTENDED AUDIENCE

This report is intended for anyone interested in better understanding the role of the rapidly growing spine segment of the broader orthopedic and biologic markets. Executives, consultants, trade associations, and marketing professionals in the medical device industry, health insurance industry, orthopedics and biologics fields, and ambulatory surgery and broader hospital sector would benefit from this report. Additionally, stock analysts, VC funders, and investors focused on the spine segment or those who are interested in expanding markets for orthopedic implants, minimally invasive surgical instrumentation and techniques, and biologic applications would also benefit. Manufacturers and distributors of the technology discussed in this report are also an intended audience.

INFORMATION SOURCES

BCC Research reviewed reports, white papers, technical product specifications, and studies produced by industry, trade associations, corporations, professional organizations, payers, governments, healthcare providers, and peer-reviewed journal articles. Various original data sources were analyzed. Data were compiled from the U.S. Census Bureau, U.S. Patent and Trademark Office, the Department of Health and Human Services, and sub-agencies, including the FDA medical device data registry, CMS, AHRQ, CDC, and the National Center for Health Statistics. International data sources included WHO, OECD, Eurostat, Spine Tango, and databases from various countries' federal statistics offices. Interviews were conducted with industry sources, consultants, manufacturers, surgeons, and researchers.

Table of Contents

Chapter- 1: INTRODUCTION -- Complimentary 5

• INTRODUCTION 1
• STUDY GOALS AND OBJECTIVES 2
• REASONS FOR DOING THE STUDY 2
• SCOPE OF REPORT 3
• INTENDED AUDIENCE 3
• INFORMATION SOURCES 4
• ANALYST CREDENTIALS 4
• RELATED BCC REPORTS 4
• BCC ONLINE SERVICES 4
• DISCLAIMER 5

Chapter-2: SUMMARY 2

• SUMMARY 6
• SUMMARY TABLE GLOBAL FORECAST SPINAL SURGICAL DEVICES BY CATEGORY, THROUGH 2015 ($ MILLIONS) 7
• SUMMARY FIGURE GLOBAL FORECAST SPINAL SURGICAL DEVICES BY CATEGORY, 2008-2015 ($ MILLIONS) 7

Chapter-3: OVERVIEW 43

• SPINAL ANATOMY 8
• SPINAL COLUMN 8
• Intervertebral Discs 8
• Boney Structures 9
• NEURAL ELEMENTS 9
• SUPPORTING STRUCTURES 9
• TABLE 1 FUNCTIONAL ROLE OF THE SPINAL COLUMN COMPONENTS 10
• BACK PAIN 10
• HISTORY OF BACK PAIN AND EARLY TREATMENT 10
• BACK PAIN TODAY 11
• TABLE 2 GLOBAL SAMPLING OF FREQUENCY OF BACK PAIN, 2002 - 2009 12
• Cost of Back Pain 12
• TABLE 3 U.S. MEDICAL ENCOUNTERS BY SETTING FOR THE DIRECT TREATMENT OF BACK PROBLEMS, 2007 (THOUSANDS) 12
• TABLE 4 HOSPITAL DISCHARGES BY BACK-RELATED DIAGNOSIS IN SELECT EUROPEAN COUNTRIES, THROUGH 2008 13
• TABLE 5 U.S. DIRECT MEDICAL EXPENSES FOR BACK PROBLEMS, 2007 ($ MILLIONS) 14
• TABLE 6 U.S. DISTRIBUTION OF DIRECT BACK-RELATED MEDICAL EXPENSES BY PAYER, 2007 (%) 14
• TABLE 7 U.S. PATIENTS WITH BACK PROBLEMS, THROUGH 2007 (MILLIONS) 15
• TABLE 8 U.S. MEDICAL EXPENDITURES FOR THE DIRECT TREATMENT OF BACK PROBLEMS, THROUGH 2007 ($ BILLIONS) 15
• Disability from Back Pain 15
• Identifying the Cause of Back Pain 16
• TABLE 9 DISTRIBUTION OF DIAGNOSABLE BACK CONDITIONS (%) 16
• Causes of Diagnosed Back Pain 16
• Risk Factors for Back Pain 17
• Risk Factors for Diagnosable Back Disorders 17
• Genetics 17
• Aging 17
• TABLE 10 PROJECTED AGING OF THE GLOBAL POPULATION AGE 65 AND OLDER, THROUGH 2020 (MILLION) 18
• Smoking 18
• Obesity 19
• TABLE 11 GLOBAL PREVALENCE OF OBESITY, 1995 - 2005 (%) 19
• Osteoporosis 20
• TABLE 12 PROJECTED AGING OF GLOBAL FEMALE POPULATION AGE 60 - 99, THROUGH 2020 (MILLION) 20
• COMMON SPINAL CONDITIONS 20
• TABLE 13 DIAGNOSIS-RELATED ICD 9 CODES FOR SPINAL CONDITIONS 21
• TABLE 13 (CONTINUED) 22
• TABLE 14 U.S. INPATIENTS DIAGNOSED BY CODED BACK CONDITIONS, 2008 22
• ABNORMAL SPINAL CURVATURES 22
• TABLE 15 U.S. TREND FOR INPATIENT DIAGNOSIS OF ALL ABNORMAL CURVATURES OF THE SPINE, THROUGH 2015 23
• TABLE 16 U.S. INPATIENTS WITH ABNORMAL CURVATURES OF THE SPINE, 2008 23
• Kyphosis 23
• Postural Kyphosis 24
• Structural Kyphosis 24
• Gibbus Deformity 24
• Scheuermann' s Disease 24
• Congenital Kyphosis 24
• Secondary Kyphosis 24
• Treatment 25
• TABLE 17 GLOBAL FREQUENCY OF KYPHOSIS 25
• TABLE 18 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH KYPHOSIS, 2008 (%) 26
• TABLE 19 U.S. TREND OF HOSPITAL INPATIENT DIAGNOSIS OF KYPHOSIS, THROUGH 2015 26
• Lordosis 26
• Treatment 27
• TABLE 20 U.S. TREND FOR HOSPITAL INPATIENT DIAGNOSIS OF LORDOSIS, THROUGH 2015 27
• Scoliosis 27
• Congenital Scoliosis 27
• Failure of Segmentation 28
• Failure of Formation 28
• Treatment 28
• Neuromuscular Scoliosis 28
• Treatment 29
• Degenerative Scoliosis 29
• Treatment 29
• Idiopathic Scoliosis 29
• Treatment 30
• TABLE 21 GLOBAL FREQUENCY OF SCOLIOSIS 30
• TABLE 22 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH SCOLIOSIS, 2008 (%) 30
• TABLE 23 U.S. TREND FOR HOSPITAL INPATIENT DIAGNOSIS OF SCOLIOSIS, THROUGH 2015 31
• ARTHRITIC SPINAL CONDITIONS 31
• TABLE 24 U.S. TREND FOR HOSPITAL INPATIENTS WITH DIAGNOSES OF ALL ARTHRITIS-RELATED SPINAL CONDITIONS, THROUGH 2015 31
• TABLE 25 U.S. INPATIENTS WITH ARTHRITIS-RELATED SPINAL CONDITIONS, BY CONDITION, 2008 32
• Ankylosing Spondylitis 32
• TABLE 26 GLOBAL FREQUENCY OF ANKYLOSING SPONDYLITIS (%) 32
• Rheumatoid Arthritis 33
• TABLE 27 GLOBAL FREQUENCY OF RHEUMATOID ARTHRITIS (%) 33
• TABLE 28 AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH ANKYLOSING SPONDYLITIS/RHEUMATOID ARTHRITIS (%) 34
• TABLE 29 U.S. TREND FOR HOSPITAL INPATIENT DIAGNOSES OF ANKYLOSING SPONDYLITIS/RHEUMATOID ARTHRITIS, THROUGH 2015 34
• Osteoarthritis/Spondylosis 34
• TABLE 30 U.S. DISTRIBUTION OF SPONDYLOSIS BY SPINAL REGION, 2008 35
• Treatment 35
• TABLE 31 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH SPONDYLOSIS, 2008 (%) 35
• TABLE 32 U.S. TREND FOR HOSPITAL INPATIENT DIAGNOSIS OF SPONDYLOSIS, THROUGH 2015 36
• DEGENERATIVE DISC DISEASES 36
• TABLE 33 U.S. TREND FOR HOSPITAL INPATIENT DIAGNOSES WITH ALL DEGENERATIVE DISC DISEASES, THROUGH 2015 (THOUSANDS) 37
• TABLE 34 U.S. INPATIENTS DIAGNOSED WITH DEGENERATIVE DISC DISORDERS, 2008 37
• Disc Herniation 37
• TABLE 35 U.S. DISTRIBUTION OF DISC HERNIATION BY SPINAL REGION, 2008 (%) 38
• TABLE 36 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH DISC HERNIATION, 2008 (%) 39
• TABLE 37 U.S. TREND FOR INPATIENT DIAGNOSIS OF DISC HERNIATION, THROUGH 2015 (%) 39
• Treatment 39
• Disc Degeneration 40
• TABLE 38 U.S. DISTRIBUTION OF DEGENERATIVE DIAGNOSIS BY REGION OF THE SPINE, 2008 (%) 40
• TABLE 39 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH DEGENERATION OF THE INTERVERTEBRAL DISCS, 2008 (%) 40
• TABLE 40 U.S. TREND FOR INPATIENT DIAGNOSIS OF DEGENERATION OF THE INTERVERTEBRAL DISC, THROUGH 2015 (%) 41
• Spinal Stenosis 41
• TABLE 41 U.S. DISTRIBUTION OF STENOSIS BY SPINAL REGION, 2008 (%) 41
• TABLE 42 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH SPINAL STENOSIS, 2008 (%) 42
• TABLE 43 U.S. TREND INPATIENT DIAGNOSIS OF SPINAL STENOSIS, THROUGH 2015 42
• Treatment 42
• Spondylolisthesis 42
• TABLE 44 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH SPONDYLOLISTHESIS, 2008 (%) 43
• Treatment 44
• TABLE 45 U.S. TREND IN INPATIENT DIAGNOSIS OF SPONDYLOLISTHESIS, THROUGH 2015 44
• SPINAL TUMORS 44
• Treatment 45
• INJURY 45
• Vertebral Fractures 45
• TABLE 46 U.S. INPATIENTS WITH VERTEBRAL FRACTURE DIAGNOSIS, 2008 45
• TABLE 47 U.S. AND E.U. VERTEBRAL FRACTURES BY TYPE 46
• TABLE 48 U.S. AGE DISTRIBUTION FOR INPATIENTS DIAGNOSED WITH VERTEBRAL FRACTURES WITHOUT SPINAL CORD INJURY, 2008 (%) 46
• TABLE 49 U.S. TREND FOR INPATIENT DIAGNOSIS OF VERTEBRAL FRACTURE, THROUGH 2015 (%) 47
• Fracture Classification 47
• Major/Minor 47
• Stable/Unstable 47
• Denis 3-Column Model 48
• Break Type 48
• Traumatic Spinal Injury 49
• TRENDS IN FREQUENCY OF SPINAL CONDITIONS 50
• TABLE 50 U.S. FORECAST FOR INPATIENT DIAGNOSIS BY CODED SPINAL CONDITION, THROUGH 2015 (THOUSANDS) 50

Chapter-4: MARKET ANALYSIS 61

• MARKET BY APPLICATION OR PROCEDURE 51
• TABLE 51 U.S. SPINAL PROCEDURES BY VOLUME, THROUGH 2015 (THOUSANDS) 51
• TABLE 52 U.S. COSTS FOR ALL SPINAL PROCEDURES, THROUGH 2015 ($ MILLIONS) 52
• TABLE 53 U.S. DISTRIBUTION OF SPINAL SURGERY PROCEDURES BY CATEGORY, 2008 (%) 53
• TABLE 54 U.S. HIGHEST MEAN COSTS BY SPINAL SURGICAL PROCEDURE, 2008 ($) 53

Chapter-5: INDUSTRY PLAYERS 168

• FUSION 112
• POSTERIOR PEDICLE SCREW FUSION SYSTEMS 112
• Aesculap 112
• Alphatec Spine, Inc. 113
• Amedica Corp. 114
• Biomet Spine 115
• Cardo Medical, Inc. 116
• Choice Spine, LP 117
• Co-Ligne Ag 117
• DePuy Spine, Inc. 117
• DePuy Spine, Inc. (Continued) 118
• DePuy Spine, Inc. (Continued) 119
• Eden Spine, LLC 120
• Exactech, Inc. 120
• Globus Medical, Inc. 121
• Innovasis, Inc. 122
• Integra Spine 123
• Interventional Spine, Inc. 124
• Lanx, Inc. 125
• LDR Medical 125
• Life Spine 126
• Medicrea International 127
• Medtronic, Inc. 127
• Neuro France Implants 128
• NuVasive, Inc. 129
• Ortho Development Corp. 129
• Orthofix International N.V. 130
• Orthofix ... (Continued) 131
• Pioneer Surgical Technology 132
• Scient' X Group S.A.S. 132
• SeaSpine, Inc. 133
• Signus Medizintechnik GmbH 134
• Sintea Biotech, SpA 134
• Specialty Spine Products, LLC 135
• Spine Network (Eurosurgical) 135
• SpineVision SA 136
• Stryker Spine 137
• Stryker Spine (Continued) 138
• Synthes Inc. 139
• Ulrich GmbH & Co. KG 140
• VertiFlex, Inc. 141
• X-Spine Systems, Inc. 141
• Zimmer Spine, Inc. 142
• CABLE SYSTEMS 143
• Biomet Spine 143
• DePuy Spine, Inc. 144
• Pioneer Surgical Technology 145
• ANTERIOR CERVICAL PLATE SYSTEMS 145
• Aesculap 145
• Alphatec Spine, Inc. 146
• Amedica Corp. 147
• Apollo Spine 147
• Biomet Spine 148
• Cardo Medical Inc. 149
• Choice Spine, LP 149
• DePuy Spine, Inc. 150
• Exactech, Inc. 151
• Globus Medical, Inc. 151
• Innovasis, Inc. 152
• Integra Spine 152
• Lanx, Inc. 153
• Life Spine 154
• NuVasive, Inc. 154
• Ortho Development Corp. 155
• Orthofix International N.V. 155
• Pioneer Surgical Technology 156
• Scient' X Group S.A.S. 157
• SeaSpine, Inc. 157
• Signus Medizintechnik GmbH 158
• Sintea Biotech, SpA 158
• SpineVision SA 158
• Stryker Spine 159
• Synthes Inc. 159
• Ulrich GmbH & Co. KG 160
• X-Spine Systems, Inc. 161
• Zimmer Spine, Inc. 161
• OTHER ANTERIOR FIXATION DEVICES 162
• Alphatec Spine, Inc. 162
• DePuy Spine, Inc. 162
• DePuy Spine, Inc. (Continued) 163
• Eminent Spine 164
• Globus Medical, Inc. 164
• Life Spine 165
• Medicrea International 165
• NuVasive, Inc. 165
• Scient' X Group S.A.S. 166
• SeaSpine, Inc. 167
• Stryker Spine 167
• Synthes Inc. 168
• X-Spine Systems, Inc. 169
• Ulrich GmbH & Co. KG 170
• Zimmer Spine, Inc. 170
• INTERBODY FUSION DEVICES 171
• Vertebral Body Replacement 171
• Aesculap 171
• Alphatec Spine, Inc. 171
• Biomet Spine 172
• Co-Ligne Ag 173
• DePuy Spine, Inc. 173
• DePuy .... (Continued) 174
• Eden Spine, LLC 175
• Globus Medical, Inc. 175
• Innovasis, Inc. 176
• Integra Spine 176
• Ortho Development Corp. 177
• Orthofix International N.V. 178
• Pioneer Surgical Technology 179
• Scient' X Group S.A.S. 180
• Signus Medizintechnik GmbH 180
• SpineVision SA 181
• Spine Wave, Inc. 182
• Stryker Spine 182
• Synthes, Inc. 183
• Ulrich GmbH & Co. KG 184
• Verticor, Ltd. 185
• Metallic Interbody Fusion Devices 185
• Aesculap 185
• Life Spine 186
• Osteotech, Inc. 186
• Medtronic, Inc. 186
• RSB Spine LLC 187
• Scient' X Group S.A.S. 188
• Sintea Biotech, SpA 188
• SpineSelect, LLC 189
• Stryker Spine 189
• Titan Spine, LLC 190
• TranS1, Inc. 190
• Ulrich GmbH & Co. KG 191
• Vertebration, Inc. 192
• Zimmer Spine, Inc. 192
• Polymer Interbody Fusion Devices 193
• Aesculap 193
• Alphatec Spine, Inc. 193
• Amedica Corp. 194
• Biomet Spine 195
• Centinel Spine, Inc. 196
• Choice Spine, LP 197
• Co-Ligne AG 197
• DePuy Spine, Inc. 198
• Eminent Spine 199
• Globus Medical, Inc. 199
• Innovasis, Inc. 200
• Integra Spine 201
• LDR Medical 202
• Lanx, Inc. 203
• Medicrea International 203
• Neuro France Implants 204
• NuVasive, Inc. 205
• Orthofix International N.V. 206
• Scient' X Group S.A.S. 207
• SeaSpine, Inc. 208
• Signus Medizintechnik GmbH 209
• Sintea Biotech, SpA 210
• Spinal Elements 210
• SpineSmith 211
• Synthes Inc. 211
• Ulrich GmbH & Co. KG 212
• Vertebral Technologies, Inc. 213
• Verticor, Ltd. 213
• VertiFlex, Inc. 213
• X-Spine Systems, Inc. 214
• Zimmer Spine, Inc. 214
• Structural Spinal Allografts 215
• AlloSource 215
• Alphatec Spine, Inc. 215
• Biomet Spine 216
• Lanx, Inc. 216
• Ortho Development Corp. 217
• Osteotech, Inc. 217
• Scient' X Group S.A.S. 218
• Stryker Spine 218
• Synthes, Inc. 219
• Zimmer Spine, Inc. 220
• BONE GRAFTS 221
• Demineralized Bone Matrix (DBM) 221
• Alphatec Spine, Inc. 221
• Biomet Spine 221
• Citagenix, Inc. 222
• Etex Corp. 223
• Exactech, Inc. 223
• Integra Spine 224
• Osteotech, Inc. 225
• Synthes, Inc. 226
• Wright Medical Technology, Inc. 226
• BONE GRAFT SUBSTITUTES 227
• Amedica Corp. 227
• Biocomposites, Ltd. 227
• Citagenix, Inc. 228
• DePuy Spine, Inc. 228
• Etex Corp. 228
• Globus Medical, Inc. 229
• Innovasis, Inc. 230
• Integra Spine 230
• LDR Medical 231
• Medicrea International 231
• Medtronic, Inc. 232
• NuVasive, Inc. 232
• Orthovita 233
• Progentix Orthobiology BV 233
• Scient' X Group S.A.S. 234
• Signus Medizintechnik GmbH 234
• Synthes, Inc. 235
• Wright Medical Technology, Inc. 235
• Wright ... (Continued) 236
• Zimmer Spine, Inc. 237
• PLATELET HELPERS 237
• Stem Cells 237
• Allosource 237
• NuVasive, Inc. 238
• Growth Factors (rhBMP) 238
• BioMimetic Therapeutics, Inc. 238
• Medtronic, Inc. 239
• Stryker Spine 240
• Non-Fusion 240
• Interspinous Process Spacers 240
• Eden Spine, LLC 240
• Globus Medical, Inc. 241
• Interventional Spine, Inc. 241
• Medtronic, Inc. 242
• Paradigm Spine, LLC 243
• Privelop AG 243
• Replication Medical, Inc. 243
• VertiFlex, Inc. 244
• Dynamic Stabilization 244
• Applied Spine Technologies, Inc. 244
• Bio-Spine Corp. 245
• Disc Motion Technologies 245
• Eden Spine, LLC 246
• Paradigm Spine, LLC 246
• Scient' X Group S.A.S. 247
• SpineVision SA 247
• Ulrich GmbH & Co. KG 248
• VertiFlex, Inc. 248
• Zimmer Spine, Inc. 249
• Arthroplasty: Cervical 250
• Aesculap 250
• Globus Medical, Inc. 251
• LDR Medical 251
• Medicrea International 252
• Medtronic, Inc. 252
• NuVasive, Inc. 253
• Orthofix International N.V. 253
• Paradigm Spine, LLC 254
• Scient' X Group S.A.S. 254
• Signus Medizintechnik GmbH 255
• Spinal Kinetics 255
• Spinal Motion 256
• Stryker Corp. 256
• Synthes Inc. 257
• Arthroplasty: Lumbar 257
• Aesculap 257
• AxioMed Spine Corp. 258
• DePuy Spine, Inc. 259
• Disc Motion Technologies 259
• Eden Spine, LLC 259
• Fournitures Hospitalieres Orthopedics 260
• Integra Spine 260
• LDR Medical 261
• Pioneer Surgical Technology 262
• Ranier Technology, Ltd. 262
• Spinal Motion 263
• Synthes Inc. 263
• Zimmer Spine, Inc. 264
• Nucleus Replacement 264
• CryoLife Inc. 264
• Gentis Inc. 265
• Replication Medical, Inc. 265
• Spine Wave, Inc. 266
• TranS1, Inc. 266
• Vertebral Technologies, Inc. 267
• Facet Replacement 267
• Facet Solutions, Inc. 267
• Impliant, Inc. 268
• Interventional Spine, Inc. 268
• Spinal Elements 268
• Vertebral Column Fracture 269
• Alphatec Spine Inc. 269
• ArthoCare Corp. 269
• Benvenue Medical 270
• Biomet Spine 270
• Bone Solutions, Inc. 271
• BoneSupport AB 272
• CareFusion 272
• DePuy Spine, Inc. 273
• Dfine, Inc. 273
• Doctors Research Group, Inc. 274
• Mathys, Ltd. Bettlach 274
• Medtronic, Inc. 275
• Orthovita 275
• Sintea Biotech, SpA 276
• SpineAlign Medical, Inc. 276
• Stryker Corp. 277
• Vexim SAS 277
• Annulus Repair 278
• Anulex Technologies, Inc. 278
• Intrinsic Therapeutics, Inc. 278
• Magellan Spine Technologies, Inc. 279

Chapter-6: REFERENCES 3

• REFERENCES 280
• REFERENCES (CONTINUED) 281
• REFERENCES (CONTINUED) 282

Press Release

Global spinal surgical market is projected to reach almost $6.5 billion by 2015

Global Information Inc. would like to present a new market research report, "Spinal Surgical Devices: Technologies and Global Markets" by BCC Research.

According to the report, the global spinal surgical market is projected to reach almost $6.5 billion by 2015, a 3.4% compound annual growth rate (CAGR) over the 2010 value of $5.5 billion.

The nonfusion device segment is expected to grow at a 10% compound annual growth rate (CAGR) versus 1.3% for fusion products, but it is not expected to constitute more than 15% of the total spinal surgical device market by 2015. This sector is valued at $624 million in 2010 and is expected to reach $1 billion by 2015.

Vertebral repair is a rapidly growing market, directly related to the continued growth of the aging population and osteoporosis-related fractures. This sector is valued at $532 million in 2010 and is expected to increase at a 10% compound annual growth rate (CAGR) to reach $858 million in 2015.

This report is a business analysis that has the primary purpose of examining trends in the market for spinal surgical devices, specifically arthroplasty products and implanted instrumentation hardware. The report includes sections on the following topics:

• Current prevalence of common spinal problems, trend analysis, and factors influencing future incidence
• Market analysis by surgical procedure, including annual incidence, trend analysis, and factors influencing future predicted surgical volume
• Global demand by device and projected future trends by device category
• Risk factors and other drivers that will affect the future incidence of spine surgery and related utilization of spinal surgical devices
• U.S. and international regulation of spinal devices
• Patent analysis
• Market share and information on key device manufacturers

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