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Kinase Inhibitors: Global Markets -- Focus on Asia

The global kinase inhibitors market reached $28.1 billion in 2010 and nearly $29.1 billion in 2011. The market is expected to reach $40.2 billion by 2016, a compound annual growth rate (CAGR) of 6.7%.

The Asian market for kinase inhibitors reached $5.2 billion in 2010 and came down to $5.0 billion in 2011. The market is expected to decrease to $8.5 billion by 2016, a CAGR of 11.0%.

The antibody segment in Asia reached $3.4 billion in 2010 and came down to $3.0 billion in 2011. The segment is expected to reach $4.6 billion by 2016, a CAGR of 9.1%.

SUMMARY FIGURE
GLOBAL REVENUE OF KINASE INHIBITORS MARKET, 2009-2016
($ MILLIONS)

Source: BCC Research

STUDY OBJECTIVES

BCC's goal in conducting this study is to provide an overview of the current and future characteristics of the global market for kinase inhibitors. The key objective is to present a comprehensive analysis and the future direction of kinase inhibitors to provide an important tool for the usage of these types of enzyme inhibitors.

This report explores present and future strategies within the kinase inhibitors market, which includes tyrosine inhibitors, multi-target kinase inhibitors, serine/ threonine inhibitors and monoclonal antibody kinase inhibitors. The direction of the market, its setbacks and the needs of the market are discussed in this report. The classifications, comparisons and usage of these types of enzyme inhibitors are also examined in the report.

A detailed analysis of the kinase inhibitors industry structure has been conducted. Revenues are broken down by region. Sales figures are estimated for the five-year period from 2011 through 2016.

Applications for kinase inhibitors are also discussed separately in the report, with emphasis on the usage of the inhibitors in therapeutic categories and various disease sectors. The report also covers significant patents and a summary of patents awarded in each category.

REASONS FOR DOING THIS STUDY

Extensive research in the field of kinase inhibitors has revealed their target-specific functionality in being able to provide therapeutic treatments for various chronic diseases. Modern industries have now begun to explore the advantages of kinase inhibitors in their productions and processes. This has led to the steady market for them.

R&D spending along with increasing competition, patent expiries and new technologies are directing kinase inhibitors to new directions. The new advancements, new product launches and the changing lifestyle have influenced the market to grow in the foreseeable future. This study looks at almost all the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strengths and weaknesses of each type/ technology in light of the new technologies, growing competition and changing customer needs.

ABOUT THE AUTHOR

A team of professionals in the biotechnology industry carried out this study. The project manager is Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has over 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S.

Table of Contents

Kinase Inhibitors: Global Markets -- Focus on Asia

Chapter - 1: INTRODUCTION - Complimentary

  • STUDY OBJECTIVES
  • REASONS FOR DOING THIS STUDY
  • INTENDED AUDIENCE
  • SCOPE OF THE STUDY
  • METHODOLOGY
  • INFORMATION SOURCES
  • ABOUT THE AUTHOR
  • RELATED BCC RESEARCH REPORTS
  • BCC ONLINE SERVICES
  • DISCLAIMER

Chapter - 2: SUMMARY

  • Table Summary: GLOBAL REVENUE OF KINASE INHIBITORS MARKET, THROUGH 2016
  • Figure Summary: GLOBAL REVENUE OF KINASE INHIBITORS MARKET, 2009-2016

Chapter - 3: OVERVIEW

  • DEFINITIONS
  • ENZYME INHIBITORS
  • KINASE INHIBITORS
  • CLASSIFICATION BY TYPES OF AMINO ACID PHOSPHORYLATION
  • CLASSIFICATION BY SITE OF ACTION

Chapter - 4: REGULATORY ASPECTS

  • MARKET LEADERS AND THEIR PRODUCTS FOR KINASE INHIBITORS
    • Table 13: LEADING MANUFACTURERS AND SUPPLIERS OF RECEPTOR TYROSINE KINASE INHIBITORS
    • Table 14: LEADING MANUFACTURERS AND SUPPLIERS OF NON-RECEPTOR TYROSINE KINASE INHIBITORS
    • Table 15: LEADING MANUFACTURERS AND SUPPLIERS OF MULTI-TARGET TYROSINE KINASE INHIBITORS
    • Table 16: LEADING MANUFACTURERS AND SUPPLIERS OF SERINE AND THREONINE KINASE INHIBITORS
    • Table 17: LEADING MANUFACTURERS AND SUPPLIERS OF ANTIBODY KINASE INHIBITORS

Chapter - 5: NEW DEVELOPMENTS

  • (RECEPTOR) TYROSINE KINASE INHIBITORS (TKIS)
  • (NON-RECEPTOR) TYROSINE KINASE INHIBITORS (TKIS)
  • MULTIKINASE INHIBITORS
  • SERINE/THREONINE KINASE INHIBITOR
  • OTHER KINASE INHIBITOR PRODUCTS UNDER DEVELOPMENT
    • Table 18: CLINICAL TRIALS IN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TKIS
    • Table 19: CLINICAL TRIALS IN HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) TKIS
    • Table 20: CLINICAL TRIALS IN PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) TKIS
    • Table 21: CLINICAL TRIALS IN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (VEGFR) TKIS

Chapter - 6: GLOBAL MARKETS

  • MARKET ANALYSIS
  • MARKET SHARE
  • MARKET BY APPLICATIONS
    • Table 29: GLOBAL MARKET FOR KINASE INHIBITORS, THROUGH 2016
    • Figure 1: GLOBAL MARKET FOR KINASE INHIBITORS, 2009-2016

Chapter - 7: MARKETS IN ASIA

  • MARKET ANALYSIS
  • MARKET SHARE OF INDUSTRY LEADERS IN ASIA
  • MARKET APPLICATIONS
    • Table 45: ASIAN MARKET FOR KINASE INHIBITORS, THROUGH 2016
    • Figure 17: ASIAN MARKET FOR KINASE INHIBITORS, 2009-2016

Chapter - 8: PATENT ANALYSIS

  • PATENTS BY YEAR
  • PATENTS BY CATEGORY
  • PATENTS BY TYPE
  • PATENTS BY COMPANY
  • PATENTS BY COUNTRY
  • PATENTS BY ASSIGNEE
    • Table 61: NUMBER OF SIGNIFICANT PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012
    • Figure 32: NUMBER OF PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012
    • Figure 33: NUMBER OF PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012

Chapter - 9: CURRENT STATUS

  • CANCER AND KINASE INHIBITORS
  • MULTIPLE SINGLE KINASE INHIBITORS VERSUS SINGLE MULTIKINASE INHIBITORS
  • FUTURE DIRECTIONS

Chapter - 10: COMPANY PROFILES

  • ABBOTT LABORATORIES
  • AMGEN INC.
  • ARQULE, INC.
  • ARRAY BIOPHARMA
  • ASTRAZENECA
  • AVEO PHARMACEUTICALS, INC.
  • BAYER AG
  • BRISTOL-MYERS SQUIBB
  • BOEHRINGER INGELHEIM
  • CYTRX CORPORATION
  • EISAI INC
  • ETON BIOSCIENCE, INC.
  • EXELIXIS, INC.
  • GLAXOSMITHKLINE
  • MERCK SERONO SA
  • NOVARTIS INTERNATIONAL AG
  • OSI PHARMACEUTICALS LLC
  • PFIZER
  • ROCHE GROUP
  • S*BIO PTE LTD
  • SANOFI-AVENTIS
  • TAKEDA PHARMACEUTICALS

Chapter - 11: ABBREVIATIONS

List of Tables

  • Summary Table: GLOBAL REVENUE OF KINASE INHIBITORS MARKET, THROUGH 2016
  • Table 1: CLASSIFICATION OF ENZYME INHIBITORS
  • Table 2: HISTORY OF PROTEIN KINASES
  • Table 3: TYPES OF KINASE INHIBITORS
  • Table 4: ATP COMPETITIVE AND NON-COMPETITIVE INHIBITORS
  • Table 5: TYPES OF SERINE/THREONINE KINASE INHIBITORS
  • Table 6: TYPES OF RECEPTOR TYROSINE KINASE INHIBITORS
  • Table 7: TYPES OF NON-RECEPTOR TYROSINE KINASE INHIBITORS
  • Table 8: CLASSIFICATION OF KINASE INHIBITORS BY SITE OF ACTION
  • Table 9: FDA-APPROVED KINASE INHIBITORS, 2008 TO FEBRUARY 2012
  • Table 10: EMA-APPROVED KINASE INHIBITORS 2008 TO FEBRUARY 2012
  • Table 11: SAFETY ALERTS AND WARNINGS FOR KINASE INHIBITORS 2008 TO FEBRUARY 2012
  • Table 12: NEW DRUG APPLICATIONS OF KINASE INHIBITORS
  • Table 13: LEADING MANUFACTURERS AND SUPPLIERS OF RECEPTOR TYROSINE KINASE INHIBITORS
  • Table 14: LEADING MANUFACTURERS AND SUPPLIERS OF NON-RECEPTOR TYROSINE KINASE INHIBITORS
  • Table 15: LEADING MANUFACTURERS AND SUPPLIERS OF MULTI-TARGET TYROSINE KINASE INHIBITORS
  • Table 16: LEADING MANUFACTURERS AND SUPPLIERS OF SERINE AND THREONINE KINASE INHIBITORS
  • Table 17: LEADING MANUFACTURERS AND SUPPLIERS OF ANTIBODY KINASE INHIBITORS
  • Table 18: CLINICAL TRIALS IN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TKIS
  • Table 19: CLINICAL TRIALS IN HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) TKIS
  • Table 20: CLINICAL TRIALS IN PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) TKIS
  • Table 21: CLINICAL TRIALS IN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (VEGFR) TKIS
  • Table 22: CLINICAL TRIALS IN BCR-ABL TYROSINE KINASE INHIBITORS
  • Table 23: CLINICAL TRIALS IN JANUS KINASE (JAK) INHIBITORS
  • Table 24: CLINICAL TRIALS IN SPLEEN TYROSINE KINASE (SYK) INHIBITORS
  • Table 25: CLINICAL TRIALS IN MULTIKINASE INHIBITORS
  • Table 26: CLINICAL TRIALS IN B-RAF KINASE INHIBITORS
  • Table 27: CLINICAL TRIALS IN MAP/MEK INHIBITORS
  • Table 28: CLINICAL TRIALS IN PI3K INHIBITORS
  • Table 29: GLOBAL MARKET FOR KINASE INHIBITORS, THROUGH 2016
  • Table 30: GLOBAL MARKET FOR TYROSINE KINASE INHIBITORS THROUGH 2016
  • Table 31: GLOBAL MARKET FOR RECEPTOR TYROSINE KINASE INHIBITOR THROUGH 2016
  • Table 32: GLOBAL MARKET FOR NON-RECEPTOR TYROSINE KINASE INHIBITOR THROUGH 2016
  • Table 33: GLOBAL MARKET FOR MULTIKINASE TYROSINE INHIBITOR THROUGH 2016
  • Table 34: GLOBAL MARKET FOR SERINE/THREONINE KINASE INHIBITOR THROUGH 2016
  • Table 35: GLOBAL MARKET FOR MONOCLONAL ANTIBODY KINASE INHIBITOR, THROUGH 2016
  • Table 36: RECEPTOR TYROSINE KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Table 37: MULTI-TARGET KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Table 38: SERINE/THREONINE KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Table 39: MONOCLONAL ANTIBODY KINASE INHIBITOR MARKET SHARES BY REGION, 2010
  • Table 40: GLOBAL MARKET FOR KINASE INHIBITORS BY APPLICATIONS, THROUGH 2016
  • Table 41: GLOBAL MARKET FOR KINASE INHIBITORS USED AS ANTINEOPLASTIC AGENTS, THROUGH 2016
  • Table 42: GLOBAL MARKET FOR KINASE INHIBITORS USED AS IMMUNOSUPPRESSANTS, THROUGH 2016
  • Table 43: GLOBAL MARKET FOR KINASE INHIBITORS USED IN AGE-RELATED MACULAR DEGENERATION, THROUGH 2016
  • Table 44: GLOBAL MARKET SHARE OF APPLICATIONS OF KINASE INHIBITORS, 2010
  • Table 45: ASIAN MARKET FOR KINASE INHIBITORS, THROUGH 2016
  • Table 46: ASIAN MARKET FOR TYROSINE KINASE INHIBITORS, THROUGH 2016
  • Table 47: ASIAN MARKET FOR RECEPTOR TYROSINE KINASE INHIBITOR, THROUGH 2016
  • Table 48: ASIAN MARKET FOR NON-RECEPTOR TYROSINE KINASE INHIBITORS, THROUGH 2016
  • Table 49: ASIAN MARKET FOR MULTIKINASE TYROSINE KINASE INHIBITORS, THROUGH 2016
  • Table 50: ASIAN MARKET FOR SERINE/THREONINE KINASE INHIBITORS THROUGH 2016
  • Table 51: ASIAN MARKET FOR MONOCLONAL ANTIBODY KINASE INHIBITORS, THROUGH 2016
  • Table 52: ASIAN MARKET SHARE OF RECEPTOR TYROSINE KINASE INHIBITOR MANUFACTURERS, 2010
  • Table 53: ASIAN MARKET SHARE OF MULTI-TARGET KINASE INHIBITOR MANUFACTURERS, 2010
  • Table 54: ASIAN MARKET SHARE OF SERINE/THREONINE KINASE INHIBITOR MANUFACTURERS, 2010
  • Table 55: ASIAN MARKET SHARE OF ANTIBODY KINASE INHIBITOR MANUFACTURERS, 2010
  • Table 56: ASIAN MARKET FOR KINASE INHIBITORS BY APPLICATIONS THROUGH 2016
  • Table 57: ASIAN MARKET FOR KINASE INHIBITORS USED AS ANTINEOPLASTIC AGENTS, THROUGH 2016
  • Table 58: ASIAN MARKET FOR KINASE INHIBITORS USED AS IMMUNOSUPPRESSANTS, THROUGH 2016
  • Table 59: ASIAN MARKET FOR KINASE INHIBITORS USED IN AGE-RELATED MACULAR DEGENERATION, THROUGH 2016
  • Table 60: MARKET SHARE OF KINASE INHIBITORS IN ASIA, BY APPLICATION, 2010
  • Table 61: NUMBER OF SIGNIFICANT PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012
  • Table 62: PATENTS BY CATEGORY FOR KINASE INHIBITORS 2008 TO END OF FEBRUARY 2012
  • Table 63: PATENTS BY TYPE FOR TYROSINE KINASE INHIBITORS 2008 TO END OF FEBRUARY 2012
  • Table 64: PATENTS BY TYPE FOR SERINE/THREONINE KINASE INHIBITORS, 2008 TO END OF FEBRUARY 2012
  • Table 65: NUMBER OF U.S. PATENTS BY COMPANY FOR INDUSTRIAL ENZYMES, 2008 TO END OF FEBRUARY 2012
  • Table 66: NUMBER OF U.S. PATENTS BY COUNTRY FOR KINASE INHIBITORS, 2008 TO END OF FEBRUARY 2012
  • Table 67: PATENT SHARE BY COUNTRY FOR KINASE INHIBITORS, 2010-2012
  • Table 68: PATENTS BY ASSIGNEE FOR KINASE INHIBITORS, 2008 THROUGH END OF FEBRUARY 2012

List of Figures

  • Summary Figure: GLOBAL REVENUE OF KINASE INHIBITORS MARKET, 2009-2016
  • Figure 1: GLOBAL MARKET FOR KINASE INHIBITORS, 2009-2016
  • Figure 2: GLOBAL MARKET FOR TYROSINE KINASE INHIBITORS 2009-2016
  • Figure 3: GLOBAL MARKET FOR RECEPTOR TYROSINE KINASE INHIBITOR, 2009-2016
  • Figure 4: GLOBAL MARKET FOR NON-RECEPTOR TYROSINE KINASE INHIBITOR, 2009-2016
  • Figure 5: GLOBAL MARKET FOR MULTIKINASE TYROSINE INHIBITOR, 2009-2016
  • Figure 6: GLOBAL MARKET FOR SERINE/THREONINE KINASE INHIBITORS, 2009-2016
  • Figure 7: GLOBAL MARKET FOR MONOCLONAL ANTIBODY KINASE INHIBITOR, 2009-2016
  • Figure 8: RECEPTOR TYROSINE KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Figure 9: MULTI-TARGET KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Figure 10: SERINE/THREONINE KINASE INHIBITOR MARKET SHARE BY REGION, 2010
  • Figure 11: MONOCLONAL ANTIBODY KINASE INHIBITOR MARKET SHARES BY REGION, 2010
  • Figure 12: GLOBAL MARKET FOR KINASE INHIBITORS BY APPLICATIONS, 2009-2016
  • Figure 13: GLOBAL MARKET FOR KINASE INHIBITORS USED AS ANTINEOPLASTIC AGENTS, 2009-2016
  • Figure 14: GLOBAL MARKET FOR KINASE INHIBITORS USED AS IMMUNOSUPPRESSANTS, 2009-2016
  • Figure 15: GLOBAL MARKET FOR KINASE INHIBITORS USED IN AGE-RELATED MACULAR DEGENERATION, 2009-2016
  • Figure 16: GLOBAL MARKET SHARE OF APPLICATIONS OF KINASE INHIBITORS, 2010
  • Figure 17: ASIAN MARKET FOR KINASE INHIBITORS, 2009-2016
  • Figure 18: ASIAN MARKET FOR TYROSINE KINASE INHIBITORS, 2009-2016
  • Figure 19: ASIAN MARKET FOR RECEPTOR TYROSINE KINASE INHIBITORS 2009-2016
  • Figure 20: ASIAN MARKET FOR MULTIKINASE KINASE INHIBITORS, 2009-2016
  • Figure 21: ASIAN MARKET FOR SERINE/THREONINE KINASE INHIBITORS, 2009-2016
  • Figure 22: ASIAN MARKET FOR MONOCLONAL ANTIBODY KINASE INHIBITORS, 2009-2016
  • Figure 23: ASIAN MARKET SHARE OF RECEPTOR TYROSINE KINASE INHIBITOR MANUFACTURERS, 2010
  • Figure 24: ASIAN MARKET SHARES OF MULTI-TARGET KINASE INHIBITOR MANUFACTURERS, 2010
  • Figure 25: ASIAN MARKET SHARES OF SERINE/THREONINE KINASE INHIBITOR MANUFACTURERS, 2010
  • Figure 26: ASIAN MARKET SHARES OF ANTIBODY KINASE INHIBITOR MANUFACTURERS, 2010
  • Figure 27: ASIAN MARKET FOR KINASE INHIBITORS BY APPLICATIONS 2009-2016
  • Figure 28: ASIAN MARKET FOR KINASE INHIBITORS USED AS ANTINEOPLASTIC AGENTS, 2009-2016
  • Figure 29: ASIAN MARKET FOR KINASE INHIBITORS USED AS IMMUNOSUPPRESSANTS, 2009-2016
  • Figure 30: ASIAN MARKET FOR KINASE INHIBITORS USED IN AGE-RELATED MACULAR DEGENERATION, 2009-2016
  • Figure 31: MARKET SHARE OF KINASE INHIBITORS IN ASIA, BY APPLICATION, 2010
  • Figure 32: NUMBER OF PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012
  • Figure 33: NUMBER OF PATENTS BY YEAR, 2008 TO END OF FEBRUARY 2012
  • Figure 34: PATENTS BY CATEGORY FOR KINASE INHIBITORS 2008 TO END OF FEBRUARY 2012
  • Figure 35: PATENTS BY TYPE FOR TYROSINE KINASE INHIBITORS 2008 TO END OF FEBRUARY 2012
  • Figure 36: PATENTS BY TYPE FOR SERINE/THREONINE KINASE INHIBITORS, 2008 TO END OF FEBRUARY 2012
  • Figure 37: NUMBER OF U.S. PATENTS BY COUNTRY FOR KINASE INHIBITORS, 2008 TO END OF FEBRUARY 2012
  • Figure 38: PATENT SHARES BY COUNTRY FOR KINASE INHIBITORS, 2010-2012
  • Figure 39: PATENTS BY ASSIGNEE FOR KINASE INHIBITORS, 2008 THROUGH END OF FEBRUARY 2012
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