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Cell-Based Assays

Abstract

Description

This report analyzes the worldwide markets for Cell-Based Assays in US$ Million by the following Product Segments: Assay Kits (Functional Assays, Cell Death-Associated Assays, & Cell Growth-Associated Assays), and Laboratory Automation. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 73 companies including many key and niche players such as BD Biosciences, Beckman Coulter, Inc., BioVision, Inc., Caliper Life Sciences, Inc., Cisbio Bioassays, DiscoveRx Corporation, EMD Millipore, Enzo Life Sciences, Inc., Evotec AG, GE Healthcare Life Sciences, Life Technologies Corp., New England Biolabs Inc., PerkinElmer, Inc., Promega Corporation, ProQinase GmbH, Qiagen NV, Sigma-Aldrich, StemCells, Inc., Thermo Fisher Scientific, Inc., and Xenometrix AG. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

  • Study Reliability and Reporting Limitations
  • Disclaimers
  • Data Interpretation & Reporting Level
    • Quantitative Techniques & Analytics
  • Product Definitions and Scope of Study
    • Assay Kits
      • Functional Assays
      • Cell Death-Associated Assays
      • Cell Growth-Associated Assays
    • Lab Automation

II. EXECUTIVE SUMMARY

1. CELL-BASED ASSAYS: A PRIMER

2. INDUSTRY OVERVIEW

  • Cell-based Assays: A Prelude
  • Cell-Based Assays Emerge as a Popular Tool in Drug Discovery and Basic Research
  • HTS and UHTS (High Throughput Screening and Ultrahigh-throughput Screening Assays)
  • Trends in Cell-Based Assay Market
  • Growing Inclination Towards In-vitro Assays for Toxicology Studies
  • Industry Trends
  • Cell-Based Assays: A Leading Drug Discovery Methodology
    • Economy of Time and Cost Drives the Use of Cell-Based Assays Over Other Techniques
  • Growing Focus on the Development of Reproducible and Robust Cell-based Assays
  • HTS and Advancements in the Stem Cell Arena: A Growing Trend
  • Increasing Use of Cell-Based Assays over Other Methods in Toxicity Testing
  • Functional Assays: An Effective Way of Predicting Specific Toxic Effects
  • Rising Interest in Cell-based Assays Propels the Development of Improved Product Offerings
  • Automation of Cell-based Assays: A Growing Trend
  • Technological Advancements in Drug Discovery Processes Spurs Cell-Based Assay Market
  • Development of Label-free Cell-based Assays: A Recent Trend in Biological Assays
  • Role of Surface Chemistries
  • Limitations
  • Microfluidics Systems in Cell-based Assays
  • Cell-Based Assays Likely to Gain from Microfluidic Devices
  • Other Trends

3. CELL-BASED ASSAYS: AN OVERVIEW

  • What Drives Advances in Cell-based Assays?
  • Cell Culture Fundamentals
  • An Insight into Cell Biology
  • Cell-based Assays: Basic Facts
  • Defining Cell-based Assays
  • Assays
  • Biological Assays
  • Quantification of Biological Activity
  • Cell-based Assays
  • Cell Based Assays: Prerequisites for Proof Of Concept
  • List of Factors to be Considered in Cell-Based Assays
  • Contamination with Mycoplasma: A Critical Factor
  • Modes of Contamination
  • Prevention
  • Uses of Cell-Based Assays
  • Challenges
  • Transient Transfection Cells
  • Limitations
  • Cell-based Assays: Product Segmentation
  • Assay Kits
    • Cell Function-Associated Assays
    • Cell Growth-Associated Assays
    • Cell Death-Associated Assays
  • Lab Automation
  • MIACA
  • Innovations in Cell-based Assays for Screening
  • MultiScreen Filter Plates from Millipore
  • MultiScreen Filter Plates from Millipore by Type of Assay
  • The Road Ahead

4. PRODUCT INTRODUCTIONS/INNOVATIONS

  • ACEA, Roche, and Vivo to Co-develop Novel xCELLigence System Assays
  • GE Healthcare and Geron Launch First Human Cardiomyocyte Product
  • Biomonitor Unveils Novel Products in iLite™ Product Line
  • Biomoda Receives Patent for Assay Use and Formulation
  • TGR BioSciences Expands 'No-Wash' SureFire Cellular Kinase Assay Portfolio
  • Hamamatsu Launches FDSS/uCELL Imaging Plate Reader
  • Nexcelom Bioscience Launches Cellometer® Auto X4
  • SRU Biosystems Advances Label-free BIND Biosensors Range
  • BioTek Instruments Introduces ELx405TM Microplate Bead Washer
  • Platypus Technologies Purchases Oris™ Pro Cell Migration Assay
  • Millipore Unveils MILLIPLEX® MAP EpiQuantTM Assay Panels
  • Corning Launches Osteo-Assay Surface for Bone Cell Assays
  • VisEn Medical Introduces Cat B 750 FAST Imaging Agent
  • Roche Launches xCELLigence System and FuGENE HD
  • Cisbio Bioassays Introduces Cellul'erk
  • AnaSpec Launches Calcein Acetoxymethyl Ester
  • Patheon Launches Cell-based Assay Services
  • Sigma-Aldrich Launches Precisio (TM) Kinases
  • CXR Biosciences and Millipore Launch ToxReporter™
  • Beckman Coulter Launches Gallios Flow Cytometer

5. PRODUCT INTRODUCTIONS/INNOVATIONS - A HISTORIC PERSPECTIVE BUILDER

  • Cisbio Bioassays Introduces HTRF® Terbium Platform for GPCR Screening
  • Corning Launches Integrated LHA for the Epic® System
  • PerkinElmer Unveils New AlphaScreen® SureFire® Assays
  • Millipore Introduces High Content Kits for Neurotoxicity
  • MaxCyte to Unveil MaxCyte STX Scalable Transfection System
  • LSG and Gentronix to Launch Human Cell-Based Assays for Genotoxicity in Japan
  • Innovatis Introduces Cellavista
  • Roche Applied Science Introduces xCELLigence System
  • Bravo Introduces Liquid Handling Platform
  • Cellix Introduces VenaFlux Platform
  • MaxCyte Unveils ITF Inline Transfection System
  • Thermo Fisher Scientific Expands Thermo Scientific Stem CELLExcellence Program
  • Tecan Group to Introduce New Infinite M1000 Multimode Microplate Reader
  • Beckman Coulter Integrates Quanta SC MPL with Cell Culture System
  • Genetix Launches CellReporter Cell-Based Assay Platform
  • Greiner Bio-One Unveils CELLSTAR® Plates
  • PBL InterferonSource Introduces Gene Reporter Cell-Based Assay Kit

6. RECENT INDUSTRY ACTIVITY

  • Merck Acquires Millipore, Forms New EMD Millipore Division
  • DiscoveRx Acquires KINOMEscan™ Division from Ambit
  • Asterand Takes over BioSeek
  • LGC Standards Inks Partnership Agreement with Gentronix
  • Cellular Dynamics International Partners with Promega
  • CCS Cell Culture Service Acquires MaxCyte® STXTM Scalable Transfection System
  • Gentronix Inks Three-Year Agreement with GlaxoSmithKline
  • DiscoveRx Enters into Co-Marketing Agreement with Jubilant
  • Qiagen Takes Over SABiosciences
  • Galapagos Signs Agreement with Dart Neuroscience
  • Asterand Extends Collaboration with Bristol-Myers Squibb
  • Pfizer Extends JAK3 Research Collaboration with Ligand Pharmaceuticals
  • StemCells to Expand Cell-Based Assay Platforms
  • Caliper Life Sciences to Utilize Label-Free Bind Technology of SRU Biosystems
  • O2h Enters into First Biology Affiliate Partnership with Hypoxium
  • Evotec and DiscoveRx Ink Agreement to Support HTS Services
  • Millipore Takes Over Guava Technologies
  • Beckman Coulter and Propel Labs Collaborate for Flow Cytometry
  • Beckman Coulter Interfaces CyAn™ Flow Cytometer with IntelliCyt's HyperCyt®
  • XenoBiotic to Establish New Laboratory in China
  • StemCells Acquires Stem Cell Sciences
  • PerkinElmer Enters into Collaboration with Sangmyung University
  • Seahorse Bioscience Takes Over BioProcessors
  • Roche Inks Co-development and Marketing Agreement with Axiogenesis
  • ChanTest Takes over Applied Cell Sciences

7. STRATEGIC CORPORATE DEVELOPMENTS - A HISTORIC PERSPECTIVE BUILDER

  • Applied Biosystems and Invitrogen Merge to form Life Technologies Corp.
  • IBA Acquires Majority Stake in CISBIO
  • Emory University Acquires Corning® Epic® System
  • Biomonitor Takes Over Neutekbio
  • Affymetrix to Take Over Panomics
  • BioForce to Ink Agreement with University Pierre & Marie Curie and Centre National de Recherche Scientifique
  • Gentronix Inks Agreement with LSG
  • Veridex Acquires Immunicon
  • Caliper Life Sciences Partners with DiscoveRx
  • BioSeek Inks Agreement with Dainippon Sumitomo Pharma
  • 3M Takes Over Acolyte Biomedica
  • Invitrogen Corporation Acquires BioSource
  • Caliper Life Sciences Acquires NovaScreen Biosciences

8. FOCUS ON SELECT GLOBAL PLAYERS

  • BD Biosciences (US)
  • Beckman Coulter, Inc. (US)
  • BioVision, Inc. (US)
  • Caliper Life Sciences, Inc. (US)
  • Cisbio Bioassays (US)
  • DiscoveRx Corporation (US)
  • EMD Millipore (US)
  • Enzo Life Sciences, Inc. (US)
  • Evotec AG (Germany)
  • GE Healthcare Life Sciences (UK)
  • Life Technologies Corp. (US)
  • New England Biolabs Inc. (USA)
  • PerkinElmer, Inc. (US)
  • Promega Corporation (US)
  • ProQinase GmbH (Germany)
  • Qiagen NV (The Netherlands)
  • Sigma-Aldrich (USA)
  • StemCells, Inc. (US)
  • Thermo Fisher Scientific, Inc. (US)
  • Xenometrix AG (Switzerland)

9. GLOBAL MARKET PERSPECTIVE

    • Table 1: World Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 2: World Historic Review for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 3: World 15-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 and 2017 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

  • A. Market Analysis
    • Functional Assays - The Fastest Growing Product Segment
    • Cell-Based Assay Market to Witness Significant Growth
    • Life Science Remains the Largest End-Use Sector
    • Market Trends
      • Consolidation Rife in the Industry
      • Select Acquisitions in the Industry (2006-2010)
      • Increased Usage Drives Growth of Cell-based Assays
      • Automation, High-Throughput Screening Pulls Down CBA Market Growth, to a Certain Extent
      • Custom Designed Assays to Drive the US Cell-based Assay Market
    • Competitive Scenario
      • US Functional Cell Assays Market
    • Table 4: Leading Players in the US Functional Cell-Based Assays Market (2009): Percentage Breakdown of Revenues for Millipore, Promega, New England Biolabs, Sigma-Aldrich, BD Biosciences and Others (includes corresponding Graph/Chart)
    • Table 5: Leading Players in the US Cell-Based Assays Market (2009): Percentage Breakdown of Revenues for Millipore, Promega, EMD Biosciences, BD Biosciences, New England Biolabs and Others (includes corresponding Graph/Chart)
    • Table 6: Leading Players in the US Cell Growth-Based Assays Market (2009): Percentage Breakdown of Revenues for Promega, Life Technologies (Invitrogen), EMD Biosciences, Millipore, BD Biosciences and Others (includes corresponding Graph/Chart)
    • Table 7: Leading Players in the US Cell Death-Based Assays Market (2009): Percentage Breakdown of Revenues for EMD Biosciences, Millipore, BD Biosciences, Life Technologies (Invitrogen), Promega and Others (includes corresponding Graph/Chart)
    • Product Launches
    • Strategic Corporate Developments
    • Focus on Select Players
  • B. Market Analytics
    • Table 8: The US Recent Past, Current and Future Analysis for Cell-Based Assays by Type - Assay Kits (Functional Assays, Cell Death-Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 9: The US Historic Review for Cell-Based Assays by Type - Assay Kits (Functional Assays, Cell Death-Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 10: The US 15-Year Perspective for Cell-Based Assays by Type - Percentage Breakdown of Dollar Sales for Assay Kits (Functional Assays, Cell Death- Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation for Years 2003, 2011 and 2017 (includes corresponding Graph/Chart)

2. JAPAN

  • A. Market Analysis
    • Strategic Corporate Developments
  • B. Market Analytics
    • Table 11: Japanese Recent Past, Current and Future Analysis for Cell-Based Assays Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 12: Japanese Historic Review for Cell-Based Assays Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)

3. EUROPE

  • A. Market Analysis
    • Table 13: European Cell-Based Assay Market by End-Use Sector (2011): Percentage Breakdown of Revenues for Pharmaceuticals, Biotech Companies and Research/ Academia (includes corresponding Graph/Chart)
    • Market Outlook
      • Cell-Based Assays Continue to Gain Impetus
      • GPCR Targets to Drive Growth in Functional Cell Assay Market
      • Growth in Cell Growth-Based Assay Kits Trails Behind Other Segments
      • Drive Towards Improved Efficiency in Development Programs Provides Impetus to Cell Death Based Assays
    • Market Trends
      • Rising Number of Drug Targets Surge Demand for Cell-Based Assays
      • Laboratory Automation Drives the Growth of European CBA Market
      • Cell-based Assays Represent the Primary Drug Discovery Tool in HTS Laboratories
      • Advancements in Technology, Identification Methods, and Lab Disciplines in the CBA Market
      • Cell-Based Assays: Regulatory Requirements
      • Validation Assays for Compliance with ICH Guidelines
      • Outsourcing of Validation Studies to CTOs
      • Important Considerations for Outsourcing Validation Assays to CTOs
    • Competitive Landscape
    • Product Launches
    • Strategic Corporate Developments
    • Focus on Select Players
  • B. Market Analytics
    • Table 14: European Recent Past, Current and Future Analysis for Cell-Based Assays by Type - Assay Kits (Functional Assays, Cell Death-Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 15: European Historic Review for Cell-Based Assays by Type - Assay Kits (Functional Assays, Cell Death-Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 16: European 15-Year Perspective for Cell-Based Assays by Type - Percentage Breakdown of Dollar Sales for Assay Kits (Functional Assays, Cell Death- Associated Assays, Cell Growth-Associated Assays) and Laboratory Automation for Years 2003, 2011 and 2017 (includes corresponding Graph/Chart)

4. REST OF WORLD

  • A. Market Analysis
    • Product Launch
    • Strategic Corporate Developments
  • B. Market Analytics
    • Table 17: Rest of World Recent Past, Current and Future Analysis for Cell-Based Assays Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 18: Rest of World Historic Review for Cell-Based Assays Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

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