Abstract
Executive Summary
BioSeeker Group have identified 207 companies plus partners who are today
developing 254 cancer stem cells and developmental pathways drugs in 712
developmental projects in cancer across 177 different targets. In addition,
there are 3 suspended drugs and another 124 drugs where development has been
ceased.
For busy executives within Pharma, Biotech and Investment companies who know
they need to stay on top of the developmental environment in their field, we
offer the Drug Pipeline update series.
You get detailed, world-wide drug pipeline information, delivered in an
unbiased and independent pipeline progress analysis for each identified drug.
Buying the Cancer Stem Cells Drug Pipeline Update 2012 will mean you have this
important data at your fingertips and ensure that you can:
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc. and track
them by their products.
- Jump start competitive drug intelligence operations
- Benchmark your own development against world wide data
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/outlicensing strategy work
Some facts about Cancer Stem Cells Drug Pipeline Update 2012
Treatments designed to target and destroy cancer stem cells may come to
revolutionize how we treat cancer. This unique product covers both explicit
cancer stem cell drug development and cancer drugs which are inhibitors of the
Hedgehog, Notch, and WNT Pathway. These developmental pathways are frequently
activated in neoplasms, and particularly in the rare subpopulation of cancer
stem cells.
There are today 207 companies plus partners developing 254 cancer stem cells
and developmental pathways drugs in 712 developmental projects in cancer. In
addition, there are 3 suspended drugs and the accumulated number of ceased
drugs over the last years amount to another 124 drugs. Cancer Stem Cells Drug
Pipeline Update lists all drugs and gives you a progress analysis on each one
of them. Identified drugs are linked to 177 different targets. These targets
are further categorized on in the software application by 38 classifications
of molecular function and with pathway referrals to BioCarta, KEGG and NetPath.
Table of Contents
This short overview shows actual findings from the Cancer Stem Cells Drug
Pipeline Update 2012 report.
Investigators
Includes more than 207 principal investigators plus their collaborators. There
is direct access from inside the application to web pages of all principal
investigators.
Note: You are able to sort and find drugs according to investigators
and partners from drop-down menus in the application. You may also sort and
find drugs according to country of investigator.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 254 cancer stem cells and developmental
pathways drugs in development, which have a total of 712 developmental
projects in cancer. In addition there are suspended and ceased drugs.
Pipeline Breakdown According to Number of Drugs:
- Marketed# 17
- Registered# 1
- Pre-registration# 2
- Phase III# 11
- Phase II# 60
- Phase I# 79
- Preclinical# 172
- No Data# 3
- Suspended# 3
- Ceased# 124
Note: You are able to sort and find drugs according to developmental
stage from drop-down menu in the application.
Indications
Included cancer stem cells and developmental pathways drugs are also in
development for 134 other indications, where of 77 are different cancer
indications.
Note: You are able to find and sort drugs according to type of
indication from drop-down menu in the application.
Targets
Identified drugs are linked to more than 177 different targets, divided into
38 classifications of molecular function:
- ATPase activity
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Cysteine-type peptidase activity
- Cytokine activity
- Cytoskeletal protein binding
- DNA binding
- DNA repair protein
- DNA topoisomerase activity
- G-protein coupled receptor activity
- Growth factor activity
- GTPase activity
- Isomerase activity
- Kinase activity
- Kinase binding
- Kinase regulator activity
- Ligand-dependent nuclear receptor activity
- Lipase activity
- Lipid kinase activity
- Metallopeptidase activity
- Molecular function unknown
- Oxidoreductase activity
- Protein binding
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor binding
- Receptor signaling complex scaffold activity
- Receptor signaling protein serine/threonine kinase activity
- Structural constituent of cytoskeleton
- Structural molecule activity
- Transcription factor activity
- Transcription regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
- Ubiquitin-specific protease activity
Identified targets are categorized into 28 different primary and alternate
sub-cellular localizations:
- Basolateral membrane
- Cell junction
- Centrosome
- Chromosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytoskeleton
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Golgi apparatus
- Integral to membrane
- Kinetochore
- Microtubule
- Mitochondrial membrane
- Mitochondrion
- Nuclear membrane
- Nucleolus
- Nucleoplasm
- Nucleus
- Perinuclear region
- Perinuclear vesicle
- Plasma membrane
- Secreted
- Synaptic vesicle
- Vesicle
Note: You are able to find and sort drugs according to target gene
name, molecular function of target, and target localization from drop-down
menus in the application.
Target Expression Profile
Direct links are provided from inside the application to 259 protein
expression profiles of 149 drug targets in various human tissues and cancer
types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referals
Identified targets have been cross referenced against their involvement in
different cellular pathways, according to BioCarta, KEGG and NetPath.
- BioCarta# 220 Pathways
- KEGG# 133 Pathways
- NetPath# 25 Signaling Pathways
Note: You are able to find and sort drugs according to targeted
pathways from drop-down menus in the application.
Mechanism
In total there are different drug mechanism of action represented in this Drug
Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of
action from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type
from drop-down menu in the application.
The Drug Profiles: Progress analysis and review of drug development.
Cancer Stem Cells Drug Pipeline Update 2012 provides you with a profile for
each identified drug. A typical drug profile reports on, depending on stage of
development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms.
Principal Investigator & Partners
Presentation of principal investigator and partners.
Target and Molecular Function of Target
Described target(s) is/are presented with: of Target
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular
Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles Links to protein expression profile(s) of target(s)
in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways
according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication,
developmental stage and status.
Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight.
Patent Data
Available patent information related to the drug is presented here.
Analysis
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific
data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific
data.
Licensing Information
Availability for licensing.
About the unique Drug Pipeline Update Software Application
After purchase, the Drug Pipeline Update is delivered to you via electronic
download in a powerful yet easy to use desktop application which requires no
installation.
Find and sort drugs by twelve different parameters plus free text search
field. Our dynamic report generator lets you easily and quickly generate HTML
drug profile reports directly in your web browser, whether it is a single drug
profile or your own report selection of drugs that match your criteria.
Application Features
Use 13 different parameters, available in drop-down menus, to find and sort
among drugs:
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas,
KEGG, and NetPath
- Direct links to company web pages of principal investigators
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html
reports directly in your web browser (Internet Explorer), whether it is a
single drug profile or an entire search you want have a report of.
System Requirements
- Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow
Leopard) and OS X 10.7 (Lion)
- Browser Application (Internet Explorer)
- Internet access (to access related internet resources)
Cancer Stem Cells Drug Pipeline Update 2013 published by BioSeeker Group AB in April 22, 2013. This report price starts from US $ 2249.
The contents of this page may be different from the latest version. Please contact us for details.
