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Enzymes (US Market & Forecasts)

Abstract

US demand to increase 5.1% annually through 2014

Demand for enzymes in the US is forecast to rise more than five percent annually to $2.7 billion in 2014. Solid industry growth in recent years has been founded upon advances in higher-value, specialty enzymes used in applications such as pharmaceuticals, research and biotechnology, and biocatalysts, as well as the emerging biofuels market. Going forward, gains will come from continued expansion in these areas as enzyme producers create new niches in the treatment of lysosomal storage disorders LSDs), the use of biocatalysts in pharmaceutical and fine chemical manufacturing, and in new cellulase formulations enabling biomass-based ethanol refining to reach an economically feasible industrial scale.

Dynamic growth to shape key pharmaceutical market

Over the past decade, pharmaceuticals surpassed the former mainstay of the enzyme market, food and beverage processing, to become the highest value source of enzyme demand. The nearly double-digit growth in pharmaceutical enzymes seen from 1999 to 2009 was driven by several key enzyme medications holding orphan drug status for treating rare LSDs, most notably imiglucerase for Gaucher disease. Along with imiglucerase, key enzyme replacement therapies (ERTs) have included treatments for Hurler syndrome, Fabry disease and Pompe disease. Pharmaceutical enzymes have also gained ground due to the explosive sales growth of neuromodulators botulinum toxin A and B. Through 2014, the likely approval of new medical indications for neuromodulators and the entrance of new competition for BOTOX in both cosmetic and noncosmetic applications will shape the prospects for this market segment.

Biofuels market to see shift toward cellulase enzymes

Demand for enzymes used in making biofuels has grown strongly as the industry has rapidly scaled up its production capacity and invested in new technology to meet government quotas. To date, enzyme growth in the biofuels market has come largely from alpha amylases and glucoamylases used in conventional starch-based ethanol processing. Gains in the future will be derived from a shift in the product mix toward cellulases and related enzymes needed to refine biomass (cellulosic) ethanol, which is mandated to reach production of 8.5 billion gallons in 2019.

Industrial enzymes to see stable growth

Although specialty enzymes are becoming the higher-value segment, industrial enzymes will continue to see stable growth in markets such as pulp and paper processing, animal feed, cosmetics and toiletries, and cleaning products. Market leaders such as Novozymes and Danisco, competing in the industrial segment, will continue to fight off the downward sales pressures coming from commoditization and maturing markets by introducing new, more technical and specially tailored enzymes. In food and beverage applications, novel enzymes are raising beer and wine manufacturing efficiencies, and improving the health profile of fats and oils. The animal feed enzyme market will see moderating benefits from the widespread adoption of phytases as this application matures. In all industrial markets, demand for enzymes will be supported by their more environmentally friendly nature on a variety of levels, including their ability to substitute for harsh chemical solvents.

Study coverage

This new Freedonia industry study, Enzymes, historical demand data (1999, 2004 and 2009) plus forecasts for 2014 and 2019 by market and product. The study also considers market environment factors, evaluates company market share and profiles 34 industry competitors.

This study can help you:

  • Determine your market & sales potential
  • Learn more about industry competitors
  • Assess new products & technologies
  • Identify firms to merge with or acquire
  • Complement your research & planning
  • Gather data for presentations
  • Confirm your own internal data
  • Make better business decisions

Freedonia' s methods involve:

  • Establishing consistent economic and market forecasts
  • Using input/output ratios, flow charts and other economic methods to quantify data
  • Employing in-house analysts who meet stringent quality standards
  • Interviewing key industry participants, experts and end users
  • Researching a proprietary database that includes trade publications, government reports and corporate literature

Table of Contents

INTRODUCTION

I. EXECUTIVE SUMMARY

II. MARKET ENVIRONMENT

  • General
  • Demographic Trends
  • Macroeconomic Outlook
    • Consumer Spending
    • Manufacturing Trends
  • Food & Beverage Industry Outlook
  • Agricultural Outlook
    • Crop Production
    • Livestock & Poultry
  • National Health Expenditures
  • Petroleum & Refining Industry Outlook
  • Historical Market Trends
  • Pricing & Product Mix
  • Environmental & Regulatory Considerations
  • Intellectual Property Considerations
  • International Activity
  • Foreign Trade & US Production
    • Imports
    • Exports

III. TECHNOLOGY

  • General
  • Enzyme Production Overview
  • Recombinant DNA Technology
  • Directed Evolution & Gene Shuffling
  • Protein Engineering Technology
  • Molecular Screening & Bioinformatics
  • Enzyme Immobilization
  • Extremophilic Enzymes
  • Enzyme Factories

IV. MARKETS

  • General
  • Pharmaceuticals
    • Pharmaceutical Industry Outlook
    • Enzyme Demand
      • Enzyme Replacement Therapy
      • Neuromodulator
        • Cosmetic
        • Noncosmetic
      • Digestive
        • Pancreatic Enzymes
        • Other Digestive Enzymes
      • Cardiovascular Thrombolytic
      • Other Pharmaceutical
        • Pulmonary
        • All Other
  • Biofuels
    • Biofuel Industry Outlook
    • Enzyme Demand
      • Starch Enzymes
      • Cellulosic & Other Biofuel Enzymes
  • Food & Beverage Processing
    • Sweeteners
      • Corn Sweetener Industry Outlook
      • Enzyme Demand
    • Dairy Products
      • Dairy Industry Outlook
      • Enzyme Demand
        • Cheese Production
        • Other Dairy Products
    • Bakery Products
      • Baked Goods Industry Outlook
      • Enzyme Demand
    • Beverage Processing
      • Beverage Industry Outlook
      • Enzyme Demand
        • Wine & Fruit Juice Production
        • Beer, Distilled Spirits & Other Beverages
    • Other Food & Beverage Applications
  • Research & Biotechnology
    • Research & Biotechnology Industry Outlook
    • Enzyme Demand
      • DNA Amplification & Sequencing
      • Other Research Enzyme Applications
  • Cleaning Products
    • Cleaning Product Industry Outlook
    • Enzyme Demand
      • Laundry Detergents
      • Dishwashing Detergents & Other Cleaners
  • Diagnostics
    • Diagnostic Industry Outlook
    • Enzyme Demand
  • Animal Feed
    • Animal Feed Industry Outlook
    • Enzyme Demand
      • Non-Starch Polysaccharides
      • Phytate & Other
  • Other Enzyme Markets
    • Biocatalysts
    • Cosmetics & Toiletries
    • Textiles & Leather
      • Textiles
      • Leather
    • Pulp & Paper
    • All Other
      • Oilfield Recovery & Production
      • Water Treatment
      • Odor Control & Decontamination
      • Waste Treatment
      • Rubber
      • Developing Applications

V. PRODUCTS

  • General
  • Carbohydrases
    • Alpha Amylases
    • Glucoamylases
    • Recombinant Human Glycosidases
    • Cellulases
    • Glucose Isomerases
    • Lactases
    • Pectinases
    • Other Carbohydrases
  • Proteases
    • Microbial Proteases
    • Fibrinolytic Proteases
    • Rennet/Chymosin
    • Other Proteases
  • Polymerases
  • Nucleases
    • DNases
    • Other Nucleases
  • Lipases
  • Other Enzymes

VI. INDUSTRY STRUCTURE

  • General
  • Market Share
    • Novozymes
    • Danisco
    • Roche
    • Allergan
    • Genzyme
    • Other
  • Competitive Strategies
    • Research & Development
    • Cooperative Agreements
    • Acquisitions & Divestitures
  • Manufacturing
  • Marketing & Distribution

COMPANY PROFILES

  • AB Enzymes, see Associated British Foods
  • Abbott Laboratories
  • Agilent Technologies Incorporated
  • Alere Incorporated
  • Allergan Incorporated
  • Amano Enzyme Incorporated
  • Associated British Foods plc
  • Axcan Intermediate Holdings Incorporated
  • BASF SE
  • British Biocell International, see Alere
  • Cargill Incorporated
  • Chr. Hansen A/S
  • Codexis Incorporated
  • Danisco A/S
  • DFB Pharmaceuticals Incorporated
  • Dyadic International Incorporated
  • Frutarom Limited
  • Genencor, see Danisco
  • Genentech, see Roche Holding
  • Genzyme Corporation
  • Healthpoint, see DFB Pharmaceuticals
  • Iogen Corporation
  • Ipsen
  • Johnson & Johnson
  • Life Technologies Corporation
  • Lonza Group Limited
  • Microbix Biosystems Incorporated
  • MP Biomedicals LLC
  • National Enzyme Company
  • New England BioLabs Incorporated
  • Novozymes A/S
  • Promega Corporation
  • Roche Holding Limited
  • Royal DSM NV
  • Shire plc
  • Solstice Neurosciences Incorporated
  • Solvay SA
  • Specialty Enzymes & Biotechnologies Company
  • Verenium Corporation
  • Other Companies Mentioned in Study

LIST OF TABLES

SECTION I -- EXECUTIVE SUMMARY

  • Summary Table

SECTION II -- MARKET ENVIRONMENT

  • Population & Households
  • Macroeconomic Indicators
  • Personal Consumption Expenditures
  • Manufacturers' Shipments
  • Food & Beverage Shipments
  • Agricultural Indicators
  • Major Crop Production
  • Livestock & Poultry Population
  • National Health Expenditures
  • Petroleum Industry Indicators
  • Enzyme Market, 1999-2009
  • Selected Enzyme Pricing
  • Enzyme Production & Foreign Trade

SECTION IV -- MARKETS

  • Enzyme Demand by Market
  • Pharmaceutical Shipments
  • Pharmaceutical Enzyme Demand by Market, Status & Product
  • Enzyme Replacement Therapy Demand by Pharmaceutical & Product
  • Neuromodulator Enzyme Demand
  • Digestive Enzyme Demand by Application & Product
  • Cardiovascular Thrombolytic Enzyme Demand by Application, Type & Product
  • Other Pharmaceutical Enzyme Demand by Type & Product
  • Biofuel Supply & Demand
  • Biofuel Enzyme Demand by Application & Product
  • Food & Beverage Enzyme Demand by Application & Product
  • Corn Sweetener Supply & Demand
  • Corn Sweetener Enzyme Demand by Application & Product
  • Dairy Product Shipments
  • Dairy Enzyme Demand by Application & Product
  • Cheese Enzyme Demand
  • Other Dairy Product Enzyme Demand
  • Bakery Product Shipments
  • Bakery Product Enzyme Demand
  • Beverage Shipments
  • Beverage Enzyme Demand
  • Other Food & Beverage Enzyme Demand
  • Research Expenditures
  • Research & Biotechnology Enzyme Demand by Type & Product
  • DNA Amplification & Sequencing Enzyme Demand
  • Other Research & Biotechnology Enzyme Demand
  • Cleaning Product Supply & Demand
  • Cleaning Product Enzyme Demand by Application & Product
  • Laundry Detergent Enzyme Demand
  • Dishwashing & Other Cleaning Product Enzyme Demand
  • In Vitro Diagnostic Product Shipments
  • Diagnostic Enzyme Demand
  • Animal Feed Shipments
  • Animal Feed Enzyme Demand by Application & Product
  • Other Enzyme Demand by Market & Product
  • Biocatalyst Enzyme Demand
  • Cosmetic & Toiletry Enzyme Demand
  • Textile & Leather Enzyme Demand by Application & Product
  • Pulp & Paper Enzyme Demand
  • All Other Enzyme Markets

SECTION V -- PRODUCTS

  • Enzyme Demand by Product
  • Carbohydrase Demand by Product & Market
  • Alpha Amylase Demand
  • Glucoamylase Demand
  • Recombinant Human Glycosidase Demand
  • Cellulase Demand
  • Glucose Isomerase Demand
  • Lactase Demand
  • Pectinase Demand
  • Other Carbohydrase Demand
  • Protease Demand by Product & Market
  • Microbial Protease Demand
  • Fibrinolytic Protease Demand
  • Rennet/Chymosin Demand
  • Other Protease Demand
  • Polymerase Demand
  • Nuclease Demand by Product & Market
  • DNase Demand
  • Other Nuclease Demand
  • Lipase Demand
  • Other Enzyme Demand

SECTION VI -- INDUSTRY STRUCTURE

  • Enzyme Sales by Company, 2009
  • Selected Cooperative Agreements
  • Selected Acquisitions & Divestitures

LIST OF CHARTS

SECTION II -- MARKET ENVIRONMENT

  • Enzyme Market, 1999-2009
  • US Enzyme Imports by Source, 2009
  • US Enzyme Exports by Destination, 2009

SECTION IV -- MARKETS

  • Enzyme Demand by Market, 2009

SECTION V -- PRODUCTS

  • Enzyme Demand by Product, 2009

SECTION VI -- INDUSTRY STRUCTURE

  • US Enzyme Market Share by Company, 2009
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