This report examines the background to the whole MI market, providing
estimates and evaluation in key areas and examining in-depth the companies,
innovative products and academic research that are driving change.
Molecular imaging is radically impacting the diagnosis of disease and the
development of pharmaceuticals.
Molecular Imaging (MI) encompasses a range of rapidly developing diagnostic
imaging techniques that combine new-generation imaging agents and advanced
imaging tools to capture specific molecular pathways in the body, particularly
disease targets.
The clinical benefits of MI are clear. If potentially lethal conditions such
as cancer or cardiovascular disease can be detected before they take hold,
patient outcomes can improve and healthcare costs will fall as the need for
surgery or late-stage treatments declines. When MI reaches its full potential,
it will fundamentally change the diagnosis and treatment of disease.
Much has happened recently in the field of MI. Many companies have entered
this new market and advanced contrast agents and imaging systems have been
launched, with more nearing commercialisation. New alliances, mergers and
acquisitions have taken place to bolster companies' prospects in the field,
with market leaders beginning to emerge.
The MI sector faces challenges: the agreement of standards and the development
of imaging technology and agents capable of being able to provide a meaningful
image at the cellular level. Few in the industry see these providing
significant hurdles to progress.
“Advances in imaging technology, along with increased understanding
of molecular and cellular processes, will revolutionise the early diagnosis
and treatment of major diseases”
The emergence of molecular imaging strategies is largely due to recent
unprecedented advances in molecular and cell biology techniques, the use of
transgenic animal models, availability of newer imaging drugs and probes that
are highly specific, and successful development of small-animal imaging
instrumentation.
These factors, along with continued expansion of scientific horizons in the
current post-genomic era, have been pivotal in the drive toward a new standard
that allows linking established in vitro and cell culture experimental assays
to imaging studies within living subjects.
Table of Contents
Table of Contents
MOLECULAR IMAGING
Molecular Imaging Modalities
Imaging technologies - comparison of characteristics
New MR-PET Hybrid Imaging Technology
Imaging Biomarkers
Drug Development
Initiatives for the Advancement of Molecular Imaging
Microdosing in Phase 0 Trials
Shortening Timelines for Drug Development
SNM
ACRIN
Collaborative Imaging Biomarker Center
Disease Focus - Key Areas
Alzheimer' s Disease
ADNI Study
Cancer
Prostate Cancer
Breast Cancer
Lung Cancer
Cardiovascular Disease
Challenges for Molecular Imaging Product Development
Summary - Challenges for Imaging in Clinical Trials
MARKET ESTIMATES
Fig.1: Medical Imaging Market, 2005-2010E (EUR billion)*
Fig.2: Medical Imaging Systems Market by Modality, 2005*
Fig.3: Medical Imaging Systems Market by Region, 2005*
Bayer Schering Pharma AG' s Radiopharmaceutical Operations
Eastern Isotopes
New Mexico Positron and Lubbock West Texas Positron
Divestitures
Scanditronix Magnet AB
Financials
Fiscal 2006
IMAGING DIAGNOSTIC SYSTEMS
CTLM system
Laser Imager for Lab Animals (LILA)
Patents
KEREOS
Product Pipeline
R&D Collaborations
Washington University
Dow Chemical Company
Bristol-Myers Squibb Medical Imaging (BMSMI)
Philips Medical Systems
LIGHTOOLS RESEARCH
MI Products
Pan-A-See-Ya Panorama
Illumatool Bright Light System
Macro-Imaging System Plus
MACROCYCLICS (MAGNETIC RESONANCE SOLUTIONS)
Research and Development
Research Agreements
MDS Nordion
University of Texas at Dallas
Research Grants
National Cancer Institute
MALLINCKRODT (COVIDIEN)
Products
Computed Tomography Contrast Media
Optiray
Magnetic Resonance Contrast Media
OptiMARK
Radiopharmaceuticals
Nuclear Oncology
Nuclear Cardology
Myoview
Financials
Fiscal 2006
MDS NORDION
Products
Medical Isotopes and Radiopharmaceuticals
Research Agreements
University of Ottawa Heart Institute
Avid Radiopharmaceuticals
Bradmer Pharmaceuticals
Molecular Insight Pharmaceuticals
Macrocyclics
Financials
First Quarter of 2007
Fiscal 2006
MEDISCIENCE TECHNOLOGY
Basis for Technology
Initial Products
CD-Ratiometer
Compact Photonic Pill
Funding
Market Size
Alliances
Alfanix Technology
Infotonics Technology Center
City University of New York (CUNY)
City College' s Institute for Ultrafast Spectroscopy and Lasers
Stokes Shift Emission Spectroscopy
MILABS
Products
U-SPECT II Scanners
Resolution - 0.35 mm in 3 dimensions (0.04 μl)
Dynamic 4D imaging
MIR PRECLINICAL SERVICES
MIR - Services
Efficacy Testing
Imaging
Pharmacokinetics
Pharmacodynamics
Drug Efficacy Testing in Models of Rheumatoid Arthritis (Experimental)
In Vitro Services
Preclinical Consulting
Validation of Clinical Imaging Technologies
Model Development
Evaluation of Imaging Contrast Agents
Independent Research
Imaging Systems
Proprietary Technology
In Vivo Caspase 3 Activation Assay
Ef-luc Transgenic Mouse
Agreements
Emiliem
Licensing Agreements
Biophotonic Imaging - Xenogen
Funding
State of Michigan' s 21st Century Jobs Fund
SBIR Grant
Facility
MOLECULAR INSIGHT PHARMACEUTICALS
Product Pipeline
Zemiva
Clinical Profile and Development
Azedra
Onalta
Other Pipeline Product Candidates
Oncology - Solazed
Prostate Cancer
Trofex (MIP-220)
Cardiology - MIP-190
Neurology - MIP-170D
Acquisitions
Radiopharmaceutical Manufacturing Facility
Agreements
Bayer Schering Pharma
Novartis Pharma AG
MDS Nordion
Eastern Isotopes (Ion Beam Applications)
Recent R&D Highlights
Financials
First quarter of 2007
Molecular Insight Operational Guidance
Patents
MOLECULAR NEUROIMAGING
Clinical Ligand Innovation Program (CLIP)
Clinical Imaging Site Coordination and Management (CLIC)
MNI Resources and Capabilities
NAVISCAN PET SYSTEMS
Products
PEM Flex Solo II
Agreements
Mayo Clinic
Funding
OLYMPUS
In Vivo Imaging Systems
IV100 Intravital Laser Scanning System
OV100 Small Animal Imaging System
Acquisitions and Alliances
Single Molecule Fluorescence Spectroscopy - Evotec Technologies
VisEn Medical
Cangen Biotechnologies
AntiCancer
PHILIPS MEDICAL SYSTEMS
MI Products
Preclinical Imaging Systems
Mosaic HP
NanoSPECT/CT
Clinical Products
Precedence SPECT/CT Systems
BrightView
JETStream Workspace 3.0
Gemini PET/CT Systems
Additional New Product Offerings
Gamma Cameras
Agreements
Bioscan
MRI Research Facility
Research Collaborations
University Medical Center Hamburg-Eppendorf (UKE)
MRI/PET Image Software Tool
Organon
BG Medicine
Dartmouth College
Bayer Schering Pharma AG
CellPoint
Kereos
Epix Pharmaceuticals
Financials
First Quarter of Fiscal 2007
Fiscal 2006
Key Financial Data, 2004-2006
PHOTOMETRICS (ROPER SCIENTIFIC)
Products
Lumazone CM Manual Chemiluminescence System
Lumazone CA Automated Chemiluminescence System
Lumazone FM Manual Fluorescence System
Lumazone FA Automated Fluorescence System
Spectral Imaging System for Fluorescence Microscopy
POSITRON
Products
mPower PET Scanner
Agreements
Dr. George Diamond - Cadenza Software
Mayerick Corporation
Funding
Patents
SA INSTRUMENTS
Small Animal Monitoring and Gating Products
Model 1025 Monitoring and Gating System
Model 1025L Monitoring and Gating System
SIEMENS MEDICAL SOLUTIONS
Products
Clinical Imaging
Biograph PET-CT Systems with TruePoint Technology
TruePoint SPECT-CT Systems
HD-PET
SPECT
c.cam
e.cam Signature Series
Symbia S
Clinical Applications
syngo
Preclinical Imaging
Inveon
microPET
microCAT
PETNET Solutions
PET Biomarkers
Research and Development
Imaging Biomarker for Alzheimer' s Disease Phase I Clinical Trial
FL-thymidine (FLT)
Serum HER-2/neu
Ultrasound - Liver Fibrosis Markers
MR Imaging - Magnetic Nanoparticles
IT Integration
Prototype Hybrid MRI-PET Imaging System
Siemens' Molecular Imaging Biomarkers Research Facility
Abu Dhabi - First Molecular Imaging Centre
Research Agreements
Wyeth Pharmaceuticals
University of Texas M. D. Anderson Cancer Center
Center for Molecular Imaging Research (CMIR)
Cytogen and University Hospitals of Cleveland
VisEn Medical
Commissariat à l' Energie Atomique
Emory University
Licensing Agreements
Cleveland Clinic
Acquisitions
Bayer Diagnostics and Diagnostic Products Corporation
CTI Molecular Imaging
Financials
Fiscal 2006
Fiscal 2007
First Quarter of Fiscal 2007
Second Quarter of Fiscal 2007
SPECTRUM DYNAMICS
Products
D-SPECT Cardiac Imaging System
D-SPECT Clinical Trials
Future Products
D-SPECT Hybrid CT
TK SIGNAL
Funding
Research Projects
Radioactive Tracers
ULTRASPECT
Products
Xpress.cardiac
Xact.bone
Xpress.bone
Funding
VISEN MEDICAL
Animal Imaging Products
Optical Probes
MMPSense - Probes capable of visualising MMP activity in tumours and
other sites of inflammation
AngioSPARK - Probes capable of enabling prolonged in vivo observation
AminoSPARK - Probes capable of enabling fluorescent tagging of
target molecules
ProSense
AngioSense
OsteoSense
Superhance
VivoTag
Genhance
Fluorescence Molecular Tomographic (FMT) Imaging System
Clinical Product Development
MI Alliances
Merck
Olympus
Analogic
Siemens
VISUALSONICS
Micro-ultrasound
Vevo 770
Applications
Techniques
Image-guided Injection
Screening
Blood Flow Analysis
3D Visualisation
Agreements
Bracco
University of Virginia
WILEX
Agreements
IBA Molecular
Financial Results
ZECOTEK MEDICAL SYSTEMS
PET-MRI Research Project - University of Washington
Scintillation Crystals
Silicon Photo-Multiplier
OCT Light Source - University of British Columbia
Funding
Patent Applications
ZYGOGEN
Z-Tag and Z-Lipotrack Zebrafish Technology
Angiogenesis
Anti-angiogenesis assay
Pro-angiogenesis assay
Neurodegeneration
Thrombosis
Lipid Metabolism
Toxicity
Predict QT Prolongation in heart-specific fluorescent zebrafish
Cytochrome P450 3A Activity
Target Validation
Compound Screening
Licensing Agreements
University of Minnesota - Morpholino Antisense Technology
DanioLabs - Z-Tag
SELECTED ACADEMIC AND RESEARCH INSTITUTIONS
UNITED STATES
Case Western Reserve University - NFCR Center for Molecular Imaging
CAMEL
City of Hope
Beckman Research Institute
Division of Molecular Medicine
Division of Medical Oncology & Therapeutics Research
Duke University
Duke Comprehensive Cancer Center
Center for Molecular and Biomolecular Imaging (CMBI)
Pulse Shaping and Heterodyne
Johns Hopkins University
JHU - In Vivo Cellular Molecular Imaging Center (ICMIC)
Development Projects
Massachusetts General Hospital - Center for Molecular Imaging Research
CMIR Programmes
Clinical Discovery Program
Mayo Clinic
Patterns between MRI-detected tumours and contralateral tumours
Mayo Clinic - Ramirez-Alvarado Lab (Protein Misfolding)
Molecular Imaging of Alzheimer' s Plaques
Research Collaboration with Gamma Medica
Memorial Sloan-Kettering Cancer Center
PET Imaging Identifies Aggressive Kidney Cancers that Require Surgery
Mount Sinai School of Medicine
Combining Molecular Imaging Technologies To Stop/Prevent Heart
Attacks
National Institutes of Health
National Cancer Institute
NIGMS - Exploratory Centres for the Development of High Resolution
Probes for Cellular Imaging
Fluorescent Probes for Multiplexed Intracellular Imaging
Sub-nm Dendrimer-Metal Nanoclusters as Ultrabright, Modular
Targeted in vivo Single Molecule Raman and Fluorescence Labels
Single-Molecule Fluorophores for Cellular Imaging
Bioaffinity Nanoparticle Probes for Molecular/Cellular Imaging
Probes for Quantitative Optical and Electron Microscopy
Imaging Single Proteins In Vivo with Quantum Dots
Light-Activated Gene Expression in Single Cells
Library-Based Development of New Optical Imaging Probes
Genetically Targetable Labels for Light and EM
Purdue University
New Imaging Approach Promises Insights into Multiple Sclerosis
Stanford University
Molecular Imaging Program at Stanford
Research on PET and CT separately and in combination in managing
patients with melanoma
Center of Excellence for Cancer Early Detection
Study findings - CT scans may reveal genetic activity of liver
tumours
Thomas Jefferson University
Circulating Tumour Cells Predict How Hormone-Resistant Prostate
Cancer Patients Fare
Translational Genomics Research Institute (TGen)
Alzheimer' s Disease Study
University of California
University of California, Los Angeles (UCLA)
Center for In Vivo Imaging in Cancer Biology
UCLA - Department of Molecular and Medical Pharmacology
Crump Institute for Molecular Imaging
New Brain Imaging Compound Shows Promise For Earlier Detection of
Alzheimer' s Disease
University of California, San Diego (UCSD)
University of California, Davis
Center for Molecular and Genomic Imaging (CMGI)
Cherry Laboratory - CMGI
University of Chicago
CAD technology may prove beneficial for tumour detection by PET
University of Michigan Health System
University of Minnesota
PET-CT is better for early detection of muscular lymphoma than CT
alone
University of Texas M.D. Anderson Cancer
Center for Advanced Biomedical Imaging Research
Department of Experimental Diagnostic Imaging
Targeted Molecular Imaging of Cancer
Washington University, St. Louis
Mallinckrodt Institute of Radiology
Optical Radiology Laboratory (ORL)
Lewis Lab
Center for Clinical Imaging Research
Cardiovascular Magnetic Resonance Imaging Laboratories (CMRL)
Siteman Center of Cancer Nanotechnology Excellence
Nanoparticles can track cells deep within living organisms
CANADA
McMaster Institute of Applied Radiation Sciences (McIARS)
University of Toronto, Ontario
Laboratory of Molecular Imaging and Targeted Radiotherapeutics
EUROPE
Belgium
University Hospital of Liège
Finland
Kuopio University, A.I Virtanen Institute for Molecular Sciences
France
CEA
SHFJ - First complete simulation of PET imaging scan of entire human
body
NeuroSpin
CNRS / Université VI Paris, Paris, France
Targeted and Functional Ultrasound, Laboratoire d' Imagerie
Paramétrique - UMR 7623
CNRS / University Victor Segalen, Bordeaux
Molecular and Functional Imaging: From Physiology to Therapy
Technological Research Team
Germany
Technical University of Munich, Munich
Fraunhofer Institute/Medical School, Hanover
Italy
University of Milan, Milan
Centre of Excellence on Neurodegenerative Diseases
Netherlands
Netherlands Cancer Institute
Department of Radiology
Impact of preoperative contrast-enhanced MRI in patients eligible
for breastconserving therapy: update on 325 patients15
Benefit of semi-automatic volumetric measurement of extent of breast
tumours from contrast-enhanced MRI
Accurate extent definition of non-small cell lung tumours using
pathology validated PET-CT
Optimising functional imaging approaches in a preclinical setting;
molecular imaging in mice
Sweden
Uppsala University
Karolinska Institutet, Uppsala, Sweden
Department of Geriatric Medicine, Neurotec and Uppsala PET Centre /
Imanet
Collaboration with AstraZeneca
United Kingdom
Cancer Research UK
Imperial College of Science, Technology and Medicine, London,
Neurology Group, MRC Clinical Sciences Centre, Hammersmith Hospital
Oxford University - Centre for Functional Magnetic Resonance Imaging
of the Brain (FMRIB)
University of Durham
Department of Chemistry
University of Manchester - Wolfson Molecular Imaging Centre,
University of Cambridge - Wolfson Brain Imaging Centre
University of Edinburgh, Edinburgh
SHEFC Brain Imaging Centre for Scotland, West of Scotland
Radionuclide Dispensary, and Institute of Neurological Sciences Glasgow
ASIA
Japan
National Institute of Radiological Sciences - Molecular Imaging Center
MIC Diagnostic Imaging Group
Molecular Diagnosis Team
Biomolecule Team
MIC - Molecular Neuroimaging Group
Molecular Neurobiology Team
System Neurochemistry Team
Molecular Probe Group
Probe Research Team
Biophysics Group
MR Molecular Imaging Team
Biosignal Physiology Team
Imaging Analysis Team
Imaging Physics Team
AUSTRALIA
Austin Hospital, Melbourne
Study - Amyloid Imaging in the Differential Diagnosis of Dementia
University of Sydney, Sydney
Academic Research Institute /Industry Collaborations
REFERENCES
REPORT METHODOLOGY
The Executive Guide to Molecular Imaging 2007 - 3rd Edition published by Espicom Business Intelligence in July 17, 2007. This report consists of 306+ PAGES and the price starts from US $ 1130.
The contents of this page may be different from the latest version. Please contact us for details.
