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Special Report: Infectious Disease Vaccines--Unmet Needs and Opportunities for Pharma

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This publication has been discontinued on July 17, 2013.

Abstract

Introduction:

"By sheer numbers, it' s a huge pool of people that immunizations could really reach and make an enormous impact." So one surveyed physician describes the potential impact of vaccines for infectious disease. Indeed, the size of the population is one reason why companies are taking a fresh look at the vaccine sector. An increasing global reach, clinical accomplishments, strides in establishing vaccine safety and manufacturer security, and ongoing unmet needs are also fueling vaccine development.

Questions Answered in This Report:

  • The vaccine marketplace is highly concentrated. What is the size of this market, and what is its growth trend? Which companies are the leaders based on 2010 sales? Will those rankings change? What opportunities are available to these and other contenders in the vaccines space?
  • Pfizer bought its way into the upper echelons of the vaccine marketplace by acquiring Wyeth in 2009. Why would a company like Pfizer be attracted to a potential acquiree' s vaccine assets? What other notable recent deals have occurred in the vaccines arena?
  • Shortly after HIV was identified as the cause of AIDS in the early 1980s, Health and Human Services Secretary Margaret Heckler famously declared that a vaccine would be available within two years. What is the status of HIV vaccine development? What challenges must researchers confront? What are the considerations related to prophylactic versus therapeutic vaccines for HIV?
  • In December 2010, the FDA approved Merck' s Gardasil for the prevention of anal cancers. What is next for Gardasil and GlaxoSmithKline' s Cervarix? What impact will their availability have on approaches to immunization for adolescents?
  • Studies have shown that vaccines are not the cause of autism. How is this finding influencing perceptions of vaccine safety, according to surveyed clinicians? What other steps are being taken to ensure vaccine safety - and vaccine manufacturer security?
  • Emerging markets are drawing the attention of pharmaceutical companies, including vaccine manufacturers. What are the pros and cons of selling vaccines in emerging markets? Which companies have established a notable presence in emerging markets?

Scope:

Primary research: Results from a Web-based survey of 106 U.S. physicians who administer infectious disease vaccines: infectious disease specialists, pediatricians, and primary care physicians (PCPs).

Market size: Worldwide and U.S. market size over 2005-2017; key competitors and their market share; market drivers and constraints.

Unmet needs: By segment, age-group, pathogen, and need in the clinical setting.

Salient events and trends: HIV vaccine development, prime-boost approach, RV-144, broadly active neutralizing antibodies (bnAbs), therapeutic versus prophylactic HIV vaccines, HPV vaccinations, adolescent immunization schedules, vaccine safety, vaccine/autism link, vaccine needs and challenges in emerging markets.

Deals: Select mergers, acquisitions, and partnerships and how they demonstrate opportunity and strategy.

Displays: 27 data-rich tables and figures.

Table of Contents

Executive Summary

  • Strategic Considerations
  • Stakeholder Implications

Introduction

Vaccine Market

Key Developments and New Opportunities

  • HIV Vaccine Development
  • HPV Vaccines - Cervical Cancer and Beyond
    • HPV Vaccines and Cervical Cancer
    • HPV Vaccines and Other Cancers.
    • HPV Vaccines in Emerging Markets
    • HPV Vaccines and the Potential to Extend Adolescent Vaccination and Vaccination Against STDS
  • Vaccine Safety
  • Emerging Markets
    • Favorable Population Dynamics
    • Healthcare System Development.
    • Expansion of Public and Private Healthcare Funding
    • Immunization Rate Momentum
    • Multinationals' Vaccine Strategies in Emerging Markets.

Survey Findings

  • Guidelines.
  • Current Practice.
  • Issues Concerning Pediatric Vaccines.
  • Access 33

Clinical Unmet Needs for Vaccine Products

  • Novel Vaccine Products.
  • Greater Access to and Funding for Vaccines
  • Improving Patient Compliance with Recommended Immunization Schedules
  • Identification of High-Risk Patients

Big Pharma' s Vaccine Ventures - Key Deals.

  • Pfizer/Wyeth
  • Johnson & Johnson/Crucell
  • Intercell/?
  • Sanofi/VaxDesign
  • Emergent BioSolutions/Various Partners
  • Merck/Hawaii Biotech
  • Liquidia Technologies/Bill and Melinda Gates Foundation

Outlook.

  • Vaccine Market Drivers
    • Growth in Established Disease Areas
    • Improving Price Environment in Developed Markets
    • Expanding Addressable Populations
    • Slowly Declining Fears over Vaccine Safety
  • Vaccine Market Constraints
    • Fewer Novel Vaccine Launches
    • Competition from Antibiotics and Antivirals.
    • Potential Obstacles in Emerging Markets

Tables

  • 1. Challenges in Developing a Vaccine Against HIV
  • 2. U.S. Vaccination Guidelines

Figures

  • 1. Worldwide Sales of Vaccines, 2005-2010.
  • 2. Vaccines: Top Companies Based on Worldwide Sales, 2010
  • 3. Worldwide Market Share: Vaccines by Indication, 2010
  • 4. Human Immunodeficiency Virus Structure
  • 5. Effect of HPV Vaccination on Number of Newly Diagnosed Incident Cases of Cervical Cancer in the United States, Europe, and Japan, 2010-2040
  • 6. Incidence of HPV-Related Cancers and Proportion of HPV 16/18 Cancers in Men and Women in the Netherlands, 1999-2003
  • 7. Survey Question: For your patients who take Gardasil, what are the top two reasons for patient noncompliance in completing all doses of Gardasil?
  • 8. Immunization Rates in Developing Countries
  • 9. Survey Question: In what region is your practice(s) located?
  • 10. Survey Question: Do you feel that pediatric and adult immunization guidelines are kept sufficiently up-to-date?
  • 11. Survey Question: Do you feel that pediatric and adult immunization guidelines are sufficiently comprehensive?
  • 12. Survey Question: Do you feel that pediatric and adult immunization guidelines are well communicated to physicians?
  • 13. Survey Question: What percentage of your patients receives the following vaccines each year?
  • 14. Survey Question: What percentage of your patients receives the following vaccines each year (by specialty)?
  • 15. Survey Question: In the past (3+ years ago), did you find that parents of pediatric patients declined or hesitated to vaccinate children because of fears of adverse outcomes such as autism?
  • 16. Survey Question: What is your opinion regarding administration of three to four pediatric vaccines simultaneously?
  • 17. Survey Questions: What percentage of patients in general do you believe miss out on recommended vaccinations based on lack of access to care?
  • 18. Survey Question: What factors might prevent an insurance company from paying for a vaccine?.
  • 19. Survey Question: Which subgroup of patients do you believe has the greatest unmet needs?
  • 20. Survey Question: Which do you believe the greatest unmet need to be?
  • 21. Survey Question: What are the top three pathogens for which emerging vaccines would deliver the greatest overall benefit (six highest-ranking pathogens)?
  • 22. Estimated Worldwide Sales of Vaccines, 2011-2017
  • 23. Vaccines: Top Companies Based on Projected Worldwide Sales, 2017.
  • 24. Survey Question: Where do you think near-term (next five years) investment in vaccines will come?
  • 25. Worldwide Market Share: Current and Emerging Vaccines, 2017
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