Nanocrystals will account for 60% of a $136 billion nanotechnology-enabled
drug delivery market by 2021. We forecast the total market size in 2021 to be
US$136 billion, with a 60/40 split between nanocrystals and nanocarriers
respectively.
Since we now understand that most (if not all) biological processes occur at
the nanoscale, the application of life science principles - studying the
causes of biological phenomena at the molecular level - means that medical and
biomedical research is increasingly using a bottom-up (rather than the
top-down) approach.
One of the biggest challenges researchers face when developing a new drug is
how to maximise its solubility in the body. Poor solubility in water
correlates with poor bioavailability, which in turn leads to poor delivery.
Nanocrystals are ground in special mills producing nano-sized drugs, which are
applicable intravenously as nanosuspensions. This procedure enhances the
surface/volume-ratio and thus the solubility and bioavailability of most
insoluble pharmaceuticals.
The low bioavailability resulting from traditional oral and intravenous drug
delivery methods and the market forces at work in the pharmaceutical industry
- where patents expire after a relatively short period of time unless a novel
form of drug delivery is developed that will extend the patent - are two major
forces that will fuel the growth of the nano tech enabled drug delivery market.
The healthcare market is changing. We are seeing a paradigm shift away from
blockbusters and a 'one-size fits all' approach to a more personalised
medicine based on an individual's unique genome and immune response. The more
scientists learn about the molecular causes for disease the more targeted and
effective nanotechnology-enabled drug delivery therapies will become.
Table of Contents
Table of Contents
TABLE OF EXHIBITS
EXECUTIVE SUMMARY
CHAPTER 1 - INTRODUCTION
REPORT SCOPE
METHODOLOGY
Procurement
Calculation of CAGR
THE NANOSCALE
Two biological examples that illustrate nanoscale:
CHAPTER 2 - NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
OVERVIEW OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
Why is Nanotechnology A Critical Application for Medicine and
Biomedicine?
Why Nanotechnology Is Needed for Medicine and Biomedicine
WHAT ARE THE KEY DRIVERS FOR ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND
BIOMEDICINE?
The Aim Of Drug Targeting
Rapid Market Growth
Market Drivers For Enhanced Drug Delivery
Increasing Proportion of The Ageing Population
Demand For More Affordable Health Care
Public Health - Ending disease
Demand for More Innovation
Social responsibility
THE KEY APPLICATIONS OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE
How Nanotechnology Can Benefit Drug Delivery
Nanotechnology in Medical and Biomedical Diagnostics
Nanotechnology in Regenerative Medicine and Tissue Engineering
Other Applications For Nanomaterials In The Medical And Pharmaceutical
Sector
PROMISING EXAMPLES OF NANOTECHNOLOGY ENABLED DRUG DELIVERY
Case Study 1 - Magnetic Field Acts as "Remote Control" to Deliver
Nanomedicine
Case Study 2 - Adaptive Micro and Nanoparticles: Temporal Control Over
Carrier
Properties to Facilitate Drug Delivery
Case Study 3 - Fabrication of a Nanocarrier System Through Self-Assembly
of Plasma
Protein And Its Tumour Targeting
Case Study 4 - IBM And The Institute of Bioengineering And
Nanotechnology Find
Breakthrough For MRSA
CHAPTER 3 - RISK & REGULATION
THREE KEY BARRIERS TO THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND
BIOMEDICINE
Nanotoxicity, Nanopollution and Nanosafety
Ethical Considerations Of Nanotherapies
Delayed Nanoregulation
FIVE CURRENT & FUTURE CHALLENGES IN THE ADOPTION OF NANOTECHNOLOGY IN
MEDICINE AND BIOMEDICINE
Current & Future Challenges of Nanosafety And Risk Management
Current & Future Challenges of Nanoregulation
Current & Future Challenges for the Nanomedicine Industry
Current & Future Challenges of Sustained Innovation
Current & Future Challenges of Cooperation
CHAPTER 4 - MARKET FOR NANOCRYSTALS
GLOBAL NDD MARKET ANALYSIS: 2000-2010
GLOBAL NDD MARKET FORECAST: 2011-2021
DISCUSSION OF NANOPARTICLES AND NANOCRYSTALS
Overview of The Key Nanotechnologies Used in Drug Delivery Sorted by
Applications
Nanopharmaceuticals
Nanotechnology In Drug Delivery
Nanobiotechnology In Drug Delivery
Analytical Techniques For Nanoparticle Drug Delivery
Properties
Production of Nanoparticles
Measuring Dispersion of Nanoparticles
Characterisation of Delivery Systems
What Can Nanoparticles do in Drug Delivery?
Drug Nanocrystals: Nanosizing The Drugs
Clinically Approved Nanocrystals-Based Drug Formulations With Presence
on The Market
Production methods
Projected Product Pipeline For Nanocrystals-Based Drug Formulations In
Drug Delivery
Market
Semapimod&rec;(cytokine, pharmasciences)
Paxceed™
Theralux™
Nucryst&rec;
iSPERSE™
ANALYSIS OF TAM FOR NANOCRYSTALS: 2000-2010
TAM FORECAST FOR NANOCRYSTALS: 2011-2021
APPENDIX
Table of Exhibits
Exhibit 1.1
Formula for the calculation of the Compound Annual Growth Rate (CAGR),
(top).
Formula for the calculation of the Compound Annual Growth Rate (CAGR) in
this report, for the 2011-2021 period, (bottom) [2].
Exhibit 1.2
Formula for the verification of the calculated values of the Compound
Annual Growth Rate (CAGR), (top).
Formula for the verification of the calculated values of the Compound
Annual Growth Rate (CAGR) in this report, for the 2011-2021 period, (bottom)
[2].
Exhibit 1.3
Nanometers in a meter (top). Meters in a nanometer (bottom).
Exhibit 2.1
Illustration of the fact that the periodic table of elements, as we know
it (at meter scale) governed by classic
Newtonian laws of physics. However, when perceived at nanoscale, those
elements are governed by the laws of quantum physics.
Exhibit 2.2
Proportion of the population aged over 65 and over 80 [7].
Exhibit 2.3
Illustration of a diagram of each property of nanocarriers (size, shape,
surface chemistry and mechanical properties) and their parameters subjected
to optimization in order to improve their efficiency [10].
Exhibit 3.1
Specified expected barriers in the development of particular types of
nanoparticles (Courtesy of CienNanoroadmap Synthesis Report), [6].
Exhibit 3.2
Illustration of the measures adoption roadmap to combat/attenuate the
key barriers to the adoption of nanotechnology in medicine and biomedicine
(Source: Cientifica, Ltd.).
Exhibit 3.3
Table representing the Total Addressable Market, TAM (2000-2010), for
nanotechnology in drug delivery, without segmentation, source: Cientifica
(all figures US$ Million Dollars).
Exhibit 3.4
Line chart representing Total Addressable Market, TAM (2000-2010), for
nanotechnology in drug delivery, without segmentation, source: Cientifica
(all figures US$ Million Dollars).
Exhibit 3.5
Bar chart representing Total Addressable Market, TAM (2000-2010), for
nanotechnology in drug delivery, without segmentation, source: Cientifica
(all figures US$ Million Dollars).
Exhibit 3.6
Table representing the Total Addressable Market, TAM forecast by 2021
(for the 2011-2021 period), for nanotechnology in drug delivery, without
segmentation, source: Cientifica (all figures US$ Million Dollars).
Exhibit 3.7
Line chart representing the Total Addressable Market, TAM forecast by
2021 (for the 2011-2021 period), for nanotechnology in drug delivery,
without segmentation, source: Cientifica (all figures US$ Million Dollars).
Exhibit 3.8
Bar chart representing the Total Addressable Market, TAM forecast by
2021 (for the 2011-2021 period), for nanotechnology in drug delivery,
without segmentation, source: Cientifica (all figures US$ Million Dollars).
Exhibit 4.1
Typical Image of Colloidal Gold Nanoparticles [1].
Exhibit 4.26
Table representing the Total Addressable Market, TAM forecast by 2021
(for the 2011-2021 period), for nanocrystals, source: Cientifica (all
figures US$ Million Dollars).
Exhibit 4.4
Advantages and disadvantages of different methods for the production of
drug nanocrystals [6].
Exhibit 4.67
Table representing the Total Addressable Market, TAM forecast by 2021
(for the 2011-2021 period), for nanocrystals, source: Cientifica (all
figures US$ Million Dollars).
Exhibit 4.7
Representative examples of clinically approved nanocrystals-based drug
formulations with presence on the market [6]
Exhibit 4.37
3-D pie chart representing the Total Addressable Market, TAM in 2010,
for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals,
source: Cientifica (all figures in percentage).
Exhibit 4.38
Line chart representing the Total Addressable Market, TAM (2000-2010),
for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals,
source: Cientifica (all figures US$ Million Dollars).
Exhibit 4.39
3-D stacked vertical bar graph representing the Total Addressable
Market, TAM (2000-2010) , for nanotechnology in drug delivery, nanocarriers
versus drug nanocrystals, source: Cientifica (all figures US$
Million Dollars).
Exhibit 4.40
3-D stacked area chart representing the Total Addressable Market, TAM
(2000-2010) , for nanotechnology in drug delivery, nanocarriers versus drug
nanocrystals, source: Cientifica (all figures US$ Million Dollars).
Exhibit 4.45
In vivo effects of nanocrystals-based drug formulations [6].
Exhibit 4.78
3-D pie chart representing the Total Addressable Market, TAM forecast in
2021, for nanotechnology in drug delivery, nanocarriers versus drug
nanocrystals, source: Cientifica (all figures in percentage).
Exhibit 4.79
Horizontal bar graph representing the Total Addressable Market, TAM
forecast in 2021, for nanotechnology in drug delivery, nanocarriers versus
drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).
Exhibit 4.80
Line chart representing the Total Addressable Market, TAM forecast by
2021 (for the 2011-2021 period), for nanotechnology in drug delivery,
nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$
Million Dollars).
Exhibit 4.81
3-D stacked vertical bar graph representing the Total Addressable
Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology
in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica
(all figures US$ Million Dollars).
Exhibit 4.82
3-D stacked area chart representing the Total Addressable Market, TAM
forecast by 2021 (for the 2011-2021 period), for nanotechnology in drug
delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all
figures US$ Million Dollars).
Appendix
Exhibit A.1
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: North America; country: USA.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.2
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: European Union; country:
Germany.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.3
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: European Union; country:
France.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.4
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: European Union; country: UK.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.5
Table of publishing activity in PubMed periodicals (2000-2010), based on
PubMed, for Nanotechnology in Drug Delivery. Country: Russian Federation.
Organizations are ordered alphabetically (increasing order).
Exhibit A.6
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: Asia; country: India.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.7
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: Asia; country: India.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.8
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: Asia; country: Japan.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.9
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: Asia; country: P R China.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.10
Table of the top 20 organizations showing the highest publishing
activity in PubMed periodicals (2000-2010), based on PubMed, for
Nanotechnology in Drug Delivery. World Region: Asia; country: South Korea
(Republic of Korea).
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Exhibit A.11
Table of publishing activity in PubMed periodicals (2000-2010), based on
PubMed, for Nanotechnology in Drug Delivery. Asia; country: Taiwan.
Organizations are ordered first by descending order of total articles
published and then ordered alphabetically (increasing order), if applicable.
Nanotechnology for Drug Delivery: Global Market for Nanocrystals published by Cientifica Ltd in February 29, 2012. This report price starts from US $ 1599.
