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TNF-Alpha Signaling Pathway in Oncology Drug Pipeline Update 2014

The TNF-alfa signaling pathway stimulates the MAPK signaling module and activates NFkB.

There are today 366 companies plus partners developing 550 TNF-alpha pathway targeting drugs in 2048 developmental projects in cancer. In addition, there are 6 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 257 drugs. Tnf-Alpha Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 261 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 257 out of the 259 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 56 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

  • Includes more than 366 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
  • Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

  • Lists commercial, generic and code names for drugs.

Developmental stage

  • This Drug Pipeline Update contains 550 TNF-alpha pathway targeting drugs in development, which have a total of 2048 developmental projects in cancer. In addition there are suspended and ceased drugs.
  • Pipeline Breakdown According to Number of Drugs
  • Marketed# 40
  • Registered# 1
  • Pre-registration# 5
  • Phase III# 67
  • Phase II# 197
  • Phase I# 239
  • Preclinical# 282
  • No Data# 9
  • Suspended# 6
  • Ceased# 257
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

  • Included TNF-alpha pathway targeting drugs are also in development for 230 other indications, where of 146 are different cancer indications.
  • Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

  • Mutations
  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 257 out of the 259 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
  • Biological Structures
  • The identity of available biological structures on 214 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3622 structures available today among drug targets.
  • Identified drugs are linked to more than 261 different targets, divided into 56 classifications of molecular function:
  • Acid phosphatase activity
  • ATPase activity
  • Binding
  • Carboxypeptidase activity
  • Caspase activator activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chromatin binding
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deacetylase activity
  • DNA binding
  • DNA repair protein
  • DNA topoisomerase activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Glutathione transferase activity
  • Growth factor activity
  • GTPase activity
  • Heat shock protein activity
  • Isomerase activity
  • Kinase activity
  • Kinase binding
  • Kinase regulator activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • Molecular function unknown
  • Oxidoreductase activity
  • Peroxidase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein threonine/tyrosine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein tyrosine/serine/threonine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • Serine-type peptidase activity
  • Signal transducer activity
  • Structural constituent of cytoskeleton
  • Structural molecule activity
  • Superoxide dismutase activity
  • Transcription factor activity
  • Transcription regulator activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Unclassified
  • Sub-Cellular Localization
  • Identified targets are categorized into 38 different primary and alternate sub-cellular localizations:
  • Basolateral membrane
  • Cell junction
  • Cell projection
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Extracellular matrix
  • Focal adhesion
  • Golgi apparatus
  • Golgi membrane
  • Immunological synapse
  • Integral to membrane
  • Kinetochore
  • Lysosome
  • Membrane fraction
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleoplasm
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Ribosome
  • Sarcoplasmic reticulum
  • Secreted
  • Synaptic vesicle
  • Vesicle
  • Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

  • Direct links are provided from inside the application to 405 protein expression profiles of 237 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referals

  • Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
  • BioCarta# 251 Pathways
  • KEGG# 171 Pathways
  • NCI-Nature# 254 Pathways
  • NetPath# 32 Pathways
  • Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

  • In total there are different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
  • Presentation of drug name and synonyms

Principal Company & Partners

  • Presentation of principal company and partners

Target and Molecular Function of Target

  • Described target(s) is/are presented with:
  • Official Gene Symbol - Chromosome Location - Gene & Protein Name - Molecular Function

Target Localization

  • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
  • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Mutation

  • All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
  • Biological Structures
  • The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

  • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

  • Drug mechanism of action

Developmental Projects

  • Summary field of developmental projects for the drug, including indication, developmental stage and status.
  • Example:
  • Cancer, myeloma - Phase II Clinical Trial - Active
  • Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

  • Short introduction to drug

Compound Data

  • Compound type, Chemical name, CAS Number and molecular weight

Patent Data

  • Available patent information related to the drug is presented here.

Fillings and Approvals

  • Approvals and submissions
  • Analyst comments
  • Deals & Licensing
  • Collaborations and deals
  • Availability for licensing

Phase IV Data

  • Available Phase IV development data, developmental history and scientific data.

Phase III Data

  • Available Phase III development data, developmental history and scientific data.

Phase II Data

  • Available Phase II development data, developmental history and scientific data.

Phase I Data

  • Available Phase I development data, developmental history and scientific data.

Phase 0 Data

  • Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

  • Available preclinical development data, developmental history and scientific data.

Discovery Data

  • Available discovery development data, developmental history and scientific data.

Application Features

Dynamic Report Generator

System Requirements

  • Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
  • Browser Application (Internet Explorer, Firefox, Chrome, Safari)
  • Internet access (to access related internet resources)
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