• Japanese
  • Korean
  • Chinese
Cover Image

Global Markets for Media, Sera and Reagents in Biotechnology

The global market for cell culture products will grow from nearly $3.2 billion in 2014 to nearly $4.1 billion by 2019 at a compound annual growth rate (CAGR) of 5.1% between 2014 and 2019.

This report provides:

  • An overview of the global markets and technologies for media, sera and reagents used in biotechnology.
  • Analyses of global market trends, with data from 2013, estimates for 2014, and projections of compound annual growth rates (CAGRs) through 2019.
  • Information on different types of cell cultures and products from cell culture technology as well as the advantages and disadvantages for the use of various types of media are also covered.
  • Detailed analysis of the cell culture industry's structure.
  • Discussion covering the applications of cell culture technology with an emphasis on usage in the research, production and contract segments.
  • Comprehensive profiles of major players in the media, sera, and reagents industry.

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REPORT SCOPE

SCOPE OF THE STUDY

The study entails the current cell culture products market. The scope of this study encompasses the biotechnology, pharmaceutical and medical markets. The report analyzes the market trends in three major cell culture products, that is, media, sera and reagents and their applications in production, research, contract and others sectors. In addition to the current and future markets, it includes regulatory aspects, new development in cell culture techniques, and patent analysis and growth and restriction factors for the market during the forecast period. Technological issues include the latest trends and developments. The emerging market for media, sera and reagents in biotechnology includes countries like India, China, Japan, Korea, Taiwan, Canada, Africa, Australia, New Zealand, etc.

ANALYST'S CREDENTIALS

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has more than 14 years of industry experience. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S.

Table of Contents

CHAPTER 1 INTRODUCTION

  • STUDY OBJECTIVES
  • REASONS FOR DOING THIS STUDY
  • CONTRIBUTIONS OF THE STUDY
  • SCOPE OF THE STUDY
  • METHODOLOGY
  • INFORMATION SOURCES
  • ANALYST'S CREDENTIALS
  • RELATED BCC RESEARCH REPORTS
  • BCC RESEARCH WEBSITE
  • DISCLAIMER

CHAPTER 2 SUMMARY

  • SUMMARY TABLE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
  • SUMMARY FIGURE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)

CHAPTER 3 OVERVIEW

  • TERMINOLOGY
    • CELL CULTURE
    • CULTURE MEDIA
    • CELL LINE
    • PROKARYOTES
    • EUKARYOTES
    • SUBCULTURE
    • OSMOLALITY
    • ZWITTERION
    • ANEUPLOIDY
    • HETEROPLOIDY
    • MONOLAYER SLOUGHING
    • SERUM
    • HOMEOSTASIS
    • PROTEOLYSIS
    • PHOSPHORYLATION
    • MUTAGENESIS
    • CARCINOGENESIS
    • TUMOROGENICITY
  • HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
  • TABLE 1 HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
  • TYPES OF CELL CULTURE
    • PRIMARY CELL CULTURE
    • TABLE 2 ADHERENT VERSUS SUSPENSION CULTURE
    • TABLE 3 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL CULTURE
    • SECONDARY CELL CULTURES
  • CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES
  • MORPHOLOGY OF CELLS IN CULTURE
  • QUALITY CONTROL CONSIDERATIONS IN CELL CULTURE
    • QUALITY OF REAGENTS AND MATERIALS USED
    • PLACE OF ORIGIN AND INTEGRITY OF CELL LINES
    • MICROBIAL CONTAMINATION
    • ENVIRONMENTAL MONITORING
  • FACTORS AFFECTING CELL CULTURE
    • TEMPERATURE
    • PH
    • OSMOLALITY
    • CARBON DIOXIDE (CO2)
    • HUMIDITY
    • CONCENTRATION OF THE NUTRIENTS
  • PROBLEMS ARISING DURING CELL CULTURE
  • BASIC REQUIREMENTS OF CELL CULTURE
    • CELL CULTURE MEDIA
      • Basal Media
      • Reduced-Serum Media
      • Serum-Free Media
      • TABLE 4 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE MEDIA
    • BASIC CONSTITUENTS OF CULTURE MEDIA
      • Buffering Systems
      • Phenol Red
      • Inorganic Salt
      • TABLE 5 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS
      • Amino Acids
      • Carbohydrates
      • Proteins and Peptides
      • Fatty Acids and Lipids
      • Vitamins
      • Trace Elements
      • Media Supplements
      • Antibiotics
      • Serum
      • TABLE 6 ADVANTAGES AND DISADVANTAGES OF SERUM
    • TYPES OF CELL CULTURE MEDIA FOR ANIMAL CELL CULTURE
      • Natural Media
      • Artificial Media
        • Serum-free Media
        • Protein-free Media
        • Chemically Defined Media
        • TABLE 7 TYPES OF MEDIA USED FOR ANIMAL CELL CULTURE
    • SERUM
      • Risks Associated with the Use of Serum
      • Sources of Serum
    • CELL CULTURE REAGENTS
      • Cell Dissociation Reagents
      • Other Reagents
        • Antibiotics
        • TABLE 8 COMMONLY USED ANTIBIOTICS
        • Amino Acids
        • Other Growth Supplements
          • Zinc
          • Transferrin
          • Hydrolysates
  • APPLICATIONS OF CELL CULTURE
    • MODEL SYSTEM
    • CANCER RESEARCH
    • VIROLOGY
    • TOXICITY TESTING
    • VACCINE PRODUCTION
    • TABLE 9 CULTURE MEDIA USED IN VARIOUS VACCINES
    • THERAPEUTIC PROTEIN
    • TABLE 10 THERAPEUTIC PROTEINS MADE BY CELL CULTURE
    • REPLACEMENT TISSUE OR ORGAN
    • GENETIC COUNSELING
    • PRENATAL DIAGNOSTICS
    • GENETIC ENGINEERING
    • GENE THERAPY
    • DRUG SCREENING AND DEVELOPMENT

CHAPTER 4 REGULATORY ASPECTS

  • BIOLOGICAL LICENSE APPLICATION
  • TABLE 11 APPROVALS OF BIOLOGICAL LICENSE APPLICATION, 2010-NOVEMBER 2014
  • BIOLOGICS ADMINISTRATIVE ACTIONS
  • TABLE 12 BIOLOGICAL ADMINISTRATIVE ACTIONS AGAINST HCT/P MANUFACTURERS, 2010-NOVEMBER 2014
  • RECALLS
  • TABLE 13 RECALLS, 2010-NOVEMBER 2014
  • OTHER REGULATORY ISSUES 48

CHAPTER 5 NEW DEVELOPMENTS

  • TABLE 14 NEW DEVELOPMENTS IN CELL CULTURE INDUSTRY, JANUARY 2010-OCTOBER 2014
  • NEW DEVELOPMENTS IN CELL CULTURE APPLICATION
  • TABLE 15 NEW DEVELOPMENTS IN APPLICATION OF CELL CULTURE

CHAPTER 6 MARKET ANALYSIS

  • TABLE 16 GLOBAL MARKET FOR CELL CULTURE, THROUGH 2019 ($ MILLIONS)
  • FIGURE 1 GLOBAL MARKET FOR CELL CULTURE, 2012-2019 ($ MILLIONS)
  • MEDIA
    • MARKET OVERVIE
    • MARKET REVENUE
    • TABLE 17 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)
    • MARKET SHARES
    • TABLE 18 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
    • FIGURE 3 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
    • SERUM-REQUIRING AND SERUM-FREE MEDIA
      • Serum-Free Media Market Revenue
      • TABLE 19 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, THROUGH 2019 ($ MILLIONS)
      • FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
      • Serum-Requiring Media Market Revenue
      • TABLE 20 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • POWDERED AND LIQUID MEDIA
    • Powdered Media Market Revenue
    • TABLE 21 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
    • Liquid Media Market Revenue
    • TABLE 22 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • CLASSICAL AND SPECIALTY MEDIA
    • Classical Media Market Revenue
    • TABLE 23 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • Specialty Media Market Revenue
    • TABLE 24 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • SERA
    • MARKET OVERVIEW
    • MARKET REVENUE
    • TABLE 25 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 10 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • MARKET SHARES
    • TABLE 26 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
    • FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
    • BOVINE SERA OR FETAL BOVINE SERA
      • Market Overview
      • Market Revenue
      • TABLE 27 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 12 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • OTHER SERA
      • Market Overview
      • Market Revenue
      • TABLE 28 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 13 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • REAGENTS
    • MARKET OVERVIEW
    • MARKET REVENUE
    • TABLE 29 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, 2012-2019 ($ MILLIONS)
    • MARKET SHARES
    • TABLE 30 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
    • FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
    • BIOLOGICAL RESPONSE MODIFIERS
      • Market Revenue
      • TABLE 31 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • GROWTH FACTORS MARKET REVENUE
    • TABLE 32 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • CYTOKINES MARKET REVENUE
    • TABLE 33 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 18 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, 2012- 2019 ($ MILLIONS)
    • OTHER BIOLOGICAL RESPONSE MODIFIERS MARKET REVENUE
    • TABLE 34 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
    • FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • CELL DISSOCIATION REAGENTS
      • Market Revenue
      • TABLE 35 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
    • OTHER REAGENTS
      • Market Revenue
      • TABLE 36 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
      • FIGURE 21 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)

CHAPTER 7 LEADING MANUFACTURERS IN THE INDUSTRY AND THEIR PRODUCTS

  • MEDIA MANUFACTURERS/SUPPLIERS
  • TABLE 37 LEADING MANUFACTURERS OF MEDIA
  • SERA MANUFACTURERS/SUPPLIERS
  • TABLE 38 LEADING MANUFACTURERS OF SERA
  • REAGENTS MANUFACTURERS/SUPPLIERS
  • BIOLOGICAL RESPONSE MODIFIERS
  • TABLE 39 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE MODIFIERS
  • CELL DISSOCIATION REAGENTS
  • TABLE 40 LEADING MANUFACTURERS OF CELL DISSOCIATION REAGENTS
  • ANTIBIOTICS AND ANTIMYCOTICS
  • TABLE 41 LEADING MANUFACTURERS OF ANTIBIOTICS AND ANTIMYCOTICS USED IN CELL CULTURE
  • OTHER REAGENTS
  • TABLE 42 LEADING MANUFACTURERS OF OTHER REAGENTS
  • INDUSTRY STRUCTURE IN 2013 WITH MARKET SHARES
    • MEDIA
      • Serum-Free Media
      • TABLE 43 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
      • FIGURE 22 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
      • Serum-Requiring/Containing Media
      • TABLE 44 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
      • FIGURE 23 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
      • Powdered Media
      • TABLE 45 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
      • FIGURE 24 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
      • Liquid Media
      • TABLE 46 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
      • FIGURE 25 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
      • Classical Media
      • TABLE 47 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
      • FIGURE 26 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
      • Specialty Media
      • TABLE 48 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
      • FIGURE 27 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
    • SERA
      • Bovine Sera
      • TABLE 49 MARKET SHARES OF BOVINE SERA, 2013 (%)
      • FIGURE 28 MARKET SHARES OF BOVINE SERA, 2013 (%)
      • Other Sera
      • TABLE 50 MARKET SHARES OF OTHER SERA, 2013 (%)
      • FIGURE 29 MARKET SHARES OF OTHER SERA, 2013 (%)
      • REAGENTS
      • Biological Response Modifiers
      • TABLE 51 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
      • FIGURE 30 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
      • Cell Dissociation Reagents
      • TABLE 52 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
      • FIGURE 31 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
      • Other Reagents
      • TABLE 53 MARKET SHARES OF OTHER REAGENTS, 2013 (%)
      • FIGURE 32 MARKET SHARES OF OTHER REAGENTS, 2013 (%)

CHAPTER 8 MARKET BY END USERS

  • TABLE 54 MEDIA, SERA AND REAGENT MARKET BY SEGMENT, THROUGH 2019 ($ MILLIONS)
  • FIGURE 33 MEDIA, SERA AND REAGENT MARKET BY END SEGMENT, THROUGH 2019 ($ MILLIONS)
  • MARKET SHARE
  • TABLE 55 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
  • FIGURE 34 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
  • RESEARCH SEGMENT
    • MARKET REVENUE
    • TABLE 56 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($MILLIONS)
    • FIGURE 35 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($ MILLIONS)
  • PRODUCTION SEGMENT
  • TABLE 57 PROTEIN DRUGS MADE BY CELL CULTURE
    • MARKET REVENUE
    • TABLE 58 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, THROUGH 2019 ($ MILLIONS)
    • FIGURE 36 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2012-2019 ($ MILLIONS)
  • CONTRACT SEGMENT
    • MARKET REVENUE
    • TABLE 59 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, THROUGH 2019 ($ MILLIONS)
    • FIGURE 37 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2012-2019 ($ MILLIONS)
  • OTHERS SEGMENT
    • MARKET REVENUE
    • TABLE 60 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, THROUGH 2019 ($MILLIONS)
    • FIGURE 38 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, 2012-2019 ($ MILLIONS)

CHAPTER 9 PATENT ANALYSIS

  • PATENTS BY YEAR
  • TABLE 61 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
  • FIGURE 39 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
  • PATENTS BY TYPE
  • TABLE 62 PATENTS BY TYPE, 2011-OCTOBER 2014
  • FIGURE 40 PATENTS BY TYPE, 2011-OCTOBER 2014
  • TABLE 63 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (NO./%)
  • FIGURE 41 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (%)
  • PATENTS BY COMPANY
  • TABLE 64 PATENTS BY COMPANY, 2011-OCTOBER 2014
  • PATENTS BY COUNTRY
  • TABLE 65 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
  • FIGURE 42 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
  • TABLE 66 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NO./%)
  • FIGURE 43 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NUMBER OF PATENTS)
  • PATENTS BY ASSIGNEE
  • TABLE 67 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)
  • FIGURE 44 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)

CHAPTER 10 CURRENT SITUATION

  • TRENDS AND ISSUES IN CELL CULTURE MARKET
    • GLOBAL ECONOMY
    • INCREASED RESEARCH AND DEVELOPMENT BUDGET
    • TABLE 68 R &D BUDGETS OF TOP 10 COMPANIES IN 2013 ($ MILLIONS)
    • GROWING DEMAND AND RICH PIPELINE OF BIOTHERAPEUTICS
    • LIFESTYLE CHANGES
    • INCREASED EMPHASIS ON CELL-CULTURE-BASED VACCINES
    • BIOMEDICAL RESEARCH
    • STEM CELL RESEARCH
    • GOVERNMENT POLICIES ON RESEARCH
    • INNOVATIONS
    • ETHICAL AND ANIMAL WELFARE ISSUES
    • REGULATORY ISSUES
    • MERGERS, ACQUISITIONS AND ALLIANCES
    • CONTRACT MANUFACTURING

CHAPTER 11 COMPANY PROFILES

  • ADVANCED BIOTECHNOLOGIES INC.
  • AFFYMETRIX
  • AKORN BIOTECHNOLOGY LLC
  • AMRESCO LLC
  • ATLANTA BIOLOGICALS INC.
  • ATHENA ENVIRONMENTAL SCIENCES INC.
  • BD BIOSCIENCES
  • BIO RECLAMATION INC.
  • BOVOGEN BIOLOGICALS
  • CELL APPLICATIONS INC.
  • CELL CULTURE TECHNOLOGIES
  • CIASSON LABORATORIES
  • CLONETECH LABORATORIES INC.
  • CORNING INC.
  • EMD MILLIPORE
  • EQUITECH BIO INC.
  • GEMINI BIO PRODUCTS
  • GE HEALTHCARE LIFE SCIENCES
  • GENEX INDIA BIOSCIENCE PVT. LTD.
  • HIMEDIA LABORATORIES
  • IRVINE SCIENTIFIC
  • J R SCIENTIFIC INC.
  • KRISHGEN BIOSYSTEMS
  • LABMATE (ASIA) PVT. LTD.
  • LONZA GROUP LTD
  • MEDIATECH INC.
  • MEDOX BIOTECH INDIA PVT. LTD.
  • MP BIOMEDICALS
  • PEPROTECH INC.
  • PROMOCELL GMBH
  • QUALITY BIOLOGICAL INC.
  • R AND D SYSTEMS
  • REPROCELL INC.
  • ROCHE DIAGNOSTICS CORP.
  • SARTORIUS AG
  • SERA LABORATORIES INTERNATIONAL LTD.
  • SIGMA ALRICH
  • STEM CELLS INC.
  • STEMCELL TECHNOLOGIES INC.
  • THERMOFISHER SCIENTIFIC INC.
  • TICO EUROPE
  • VALLEY BIOMEDICAL
  • ZELLE BIOTECHNOLOGY PVT. LTD.
  • ZENBIO INC.

CHAPTER 12 APPENDIX I-ABBREVIATIONS

  • ABBREVIATIONS

LIST OF TABLES

  • SUMMARY TABLE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 1 HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
  • TABLE 2 ADHERENT VERSUS SUSPENSION CULTURE
  • TABLE 3 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL CULTURE
  • TABLE 4 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE MEDIA
  • TABLE 5 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS
  • TABLE 6 ADVANTAGES AND DISADVANTAGES OF SERUM
  • TABLE 7 TYPES OF MEDIA USED FOR ANIMAL CELL CULTURE
  • TABLE 8 COMMONLY USED ANTIBIOTICS
  • TABLE 9 CULTURE MEDIA USED IN VARIOUS VACCINES
  • TABLE 10 THERAPEUTIC PROTEINS MADE BY CELL CULTURE
  • TABLE 11 APPROVALS OF BIOLOGICAL LICENSE APPLICATION, 2010-NOVEMBER 2014
  • TABLE 12 BIOLOGICAL ADMINISTRATIVE ACTIONS AGAINST HCT/P MANUFACTURERS, 2010-NOVEMBER 2014
  • TABLE 13 RECALLS, 2010-NOVEMBER 2014
  • TABLE 14 NEW DEVELOPMENTS IN CELL CULTURE INDUSTRY, JANUARY 2010-OCTOBER 2014
  • TABLE 15 NEW DEVELOPMENTS IN APPLICATION OF CELL CULTURE
  • TABLE 16 GLOBAL MARKET FOR CELL CULTURE, THROUGH 2019 ($ MILLIONS)
  • TABLE 17 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 18 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
  • TABLE 19 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, THROUGH 2019 ($ MILLIONS)
  • TABLE 20 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 21 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 22 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 23 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 24 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 25 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 26 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
  • TABLE 27 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 28 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 29 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 30 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
  • TABLE 31 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 32 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 33 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 34 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 35 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 36 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
  • TABLE 37 LEADING MANUFACTURERS OF MEDIA
  • TABLE 38 LEADING MANUFACTURERS OF SERA
  • TABLE 39 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE MODIFIERS
  • TABLE 40 LEADING MANUFACTURERS OF CELL DISSOCIATION REAGENTS
  • TABLE 41 LEADING MANUFACTURERS OF ANTIBIOTICS AND ANTIMYCOTICS USED IN CELL CULTURE
  • TABLE 42 LEADING MANUFACTURERS OF OTHER REAGENTS
  • TABLE 43 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
  • TABLE 44 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
  • TABLE 45 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
  • TABLE 46 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
  • TABLE 47 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
  • TABLE 48 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
  • TABLE 49 MARKET SHARES OF BOVINE SERA, 2013 (%)
  • TABLE 50 MARKET SHARES OF OTHER SERA, 2013 (%)
  • TABLE 51 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
  • TABLE 52 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
  • TABLE 53 MARKET SHARES OF OTHER REAGENTS, 2013 (%)
  • TABLE 54 MEDIA, SERA AND REAGENT MARKET BY SEGMENT, THROUGH 2019 ($ MILLIONS)
  • TABLE 55 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
  • TABLE 56 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($MILLIONS)
  • TABLE 57 PROTEIN DRUGS MADE BY CELL CULTURE
  • TABLE 58 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, THROUGH 2019 ($ MILLIONS)
  • TABLE 59 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, THROUGH 2019 ($ MILLIONS)
  • TABLE 60 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, THROUGH 2019 ($MILLIONS)
  • TABLE 61 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
  • TABLE 62 PATENTS BY TYPE, 2011-OCTOBER 2014
  • TABLE 63 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (NO./%)
  • TABLE 64 PATENTS BY COMPANY, 2011-OCTOBER 2014
  • TABLE 65 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
  • TABLE 66 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NO./%)
  • TABLE 67 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)
  • TABLE 68 R &D BUDGETS OF TOP 10 COMPANIES IN 2013 ($ MILLIONS)

LIST OF FIGURES

  • SUMMARY FIGURE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 1 GLOBAL MARKET FOR CELL CULTURE, 2012-2019 ($ MILLIONS)
  • FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 3 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
  • FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
  • FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
  • FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 10 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
  • FIGURE 12 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 13 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
  • FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 18 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, 2012- 2019 ($ MILLIONS)
  • FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 21 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
  • FIGURE 22 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
  • FIGURE 23 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
  • FIGURE 24 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
  • FIGURE 25 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
  • FIGURE 26 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
  • FIGURE 27 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
  • FIGURE 28 MARKET SHARES OF BOVINE SERA, 2013 (%)
  • FIGURE 29 MARKET SHARES OF OTHER SERA, 2013 (%)
  • FIGURE 30 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
  • FIGURE 31 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
  • FIGURE 32 MARKET SHARES OF OTHER REAGENTS, 2013 (%)
  • FIGURE 33 MEDIA, SERA AND REAGENT MARKET BY END SEGMENT, THROUGH 2019 ($ MILLIONS)
  • FIGURE 34 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
  • FIGURE 35 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($ MILLIONS)
  • FIGURE 36 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2012-2019 ($ MILLIONS)
  • FIGURE 37 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2012-2019 ($ MILLIONS)
  • FIGURE 38 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, 2012-2019 ($ MILLIONS)
  • FIGURE 39 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
  • FIGURE 40 PATENTS BY TYPE, 2011-OCTOBER 2014
  • FIGURE 41 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (%)
  • FIGURE 42 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
  • FIGURE 43 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NUMBER OF PATENTS)
  • FIGURE 44 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)
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