• Japanese
  • Korean
  • Chinese
Cover Image

Nanotechnology for Drug Delivery: Global Market for Nanocrystals

Abstract

Nanocrystals will account for 60% of a $136 billion nanotechnology-enabled drug delivery market by 2021. We forecast the total market size in 2021 to be US$136 billion, with a 60/40 split between nanocrystals and nanocarriers respectively.

Since we now understand that most (if not all) biological processes occur at the nanoscale, the application of life science principles - studying the causes of biological phenomena at the molecular level - means that medical and biomedical research is increasingly using a bottom-up (rather than the top-down) approach.

One of the biggest challenges researchers face when developing a new drug is how to maximise its solubility in the body. Poor solubility in water correlates with poor bioavailability, which in turn leads to poor delivery. Nanocrystals are ground in special mills producing nano-sized drugs, which are applicable intravenously as nanosuspensions. This procedure enhances the surface/volume-ratio and thus the solubility and bioavailability of most insoluble pharmaceuticals.

The low bioavailability resulting from traditional oral and intravenous drug delivery methods and the market forces at work in the pharmaceutical industry - where patents expire after a relatively short period of time unless a novel form of drug delivery is developed that will extend the patent - are two major forces that will fuel the growth of the nano tech enabled drug delivery market.

The healthcare market is changing. We are seeing a paradigm shift away from blockbusters and a 'one-size fits all' approach to a more personalised medicine based on an individual's unique genome and immune response. The more scientists learn about the molecular causes for disease the more targeted and effective nanotechnology-enabled drug delivery therapies will become.

Table of Contents

TABLE OF EXHIBITS

EXECUTIVE SUMMARY

CHAPTER 1 - INTRODUCTION

  • REPORT SCOPE
  • METHODOLOGY
    • Procurement
    • Calculation of CAGR
  • THE NANOSCALE
    • Two biological examples that illustrate nanoscale:

CHAPTER 2 - NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE

  • OVERVIEW OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
    • Why is Nanotechnology A Critical Application for Medicine and Biomedicine?
    • Why Nanotechnology Is Needed for Medicine and Biomedicine
  • WHAT ARE THE KEY DRIVERS FOR ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND
  • BIOMEDICINE?
    • The Aim Of Drug Targeting
    • Rapid Market Growth
    • Market Drivers For Enhanced Drug Delivery
    • Increasing Proportion of The Ageing Population
    • Demand For More Affordable Health Care
    • Public Health - Ending disease
    • Demand for More Innovation
    • Social responsibility
  • THE KEY APPLICATIONS OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
    • How Nanotechnology Can Benefit Drug Delivery
    • Nanotechnology in Medical and Biomedical Diagnostics
    • Nanotechnology in Regenerative Medicine and Tissue Engineering
    • Other Applications For Nanomaterials In The Medical And Pharmaceutical Sector
  • PROMISING EXAMPLES OF NANOTECHNOLOGY ENABLED DRUG DELIVERY
    • Case Study 1 - Magnetic Field Acts as "Remote Control" to Deliver Nanomedicine
    • Case Study 2 - Adaptive Micro and Nanoparticles: Temporal Control Over Carrier
    • Properties to Facilitate Drug Delivery
    • Case Study 3 - Fabrication of a Nanocarrier System Through Self-Assembly of Plasma
    • Protein And Its Tumour Targeting
    • Case Study 4 - IBM And The Institute of Bioengineering And Nanotechnology Find
    • Breakthrough For MRSA

CHAPTER 3 - RISK & REGULATION

  • THREE KEY BARRIERS TO THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
    • Nanotoxicity, Nanopollution and Nanosafety
    • Ethical Considerations Of Nanotherapies
    • Delayed Nanoregulation
  • FIVE CURRENT & FUTURE CHALLENGES IN THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
    • Current & Future Challenges of Nanosafety And Risk Management
    • Current & Future Challenges of Nanoregulation
    • Current & Future Challenges for the Nanomedicine Industry
    • Current & Future Challenges of Sustained Innovation
    • Current & Future Challenges of Cooperation

CHAPTER 4 - MARKET FOR NANOCRYSTALS

  • GLOBAL NDD MARKET ANALYSIS: 2000-2010
  • GLOBAL NDD MARKET FORECAST: 2011-2021
  • DISCUSSION OF NANOPARTICLES AND NANOCRYSTALS
  • Overview of The Key Nanotechnologies Used in Drug Delivery Sorted by Applications
    • Nanopharmaceuticals
    • Nanotechnology In Drug Delivery
    • Nanobiotechnology In Drug Delivery
    • Analytical Techniques For Nanoparticle Drug Delivery
    • Properties
    • Production of Nanoparticles
    • Measuring Dispersion of Nanoparticles
    • Characterisation of Delivery Systems
    • What Can Nanoparticles do in Drug Delivery?
    • Drug Nanocrystals: Nanosizing The Drugs
    • Clinically Approved Nanocrystals-Based Drug Formulations With Presence on The Market
    • Production methods
    • Projected Product Pipeline For Nanocrystals-Based Drug Formulations In Drug Delivery
    • Market
    • Semapimod&rec;(cytokine, pharmasciences)
    • Paxceed™
    • Theralux™
    • Nucryst&rec;
    • iSPERSE™
  • ANALYSIS OF TAM FOR NANOCRYSTALS: 2000-2010
  • TAM FORECAST FOR NANOCRYSTALS: 2011-2021

APPENDIX

Table of Exhibits

  • Exhibit 1.1
    • Formula for the calculation of the Compound Annual Growth Rate (CAGR), (top).
    • Formula for the calculation of the Compound Annual Growth Rate (CAGR) in this report, for the 2011-2021 period, (bottom) [2].
  • Exhibit 1.2
    • Formula for the verification of the calculated values of the Compound Annual Growth Rate (CAGR), (top).
    • Formula for the verification of the calculated values of the Compound Annual Growth Rate (CAGR) in this report, for the 2011-2021 period, (bottom) [2].
  • Exhibit 1.3
    • Nanometers in a meter (top). Meters in a nanometer (bottom).
  • Exhibit 2.1
    • Illustration of the fact that the periodic table of elements, as we know it (at meter scale) governed by classic
    • Newtonian laws of physics. However, when perceived at nanoscale, those elements are governed by the laws of quantum physics.
  • Exhibit 2.2
    • Proportion of the population aged over 65 and over 80 [7].
  • Exhibit 2.3
    • Illustration of a diagram of each property of nanocarriers (size, shape, surface chemistry and mechanical properties) and their parameters subjected to optimization in order to improve their efficiency [10].
  • Exhibit 3.1
    • Specified expected barriers in the development of particular types of nanoparticles (Courtesy of CienNanoroadmap Synthesis Report), [6].
  • Exhibit 3.2
    • Illustration of the measures adoption roadmap to combat/attenuate the key barriers to the adoption of nanotechnology in medicine and biomedicine (Source: Cientifica, Ltd.).
  • Exhibit 3.3
    • Table representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 3.4
    • Line chart representing Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 3.5
    • Bar chart representing Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 3.6
    • Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 3.7
    • Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 3.8
    • Bar chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.1
    • Typical Image of Colloidal Gold Nanoparticles [1].
  • Exhibit 4.26
    • Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.4
    • Advantages and disadvantages of different methods for the production of drug nanocrystals [6].
  • Exhibit 4.67
    • Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.7
    • Representative examples of clinically approved nanocrystals-based drug formulations with presence on the market [6]
  • Exhibit 4.37
    • 3-D pie chart representing the Total Addressable Market, TAM in 2010, for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures in percentage).
  • Exhibit 4.38
    • Line chart representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.39
    • 3-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$
    • Million Dollars).
  • Exhibit 4.40
    • 3-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.45
    • In vivo effects of nanocrystals-based drug formulations [6].
  • Exhibit 4.78
    • 3-D pie chart representing the Total Addressable Market, TAM forecast in 2021, for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures in percentage).
  • Exhibit 4.79
    • Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021, for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.80
    • Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$
    • Million Dollars).
  • Exhibit 4.81
    • 3-D stacked vertical bar graph representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).
  • Exhibit 4.82
    • 3-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Appendix

  • Exhibit A.1
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: North America; country: USA.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.2
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country: Germany.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.3
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country: France.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.4
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country: UK.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.5
    • Table of publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. Country: Russian Federation.
    • Organizations are ordered alphabetically (increasing order).
  • Exhibit A.6
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: India.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.7
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: India.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.8
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: Japan.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.9
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: P R China.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.10
    • Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: South Korea (Republic of Korea).
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
  • Exhibit A.11
    • Table of publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. Asia; country: Taiwan.
    • Organizations are ordered first by descending order of total articles published and then ordered alphabetically (increasing order), if applicable.
Show More
Pricing
Get Notified
Email me when related reports are published