This report analyzes the worldwide markets for Regenerative Medicine in US$ million. The report provides separate comprehensive analytics for the US, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2010 through 2018. A six-year historic analysis is also provided for these markets. The report profiles 93 companies including many key and niche players such as BioVest International, Inc., Curis, Inc., Cytori Therapeutics, Inc., Evotec AG, Forticell Bioscience, Inc., Geron Corporation, Integra LifeSciences Corporation, LifeCell Corporation, Osiris Therapeutics, Inc., Tengion, Inc., Tepha Inc., and TiGenix N.V. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.
Table of Contents
Table of Contents
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study
II. EXECUTIVE SUMMARY
1. INDUSTRY OVERVIEW
A Primer
Current and Future Analysis
Current Global Market for Regenerative Medicine
Therapeutic Companies and Products in Regenerative Medicine - Current Status
Select Therapeutic Regenerative Medicine Products in the Global Market
Market Potential
2. REGENERATIVE MEDICINE IN BONE AND JOINT APPLICATIONS
An Overview of Regenerative Medicine in Bone and Joint Applications
Bone Graft Substitutes - Penetration in Foot and Ankle Surgeries
Repair of Non-Healing Bones - High Market Potential
Market Potential of Bone Graft Substitutes (BGSs)
Table 1: Global Bone Graft Substitute Market (2010): Percentage Share Breakdown of Sales for DePuy, OrthoVita, ApaTech/Baxter, Wright Medical, Medtronic/RTI, Biomet, and Others (includes corresponding Graph/Chart)
Synthetic Bone Graft Substitutes to Replace Traditional Autografts and Allografts
Select Synthetic Products in Orthobiologics
Bone Morphogenic Proteins (BMPs) Gaining Popularity
Bone Morphogenic Protein products in Orthobiology
Table 2: Global Bone Morphogenic Protein Market (2010): Percentage Share Breakdown of Sales for Medtronic/RTI, and Stryker (includes corresponding Graph/Chart)
Demineralized Bone Matrices (DBMs) Market Getting Crowded
Table 3: Global Demineralized Bone Matrix Market (2011): Percentage Share Breakdown of Value Sales for Medtronic/RTI, Synthes/MTF, Integra LifeSciences, Altiva, Bacterin, and Others (includes corresponding Graph/Chart)
Select DBM products in Orthobiologics market
Biomaterials Market - Promising Opportunities for Cost-Effective Products
Existing Bone Graft Procedures - Limitations and Concerns
Autograft Procedures
Allograft - DBM and Other Allografts
BMPs and Other Synthetic Growth Factors
Medical Devices and Implants for Orthopedics
Expanding Opportunities in Hip and Knee Market
Extremity Reconstruction - A Growing Market
Tissue Engineered Cartilage Market - An Overview
Tissue Engineered Cartilages - A Promising Solution for Cartilage Repair
Market Potential of Tissue Engineered Cartilage Products
Potential Applications of Tissue Engineered Cartilage Products
Commercially Available tissue engineered cartilage products
Challenges in Clinical Application of Tissue Engineered Cartilage Products
Bone Marrow Transplants (BMTs)
Market Potential for BMTs
Companies Engaged in CBSC Research for BMTs
Table 4: Global Orthobiologics Market (2010): Percentage Share Breakdown of Value Sales for Medtronic/RTI, Synthes/MTF, DePuy, Osteotech, Orthofix, and Others (includes corresponding Graph/Chart)
Table 5: Global Orthobiologics Market (2010): Percentage Share Breakdown of Value Sales by Product Type for Growth Factors, Synthetics, DMBs, Allografts, and Stem Cells (includes corresponding Graph/Chart)
Table 6: Global Machined Bone and Allograft Market (2010): Percentage Share Breakdown of Value Sales for Synthes/MTF, DePuy, Medtronic/RTI, Osteotech, RTIX, and Others (includes corresponding Graph/Chart)
Table 7: Global Stem Cell Orthobiologics Market (2010): Percentage Share Breakdown of Value Sales for Nuvasive, and Otrhofix includes corresponding Graph/Chart)
Table 8: Global Bone Growth Stimulation Market (2010): Percentage Share Breakdown of Value Sales for Orthofix, Biomet, DJO and Smith & Nephew (includes corresponding Graph/Chart)
Table 9: Global Spinal Stimulation Market (2010): Percentage Share Breakdown of Value Sales for Orthofix, Biomet and DJO (includes corresponding Graph/Chart)
Table 10: Global Long Bone Stimulation Market (2010): Percentage Share Breakdown of Value Sales for Smith& Nephew, DJO, Biomet and Orthofix (includes corresponding Graph/Chart)
Regenerative Medicine in Other Areas
Wound Healing - The Second Largest Segment
Cardiology - Promising Opportunities
Diabetes - Highly Effective Innovative Treatments
Neurodegenerative Diseases - Great Potential
Body Sculpting/Cosmetics - High Potential
Table 11: Global Market for Regenerative Medicine in Body Reconstruction and Cosmetics (2014): Value Sales by Target Area (in US$ Million) (includes corresponding Graph/Chart)
Regenerative Medicine - the Past, the Present, & the Future
Another Revolution in the Making?
Conventional Chemical Medicine Vs Regenerative Medicine
Regenerative Medicine - The Need of Modern Era
Regenerative Medicine Throws in Several New Therapies
What's in Store?
Regenerative Medicine to Arrest Ageing?
Thriving on an Aging World Population
Faster Healing Process
Regenerative Medicine to Overcome Donor Organs Shortage
Possible Scenarios
Stem Cell Research - Not Just Another Medical Advancement
Sources of Stem Cells
Japanese Technology in the Area of Stem Cells
Progenitor Cell Therapy to Witness No Holds Barred Growth
Key Issues at Play
Ethical Angle of Embryonic Stem Cell Research
Growth Drivers for Regenerative Medicine
A Combination of Factors to Drive Regenerative Medicine Market
Aging Population Provides a Ready Market for Innovative Therapies
Scientific and Technological Advances in Associated Areas
Government Support and Increased Private Sector Participation
Investment and Funding Landscape
3. TRENDS & ISSUES
A Promising Outlook
Increased Activity in the Field of Regenerative Medicine
Recent Advancements in the Science of Regenerative Medicine
Nanotechnology in Regenerative Medicine
Advances in Nanotechnology Assist Regenerative Medicine
Players Embrace Automation in Production Facilities
Contract Manufacturing - A Growing Sector
Issues to be Sorted Out
Need for New Scientific and Technological Standards
Standardized Guidelines
Clinical Translation - Collaboration of Multidisciplinary Skills is Essential
The Question of Apt Business Models - The Service and Product Approach
Table 12: Percentage Breakdown of Autologous and Allogeneic Approach by Therapeutic Firms Across Select Countries (2011) (includes corresponding Graph/Chart)
Autologous or Service Approach Preferred by European Firms
Allogeneic or Product Approach - Slow to Develop
Regenerative Medicine Requires Improved Biomaterials
Assessment of Worldwide R&D Activities in the Area of Biomaterials
Investors Wary of Funding Regenerative Medicine
Regenerative Medicine Field Lags Behind due to Segregated Focus
Challenges Encountered by Regenerative Medicine
Scientific and Technological Challenges
Barriers in Sharing Intellectual Property Rights
Viable Manufacturing Technologies and Skilled Personnel Crucial
Strict Regulations Push up Operational Costs
Scientific and Technological Challenges in Orthopedics
Bone Regeneration
Clinical Approaches in Bone Regeneration and Their Limitations
4. PRODUCT OVERVIEW
Regenerative Medicine Advances in Four Phases
Human Substances
Tissue Engineering
Therapeutic Cloning
Nanotechnology-Driven Biomaterials
Types of Regenerative Medicine
Type I - Regenerative Medicine
Human Proteins and Genes are Drugs in Regenerative Medicine
Type-2 Regenerative Medicine
Therapies Based on Human Cells and Tissues
Type-3 Regenerative Medicine
Based on Embryonic Stem Cells
The Opponents of the ESC Theory
Embryonic Stem Cells - Shortcomings
Type-4 Regenerative Medicine
Based on Novel Materials / Material Science Advancements
Overview of Major Regenerative Medicine Techniques
Natural Regenerative Proteins
Tissue Engineering Capable of Culturing Replacement Organs
All About Stem Cells
Adult Stem Cells
Adult Stem Cell Research Eludes Ethical Dispute
hESC - Highly Capable of Differentiating and Multiplying
Stem Cell Research in Development of Regenerative Medicine
Neural Stem Cell to Restore Memory Functioning
Pancreatic Islet Cells to Control Blood Sugar in Diabetics
Therapeutic Cloning to Cure Parkinson's
5. REGULATORY ENVIRONMENT
Global Regulatory Landscape
US
EU
Japan
Regulatory Norms Governing ES Cell Research
Milestones in the Human Embryonic Stem Cell Research: 2001
Legality of ES Cell Use in Major Developed Nations
6. TECHNOLOGICAL INNOVATIONS/ BREAKTHROUGHS
BioMimetic Therapeutics to Launch Augmatrix(tm) Biocomposite Bone Graft
TEI Biosciences Introduces PriMatrix(tm) Ag Antimicrobial Dermal Repair Scaffold
7. TECHNOLOGICAL INNOVATIONS IN RECENT PAST A PERSPECTIVE BUILDER
SANUWAVE Health Introduces orthoPACE(tm) in Europe
Kensey Nash's Medeor ECM Receives Approval from US FDA
Celling Technologies Unveils Res-Q Device
Kinetic Wins FDA Approval for LifeCell Tissue Matrix
8. RECENT INDUSTRY ACTIVITY
BioMimetic Therapeutics Secures CE Mark Approval for GEM 21S(r) in EU
WFIRM and Nantong University Set-up China-US Regenerative and Translational Medicine Research Center
EMD Millipore Collaborates with Centre for Commercialization of Regenerative Medicine
American CryoStem Associates with Alliance for Regenerative Medicine
TAP Biosystems Collaborates with a leading Regenerative Medicine Company
Cytomedix Acquires Aldagen
Centre for Commercialization of Regenerative Medicine Sets Up Industry Consortium
Tengion Conducts Preclinical Study for Small Intestine Regeneration
TiGenix Inks Agreement with Cellerix for Combining Business Operations
La Jolla Pharmaceutical Acquire Rights to Regenerative Immunophilin Ligands from GliaMed
Medtronic Acquires Minority Stake in Tengion
ImageIQ to Enter into Partnership with CCBC, NCRM and Cleveland Clinic
Centre for Commercialization of Regenerative Medicine Collaborates with McEwen Centre for Regenerative Medicine
LifeNet Health Sets Up Institute of Regenerative Medicine
UK Government Sets Out Plan for Regenerative Medicine
9. CORPORATE ACTIVITY IN RECENT PAST - A PERSPECTIVE BUILDER
Healthpoint Acquires Cell-based Technologies and Allied Assets from Intercytex
Astellas Pharma to Acquire Equity Stake in Cytori Therapeutics
Cephalon Enters into Partnership with Mesoblast
BioTime and California Institute for Regenerative Medicine Ink Agreement
The Automation Partnership Extends Partnership with EPSRC Centre for Innovative Manufacturing in Regenerative Medicine
The Alliance for Regenerative Medicine Introduces Regenerative Medicine Promotion Act
Power3 Medical Inks Definitive Agreement to Acquire StemTroniX
Healthpoint Acquires CYZACT(tm) and ICX-SKN Technologies from Intercytex
Stem Cell Therapy International Merges with Histostem
TiGenix Acquires Orthomimetics
Integra Inks Licensing Deal with Organogenesis
DePuy Spine Collaborates with ATRM
Epistem Enters into Partnership with Novartis
Athersys Inks Agreement with Pfizer
Beike Biotechnology Signs Investment Agreement with Biomaster
Fujifilm Establishes New Drug Discovery Labs
10. FOCUS ON SELECT GLOBAL PLAYERS
BioVest International, Inc. (US)
Curis, Inc. (US)
Cytori Therapeutics, Inc. (US)
Evotec AG (Germany)
Forticell Bioscience, Inc. (US)
Geron Corporation (US)
Integra LifeSciences Corporation (US)
LifeCell Corporation (US)
Osiris Therapeutics, Inc. (US)
Tengion, Inc. (US)
Tepha Inc. (US)
TiGenix N.V. (Belgium)
11. GLOBAL MARKET PERSPECTIVE
Table 13: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2010 through 2018 (includes corresponding Graph/Chart)
Table 14: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart)
Table 15: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2004, 2011 & 2018 (includes corresponding Graph/Chart)
Regenerative Medicine Market by Application
Table 16: World Recent Past, Current & Future Market Analysis for Regenerative Medicine Products for Bone and Joint Applications by Application - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2010 through 2018 (includes corresponding Graph/Chart)
Table 17: World Historic Review for Regenerative Medicine Products for Bone and Joint Applications by Application - Bone Replacements, Bone Stimulators, and Tissue Replacements Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart)
Table 18: World 15-Year Perspective for Regenerative Medicine Products for Bone and Joint Applications by Application - Percentage Breakdown of Dollar Sales for Bone Replacements, Bone Stimulators, and Tissue Replacements Markets for Years 2004, 2011 & 2018 (includes corresponding Graph/Chart)
III. MARKET
1. THE UNITED STATES
A. Market Analysis
Current and Future Analysis
US to Retain Leadership Position
The Strength of US in Regenerative Medicine - A Glance
Factors Driving the US Market of Regenerative Medicine
Millions of American Patients Put their Hope in Stem Cell Research
Table 19: Prevalence of Various Diseases in the US (includes corresponding Graph/Chart)
High Potential for Regenerative Medicine in Orthopedics
Regenerative Medicine in Bone and Joint Applications
Regenerative Therapy - Best Fit for Joint Problems
Table 20: US Market for Regenerative Medicine Products for Bone and Joint Applications (2011, 2015 & 2018): Percentage Breakdown of Value Sales for Bone Replacement Grafting, Bone Growth Stimulators, and Tissue Engineering Cartilage (includes corresponding Graph/Chart)
Table 21: US Demineralized Bone Matrices Market (2011): Percentage Share Breakdown of Value Sales for Leading Players (includes corresponding Graph/Chart)
Table 22: US Cartilage Procedure Market by Volume: 2012-2018 (in Million Procedures) (includes corresponding Graph/Chart)
Regenerative Medicine - Other Areas of Application
Regenerative Medicine - Face of Future Revolution in Cardiology
Regenerative Medicine in Wound Healing - The Most Widespread Application
Regenerative Medicine in Diabetes - A Number of Emerging Applications
Regenerative Medicine - A Ray of Hope for Neurodegenerative Disease Patients
Major Scientific Breakthroughs and Developments in Regenerative Medicine
CBI's Human Tissue Products for Treating Liver Failure and Diabetes
Market for Liver and Pancreas Transplantation
Implantable Regenerative Products Take Over Sports Medicine
Challenges in the Area of Product Development
Process of Integration Continues
Legal Entangles in the Field of Regenerative Medicine - Cause for Concern
Scientific and Technological Challenges to be Tackled
Dominant Patents a Cause of Concern
Technological Innovations/Breakthroughs
Strategic Corporate Developments
Key Players
B. Market Analytics
Table 23: US Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2010 through 2018 (includes corresponding Graph/Chart)
Table 24: US Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart)
2. EUROPE
A. Market Analysis
Current and Future Analysis
Great Potential for Regenerative Medicine
Challenges Faced by European Regenerative Medicine Industry
Financial Viability - A Growing Concern in the Backdrop of Euro Crisis
The Need to Embrace Newer Technologies
Complex Regulatory Scenario with Multi-tier Governance System
Need for More Integration
Policies Regarding Egg Procurement Weigh Down Research Progress
Need for Harmonized Clinical Trial Regulation
International Alliances - Outsourcing Options with Developing Countries
Patenting Issues in hESC Research
Oral Tissue Regeneration
Table 25: European Oral Tissue Regeneration Market (2011): Percentage Breakdown of Value Sales for Bone Graft Material, Membranes, and Tissue Regeneration (includes corresponding Graph/Chart)
Overview of select regional markets
Germany
United Kingdom
UK Government Sets Out Plan for Regenerative Medicine
Barriers to Commercialization
Strategic Corporate Developments
Key players
B. Market Analytics
Table 26: European Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2010 through 2018 (includes corresponding Graph/Chart)
Table 27: European Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart)
3. REST OF WORLD
A. Market Analysis
Current and Future Analysis
Canada
A Significant Player in the Field of Regenerative Medicine
Regulatory and Legislative Scenario
University of Toronto - Spearheading Regenerative Medicine Research
Asia-Pacific
Japan
Growth Drivers
Regenerative Medicine Market for Bone and Joint Applications
The Expanding RM market for Cartilage Grafts
Regenerative Bone Grafts - Slow Progress of Research a Concern
Other Areas in Regenerative Medicine
Skin Transplantation
Pancreas & Liver Transplantation
Research Activity in Regenerative Medicine Field
More Companies Eye the Regenerative Medicine Potential
Competition Heats up Behind Closed Doors
Japanese Firms Need to Catch Up with US and European Competitors
Science Ministry Rolls Out Regenerative Medicine Project
Regenerative Medicine Exempted from Ban on Human Cloning
Issues and Concerns
Regulatory Issues - Need for Faster Approvals
Need for Participation in International Standardization
China
Substantial Government Support
India
CSIR- Leading the way in Regenerative Medicine Research
High Growth Opportunities
South Korea
Malaysia
Singapore
Latin America
Argentina
Brazil
Highly Promising but Challenges Remain
Inconsistent Government Funding Poses Hurdles for Long-Term Research
Import Costs and Delays - An Impediment for the RM Sector
Underestimation of Brazilian Innovation - A Concern
Greater Integration Needed the Need of the Hour
Lack of Interest in IP Protection Results in Lesser Patents
Africa
South Africa
Strategic Corporate Developments
Key players
B. Market Analytics
Table 28: Rest of World Recent Past, Current & Future Analysis for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2010 through 2018 (includes corresponding Graph/Chart)
Table 29: Rest of World Historic Review for Regenerative Medicine Products for Bone and Joint Applications Market with Annual Sales Figures in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart)
Regenerative Medicine published by Global Industry Analysts, Inc. in November 1, 2012. This report consists of Pages: 392 and the price starts from US $ 4950.
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