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Regenerative Medicine

This report analyzes the worldwide markets for Regenerative Medicine in US$ Million. The report provides separate comprehensive analytics for the US, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 46 companies including many key and niche players such as -

AlloSource
Anika Therapeutics, Inc.
Biomet, Inc.
Bioventus LLC
DePuy Synthes Companies

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

  • Study Reliability and Reporting Limitations
  • Disclaimers
  • Data Interpretation & Reporting Level
    • Quantitative Techniques & Analytics
  • Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1. OUTLOOK

  • Regenerative Medicine: A Preface
  • An Overview of Regenerative Medicine in Bone and Joint Applications
  • Current and Future Analysis
  • Developed Markets Dominate, Developing to Drive Growth

2. REGENERATIVE MEDICINE - A MACRO PERSPECTIVE

  • Regenerative Medicine - The Past, the Present, & the Future
  • Another Revolution in the Making?
  • Conventional Chemical Medicine Vs Regenerative Medicine
  • Regenerative Medicine - The Need of Modern Era
  • Regenerative Medicine Throws Up Several New Therapies
  • Current Global Market for Regenerative Medicine
  • Market Potential
  • Therapeutic Companies and Products in Regenerative Medicine - Current Status
  • Key Statistical Data
    • Table 1: Global Regenerative Medicine Industry Value by Activity/Segment (2012): Percentage Breakdown for Regenerative Therapies, Manufacturing & Services, and Tools & Non-Therapeutic Products (includes corresponding Graph/Chart)
    • Table 2: Global Regenerative Medicines Market by Category (2012): Percentage Breakdown for Biopharmaceuticals, Cell and Tissue-Based Therapies, and Regenerative Devices & Compounds (includes corresponding Graph/Chart)
    • Table 3: Global Market for Cell and Tissue-based Therapies (2012): Percentage Breakdown of Number of Therapies Being Tested or Sold (includes corresponding Graph/Chart)
    • Table 4: Global Market for Cell and Tissue-based Therapies (2012): Percentage Breakdown of Number of Commercially Available Products by Application (includes corresponding Graph/Chart)
    • Table 5: Clinical Development Pipeline of Cell and Tissue-Based Therapies by Stage (2012): Percentage Breakdown of Number of Products in Phase III or Pivotal Trials, Phase II Trials, Phase I Trials and Commercially Distributed (includes corresponding Graph/Chart)
    • List of Major Commercially Available Cell Therapy Products
    • Select Commercial Regenerative Medicine Products in the Global Market
    • Select Regenerative Products in Mid-to-Late-Stage Clinical Development
  • Growth Drivers for Regenerative Medicine
  • A Combination of Factors to Drive Regenerative Medicine Market
  • Burgeoning Global Population Offers Significant Growth Opportunities
    • Table 6: Top 25 Countries Worldwide in Terms of Population (2010 & 2013) (includes corresponding Graph/Chart)
  • Aging Global Population: Need for New Effective Treatments
    • Table 7: Global Population Statistics for the 65+ Age Group (2012) (includes corresponding Graph/Chart)
    • Table 8: Over-65 Years Population as a % of Total Population (2010 & 2020P) (includes corresponding Graph/Chart)
    • Table 9: Elderly Population (65+ Years) as a % of Total Population (2000 & 2025) (includes corresponding Graph/Chart)
  • Increasing Healthcare Spending in Emerging Markets: Opportunities in Store
    • Table 10: Healthcare Spending as % of GDP in Select Countries (2011) (includes corresponding Graph/Chart)
  • Scientific and Technological Advances in Associated Areas
  • Government Support and Increased Private Sector Participation
  • Investment and Funding Landscape
    • Major M&A Activity and Strategic Alliances in Regenerative Medicine: 2011-2013
  • Recent Advancements in the Science of Regenerative Medicine
  • Advanced Ceramics Gaining Preeminence in Regenerative Medicine Field
    • Table 11: Global Medical Ceramics Market (2013): Percentage Breakdown of Value Sales by Application (includes corresponding Graph/Chart)
  • 3D Organ & Tissue Printing: Still in Early Stages
  • Nanotechnology in Regenerative Medicine
    • Advances in Nanotechnology Assist Regenerative Medicine
  • Issues to be Sorted Out
  • Need for New Scientific and Technological Standards
  • Standardized Guidelines
  • Clinical Translation - Collaboration of Multidisciplinary Skills is Essential
  • The Question of Apt Business Models - The Service and Product Approach
  • Autologous or Service Approach Preferred by European Firms
  • Allogenic or Product Approach - Slow to Develop
  • Regenerative Medicine Requires Improved Biomaterials
    • Assessment of Worldwide R&D Activities in the Area of Biomaterials
  • Investors Wary of Funding Regenerative Medicine
  • Regenerative Medicine Field Lags Behind due to Segregated Focus
  • Challenges Encountered by Regenerative Medicine
  • Scientific and Technological Challenges
  • Barriers in Sharing Intellectual Property Rights
  • Viable Manufacturing Technologies and Skilled Personnel Crucial
  • Strict Regulations Push up Operational Costs

3. BONE AND JOINT REGENERATIVE MEDICINE - AN OVERVIEW

  • Bone Regenerative Medicine Presents Need for Advanced Therapies
  • Limitations and Drawbacks for Different Bone Grafts
  • Key Growth Drivers
  • Rising Incidences of Degenerative Intervertebral Disc Diseases
    • Table 12: % of Women Affected by Osteoporosis (includes corresponding Graph/Chart)
  • Increase in Prevalence of Arthritis and Other Orthopedic Disorders
  • Rise in Revision Orthopedic Surgeries
  • Increase in Spinal Fusions in Private Healthcare
  • Bone Grafts Market Maintains Positive Momentum
  • Applications of Bone Grafts: A Review
    • Spine Fusion - The Largest Bone Graft Indication
    • Dental Bone Grafting - A High Potential Market
    • Table 13: Global Dental Regeneration Market (2013E): Percentage Breakdown of Value Sales for Bone Allografts, Membranes, Tissue Regeneration (includes corresponding Graph/Chart)
  • What Drives Physicians' Choice of Bone Grafts?
    • Patient Safety Emerges as a Top Priority
  • Bone Graft Substitutes (BGSs) Market: Showing Promising Potential
    • Commercially Available Bone Graft Substitutes
    • Growing Clinical Use of Bone Graft Substitutes in Surgical Procedures
  • Synthetic Bone Graft Substitutes to Replace Traditional Autografts and Allografts
    • Select Synthetic Products in Orthobiologics
  • Orthobiologics Gain Traction in the Bone Grafts Market
    • Table 14: Global Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Allograft & DBM, Blood & Marrow-based Products, Growth Factors, Hemostasis, Synthetic Bone Graft Substitutes and Viscosupplements (includes corresponding Graph/Chart)
    • Table 15: Leading Players in the Global Orthobiologics Market (2013): Percentage Breakdown of Value Sales for Baxter, J&J/ Synthes, Medtronic, Sanofi, Stryker and Others (includes corresponding Graph/Chart)
    • Table 16: Global Stem Cell Orthobiologics Market (2012): Percentage Breakdown of Value Sales for Alphatec, Nuvasive and Otrhofix (includes corresponding Graph/Chart)
  • Increasing Visibility of Orthobiological Products to Spur Grafting Options
  • Autograft: Gold Standard for Bone Grafting Procedures
  • Allograft: Leading the Race over Autografts
    • Commercially Available Allograft and Xenograft Bone Products
  • Advanced Allografts Encroaching into the Use of Autografts in Surgical Procedures
  • Technological Advancements Drive the Market for Bone Grafts
  • Foot and Extremity Reconstruction - Promising Market for Bone Grafts
  • Precision Machined Allograft Gain Surgeon Preference
  • Unmet Clinical Needs to Foster R&D Engine
  • Biological Solutions in Sports Medicine - Beyond Bone Grafting
  • What Ails the Market?
    • Disease Transmission through Bone Grafts - A Major Safety Concern
    • Lack of Standards in Bone Graft Substitute Market
    • Reimbursement Issues Continue to Haunt Bone Grafts Market
    • Table 17: Payer Mix in Orthopedic-driven Surgeries Worldwide (2012) (includes corresponding Graph/Chart)
    • Regional Regulations & Religious Beliefs Hamper Bone Graft Substitutes Market
      • Synthetic Bone Grafts - Solution for Halal Bone Graft Implantation
    • Bone Glue - A Potential Threat to the Bone Graft Market
    • Alliances with Organ Procurement Organizations: A Shot in the Arm
    • Aging Baby Boomers Render a Decreased Donor Pool
    • Limited Availability of Donor Tissues
    • Intense Competition from Alternative Tissue Repair Therapies
    • Substitute Technologies Threaten to Replace Spinal Fusions
    • Bone Grafts Termed as Tissues Suffer From Inconsistent Patient Outcomes
  • BMPs and Other Synthetic Growth Factors
  • Bone Morphogenic Proteins (BMPs): Safety Concerns Led to Downfall
    • Bone Morphogenic Protein Products in Orthobiology
  • Demineralized Bone Matrices (DBMs) Market: Strong Growth but Tough Competition
    • Table 18: Global Demineralized Bone Matrix Market (2012): Percentage Breakdown of Value Sales for Altiva, Bacterin, Integra LifeSciences, Medtronic, Synthes/MTF and Others (includes corresponding Graph/Chart)
    • Commercially Available Demineralized Bone Matrix Products
  • Biomaterials Market - Promising Opportunities for Cost-Effective Products
  • Tissue Engineered Cartilage Market - An Overview
    • Tissue Engineered Cartilages - A Promising Solution for Cartilage Repair
  • Stem Cells to Support Tissue Engineering
  • Market Potential of Tissue Engineered Cartilage Products
  • Potential Applications of Tissue Engineered Cartilage Products
  • Commercially Available tissue engineered cartilage products
  • Challenges in Clinical Application of Tissue Engineered Cartilage Products
  • Bone Marrow Transplants (BMTs)
  • Market Potential for BMTs
  • Companies Engaged in CBSC Research for BMTs
  • Stem Cell Research - Not Just Another Medical Advancement
  • Sources of Stem Cells
  • Stem Cell Based Bone Grafts - Fastest Growing Bone Graft Substitute Segment
    • Commercially Available Cell Therapy Products for Orthopedic Applications
    • Regenerative Stem Cell Products for Spine and Orthopedics in Clinical Development
  • Progenitor Cell Therapy to Witness No Holds Barred Growth
  • Stem Cell Market on the Verge of Rapid Growth
  • Clinical Development in Adult stem cells Moves Ahead, Lurches in hESCs
    • Adult Stem Cell Research Eludes Ethical Dispute
  • Teratomas - No Longer an Impediment to Stem Cell Therapy Development
  • Induced Pluripotent - A Potential Competitor to hESCs?
    • Intricate Differences Exist between hESC and iPS Cells
    • Use of iPS for Regenerative Medicine
  • Mesenchymal Stem Cells for Regenerative Medicine
    • MSC based Models for Orthopedic Repair
    • Delivery of MSCs to Regions Requiring Therapy
    • MSCs in the Treatment of Osteoarthritis
    • MSCs in the Treatment of Rheumatoid Arthritis
  • Scientific and Technological Challenges in Orthopedic Regenerative Market
  • Bone Regeneration
  • Clinical Approaches in Bone Regeneration and Their Limitations

4. COMPETITIVE LANDSCAPE

  • Bone Grafts: A Highly Fragmented Market
  • Bone Growth Stimulation Market
    • Table 19: Global Bone Growth Stimulation Market (2012): Percentage Breakdown of Value Sales for Biomet, Bioventus, DJO and Orthofix (includes corresponding Graph/Chart)

5. REGENERATIVE MEDICINE IN OTHER AREAS

  • Wound Healing - The Second Largest Segment
  • Tissue Engineered Skin Substitutes: Potential Substitutes for Skin grafts
  • Commercially Available Tissue Engineered Skin Substitutes
  • Cardiology - Promising Opportunities
  • Select Stem Cell Products in the Development for CV Indications
  • Diabetes - Highly Effective Innovative Treatments
  • Regenerative Medicine Products in Development Pipeline for Diabetes
  • Neurodegenerative Diseases - Great Potential
  • Body Sculpting/Cosmetics - High Potential
  • Platelet Rich Plasma Treatment Gains Popularity
  • Genetic Disorders
  • Osteoarthritis
  • Orthopedic Oncology
  • What's in Store?
  • Regenerative Medicine to Arrest Ageing?
  • Thriving on an Aging World Population
  • Faster Healing Process
  • Regenerative Medicine to Overcome Donor Organs Shortage
  • Possible Scenarios

6. REGULATORY ENVIRONMENT

  • Global Regulatory Landscape
  • US
  • FDA Classification of Bone Products
  • Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps)
  • Good Tissue Practices
  • DBM-based Products in US
  • Synthetic Bone Graft Substitutes
  • Tissue Banking Regulation
  • FDA Regulations on Xenograft
  • EU
  • Japan
  • Regulatory Norms Governing Embryonic Stem Cell Research
  • Human Embryonic Stem Cell Regulation in Select Countries Worldwide
  • The IP Scenario in the Embryonic Stem Cells Research
  • Diversity in Patent Regimes Pose Tremendous Challenges
  • International Divide on Patenting Dents hESC Research

7. A PEEK INTO THE GLOBAL ORTHOPEDIC INDUSTRY

  • Orthopedic Industry: An Overview
    • Table 20: Fractures by Age Group (2012): Percentage Breakdown of Number of Fractures by Age Group (includes corresponding Graph/Chart)
    • Table 21: Global Orthopedic Market by Segment (2013E): Percentage Breakdown of Value Sales for Extremities, Hips, Knees, Orthobiologics, Spice, Trauma and Others (includes corresponding Graph/Chart)
  • Medical Devices and Implants for Orthopedics
  • Expanding Opportunities in Hip and Knee Market
  • Extremity Reconstruction - A Growing Market
  • Is Consolidation Blowing in the Wind?
  • Product Mix of Reconstructive Devices Companies
  • Key Statistics in Global Orthopedics Industry
    • Table 22: Worldwide Orthopedic Market (2013E): Percentage Breakdown of Value Sales by Company for DePuy Synthes, Medtronic, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
    • Table 23: Worldwide Market for Orthopedic Implants in Spinal Procedures (2013E): Percentage Breakdown of Value Sales by Company for J&J, Medtronic and Others (includes corresponding Graph/Chart)
    • Table 24: Worldwide Market for Orthopedic Implants for Reconstructive Procedures (2013E): Percentage Breakdown of Value Sales by Company for Biomet, J& J, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
    • Table 25: Worldwide Market for Orthopedic Implants for Trauma Procedures (2013E): Percentage Breakdown of Value Sales by Company for Biomet, J&J, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
    • Table 26: Global Joint Replacement Market (2013E): Percentage Breakdown of Sales for Biomet, DePuy Synthes, Smith & Nephew, Stryker, Zimmer and Others (includes corresponding Graph/Chart)
  • Bone Grafts & Joint Revision Arthroplasty
    • Table 27: Worldwide Orthopedic Large Joint Market by Segment (2013E): Percentage Breakdown of Value Sales for Hip, Knee and Spine (includes corresponding Graph/Chart)
    • Table 28: Worldwide Orthopedic Extremities Market by Segment (2013E): Percentage Breakdown of Value Sales for Foot/Ankle, Shoulder, Wrist/Finger and Elbow (includes corresponding Graph/Chart)

8. RESEARCH AND DEVELOPMENT

  • Tissue Engineers Found New Biomaterial for Stimulating Cartilage Growth
  • Chrysalis Develops Chrysalin(r) Drug for Stimulating Tissue Growth
  • Innovative Artificial Implants Hold Promise for Bone Injuries
  • Bone Marrow Grafts Exhibit Promise for Low-Back Pain Patients
  • Charged Nanoparticles Hold Potential to Heal Cracked Bones
  • Silk Scaffolds with Excellent Mechanical Properties to Facilitate Bone Formation
  • New Fusion Protein to Stimulate Bone Tissue Regeneration
  • Researchers Develop Human Heart Tissues with Autonomous Beating
  • Scientists at Free University of Brussels Develop Thyroid Cells of Mice
  • Scientists Demonstrate New Source of Skin for Reconstructive Procedures
  • Instron TGT Bioreactor Stimulates Cell Growth by Applying Hydrostatic Pressure
  • New Ways of Fixing Broken Bones
  • BoneCure Sleeve - Heading Towards the Human Market
  • Bioactive Glass - Suitable for Weight Bearing Portion
  • Neural Stem Cell to Restore Memory Functioning
  • Pancreatic Islet Cells to Control Blood Sugar in Diabetics
  • Therapeutic Cloning to Cure Parkinson's

9. PRODUCT OVERVIEW

  • Regenerative Medicine - An Introduction
  • Bone Replacements/Grafting: Introduction
  • Bone Grafts: A Peek into their Mechanism of Action
  • Types of Bone Grafts
    • Scoring of Osteoconduction, Osteoinduction, and Osteogenesis Properties of Bone Grafts by Type
    • Autografts
    • Standard Allografts
    • Machined Bone Allografts
  • Demineralized Bone Matrix
  • Bone Morphogenetic Proteins (BMPs)
    • Basic Functions of TGF-Beta
  • Synthetic Bone Grafts
    • Collagen-based Matrices
    • Ceramic: A Material of Choice
    • Hydroxyapatite: A Major Calcium Phosphate Based Ceramic
    • Calcium Sulfate
    • Polymer Based Bone Grafts
    • Coral: A Valuable Synthetic Graft Material
  • Electrical Bone Growth Stimulators
  • Internal Bone Growth Stimulators
  • External Bone Growth Stimulators
  • Cell and Tissue-based Therpies
  • Stem Cells-Based Therapies
  • Bone Tissue Engineering
    • Hybrid Materials
    • Osteoinductive Materials
    • Immuno-modulatory Biomaterials
    • Advanced Hydrogels
    • Biodegradable Scaffolds

10. PRODUCT INNOVATIONS/INTRODUCTIONS

  • AlloSource Introduces AlloMend(tm)
  • Orthofix Launches Trinity(r) ELITE(tm)
  • Synergy Biomedical to Introduce Biosphere Putty
  • K2M Launches VENADO Bone Graft Systems
  • K2M Introduces Vesuvius DBM Putty
  • The Center for Regenerative Medicine Rolls Out Genorthix System
  • RTI Surgical Introduces BioReady(tm) DBM Putty
  • K2M Rolls Out VESUVIUS Osteobiologic Systems
  • BioHorizons Introduces MinerOss(r) Cancellous
  • Amedica Introduces Dynamic Bone
  • Orthogen Introduces NanoGen
  • SIRAKOSS Introduces MaxSi
  • BioMimetic Therapeutics to Launch Augmatrix(tm) Biocomposite Bone Graft
  • Orthofix International Introduces Collage(tm) Osteoconductive Scaffold
  • TGA Clears BioMimetic's Augment(r) Bone Graft for Commercialization in Australia
  • Medtronic Launches ARTISAN(tm) Space Maintenance System
  • NovaBone Adds MacroPor-Si+ to its Portfolio
  • RTI Surgical Announces First Implantation of map3(tm)
  • Integra Receives FDA Clearance for Accell Evo3
  • RTI Surgical Introduces BioAdapt(tm) DBM Foam
  • Integra Unveils Trel-Xpress(tm) Demineralized Bone Matrix
  • Keystone Dental Introduces DynaMatrix(tm) Plus
  • Wright Introduces FUSIONFLEX(tm) Demineralized Moldable Scaffold
  • Micromedics Launches OsteoXpress 15cc Bone Graft Delivery Device
  • Bacterin Unveils OsteoSponge(r)SC

11. RECENT INDUSTRY ACTIVITY

  • Aastrom Biosciences Acquires Cell Therapy and Regenerative Medicine Business of Sanofi
  • Olympus to Sell the OP-1 Plant
  • Wright Medical Group Divests OrthoRecon Business
  • RTI Biologics Acquires Pioneer Surgical Technology
  • Bioventus and Pfizer Enter into Agreement
  • AlloSource Enters into Partnership with Humacyte
  • Wright Medical Group Acquires BioMimetic Therapeutics
  • BioTime Inks Definitive Deal with Geron for Stem Cell Assets
  • Histogen Establishes PUR Biologics Joint Venture to Develop Biologic Products
  • Vitro Diagnostics to Acquire and Merge with Neuromics
  • Mesoblast Group Takes Over Osiris' Culture- Expanded Mesenchymal Stem Cell Business
  • ThermoGenesis and TotipotentRx Enter into Definitive Merger Agreement
  • KCI and LifeCell Merge
  • Sistemic and Roslin Cells Collaborate with Scottish Development International
  • 360ip and CCRM Join Forces
  • Olympus Biotech and BonAlive Enter into Multi-Year Exclusive Distribution Agreement
  • Mesoblast's Singapore Unit Obtains the US FDA Approval for Production of MPCs
  • Cellectis bioresearch Inks Collaboration Agreement with Stemgent
  • Bonesupport Receives CE Mark Approval for Cerament|G resorbable
  • Dainippon Sumitomo Pharma Establishes Regenerative and Cellular Medicine Office
  • StemCells Partners with R Biomedical
  • Essex Woodlands Launches Bioventus
  • J&J Takes Over Synthes
  • EastBridge Merges with Cellular Biomedicine
  • Baxter Acquires Synovis
  • Cytomedix Acquires Aldagen
  • BioMimetic Therapeutics Secures CE Mark Approval for GEM 21S(r) in EU
  • EMD Millipore Collaborates with Centre for Commercialization of Regenerative Medicine
  • American CryoStem Associates with Alliance for Regenerative Medicine
  • Stryker Acquires Orthovita
  • Zimmer Dental and Curasan Enter into Distribution Agreement
  • NuVasive Signs Licensing Agreement with AlloSource
  • Histogenics Takes Over ProChon Biotech

12. FOCUS ON SELECT PLAYERS

  • AlloSource (US)
  • Anika Therapeutics, Inc. (US)
  • Biomet, Inc. (US)
  • Bioventus LLC (US)
  • DePuy Synthes Companies (US)
  • DePuy Spine, Inc. (US)
  • Exactech, Inc. (US)
  • Histogenics Corp. (US)
  • Integra LifeSciences Holdings Corp (US)
  • LifeCell Corporation (US)
  • LifeNet Health, Inc. (US)
  • Medtronic, Inc. (US)
  • NovaBone Products LLC (US)
  • NuVasive, Inc. (US)
  • Orthofix International N.V. (Netherlands)
  • Osiris Therapeutics, Inc. (US)
  • Smith & Nephew Plc (UK)
  • Stryker Corporation (US)
  • TiGenix N.V. (Belgium)
  • Wright Medical Technology, Inc. (US)
  • BioMimetic Therapeutics LLC (US)
  • Zimmer Holdings, Inc. (US)

13. GLOBAL MARKET PERSPECTIVE

    • Table 29: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 30: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 31: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)
  • Regenerative Medicine Market by Segment
    • Table 32: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Segment - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 33: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Segment - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 34: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Segment - Percentage Breakdown of Dollar Sales for Bone Replacements, Bone Stimulators, and Tissue Replacements Markets for Years 2006, 2014 & 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

  • A. Market Analysis
    • Current and Future Analysis
    • US to Retain Leadership Position
    • The Strength of US in Regenerative Medicine - A Glance
    • Factors Driving the US Market of Regenerative Medicine
    • High Potential for Regenerative Medicine in Orthopedics
    • Regenerative Medicine in Bone and Joint Applications
      • Regenerative Therapy - Best Fit for Joint Problems
      • Bone Grafts Market - An Insight
      • Bone Graft Substitutes Market: Opportunities for Growth
      • Aging Population: A Strong Demographic Driver
    • Table 35: North American Elderly Population by Age Group (1975-2050) (includes corresponding Graph/Chart)
    • Table 36: US Population Breakdown by Age Group (2012) (includes corresponding Graph/Chart)
      • Rising Incidence of Degenerative Intervertebral Disc Diseases
      • Back Pain
      • Arthritis
    • Table 37: % of Population Diagnosed with Arthritis by Age Group (includes corresponding Graph/Chart)
      • Osteoporosis
    • Table 38: Osteoporosis Population in the US: 2002, 2005, 2008 & 2012 (includes corresponding Graph/Chart)
    • Table 39: Breakdown of Osteoporotic Fractures by Site in the US (includes corresponding Graph/Chart)
      • Rise in Revision Orthopedic Surgeries Boosts Demand
      • Increasing Visibility of Orthobiological Products to Spur Grafting Options
      • Synthetic Bone Grafts to Fan Growth
      • Spinal Surgery Market: Opportunity for Bone Grafts Market
      • Dental Bone Graft Substitutes Market: An Overview
      • Orthopedic Biomaterials Market - An Overview
      • Regulatory Challenges Limit Growth in the US Orthopedic Biomaterials Market
      • Orthobiologics Market - Overview
      • Adequate Reimbursement: An Impetus for Growth & Profitability
    • Table 40: Payer Mix for Spinal (Cervical) Fusion Procedures in the US (includes corresponding Graph/Chart)
    • Table 41: Payer Mix for Spinal (Lumbar) Fusion Procedures in the US (includes corresponding Graph/Chart)
      • Competitive Scenario
      • Standard Bone Allografts
    • Table 42: US Market for Standard Bone Allografts (2012): Percentage Market Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart)
      • Machined Bone Allografts
    • Table 43: US Market for Machined Bone Allografts (2012): Percentage Market Share Breakdown of Leading Tissue Processors (includes corresponding Graph/Chart)
      • Demineralized Bone Matrix (DBM)
    • Table 44: Leading Players in the US DBM Market (2012): Percentage Breakdown of Sales for Bacterin, Exactech, Integra, Medtronic, RTI Surgical, Stryker, Synthes/ DePuy Spine, Wright Medical and Others (includes corresponding Graph/Chart)
      • Synthetic Bone Graft Substitutes
    • Table 45: US Market for Synthetic Bone Graft Substitutes (2012): Percentage Share Breakdown of Value Sales by Company for Biomet, J&J, Stryker, Wright Medical and Others (includes corresponding Graph/Chart)
      • Stem Cell Market Outlook
      • Millions of American Patients Put their Hope in Stem Cell Research
      • Rapidly Ageing Population Also Spurs Demand for MSC based Therapies
      • Rising Governmental Investments in Stem Cell Therapies - A Growth Booster
    • Regenerative Medicine - Other Areas of Application
      • Regenerative Medicine - Face of Future Revolution in Cardiology
      • Regenerative Medicine in Wound Healing - The Most Widespread Application
      • Regenerative Medicine in Diabetes - A Number of Emerging Applications
      • Regenerative Medicine - A Ray of Hope for Neurodegenerative Disease Patients
      • CBI's Human Tissue Products for Treating Liver Failure and Diabetes
      • Market for Liver and Pancreas Transplantation
    • Implantable Regenerative Products Take Over Sports Medicine
      • Challenges in the Area of Product Development
      • Process of Integration Continues
      • Scientific and Technological Challenges to be Tackled
      • Dominant Patents a Cause of Concern
    • Product Innovations/Introductions
    • Strategic Corporate Developments
    • Key Players
  • B. Market Analytics
    • Table 46: US Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 47: US Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

2. JAPAN

  • A. Market Analysis
    • Current and Future Analysis
    • Market Overview
    • The Discovery of iPS Cells Lends Traction
      • Drug Development - A Major Application for iPS
      • Use of iPS for Regenerative Medicine
      • Intractable and Congenital Disease Treatments
      • Research & Development Rife in iPS Cells Space
    • Japan Gears Up to Devise Standards for Regenerative Medicine Products
      • Japan Revises the Pharmaceutical Affairs Law
    • General Trends in Regenerative Medicine Industry
      • Research Activity in Regenerative Medicine Field
      • More Companies Eye the Regenerative Medicine Potential
      • Competition Heats up Behind Closed Doors
      • Japanese Firms Need to Catch Up with US and European Competitors
      • Science Ministry Rolls Out Regenerative Medicine Project
      • Regenerative Medicine Exempted from Ban on Human Cloning
    • Strategic Corporate Development
  • B. Market Analytics
    • Table 48: Japanese Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 49: Japanese Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

3. EUROPE

  • A. Market Analysis
    • Current and Future Analysis
    • Great Potential for Regenerative Medicine
    • Challenges Faced by European Regenerative Medicine Industry
    • Financial Viability - A Growing Concern in the Backdrop of Euro Crisis
    • Recession Drubs Orthopedic Biomaterials Market
    • Table 50: European Bone Graft Substitutes Market by Type (2012): Percentage Share Breakdown of Value Sales for Allograft, DBM and Synthetic (includes corresponding Graph/Chart)
    • Synthetic Bone Graft Market Drives the BGS Market
    • Bone Morphogenetic Protein (BMP) Market
    • Dental Biomaterials Market in Europe: An Insight
    • Key Statistical Data
    • Table 51: European Market for Standard Bone Allografts by Leading Companies/Organizations (2012): Percentage Share Breakdown of Value Sales for LifeNet Health, Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart)
    • Table 52: European Market for Machined Bone Allografts by Leading Companies/Organizations (2012): Percentage Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical and Others (includes corresponding Graph/Chart)
    • Table 53: European Market for Demineralized Bone Matrix by Leading Companies/Organizations (2012): Percentage Market Share Breakdown of Value Sales for Medtronic, Musculoskeletal Transplant Foundation, RTI Surgical, Wright Medical Technology and Others (includes corresponding Graph/Chart)
    • Table 54: European Market for Bone Graft Substitutes by Leading Players (2012): Percentage Share Breakdown of Value Sales for Biomet, Medtronic, Stryker, Wright Medical Technology, Zimmer and Others (includes corresponding Graph/Chart)
    • The Need to Embrace Newer Technologies
    • Complex Regulatory Scenario with Multi-tier Governance System
    • Need for More Integration
    • Policies Regarding Egg Procurement Weigh Down Research Progress
    • Need for Harmonized Clinical Trial Regulation
    • International Alliances - Outsourcing Options with Developing Countries
    • Patenting Issues in hESC Research
    • Ageing Population to Drive Demand for MSC based Therapies
    • Table 55: Population Breakup by Age Group for Select European Countries: 2012 (as a Percentage of Total Population) (includes corresponding Graph/Chart)
    • Overview of Select Regional Markets
      • Germany
      • United Kingdom
      • Research Councils Announce Ambitious Project to Support Regenerative Medicine
      • Barriers to Commercialization
    • Product Launches
    • Strategic Corporate Developments
    • Key Players
  • B. Market Analytics
    • Table 56: European Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 57: European Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4. ASIA-PACIFIC

  • A. Market Analysis
    • Current and Future Analysis
    • Dental Bone Graft Substitutes and Biomaterials Market - An Overview
    • Table 58: Over 65 Years Individuals as % of Total Population in Select Asian Countries (includes corresponding Graph/Chart)
    • Overview of Select Regional Markets
      • China
      • Substantial Government Support
      • Orthopedic Biomaterials Market Poised for Robust Growth
      • India
      • High Growth Opportunities
      • Orthopedic Biomaterials and Dental Bone Grafts Market - An Insight
      • Rise in Medical Tourism Drives Bone Grafts Market
      • Adult Stem Cells - A Highly Money-Spinning Market
      • South Korea
      • Malaysia
      • Singapore
    • Product Innovations/Introduction
    • Strategic Corporate Development
  • B. Market Analytics
    • Table 59: Asia-Pacific Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 60: Asia-Pacific Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

5. REST OF WORLD

  • A. Market Analysis
    • Current and Future Analysis
    • Overview of Select Regional Markets
      • Canada
      • A Significant Player in the Field of Regenerative Medicine
      • Favorable Growth Prospects in Bone Graft Substitutes Market
      • University of Toronto - Spearheading Regenerative Medicine Research
      • Latin America
      • Argentina
      • Brazil
      • Highly Promising but Challenges Remain
      • Overview of Brazilian Orthopedic Devices Market
      • Middle East
      • Israel
      • Stem Cell Research in Full Swing
    • Strategic Corporate Developments
  • B. Market Analytics
    • Table 61: Rest of World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 62: Rest of World Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market - Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
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