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Nanoparticles in Biotechnology, Drug Development and Drug Delivery

Abstract

REPORT HIGHLIGHTS

The global market for nanoparticles in biotechnology, drug development and drug delivery was valued at $17.5 billion in 2011 and should reach nearly $21.6 billion in 2012. Total market value is expected to reach $53.5 billion in 2017 after increasing at a five-year compound annual growth rate (CAGR) of 19.9%.

Drug delivery systems are expected to increase from $11.3 billion in 2012 to $30.9 billion in 2017, a CAGR of 22.2%.

Drug development and formulation should total nearly $9.4 billion in 2012 and nearly $20.5 billion in 2017, a CAGR of 16.9%.

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REPORT SCOPE

INTRODUCTION

STUDY GOALS AND OBJECTIVES

This study provides a comprehensive analysis of the market for nanoparticles in the life sciences on a global basis. Particular attention is given to drug development and formulation and the development of new drug delivery systems. Its aim is to provide a range of information, from detailed product analyses within health and wellness subsegments to overall industry trends in order to quantify and qualify the market for drug products for treating various disease conditions in both men and women. The applicability of specific types of nanoparticles for specific applications is discussed.

Forecasts and trends are developed from a cross-reference of data points gleaned from proprietary industry sources, company publications, industry benchmarking and other divergent data sources to arrive at a cogent and coordinated forecast.

REASONS FOR DOING THE STUDY

For companies with an effective strategy, market opportunities await. Importantly, the ability to develop an effective strategy begins with knowing where opportunity exists and ends with a plan to effectively execute in order to capture profit from opportunity.

The nanoparticle drug/delivery market presents an increasingly significant part of the overall pharmaceutical product market worldwide. This study investigates the specific classes of nanoparticles and the pharmaceutical products associated with them. Existing drug products and potential drugs in the pipelines of the major pharmaceutical players in this market are reviewed. Growing health concerns in developing countries are expected to continue to contribute substantially to market growth through the forecast period (2012 through 2017). This report analyzes emerging markets by technology category. Continued growth is expected in emerging geographies driven by the health awareness of the growing middle class in emerging countries such as India, China, Brazil and Russia.

This report seeks to address the critically important topics of analyzing a changing market dynamic, emerging players and products, strategies for accessing emerging markets and awareness of specific disease prevalence and geographies thereof in order to allocate resources and make effective decisions.

SCOPE OF REPORT

Current and projected product forecasts during the forecast period of 2012 through 2017 are discussed. New product launches will be discussed. Revenue figure for 2011 are in an actual figures except where actual results have not been reported due to the timing of this report's release.

The report includes analysis of leading and emerging drug products for each nanoparticle type. Profiles of manufacturers of leading products and their specific products are provided. This report also assesses companies poised to introduce products during the forecast period and discusses how these introductions will change the face of the competitive environment. The competitive environment is examined with a special focus on how new products will alter the quality of life of patients receiving nanoparticle-associated drugs.

Market figures are based on revenues at the manufacturer level and are projected at 2011 dollar value. Inflation is not computed into the projection figures. Trends are assessed based on projected sales for existing products, for new product introductions, expanded markets for existing products and other factors affecting the market.

Included in this report are forecasts by product, product category and by company from 2010 through 2017. The study is arranged to offer an overview of existing nanoparticle technology and of drug markets; it is accompanied by nanoproduct, company, geography, and mechanism of action, with forecasts broken down and covered by geographic region or country.

Patent and clinical trial information is reviewed for various candidate nanodrugs. The status of approvals of drugs in each segment by the FDA and regulatory agencies in other countries is reviewed. Figures are reported in U.S. dollars and in each case reflect currency fluctuations within the performance of revenue change. Revenue figures do not account for variation in local currencies.

All market share data presented is on a global basis unless specifically noted.

INTENDED AUDIENCE

This report is an invaluable tool for business planners, acquisitions specialists, licensing strategists, product managers, market research analysts, investors, investor consultants and anyone interested in the nanoparticle drug market, its products, its industry participants and its future.

The importance of identifying overall market trends, product opportunities, emerging geographies, merger and acquisition (M&A) opportunities and insights that provide guidance for sales growth or defensive moves cannot be overstated for a variety of constituents, including:

Established companies in the industry shall benefit from the contents, including corporate strategy, sales and marketing, business development and R&D.

Emerging players in the segment must understand specific opportunities for out-licensing originating from the elements of differentiation of their product or technology as compared to leading, competitive and emerging products. As well, market forecasts can support investment provided a thorough and detailed substantiation is provided for the market forecast, as is found in this study.

Investment firms evaluating candidates for venture capital or hedged investments will gain insights as to the opportunities and risks that are being encountered in the industry in a product- and company-specific analysis.

Equity analysts are provided detailed forecasts for the next five years, substantiated by quantitative analysis that can support further analysis to product and company forecasts over the short and long run.

METHODOLOGY AND INFORMATION SOURCES

In-depth interviews were conducted with leading experts in the field who are executives in companies, industry analysts, and leading individuals in the field.

The nanoparticle biomedical technology market is comprised of drug products for treatment of an assortment of specific diseases of both men and women. For completeness, the current and forecasted markets are comprised of the total market opportunity for each respective segment. Within each subsection there are detailed forecasts for each driving mechanism or relevant area of growth.

Information to prepare this report was obtained from participating and emerging companies in the nanoparticle area and from the National Institute of Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), a service of Nat. Inst. of Diabetes and Digestive and Kidney Diseases (NIDDK), National Library of Medicine (NLM, NIH). Additional information was obtained from a variety of medical and technical journals in the various specialties of the nanoparticle applications. Other sources include: the New York Times, Wall Street Journal, Washington Post, other newspapers, company documents and other websites. Population estimates are based on those reported by the International database of the U.S. Census Bureau. Statistical data was obtained from the World Health Organization (WHO), National Institute of Health (NIH) and WHO Collaborating Centre for Drug Statistics Methodology (Norway).

Current and historical revenue figures for individual products have been sourced from company disclosures that exist in the public domain or from government sources.

ANALYST CREDENTIALS

Jackson Highsmith is a life sciences research consultant with more than 16 years of research experience. Jackson has been consulting with specialty pharmaceuticals and large pharmaceutical industry players since 2007. Prior to that, he worked at a large research consultancy where he focused on in-depth research; he also has worked at a large pharmaceutical company in a wide range of medical therapeutics in early- and mid-stage drug development.

Table of Contents

Chapter- 1: INTRODUCTION - Complimentary

  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • SCOPE OF REPORT
  • INTENDED AUDIENCE
  • METHODOLOGY AND INFORMATION SOURCES
  • ANALYST CREDENTIALS
  • RELATED BCC REPORTS
  • BCC ON-LINE SERVICES
  • DISCLAIMER

Chapter- 2: SUMMARY

  • Table Summary : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, THROUGH 2017
  • Figure Summary : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, 2010-2017

Chapter- 3: OVERVIEW

  • NANOPARTICLE OVERVIEW
  • BRIEF HISTORY OF NANOPARTICLES
  • NANOPARTICLES IN BIOTECHNOLOGY
  • NANOPARTICLES IN DRUG DEVELOPMENT
  • NANOPARTICLES IN DRUG DELIVERY SYSTEMS
  • NANOPARTICLES IN DIAGNOSTIC IMAGING
  • MAJOR PLAYERS IN NANOPARTICLE DRUG DELIVERY FIELD

Chapter- 4: GLOBAL MARKET FOR NANOPARTICLES IN LIFE SCIENCE

  • GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY
  • GLOBAL MARKET FOR NANOPARTICLES IN DRUG DEVELOPMENT
  • GLOBAL MARKET FOR NANOPARTICLES IN DRUG DELIVERY SYSTEMS
  • GLOBAL MARKET FOR NANOPARTICLES IN DIAGNOSTIC IMAGING
  • Table 9 : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, THROUGH 2017

Chapter- 5: NANOPARTICLES STRUCTURE

  • ADOPTION OF NANOPARTICLES IN APPLIED MARKETS

Chapter- 6: NANOPARTICLE PRODUCTION

  • METHOD OF NANOPARTICLE FORMATION
  • SELF-ASSEMBLY PRODUCTION
  • METHODS OF STABILIZATION
  • METHODS OF DRUG INTRODUCTION
  • METHODS OF LOADING BIOLOGICAL MOLECULES INTO NANOPARTICLES
  • NANOCRYSTAL DRUGS
  • PROBLEM WITH LARGE-SCALE NANOPARTICLE PRODUCTION

Chapter- 7: NANOPARTICLES IN BIOTECHNOLOGY

  • RESEARCH AND DEVELOPMENT
  • STEM CELL RESEARCH
  • CELLULAR REPAIR
  • IN VITRO IMAGING
  • PARAMAGNETIC AND SUPERPARAMAGNETIC NANOPARTICLES
  • BIOSENSORS AND QUANTUM DOTS
  • Table 17 : NANOPARTICLES IN BIOTECHNOLOGY APPLICATIONS

Chapter- 8: NANOPARTICLES IN DRUG DEVELOPMENT AND FORMULATION

  • BIOSEPARATIONS
  • RAPID DRUG ANALYSIS
  • REMOVAL OF IMPURITIES AND TOXINS
  • USING NANOPARTICLES TO INCORPORATE INSOLUBLE DRUGS
  • SCREENING/PROFILING DRUG CANDIDATES
  • COMBINING ANTIBODIES AND DRUGS INTO NANOPARTICLES
  • GOLD AND SILVER NANOPARTICLES IN BIOMEDICINE
  • DNA NANOPARTICLE DEVELOPMENT OF DNA-SPECIFIC DRUGS
  • Table 19 : NANOPARTICLES IN DRUG DEVELOPMENT APPLICATIONS

Chapter- 9: NANOPARTICLES IN DRUG DELIVERY SYSTEMS

  • NANOPARTICLES IN DRUG DELIVERY APPLICATIONS
  • DESIGNING A NANOPARTICLE DRUG DELIVERY SYSTEM
  • NANOPARTICLE DRUG STABILITY
  • SIZE HOMOGENEITY OF NANOPARTICLE PREPARATIONS
  • DRUG LOADING OF NANOPARTICLES
  • DRUG RELEASE FROM NANOPARTICLE
  • EXTERNAL TRIGGERS FOR RELEASING DRUG FROM NANOPARTICLES
  • BINDING/INCORPORATION OF BIOMOLECULES TO NANOPARTICLES
  • NANOPARTICLE TOXICITY
  • LARGE-SCALE MANUFACTURING
  • METHODS OF ADMINISTRATION OF NANOPARTICLE DRUGS
  • NANOPARTICLE DRUG DELIVERY SYSTEM CURRENTLY AVAILABLE
  • REMOVAL OF NANOPARTICLES FROM THE BODY

Chapter- 10: IN VITRO AND IN VIVO DIAGNOSTIC IMAGING

  • IN VITRO IMAGING
  • NANOPARTICLES IN DIAGNOSTIC IMAGING

Chapter- 11: BIOMEDICAL NANOPARTICLE PRODUCTS

  • CURRENT FDA-APPROVED NANOPARTICLE DRUG PRODUCTS
  • MAJOR PLAYERS IN NANOPARTICLE DRUG DELIVERY SYSTEMS
  • COMPANY PIPELINES FOR NANOPARTICLE DRUG DELIVERY
  • DRIVERS OF NANOPARTICLE PRODUCTS AND MARKETING
  • LIMITERS OF NANOPARTICLE PRODUCT DEVELOPMENT AND MARKETING

Chapter- 12: GLOBAL MARKET FOR NANOPARTICLE DRUGS AND DELIVERY SYSTEMS

  • THE GLOBAL MARKET

Chapter- 13: CLINICAL TRIALS OF NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS

  • Table 43 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS
  • Table 44 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS
  • Table 45 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS

Chapter- 14: PATENTS, LICENSING, MERGERS AND ACQUISITIONS

  • NANOPARTICLE PATENTS
  • U.S. PATENTS FOR NANOPARTICLES DRUG DEVELOPMENT
  • U.S. PATENTS FOR NANOPARTICLE DRUG DELIVERY
  • QUANTUM DOT PATENTS
  • Table 46 : MAJOR LICENSING, COLLABORATIVE PARTNERSHIPS AND MERGER AND ACQUISITION ACTIVITIES

Chapter- 15: COMPANY PROFILES

  • ABRAXIS BIOSCIENCES, INC
  • ABRAXIS PHARMACEUTICAL PRODUCTS
  • ACCESS PHARMA, INC.
  • ALNYLAM PHARMACEUTICALS, INC.
  • AMAG PHARMACEUTICALS, INC.
  • APHIOS CORPORATION
  • ASKLEPIOS BIOPHARMACEUTICAL, INC.
  • ASTRAZENECA PHARMACEUTICALS, PLC
  • BIND BIOSCIENCES, INC
  • CERULEAN PHARMA INC.
  • CONVATEC
  • DEBIOTECH, S.A.
  • ELAN PHARMACEUTICALS, INC.
  • FLAMEL TECHNOLOGIES, INC
  • GE GLOBAL RESEARCH
  • MAGFORCE NANOTECHNOLOGIES AG
  • MIV THERAPEUTICS INC.
  • NANOCARRIER CO., LTD.
  • NANO INTERFACE TECHNOLOGY, INC
  • NANOSPHERE, INC.
  • NOVARTIS INTERNATIONAL AG
  • PHARMASOL CORPORATION
  • SKYEPHARMA, PLC
  • STARPHARMA HOLDINGS, LTD
  • TALON THERAPEUTICS, INC.
  • T2 BIOSYSTEMS INC.

List of Tables

  • Summary Table : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, THROUGH 2017
  • Table 1 : DESCRIPTION OF NANOPARTICLES USED IN DRUG DELIVERY AND DIAGNOSTIC IMAGING
  • Table 2 : APPLICATION OF NANOPARTICLES IN BIOTECHNOLOGY
  • Table 3 : APPLICATION OF NANOPARTICLES IN DRUG DEVELOPMENT
  • Table 4 : APPLICATION OF NANOPARTICLES IN DRUG DELIVERY SYSTEMS
  • Table 5 : NANOPARTICLE DRUG DELIVERY SYSTEMS
  • Table 6 : NANOPARTICLES USED FOR IN VIVO DIAGNOSTIC IMAGING
  • Table 7 : MAJOR PLAYERS IN NANOPARTICLE DRUG FIELD
  • Table 8 : MAJOR PLAYER COMPANY REVENUES FOR NANOPARTICLE DRUGS, THROUGH 2017
  • Table 9 : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, THROUGH 2017
  • Table 10 : GLOBAL REVENUES BIOTECHNOLOGY APPLICATIONS OF NANOPARTICLES, THROUGH 2017
  • Table 11 : GLOBAL MARKET FOR NANOPARTICLES IN DRUG DEVELOPMENT AND FORMULATION, THROUGH 2017
  • Table 12 : GLOBAL REVENUES FROM NANOPARTICLES IN DRUG DELIVERY SYSTEMS, THROUGH 2017
  • Table 13 : GLOBAL REVENUES FROM NANOPARTICLES IN DIAGNOSTIC IMAGING SYSTEMS, THROUGH 2017
  • Table 14 : NANOPARTICLE STRUCTURE AND PROPERTIES
  • Table 15 : SAMPLE OF DRUGS DELIVERED THROUGH LIPOSOME NANOTECHNOLOGY
  • Table 16 : APPROVED NANOCRYSTAL DRUGS
  • Table 17 : NANOPARTICLES IN BIOTECHNOLOGY APPLICATIONS
  • Table 18 : NANOBIOSENSOR TECHNOLOGY UNDER DEVELOPMENT
  • Table 19 : NANOPARTICLES IN DRUG DEVELOPMENT APPLICATIONS
  • Table 20 : MONOCLONAL ANTIBODY (MAB) DRUGS WITH POTENTIAL FOR USE IN NANOPARTICLE DELIVERY SYSTEMS
  • Table 21 : SOLID LIPID NANOPARTICLE-REFORMATTED DRUGS
  • Table 22 : NANOPARTICLES IN DRUG DELIVERY APPLICATIONS
  • Table 23 : STANDARD ROUTES OF DRUG ADMINISTRATION
  • Table 24 : NANOPARTICLE TRANSDERMAL PATCH PRODUCTS
  • Table 25 : TYPES OF NANOPARTICLES SUPPLIED IN DRUG DELIVERY SYSTEMS
  • Table 26 : NANOCRYSTAL DRUGS APPROVED BY THE FDA
  • Table 27 : MECHANISMS FOR REMOVAL OF NANOPARTICLES FROM THE BODY
  • Table 28 : NANOPARTICLE CONTRAST MEDIA USED FOR IN VIVO DIAGNOSTIC IMAGING
  • Table 29 : CURRENT FDA-APPROVED NANOPARTICLE DRUG DELIVERY SYSTEMS
  • Table 30 : FDA-APPROVED DRUGS SPECIFICALLY FOR CANCER TREATMENT
  • Table 31 : FDA-APPROVED DRUGS FOR CENTRAL NERVOUS SYSTEM DISEASES
  • Table 32 : MAJOR PLAYERS IN NANOPARTICLE DRUG DEVELOPMENT AND FORMULATION MARKET
  • Table 33 : COMPANY PIPELINE FOR CARDIOVASCULAR NANOPARTICLE DRUGS
  • Table 34 : COMPANY PIPELINE FOR CNS DISEASE NANOPARTICLE DRUGS
  • Table 35 : COMPANY PIPELINE FOR GI DISEASE NANOPARTICLE DRUGS
  • Table 36 : COMPANY PIPELINE FOR INFECTIOUS DISEASE NANOPARTICLE DRUGS
  • Table 37 : COMPANY PIPELINE FOR CANCER NANOPARTICLE DRUGS
  • Table 38 : COMPANY PIPELINE FOR OPHTHALMIC NANOPARTICLE DRUGS
  • Table 39 : COMPANY PIPELINE FOR AUTOIMMUNE DISEASE NANOPARTICLE DRUGS
  • Table 40 : GLOBAL MARKET FOR NANOPARTICLE DRUGS AND DIAGNOSTIC IMAGING, THROUGH 2017
  • Table 41 : GLOBAL MARKET FOR NANOPARTICLE DRUG DEVELOPMENT AND FORMULATION AND DRUG DELIVERY SYSTEMS, THROUGH 2017
  • Table 42 : GLOBAL MARKET FOR DIAGNOSTIC IMAGING AND IN VITRO IMAGING, THROUGH 2017
  • Table 43 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS
  • Table 44 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS
  • Table 45 : CLINICAL TRIALS FOR NANOPARTICLE DRUGS AND DRUG DELIVERY SYSTEMS
  • Table 46 : MAJOR LICENSING, COLLABORATIVE PARTNERSHIPS AND MERGER AND ACQUISITION ACTIVITIES
  • Table 47 : GLOBAL PERCENTAGE SHARE OF PATENTS ISSUED BY GEOGRAPHY, FROM 2008 TO 2011
  • Table 48 : U.S. PATENTS FOR NANOPARTICLE DRUG DEVELOPMENT
  • Table 49 : U.S. PATENTS FOR NANOPARTICLE DRUG DELIVERY
  • Table 50 : U.S. PATENTS FOR QUANTUM DOT TECHNOLOGY APPLIED TO MEDICAL APPLICATIONS

List of Figures

  • Summary Figure : GLOBAL MARKET FOR NANOPARTICLES IN BIOTECHNOLOGY AND PHARMACEUTICALS, 2010-2017
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