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Triple Analysis: Breast Cancer, Prostate Cancer and Cancer Vaccines

Abstract

This triple analysis focuses on cancer drug development strategies in both Breast Cancer and Prostate Cancer and by the mechanism/target/effect of Cancer Vaccines. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Table of Contents

Key Topics Covered:

Part I: Breast Cancer

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Breast Cancer Drugs for the Highest Therapeutic Outcome and Return on Investment (234 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Breast Cancer Drugs by their Highest Stage of Development (223 Drug Target Strategies and 470 Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Breast Cancer Drugs by Compound Strategy (8 Compound Strategies)
  • 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Breast Cancer Drug Pipeline by Investigator (247 Investigators and 470 Drugs)
  • 10. Disclaimer
  • Figures: Includes 8 Figures
  • Tables: Includes 309 Tables
  • Total Number of Pages: 1,755

Part II: Prostate Cancer

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Prostate Cancer Drugs for the Highest Therapeutic Outcome and Return on Investment (227 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Prostate Cancer Drugs by their Highest Stage of Development (216 Drug Target Strategies and 394 Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Prostate Cancer Drugs by Compound Strategy (8 Compound Strategies)
  • 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Prostate Cancer Drug Pipeline by Investigator (222 Investigators and 394 Drugs)
  • 10. Disclaimer
  • Figures: Includes 8 Figures
  • Tables: Includes 283 Tables
  • Total Number of Pages: 1,493

Part III: Cancer Vaccines

  • 5.1. The Scope of this Report
  • 6. Consider the Therapeutic Target Among Cancer Vaccine Drugs for the Highest Therapeutic Outcome and Return on Investment (94 Drug Targets)
  • 7. Emerging New Products to Established Ones: Drug Target Strategies of Cancer Vaccine Drugs by their Highest Stage of Development (91 Drug Target Strategies and 155 Cancer Vaccine Drugs)
  • 8. Compound Strategies at Work: Competitive Benchmarking of Cancer Vaccine Drugs by Compound Strategy (7 Compound Strategies)
  • 9. Selecting Cancer Indications for Cancer Vaccine Drugs (42 Cancer Indications)
  • 10. Pipeline and Portfolio Planning: Competitive Benchmarking of the Cancer Vaccine Drug Pipeline by Investigator (99 Investigators)
  • 11. Disclaimer
  • 12. Drug Index
  • 13. Company Index
  • Figures: Includes 6 Figures
  • Tables: Includes 205 Tables
  • Total Number of Pages: 659

This Report Includes the Following Companies:

  • A&G Pharmaceutical
  • Abbott
  • Abiogen
  • AC Immune
  • Access
  • Active Biotech
  • Adaptimmune
  • Adherex
  • Aduro BioTech
  • Advanomics
  • Advantagene
  • Advaxis
  • AEgera
  • AEterna Zentaris
  • Affibody
  • Affimed Therapeutics
  • Aida Pharmaceuticals
  • Akela Pharma
  • Alchemia
  • Alethia Biotherapeutics
  • Allos Therapeutics
  • Alnis Biosciences
  • AlphaVax
  • Alseres Pharmaceuticals
  • Altor BioScience
  • Ambrilia Biopharma
  • American Gene Technology International
  • Amgen
  • Anavex Life Sciences
  • AndroBioSys
  • AngioChem
  • Antisense Pharma
  • Antisense Therapeutics
  • Antisoma
  • Aphios
  • ApopLogic Pharmaceuticals
  • Apotex
  • Aprea
  • Apthera
  • Ardana
  • Ariad
  • ArQule
  • Array BioPharma
  • Ascend Therapeutics
  • Ascenta Therapeutics
  • Ascepion Pharmaceuticals
  • Astellas
  • Astex Pharmaceuticals
  • AstraZeneca
  • Attenuon
  • AVI BioPharma
  • Basilea Pharmaceutica
  • Bavarian Nordic
  • Baxter International
  • Bayer
  • Bellicum Pharmaceuticals
  • Beta Pharma
  • Betagenon
  • Bioenvision
  • Biogen Idec
  • BioLineRx
  • BioMarin
  • BioNetWorks
  • Bionovo
  • BioSante
  • Biostar
  • Biotecnol
  • BioVex
  • Boehringer Ingelheim
  • Bristol-Myers Squibb
  • BTG
  • Cadila
  • Callisto Pharmaceuticals
  • Camurus
  • Cancer Research Technology
  • Cel-Sci
  • Celgene
  • Cell Genesys
  • Cell Therapeutics
  • Celldex Therapeutics
  • Celltrion
  • Celsion
  • Celtic Pharma
  • Center of Molecular Immunology
  • Cephalon
  • CG Therapeutics
  • Chemokine Therapeutics
  • Chiesi
  • Chong Kun Dang
  • Circadian Technologies
  • Cleveland BioLabs
  • Colby
  • CompleGen
  • Cosmo Bioscience
  • Cosmo Pharmaceuticals
  • CSL
  • Curaxis
  • Curis
  • Cyclacel
  • Cylene Pharmaceuticals
  • Cynvec
  • CytImmune Sciences
  • Cytokinetics
  • CytRx
  • Daiichi Sankyo
  • Dainippon Sumitomo Pharma
  • Debiopharm
  • Dendreon
  • DeveloGen
  • Domainex
  • Dong-A
  • Dongkook Pharm
  • Douglas
  • ECI
  • Eisai
  • Elara Pharmaceuticals
  • ElexoPharm
  • Eli Lilly
  • Endo Pharmaceuticals
  • Endoceutics
  • Endocyte
  • Enkam Pharmaceuticals
  • Ensemble Discovery
  • EntreMed
  • Enzon
  • Epeius Biotechnologies
  • EpiCept
  • Epizyme
  • Esperance Pharmaceuticals
  • Etubics
  • Eucodis
  • EUSA Pharma
  • Exelixis
  • Expression Drug Designs
  • Ferring
  • Formula Pharmaceuticals
  • Fresenius
  • Galectin Therapeutics
  • Galena Biopharma
  • Gemin X Pharmaceuticals
  • Genentech
  • Generex
  • Genmab
  • GenOdyssee Pharmaceuticals
  • GENova Biotherapeutics
  • Genovax
  • Genta
  • GENTICEL
  • GenVec
  • Gerolymatos
  • Geron
  • Gilead Sciences
  • GlaxoSmithKline
  • Gliknik
  • GlobeImmune
  • GlycoGenesys
  • GlyTag
  • Got-a-Gene
  • GP Pharm
  • Gradalis
  • Green Cross
  • GTx
  • Harbor BioSciences
  • Heidelberg Pharma
  • Hoffmann-La Roche
  • Hospira
  • Human Genome Sciences
  • Ichor Medical Systems
  • Idera Pharmaceuticals
  • IGF Oncology
  • ImmunoCellular Therapeutics
  • Immunocore
  • ImmunoFrontier
  • ImmunoGen
  • Immunomedics
  • Immunotope
  • ImmuPharma
  • Immutep
  • Incyte Corporation
  • Inex
  • Infinity Pharmaceuticals
  • Innate Pharma
  • InNexus Biotechnology
  • Inovio
  • Insmed
  • Insys Therapeutics
  • Intarcia Therapeutics
  • Intezyne Technologies
  • Intradigm
  • Introgen Therapeutics
  • Ipsen
  • ISA Pharmaceuticals
  • Isis Pharmaceuticals
  • Ivy Medical Chemicals
  • Jina Pharmaceuticals
  • Johnson & Johnson
  • Karo Bio
  • Kiadis
  • Kinex
  • Kyowa Hakko Kirin
  • Leo
  • Ligand
  • Lorus Therapeutics
  • MacroGenics
  • Mannkind
  • Marillion Pharmaceuticals
  • Marina Biotech
  • Med Discovery
  • Meda
  • Medarex
  • Medical Marketing International
  • MediGene
  • MedImmune
  • Mediolanum
  • Medivation
  • Menarini
  • Merck & Co
  • Merck KGaA
  • Merrimack
  • Merrion Pharmaceuticals
  • MetaMol Theranostics
  • MethylGene
  • Micromet
  • Mojave Therapeutics
  • Molecular Insight
  • MolMed
  • Mologen
  • Nektar Therapeutics
  • Nemod Biotherapeutics
  • Neovacs
  • Nereus Pharmaceuticals
  • Nerviano Medical Sciences
  • Neurocrine Biosciences
  • NexGenix Pharmaceuticals
  • Nidus Laboratories
  • NIH
  • Nimbus Discovery
  • Nippon Kayaku
  • Nippon Shinyaku
  • Non-industrial source
  • Northwest Biotherapeutics
  • Novacea
  • Novartis
  • NovaRx
  • Novogen
  • Oasmia
  • OncoGenex Pharmaceuticals
  • Oncolix
  • OncoMune
  • Onconova
  • OncoTherapy Science
  • Oncothyreon
  • Oncovir
  • Oncozyme Pharma
  • Onyvax
  • Orion Pharma
  • OSI Pharmaceuticals
  • Oxford BioMedica
  • Pacific Biotech
  • Paladin Labs
  • PanaGin
  • Pantarhei Bioscience
  • Pepscan Systems
  • Pepscan Therapeutics
  • Peregrine Pharmaceuticals
  • Pfizer
  • Pharmacyclics
  • PharmaGap
  • PharmaMar
  • Pharmexa
  • PheneX
  • Philogen
  • Pierre Fabre
  • Piramal
  • Prima Biomed
  • Progen
  • Progenics Pharmaceuticals
  • ProNAi Therapeutics
  • ProStrakan
  • Protherics
  • PTC Therapeutics
  • Q Chip
  • QLT
  • R&R
  • Radient Pharmaceuticals
  • Raptor Pharmaceutical
  • Receptor BioLogix
  • Regeneron
  • Regulon
  • responsif
  • RESprotect
  • Rexahn
  • Rigel
  • Salzburg Therapeutics
  • Samyang
  • Sanofi
  • Sanofi-Aventis
  • Santaris Pharma
  • Sapphire Therapeutics
  • Sareum
  • Savient Pharmaceuticals
  • SBIO
  • Scancell
  • Schering-Plough
  • SciClone Pharmaceuticals
  • SEEK
  • SeleXel
  • Selvita
  • Semafore Pharmaceuticals
  • Serometrix
  • SGX Pharmaceuticals
  • Shenogen
  • Shire
  • Siena Biotech
  • Sigma-Tau
  • Sirnaomics
  • Soligenix
  • Sophiris Bio
  • SRI International
  • Sun Pharma Advanced Research
  • Supratek Pharma
  • Switch Pharma
  • Synageva BioPharma
  • Synta Pharmaceuticals
  • Taiho
  • Taiwan Liposome Company
  • Takeda
  • Tapestry Pharmaceuticals
  • TapImmune
  • Targa Therapeutics
  • Tau Therapeutics
  • Taxolog
  • Telik
  • Teva
  • Thallion Pharmaceuticals
  • Therion Biologics
  • Titan Pharmaceuticals
  • to-BBB
  • Tokai Pharmaceuticals
  • TopoTarget
  • Tracon Pharmaceuticals
  • Tragara Pharmaceuticals
  • Transgene
  • Trion Pharma
  • Twinstrand Therapeutics
  • Unigene
  • United Biomedical
  • Vaccinex
  • Vaxil BioTherapeutics
  • Vaxon Biotech
  • VaxOnco
  • Vectura
  • Velacor Therapeutics
  • Verastem
  • Vernalis
  • Vical
  • Wilex
  • Vion Pharmaceuticals
  • VioQuest
  • Viragen
  • Viralytics
  • Virionics
  • ViroMed
  • ViroTarg
  • VM Discovery
  • Wyeth
  • Xerion
  • Xoma
  • Yakult Honsha
  • YM BioSciences
  • Zensun
  • Zydus Cadila

A Shortlist of Drugs Included are:

  • 177-Lu-AMBA
  • 17s-hydroxysteroid dehydrogenase-1 inhibitors
  • 2-methoxyestradiol
  • 2aG4-IL-2 fus protein + PS MAb
  • 4-hydroxytamoxifen
  • 5-FU
  • 852A
  • 9-aminocamptothecin
  • AB-16B5
  • abarelix
  • abiraterone acetate
  • ABT-510
  • ACC inhibitor
  • acolbifene
  • adecatumumab
  • aderbasib
  • Adva-27a
  • ADXS11-001
  • AE-37
  • AEE-788
  • AEG-35156
  • AEZS-108
  • afatinib
  • aflibercept
  • AFM-21
  • AG-1
  • agatolimod
  • aglycon protopanaxadiol
  • ALT-801
  • ALVAC-CEA/B7.1
  • alvespimycin hydrochloride
  • alvocidib
  • amatuximab
  • AMG-386
  • amonafide dihydrochloride
  • amonafide malate
  • amrubicin hydrochloride
  • amuvatinib
  • anastrozole
  • androgen receptor antagonist
  • angiopep+paclitaxel
  • Angiozyme
  • annamycin
  • anti-C35 MAb
  • anti-HER-2/neu antisense
  • anti-HER2 MAb
  • anti-HER2neu scFv
  • anti-Hsp90-alpha MAbs
  • anti-PCDGF MAbs
  • anticancers
  • antiestrogen
  • APC-100
  • APR-246
  • apricoxib
  • AR-002
  • AR-004
  • AR-7BD-33-11A
  • ARC-100
  • ARQ-197
  • ARQ-621
  • ARRY-380
  • arzoxifene hydrochloride
  • AS-1402
  • ASP-08126
  • astuprotimut-r
  • atamestane
  • ATN-224
  • atrasentan
  • Auto TAG vaccine
  • AUY-922
  • AVE-1642
  • AVI-4126
  • avorelin
  • AVX-701
  • axitinib
  • AZD-1480
  • AZD-4547
  • AZD-4877
  • AZD-4992
  • AZD-8931
  • bafetinib
  • BAL-27862
  • banoxantrone
  • becatecarin
  • belagenpumatucel-L
  • belinostat
  • bevacizumab
  • BEZ-235
  • BGT-226
  • BIBF-1120
  • bicalutamide
  • BIW-8556
  • BMN-673
  • BMS-599626
  • BMS-690514
  • BMS-753493
  • BMS-754807
  • BMS-777607
  • BMS-936558
  • BN-107
  • bortezomib
  • bosutinib
  • BP-GMAX-CD1
  • brca2
  • breast cancer therapy
  • breast cancer vaccine
  • BreMel/TNF-alpha
  • BrevaRex MAb
  • brivanib alaninate
  • brivudine
  • buserelin
  • BZL-101
  • CAB-051
  • Cabozantinib
  • Cadi-05
  • cancer therapy (1)
  • cancer therapy (2)
  • canertinib dihydrochloride
  • canfosfamide hydrochloride
  • capecitabine
  • carbetocin
  • carlumab
  • catumaxomab
  • CB-10-01
  • CDX-1307
  • CEA cancer vaccine
  • CEA-TRICOM
  • cediranib
  • celecoxib
  • cetuximab
  • CG-201
  • CGX-0682
  • CH-4986399
  • CHF-4227
  • cilengitide
  • cixutumumab
  • clofarabine
  • CMLVAX-100
  • CNF-2024
  • contusugene ladenovec
  • CP-724714
  • crolibulin
  • CTCE-9908
  • CTL901
  • CTP-37
  • CUDC-101
  • custirsen
  • CVac
  • CX-4945
  • CYN-101
  • D-3263
  • dabigatran etexilate
  • dalotuzumab
  • danusertib
  • dasatinib
  • daunorubicin
  • DCVax-prostate
  • degarelix
  • denosumab
  • deslorelin
  • DI-17E6
  • Diflomotecan
  • dinaciclib
  • docetaxel
  • docetaxel (1)
  • docetaxel (2)
  • docetaxel (3)
  • docetaxel (4)
  • docetaxel (5)
  • docetaxel MAb
  • dovitinib lactate
  • doxercalciferol
  • doxifluridine
  • doxorubicin
  • doxorubicin (1)
  • doxorubicin (10)
  • doxorubicin (11)
  • doxorubicin (2)
  • doxorubicin (3)
  • doxorubicin (4)
  • doxorubicin (5)
  • doxorubicin (6)
  • doxorubicin (7)
  • doxorubicin (8)
  • doxorubicin (9)
  • doxorubicin citrate
  • dutasteride
  • DXL-702
  • E-75
  • E39
  • ECI-301
  • elomotecan
  • elsamitrucin
  • emepepimut-S
  • endostatin
  • endoxifen
  • eniluracil
  • entinostat
  • enzastaurin hydrochloride
  • EP-100
  • epirubicin
  • epothilone D
  • erlotinib
  • ERR antagonists
  • ertumaxomab
  • estetrol
  • estramustine phosphate sodium
  • estrogen inhibitors
  • ethinyl estradiol sulfonate
  • everolimus
  • exatecan mesylate
  • exemestane
  • Exherin
  • exisulind
  • EZH2
  • F16-IL2
  • fadrozole
  • FASN inhibitors
  • figitumumab
  • flt-4 kinase inhibitors
  • flutamide
  • formestane (1)
  • formestane (2)
  • fosfluridine tidoxil
  • fowlpox-PSA vaccine
  • FPI-01
  • fulvestrant
  • fusion toxins
  • Galactomycin-UCLT
  • galarubicin hydrochloride
  • ganitumab
  • gataparsen
  • GDC-0980
  • gefitinib
  • gimatecan
  • glembatumumab vedotin
  • GlyB4
  • golnerminogene pradenovec
  • goserelin
  • goserelin acetate ER
  • GPR40 antagonists
  • GRNVAC1
  • GSK-1059615
  • GSK-2130579A
  • GSK-2302024A
  • GTx-758
  • GV-1001
  • GV-1002
  • GVAX
  • GVX-3322
  • GX-301
  • HAS2 inhibitor
  • HE-3235
  • Her-2/Neu peptides
  • HER2 vaccine
  • her2/neu antigen
  • Her2/neu gene therapy
  • histrelin
  • huBrE-3 tiuxetan
  • HuMax-Her2
  • HuMax-VEGF
  • icotinib hydrochloride
  • icrucumab
  • idronoxil
  • IGF-1 receptor inhibitor
  • IGN-101
  • IKKe/TBK1 inhibitor
  • imatinib mesilate
  • imetelstat
  • IMGN-388
  • immunogene therapy
  • ImmunoVEX tri-melan
  • IMO-2055
  • IMP-321
  • Imuteran
  • INCB-028060
  • indisulam
  • inecalcitol
  • ING-1
  • ingenol mebutate
  • INGN-225
  • INGN-241
  • inherbins
  • iniparib
  • INNO-206
  • INSM-18
  • interferon (s1a)
  • interleukins
  • intetumumab
  • IPH-3102
  • ipilimumab
  • IPP-204106
  • irinotecan
  • irinotecan hydrochloride
  • irosustat
  • ispinesib mesylate
  • JMR-132
  • KW-2170
  • KX2-391
  • labetuzumab
  • labetuzumab-SN-38
  • lapatinib ditosylate
  • lapuleucel-T
  • larotaxel
  • lasofoxifene
  • lenvatinib
  • leptin antagonists
  • lestaurtinib
  • letrozole
  • leucine-doxorubicin
  • leuprolide
  • leuprolide acetate
  • leuprorelin
  • leuprorelin acetate
  • linifanib
  • linsitinib
  • LIP-131I
  • LipoVIL12
  • litronesib
  • lonafarnib
  • lonaprisan
  • LOR-2040
  • LOR-2501
  • Lovaxin B
  • LY-2157299
  • LY-2275796
  • MAGE-3-TK
  • MAGH-22
  • MCS-110
  • MDV-3100
  • MDX-1140
  • ME-103
  • MEDI-547
  • Mesd-based peptides
  • MetXia
  • MGN-1601
  • MGN-1703
  • milataxel
  • mitoxantrone
  • MK-2206
  • MKC-1
  • MLN-8237
  • MM-111
  • MM-121
  • MORAb-004
  • motesanib diphosphate
  • motexafin gadolinium
  • MP-529
  • MS-209
  • MSI vaccine
  • MT-110
  • MUC-1 vaccine
  • MVA-BN
  • MVA-BN Her-2 vaccine
  • Nab-docetaxel
  • nadroparin
  • neratinib
  • nilutamide
  • nimotuzumab
  • NK-012
  • NL-0031
  • nolatrexed dihydrochloride
  • Norelin
  • NXD-30001
  • OB-cadherin antibodies
  • oblimersen sodium
  • OCM-111
  • OCM-8054
  • OCM-8224
  • OGX-225
  • OGX-427
  • olaparib
  • olaratumab
  • ON-01910
  • ON-045270
  • onartuzumab
  • Onco-L TCS
  • oncolytic viruses
  • Onyvax-105
  • orteronel
  • OSI-7904L
  • osteolytic disease therapy
  • Osteopontin-c inhibitor

OTS-102 ozarelix P276-00 paclitaxel paclitaxel (1) paclitaxel (10) paclitaxel (11) paclitaxel (12) paclitaxel (13) paclitaxel (14) paclitaxel (2) paclitaxel (3) paclitaxel (4) paclitaxel (5) paclitaxel (6) paclitaxel (7) paclitaxel (8) paclitaxel (9) paclitaxel polyglumex paclitaxel-DHA panitumumab PankoPep panobinostat PANVAC-VF patupilone pazopanib hydrochloride PD-0325901 PD-0332991 pDOM-PSMA27 pelitinib pemetrexed disodium pentamidine isethionate PEP-223 peptidomimetics perifosine pertuzumab PhG-alpha-1 pixantrone PKI-179 PKI-587 plitidepsin PLX-3397 poly-ICLC PR1:169-177 peptide pralatrexate Prolanta Prolanta ER ProstAtak prostate cancer therapy PROSTVAC PRX-302 PRX-321 PSK-3668 PTC-299 PX-104.1 PX-866 quarfloxacin quinacrine R-(-)-gossypol R-763 radiotherapeutic raloxifene hydrochloride ramucirumab retaspimycin Reximmune-C Rexin-G RG-1507 RG-7321 rhErbB3-f ridaforolimus rilotumumab rindopepimut rinfabate romidepsin RR-310 rubitecan ruxolitinib S1P3 inhibitor sabarubicin sagopilone SAI-EGF SAR-566658 saracatinib sargramostim SB-939 SBC-202 Sch-57050 SEL-24-1 seliciclib selumetinib semaxanib seocalcitol SERM + toxin SF-1126 siltuximab simotaxel sipuleucel-T siRNA gp96 therapy SM3 SN-38 (1) SN-38 (2) SNG-163 SNG-8023 SNG-8038 sorafenib tosylate SPC-2968 SR-13668 SR-16157 SR-31747 s-lapachone STA-9090 steroid sulfatase inhibitor Stimuvax STP-503 SU-14813 SU-6668 sunitinib malate survivin-2B Symadex TAK-448 talminogene laherparepvec tamoxifen (1) tamoxifen (2) tamoxifen, oral liquid tandutinib tanespimycin tariquidar TAS-108 tasquinimod tegafur + uracil telomerase vaccine temsirolimus Tenarad TG-4001 TG-4010 thiocoraline thymalfasin thymectacin tipifarnib tivozanib TLK-58130 TLN-4601 TNF + paclitaxel TNF-alpha TOK-001 toremifene citrate trastuzumab (1) trastuzumab (2) trastuzumab (3) trastuzumab emtansine trastuzumab-MMAE conjugate TRC-105 tremelimumab triapine triciribine phosphate trilostane triptorelin triptorelin pamoate TroVax TS-1 TTL-2019 TTL-3101 tucotuzumab celmoleukin UCN-01 V-930 V935 vandetanib varlitinib vatalanib veliparib verpasep caltespen vismodegib VM-206 VS-4718 VS-507 VS-5095 VX-001 WX-671 WX-UK1 XL-147 XL-647 XL-765 Y-90-labetuzumab YM-155 Zemab zibotentan ZYC-300

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