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Triple Analysis: Breast Cancer, Melanoma and Pancreatic Cancer

Abstract

This triple analysis focuses on cancer drug development strategies in Breast Cancer, Melanoma and Pancreatic Cancer. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Table of Contents

Key Topics Covered:

Part I: Breast Cancer

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Breast Cancer Drugs for the Highest Therapeutic Outcome and Return on Investment (234 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Breast Cancer Drugs by their Highest Stage of Development (223 Drug Target Strategies and 470 Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Breast Cancer Drugs by Compound Strategy (8 Compound Strategies)
  • 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Breast Cancer Drug Pipeline by Investigator (247 Investigators and 470 Drugs)
  • 10. Disclaimer
  • Figures: Includes 8 Figures
  • Tables: Includes 309 Tables
  • Total Number of Pages: 1,755

Part II: Melanoma

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Melanoma Drugs for the Highest Therapeutic Outcome and Return on Investment (170 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Melanoma Drugs by their Highest Stage of Development (151 Drug Target Strategies and 218 Melanoma Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Melanoma Drugs by Compound Strategy (8 Compound Strategies)
  • 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Melanoma Drug Pipeline by Investigator (138 Companies)
  • 10. Disclaimer
  • 11. Drug Index
  • 12. Company Index
  • Figures: Includes 6 Figures
  • Tables: Includes 196 Tables
  • Total Number of Pages: 777

Part III: Pancreatic Cancer

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Pancreatic Cancer Drugs for the Highest Therapeutic Outcome and Return on Investment (197 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Pancreatic Cancer Drugs by their Highest Stage of Development (163 Drug Target Strategies and 247 Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Pancreatic Cancer Drugs by Compound Strategy (8 Compound Strategies)
  • 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Pancreatic Cancer Drug Pipeline by Investigator (158 Investigators and Drugs)
  • 10. Drug Index
  • 11. Company Index
  • Figures: Includes 7 Figures
  • Tables: Includes 218 Tables
  • Total Number of Pages: 1,103

This Report Includes the Following Companies:

  • 3SBio
  • A&G Pharmaceutical
  • AB Science
  • Abbott
  • Abiogen
  • Abraxis BioScience
  • Access
  • Actelion
  • Active Biotech
  • Adherex
  • Advanced Life Sciences
  • Advanomics
  • Advantagene
  • Advaxis
  • AEgera
  • AEterna Zentaris
  • Affibody
  • Affimed Therapeutics
  • Aida Pharmaceuticals
  • Alchemia
  • Alethia Biotherapeutics
  • Allos Therapeutics
  • Alnis Biosciences
  • Alnylam
  • AlphaVax
  • Alseres Pharmaceuticals
  • Altor BioScience
  • Ambit Biosciences
  • Amgen
  • AngioChem
  • Antisense Pharma
  • Antisoma
  • Anza Therapeutics
  • Aphios
  • Apogee Biotechnology
  • ApopLogic Pharmaceuticals
  • Apotex
  • Ardea Biosciences
  • Ariad
  • ArQule
  • Array BioPharma
  • Ascend Therapeutics
  • Ascepion Pharmaceuticals
  • Astellas
  • Astex Pharmaceuticals
  • Astex Therapeutics
  • AstraZeneca
  • Attenuon
  • AVEO
  • AVI BioPharma
  • Basilea Pharmaceutica
  • Bavarian Nordic
  • Bayer
  • Beta Pharma
  • Betagenon
  • Betapharma
  • Bio-Medisinsk Innovasjon
  • BioAlliance Pharma
  • Biogen Idec
  • Biokine Therapeutics
  • BioMarin
  • Bionovo
  • BioNumerik
  • BioSante
  • Biosceptre
  • Biotecnol
  • BioVex
  • Boehringer Ingelheim
  • Bristol-Myers Squibb
  • BTG
  • Calando Pharmaceuticals
  • Callisto Pharmaceuticals
  • Cancer Advances
  • Cancer Research Technology
  • CDG Therapeutics
  • Cel-Sci
  • Celera
  • Celgene
  • Cell Genesys
  • Cell Therapeutics
  • Celldex Therapeutics
  • Celltrion
  • Celsion
  • Celtic Pharma
  • Center of Molecular Immunology
  • CG Therapeutics
  • Chemokine Therapeutics
  • Chiesi
  • Chong Kun Dang
  • CJ Corp
  • Clavis Pharma
  • CompleGen
  • Cornerstone Pharmaceuticals
  • Cosmo Pharmaceuticals
  • CritiTech
  • CSL
  • Curaxis
  • Curis
  • Cyclacel
  • Cylene Pharmaceuticals
  • Cynvec
  • CytImmune Sciences
  • Cytokinetics
  • CytRx
  • Daewoong
  • Daiichi Sankyo
  • Dainippon Sumitomo Pharma
  • Dara Biosciences
  • Debiopharm
  • Deciphera Pharmaceuticals
  • Dendreon
  • DNAVEC
  • Domainex
  • Dong-A
  • Dongkook Pharm
  • Douglas
  • ECI
  • EGEN Inc
  • Eisai
  • Elara Pharmaceuticals
  • ElexoPharm
  • Eli Lilly
  • Endoceutics
  • Enkam Pharmaceuticals
  • EntreMed
  • Enzon
  • Epeius Biotechnologies
  • EpiCept
  • Epizyme
  • Esperance Pharmaceuticals
  • Etubics
  • Eucodis
  • Exelixis
  • Expression Drug Designs
  • Facet Biotech
  • FibroGen
  • Flamel Technologies
  • Formula Pharmaceuticals
  • Fresenius
  • Galectin Therapeutics
  • Galena Biopharma
  • Genentech
  • Generex
  • Genmab
  • Genta
  • GenVec
  • Genzyme
  • Geron
  • Gilead Sciences
  • GlaxoSmithKline
  • GlycoGenesys
  • GlyTag
  • Got-a-Gene
  • Gradalis
  • Harbor BioSciences
  • Heidelberg Pharma
  • Hemispherx Biopharma
  • Hoffmann-La Roche
  • Hospira
  • Human Genome Sciences
  • Ichor Medical Systems
  • Idera Pharmaceuticals
  • ImmunoCellular Therapeutics
  • Immunocore
  • ImmunoGen
  • Immunomedics
  • ImmuPharma
  • Immutep
  • Incyte Corporation
  • Inex
  • Infinity Pharmaceuticals
  • Innate Pharma
  • InNexus Biotechnology
  • Innovive
  • Inotek
  • Inovio
  • Insmed
  • Insys Therapeutics
  • Intarcia Therapeutics
  • Intezyne Technologies
  • Intradigm
  • Intrexon
  • Introgen Therapeutics
  • Ipsen
  • Isis Pharmaceuticals
  • Jennerex Biotherapeutics
  • Jina Pharmaceuticals
  • Johnson & Johnson
  • Kadmon
  • Kalypsys
  • Karyon-CTT
  • Kiadis
  • Kinex
  • Kyowa Hakko Kirin
  • Leo
  • LG Life Sciences
  • Ligand
  • Lorus Therapeutics
  • MacroGenics
  • Mannkind
  • Marillion Pharmaceuticals
  • Marina Biotech
  • MBiotec
  • Meda
  • Medarex
  • MediGene
  • MedImmune
  • Mediolanum
  • Medisyn Technologies
  • Menarini
  • Merck & Co
  • Merck KGaA
  • Merrimack
  • Mersana Therapeutics
  • MetaMol Theranostics
  • MethylGene
  • Micromet
  • Mitsubishi Tanabe Pharma
  • Mochida
  • Mojave Therapeutics
  • MolMed
  • Mologen
  • Nektar Therapeutics
  • Nemod Biotherapeutics
  • Nereus Pharmaceuticals
  • Neurocrine Biosciences
  • NexGenix Pharmaceuticals
  • Nidus Laboratories
  • NIH
  • Nimbus Discovery
  • Nippon Kayaku
  • Nippon Shinyaku
  • Non-industrial source
  • Novacea
  • NovaLead
  • Novartis
  • Novogen
  • Oasmia
  • Oncalis
  • OncoGenex Pharmaceuticals
  • Oncolix
  • OncoMed
  • OncoMune
  • Onconova
  • OncoTherapy Science
  • Oncothyreon
  • Oncozyme Pharma
  • Orion Pharma
  • OSI Pharmaceuticals
  • Oxford BioMedica
  • OXiGENE
  • Pacific Biotech
  • Paladin Labs
  • PanaGin
  • Pantarhei Bioscience
  • Patrys
  • PBL Therapeutics
  • Pepscan Therapeutics
  • Peregrine Pharmaceuticals
  • Pfizer
  • Pharmacyclics
  • PharmaGap
  • PharmaMar
  • Pharmexa
  • PheneX
  • Philogen
  • PhiloGene
  • Pierre Fabre
  • Piramal
  • Plexxikon
  • Progen
  • ProMetic Life Sciences
  • ProStrakan
  • Protgen
  • PTC Therapeutics
  • R&R
  • Radient Pharmaceuticals
  • Raptor Pharmaceutical
  • Ras Therapeutics
  • Reata Pharmaceuticals
  • Receptor BioLogix
  • Regeneron
  • Regulon
  • RESprotect
  • Rexahn
  • Rigel
  • Rottapharm Madaus
  • Samyang
  • Sanofi
  • Sanofi-Aventis
  • Santaris Pharma
  • Sareum
  • Savient Pharmaceuticals
  • Scancell
  • Schering-Plough
  • SciClone Pharmaceuticals
  • Seattle Genetics
  • SEEK
  • Selvita
  • Semafore Pharmaceuticals
  • Shenogen
  • Shire
  • Sigma-Tau
  • Simcere Pharmaceuticals
  • Sirnaomics
  • Solbec Pharmaceuticals
  • Spirogen
  • SRI International
  • Sun Pharma Advanced Research
  • SuperGen
  • Supratek Pharma
  • Swedish Orphan Biovitrum
  • Synageva BioPharma
  • Synta Pharmaceuticals
  • Taiho
  • Taiwan Liposome Company
  • Takeda
  • Talon Therapeutics
  • Tapestry Pharmaceuticals
  • TapImmune
  • Targa Therapeutics
  • Targepeutics
  • Tau Therapeutics
  • Taxolog
  • Telik
  • Teva
  • Thallion Pharmaceuticals
  • Therion Biologics
  • Titan Pharmaceuticals
  • to-BBB
  • TopoTarget
  • Tracon Pharmaceuticals
  • Tragara Pharmaceuticals
  • Transgene
  • Trion Pharma
  • UMN Pharma
  • Vaccinex
  • Vaxon Biotech
  • VaxOnco
  • VBL Therapeutics
  • Vectura
  • Verastem
  • Vernalis
  • Vertex Pharmaceuticals
  • Vical
  • Wilex
  • Vion Pharmaceuticals
  • VioQuest
  • ViroMed
  • ViroTarg
  • Wyeth
  • Xerion
  • Xoma
  • Yakult Honsha
  • YM BioSciences
  • York Pharma
  • Zensun
  • Zeria
  • Zydus Cadila
  • ZymoGenetics

A Shortlist of Drugs Included are:

  • 177-Lu-AMBA
  • 17s-hydroxysteroid dehydrogenase-1 inhibitors
  • 2-methoxyestradiol
  • 2aG4-IL-2 fus protein + PS MAb
  • 4-hydroxytamoxifen
  • 5-FU
  • 852A
  • 9-aminocamptothecin
  • AB-16B5
  • abiraterone acetate
  • ABT-510
  • ACC inhibitor
  • acolbifene
  • adecatumumab
  • aderbasib
  • Adva-27a
  • AE-37
  • AEE-788
  • AEG-35156
  • AEZS-108
  • afatinib
  • aflibercept
  • AFM-21
  • AG-1
  • AG-14699
  • agatolimod
  • aglycon protopanaxadiol
  • AGS-1C4D4
  • aldesleukin
  • ALT-801
  • alvespimycin hydrochloride
  • alvocidib
  • amatuximab
  • AMG-386
  • amonafide dihydrochloride
  • amonafide malate
  • amrubicin hydrochloride
  • amuvatinib
  • anastrozole
  • androgen receptor antagonist
  • angiopep+paclitaxel
  • Angiozyme
  • annamycin
  • anti-C35 MAb
  • anti-HER-2/neu antisense
  • anti-HER2 MAb
  • anti-HER2neu scFv
  • anti-Hsp90-alpha MAbs
  • anti-PCDGF MAbs
  • anticancers
  • antiestrogen
  • APO-866
  • apricoxib
  • AR-002
  • AR-004
  • AR-7BD-33-11A
  • ARC-100
  • ARQ-197
  • ARQ-621
  • ARRY-380
  • arzoxifene hydrochloride
  • AS-1402
  • ASP-08126
  • astuprotimut-r
  • atamestane
  • ATN-224
  • atrasentan
  • Auto TAG vaccine
  • AUY-922
  • AVE-1642
  • AVI-4126
  • avorelin
  • AVX-701
  • axitinib
  • AZD-1480
  • AZD-4547
  • AZD-4877
  • AZD-4992
  • AZD-8931
  • BAL-27862
  • banoxantrone
  • bardoxolone methyl
  • becatecarin
  • belinostat
  • bevacizumab
  • BEZ-235
  • BGT-226
  • BIW-8556
  • BMN-673
  • BMS-599626
  • BMS-663513
  • BMS-690514
  • BMS-753493
  • BMS-754807
  • BN-107
  • bortezomib
  • bosentan
  • bosutinib
  • brca2
  • breast cancer therapy
  • breast cancer vaccine
  • BreMel/TNF-alpha
  • BrevaRex MAb
  • brivanib alaninate
  • brivudine
  • BZL-101
  • CAB-051
  • Cabozantinib
  • cancer therapy (1)
  • cancer therapy (2)
  • canertinib dihydrochloride
  • canfosfamide hydrochloride
  • capecitabine
  • carbetocin
  • catumaxomab
  • CDX-1307
  • CEA cancer vaccine
  • cediranib
  • celecoxib
  • cetuximab
  • CG-201
  • CGX-0682
  • CH-4986399
  • CHF-4227
  • cilengitide
  • cixutumumab
  • clofarabine
  • CNF-2024
  • conatumumab
  • contusugene ladenovec
  • cositecan
  • CP-724714
  • CPI-613
  • CRLX-101
  • crolibulin
  • CTCE-9908
  • CTP-37
  • CUDC-101
  • custirsen
  • CVac
  • CX-4945
  • CYN-101
  • D-3263
  • dabigatran etexilate
  • dalotuzumab
  • dasatinib
  • daunorubicin
  • decitabine
  • denenicokin
  • denosumab
  • Diflomotecan
  • dinaciclib
  • docetaxel
  • docetaxel (1)
  • docetaxel (2)
  • docetaxel (3)
  • docetaxel (4)
  • docetaxel (5)
  • docetaxel MAb
  • dovitinib lactate
  • doxifluridine
  • doxorubicin
  • doxorubicin (1)
  • doxorubicin (10)
  • doxorubicin (11)
  • doxorubicin (2)
  • doxorubicin (3)
  • doxorubicin (4)
  • doxorubicin (5)
  • doxorubicin (6)
  • doxorubicin (7)
  • doxorubicin (8)
  • doxorubicin (9)
  • doxorubicin citrate
  • DXL-702
  • E-75
  • E-7820
  • E39
  • ECI-301
  • elomotecan
  • elsamitrucin
  • EMD-273063
  • emepepimut-S
  • endostatin
  • endoxifen
  • eniluracil
  • entinostat
  • enzastaurin hydrochloride
  • EP-100
  • epirubicin
  • epothilone D
  • erlotinib
  • ERR antagonists
  • ertumaxomab
  • estetrol
  • estrogen inhibitors
  • everolimus
  • exatecan mesylate
  • exemestane
  • Exherin
  • exisulind
  • EZH2
  • F16-IL2
  • fadrozole
  • FASN inhibitors
  • figitumumab
  • flt-4 kinase inhibitors
  • formestane (1)
  • formestane (2)
  • fosfluridine tidoxil
  • FPI-01
  • fresolimumab
  • fulvestrant
  • fusion toxins
  • Galactomycin-UCLT
  • galarubicin hydrochloride
  • ganitumab
  • gataparsen
  • GDC-0980
  • gefitinib
  • gimatecan
  • glembatumumab
  • glembatumumab vedotin
  • GlyB4
  • golnerminogene pradenovec
  • goserelin
  • goserelin acetate ER
  • GPR40 antagonists
  • GSK-1059615
  • GSK-1120212
  • GSK-2130579A
  • GSK-2302024A
  • GT-111
  • GV-1001
  • GVAX
  • HAS2 inhibitor
  • HE-3235
  • Her-2/Neu peptides
  • HER2 vaccine
  • her2/neu antigen
  • Her2/neu gene therapy
  • histamine dihydrochloride
  • huBrE-3 tiuxetan
  • HuMax-Her2
  • HuMax-VEGF
  • icotinib hydrochloride
  • icrucumab
  • idronoxil
  • IGF-1 receptor inhibitor
  • IGN-101
  • IKKe/TBK1 inhibitor
  • imatinib mesilate
  • imetelstat
  • IMGN-388
  • immunogene therapy
  • IMO-2055
  • IMP-321
  • Imuteran
  • INCB-028060
  • indisulam
  • ING-1
  • ingenol mebutate
  • INGN-225
  • INGN-241
  • inherbins
  • iniparib
  • INNO-206
  • interferon (s1a)
  • interferon-alpha
  • interferon-alpha2
  • interferon-alpha2a
  • interferon-alpha2b
  • interferon-beta
  • interleukin-2, 2nd-generation
  • interleukins
  • intetumumab
  • IPH-1101
  • IPH-3102
  • ipilimumab
  • IPP-204106
  • irinotecan
  • irinotecan hydrochloride
  • irosustat
  • ispinesib mesylate
  • JMR-132
  • JX-594
  • kahalalide F
  • KD032
  • KW-2170
  • KX2-391
  • L19-IL2
  • labetuzumab
  • labetuzumab-SN-38
  • lapatinib ditosylate
  • lapuleucel-T
  • larotaxel
  • lasofoxifene
  • lenvatinib
  • leptin antagonists
  • lestaurtinib
  • letrozole
  • leucine-doxorubicin
  • leuprorelin
  • linifanib
  • linsitinib
  • LipoVIL12
  • lonafarnib
  • lonaprisan
  • LOR-2040
  • Lovaxin B
  • LY-2157299
  • MAGH-22
  • masitinib
  • MDX-1106
  • MDX-1140
  • ME-103
  • MEDI-547
  • Mesd-based peptides
  • MetXia
  • MGN-1601
  • MGN-1703
  • milataxel
  • mitoxantrone
  • MK-2206
  • MKC-1
  • MKC-1106-MT
  • MLN-8237
  • MM-111
  • MM-121
  • mocetinostat
  • MORAb-004
  • motesanib diphosphate
  • motexafin gadolinium
  • MP-529
  • MS-209
  • MT-110
  • MUC-1 vaccine
  • MVA-BN Her-2 vaccine
  • Nab-docetaxel
  • nadroparin
  • neratinib
  • nimotuzumab
  • NK-012
  • NL-0031
  • nolatrexed dihydrochloride
  • NXD-30001
  • OB-cadherin antibodies
  • oblimersen sodium
  • OCM-111
  • OCM-8054
  • OCM-8224
  • OGX-225
  • OGX-427
  • olaparib
  • ON-01910
  • ON-045270
  • onartuzumab
  • Onco-L TCS
  • oncolytic viruses
  • OncoVEX GM-CSF
  • OSI-7904L
  • osteolytic disease therapy
  • Osteopontin-c inhibitor
  • OTS-102
  • P-276-00
  • P276-00
  • paclitaxel
  • paclitaxel (1)
  • paclitaxel (10)
  • paclitaxel (11)
  • paclitaxel (12)
  • paclitaxel (13)
  • paclitaxel (14)
  • paclitaxel (2)
  • paclitaxel (3)
  • paclitaxel (4)
  • paclitaxel (5)
  • paclitaxel (6)
  • paclitaxel (7)
  • paclitaxel (8)
  • paclitaxel (9)
  • paclitaxel polyglumex
  • paclitaxel-DHA
  • PancAtak
  • PankoPep
  • panobinostat
  • PANVAC-VF
  • pasireotide
  • pasireotide LAR
  • patupilone
  • pazopanib hydrochloride
  • PCI-27483
  • PD-0325901
  • PD-0332991
  • peginterferon alfa-2b
  • pelitinib
  • pemetrexed disodium
  • pentamidine isethionate
  • peptidomimetics
  • perifosine
  • pertuzumab
  • PhG-alpha-1
  • pixantrone
  • PKI-179
  • PKI-587
  • plitidepsin
  • PLX-4032
  • pralatrexate
  • Prolanta
  • Prolanta ER
  • prostate cancer therapy
  • PRX-321
  • PSK-3668
  • PTC-299
  • PX-104.1
  • PX-12
  • R-763
  • radiotherapeutic
  • raloxifene hydrochloride
  • ramucirumab
  • retaspimycin
  • Reximmune-C
  • Rexin-G
  • RG-1507
  • RG-7321
  • rhErbB3-f
  • ridaforolimus
  • rinfabate
  • romidepsin
  • RR-310
  • rubitecan
  • RX-0201
  • S1P3 inhibitor
  • sabarubicin
  • sagopilone
  • SAR-566658
  • saracatinib
  • sargramostim
  • SBC-202
  • Sch-57050
  • SEL-24-1
  • seliciclib
  • selumetinib
  • semaxanib
  • seocalcitol
  • SERM + toxin
  • SF-1126
  • siltuximab
  • simotaxel
  • sipuleucel-T
  • siRNA gp96 therapy
  • SM3
  • SN-38 (1)
  • SN-38 (2)
  • SNG-163
  • SNG-8023
  • SNG-8038
  • sodium stibogluconate
  • sorafenib tosylate
  • SPC-2968
  • SR-13668
  • SR-16157
  • SR-31747
  • s-lapachone
  • STA-9090
  • steroid sulfatase inhibitor
  • STP-503
  • SU-14813
  • SU-6668
  • sunitinib malate
  • survivin-2B
  • Symadex
  • talminogene laherparepvec
  • tamoxifen (1)
  • tamoxifen (2)
  • tamoxifen, oral liquid
  • tanespimycin
  • tariquidar
  • TAS-108
  • tegafur + uracil
  • telomerase vaccine
  • temsirolimus
  • Tenarad
  • TG-4010
  • thiocoraline
  • thymalfasin
  • thymectacin
  • tigatuzumab
  • tipifarnib
  • tivozanib
  • TLK-58130
  • TLN-4601
  • TNF + paclitaxel
  • TNF-alpha
  • tocilizumab
  • topotecan
  • toremifene citrate
  • trabedersen
  • trastuzumab
  • trastuzumab (1)
  • trastuzumab (2)
  • trastuzumab (3)
  • trastuzumab emtansine
  • trastuzumab-MMAE conjugate
  • tremelimumab
  • triapine
  • triciribine phosphate
  • trilostane
  • triptorelin pamoate
  • TroVax
  • TS-1
  • TTL-2019
  • TTL-3101
  • tucotuzumab celmoleukin
  • UCN-01
  • V-930
  • V935
  • vandetanib
  • varlitinib
  • vatalanib
  • velimogene aliplasmid
  • veliparib
  • vismodegib
  • VM-206
  • volociximab
  • VS-4718
  • VS-507
  • VS-5095
  • VX-001
  • WX-671
  • WX-UK1
  • XL-147
  • XL-647
  • XL-765
  • Y-90-labetuzumab
  • YM-155
  • Z-360
  • Zemab
  • zibotentan
  • ZYC-300
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