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Cell-Based Assays

This report analyzes the worldwide markets for Cell-Based Assays in US$ Million by the following Applications: Basic Research, ADME Testing, and Drug Discovery. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 74 companies including many key and niche players such as -

BD Biosciences
Beckman Coulter, Inc.
BioVision, Inc.
Cisbio Bioassays
DiscoveRx Corporation

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

  • Quantitative Techniques & Analytics

Product Definitions and Scope of Study

  • Basic Research
  • ADME Testing
  • Drug Discovery

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW

  • Cell-based Assays: A Most Promising Area in Cellular Biology
    • Table 1: Global Market for Cell-based Assays (2013): Percentage Share Breakdown of Value Sales by Segment (includes corresponding Graph/Chart)
    • Table 2: Global Market for Cell-based Assays (2013): Percentage Share Breakdown of Value Sales by End-User (includes corresponding Graph/Chart)
  • Developed Markets Dominate, While Asia-Pacific Lends Growth Momentum
  • Major Trends, Growth Drivers and Restraints
  • Trends
  • Growth Drivers
  • Growth Restraints
  • Growing Prominence of Cell-based Assays in Drug Discovery
  • Cell-Based Assays Emerge as a Popular Tool in Basic Research
  • Use of Cell-based Assays in ADME-Toxicity Testing Gains Traction
  • Hepatotoxicity Testing Occupies Largest Market Share
  • Cell-based Assays in HTS and UHTS
  • Major Types of Cell-Based HTS Assays for Drug Screening
  • High-Content Screening (HCS) - A Rapidly Expanding Screening Technology in Cell-Based Assays
  • High Content Screening - Key Application Areas
  • HCS vs. HTS
  • Outsourcing of Pharma R&D Gathers Momentum
    • Table 3: Worldwide Annual Spending on Drugs by Category (2011 & 2015): Percentage Breakdown of Dollar Sales for Branded Drugs, Generic Drugs, and Others (includes corresponding Graph/Chart)
  • Drug Discovery Outsourcing and Type of Services Outsourced

2. MAJOR TRENDS & ISSUES

  • Growing Inclination towards In-vitro Assays for Toxicology Studies
  • Time and Cost Benefits Drive Use of Cell-Based Assays over Other Techniques
  • Rising Number of Drug Targets Surge Demand for Cell-Based Assays
  • Growing Focus on the Development of Reproducible and Robust Cell-based Assays
  • Stem Cells Exude Great Potential in Drug Toxicity Testing
  • Stem Cell Research in Cardiovascular Repair Rife with Hurdles
  • Increasing Use of Cell-Based Assays over Other Methods in Toxicity Testing
  • Functional Assays: An Effective Way of Predicting Specific Toxic Effects
  • GPCR Targets to Drive Growth in Functional Cell Assay Market
  • Innovation in Screening Guarantees Success for Drug Discovery Programs
  • 3D Cell Culture Technology to Put a New Spin on In Vitro Cell Analyses
  • 3D-CRT with Capability of Tracking Real Time 3D Position of Diffusing Nanoparticles
  • Automated Multiplexing Platforms Present Growth Opportunities
  • Miniaturized Cell-based Assays on the Horizon
  • Rising Interest in Cell-based Assays Propels Development of Improved Products
  • Automation of Cell-based Assays: A Growing Trend
  • Technology Advances in Drug Discovery Processes Spurs Cell-Based Assay Market
  • Development of Label-free Cell-based Assays: A Recent Trend in Biological Assays
  • Microfluidics Systems in Cell-based Assays
  • Cell-Based Assays Likely to Gain from Microfluidic Devices
  • Other Trends
  • Raman Spectroscopy: An Attractive Analytical Tool for Pharmaceutical Industry
  • Fluorescence Spectroscopy for Cellular Imaging Analyses
  • Cell-based Immunoassays: Novel Assay Technology for Autoantibodies Detection
  • Shift Away from Established Cell Lines to Primary Cells
  • Role of Cell-based Assays in Personalized Medicine: A Research Focus

3. CELL-BASED ASSAYS - APPLICATION AREAS

  • Cell-Based Assays in Drug Discovery
    • Table 4: Global Drug Discovery Market (2013): Percentage Share Breakdown of Revenues by Segment (includes corresponding Graph/Chart)
  • Drug Target Validation
  • Lead Identification
  • Lead Optimization
  • Sources and Types of Cells Available for Drug Screening
  • Cell-Based Assays in ADME Testing
    • Table 5: Leading Causes of Failure During New Drug Development: Percentage Share Breakdown by ADME/Tox Issues, Insufficient Efficacy, Adverse Side Effects, and Commercial Viability (includes corresponding Graph/Chart)
  • Need for Better Models: A Major Factor Driving Innovation in the Market

4. CELL-BASED ASSAYS: AN OVERVIEW

  • What Drives Advances in Cell-based Assays
  • Cell Culture Fundamentals
  • An Insight into Cell Biology
  • Cell-based Assays: Basic Facts
  • Defining Cell-based Assays
  • Assays
  • Biological Assays
  • Quantification of Biological Activity
  • Cell Based Assays: Prerequisites for Proof of Concept
  • List of Factors to be considered in Cell-Based Assays
  • Contamination with Mycoplasma: A Critical Factor
  • Modes of Contamination
  • Prevention
  • Uses of Cell-Based Assays
  • Challenges
  • Transient Transfection Cells
  • Limitations
  • Cell-based Assays: Product Segmentation
  • Assay Kits
    • Cell Function-Associated Assays
    • Cell Growth-Associated Assays
      • Select Methods of Evaluating Cell-Growth
      • Various Types of Cell Growth Associated Assays:
    • Cell Death-Associated Assays
  • Lab Automation
    • MIACA

5. PRODUCT INTRODUCTIONS/INNOVATIONS

  • InSphero Releases 3D InSight(tm) Cytotoxicity Assay Kit
  • Clinigene Introduces Cell-Based Biomarker Assay
  • BioVision Launches EZViable(tm) Calcein AM Cell Viability Assay Kit and MTS Cell Proliferation Assay Kit
  • Hepregen Rolls Out First Rat Hepatopactm Assay Kit for Toxicology Applications
  • Labstract Launches Cell-Based Assay Services
  • Hepregen Unveils Human HepatoMune(tm) Assay Kit
  • Molecular Devices Launches EarlyTox(tm) Cell Integrity Kit
  • LGC Introduces cGMP Cell-based Assay Capability
  • SymCel Rolls Out Commercial Label-Free Cell-Based Assay
  • Platypus Technologies Introduces Oris(tm) Pro 96-Well Invasion Assay
  • BioVision Launches Cell-Based Cholesterol Efflux Fluorometric Assay Kit
  • Promega Rolls Out GloMax(r) Discover Multimode Detection Plate Reader System
  • Hepregen Launches First Monkey Hepatopac(tm) Assay Kits
  • DiscoveRx Launches New Human Primary Cell-Based T Cell Autoimmune Panel
  • Hepregen Introduces Multi-Donor Human Hepatopac(tm) Assay
  • Hurel Introduces Cell-Based In Vitro Testing Product Suite
  • Thermo Fisher Scientific Releases Three New High Content Analysis Products
  • Thermo Fisher Scientific Launches Novel Incubation Solution for Cell-Based Research
  • DiscoveRx Introduces InCELL Hunter(tm) Platform
  • Cellectricon Launches Advanced Cell-Based Assay Systems
  • BioTek Launches Gas Controller for Synergy(tm) Hybrid Multi-Mode Microplate Readers
  • Intertek Releases cGMP Cell-Based Assays

6. RECENT INDUSTRY ACTIVITY

  • Promethera Biosciences Collaborates with EMD Millipore
  • Axxam and Cellectis Partner to Provide New Generation of Cell-Based Assays
  • TGR BioSciences and Abcam Enter into Licensing Agreement
  • Viradux Research Enters into JV Partnership with Benalli
  • Cellectricon Introduces Discovery Services Division
  • PPD Announces Expansion of cGMP Cell-based Assay Laboratory
  • Oxford Immunotec Enters into Licensing and Partnership Agreements with Lophius Biosciences
  • Evotec Takes Over Cell Culture Service
  • GE Healthcare Inks Sublicense Agreement with Cellular Dynamics for Cellular Assay Patents
  • Discoverx Acquires BioSeek(r)
  • CEVEC and CSS Enter into License Agreement
  • Cyprotex Enters into Licensing Deal with Sigma(r) Life Science
  • Medicyte to Collaborate with Reinnervate to Develop 3D Cell Toxicity Assays
  • Affymetrix Acquires eBioscience Holding Company
  • SGS Inaugurates New Cell-Based Assay Laboratory
  • Corning Acquires Majority of BD's Discovery Labware Unit

7. FOCUS ON SELECT GLOBAL PLAYERS

  • BD Biosciences (US)
  • Beckman Coulter, Inc. (US)
  • BioVision, Inc. (US)
  • Cisbio Bioassays (US)
  • DiscoveRx Corporation (US)
  • EMD Millipore Corp. (US)
  • Enzo Life Sciences, Inc. (US)
  • Evotec AG (Germany)
  • GE Healthcare Life Sciences (UK)
  • New England Biolabs, Inc. (US)
  • PerkinElmer, Inc. (US)
  • Promega Corporation (US)
  • ProQinase GmbH (Germany)
  • Qiagen NV (The Netherlands)
  • Sigma-Aldrich Corporation (US)
  • StemCells, Inc. (US)
  • Thermo Fisher Scientific, Inc. (US)
  • Life Technologies Corp. (US)
  • Xenometrix AG (Switzerland)

8. GLOBAL MARKET PERSPECTIVE

    • Table 6: World Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 7: World Historic Review for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 8: World 15-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
  • Cell-Based Assays Market by Application
    • Table 9: World Recent Past, Current and Future Analysis for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 10: World Historic Review for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 11: World 15-Year Perspective for Cell-Based Assays for Basic Research by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
    • Table 12: World Recent Past, Current and Future Analysis for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 13: World Historic Review for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 14: World 15-Year Perspective for Cell-Based Assays for ADME Testing by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
    • Table 15: World Recent Past, Current and Future Analysis for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 16: World Historic Review for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 17: World 15-Year Perspective for Cell-Based Assays for Drug Discovery by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

  • A. Market Analysis
    • Cell-Based Assay Market to Witness Significant Growth
    • Functional Cell Assays - A Key Segment
    • Increased Usage Drives Growth of Cell-based Assays
    • Impact of Automation & High-Throughput Screening on CBA Market
    • Custom Designed Assays to Drive the US Cell-based Assay Market
    • Clinical Trials Market in the US
    • Competitive Scenario
    • Table 18: Leading Players in the US Cell-Based Assays Market (2013): Percentage Breakdown of Revenues for Millipore, Promega, EMD Biosciences, BD Biosciences, New England Biolabs and Others (includes corresponding Graph/Chart)
    • Product Launches
    • Strategic Corporate Developments
    • Focus on Select Players
  • B. Market Analytics
    • Table 19: US Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 20: US Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 21: US 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

2. JAPAN

  • Market Analysis
    • Table 22: Japanese Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 23: Japanese Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 24: Japanese 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

3. EUROPE

  • A. Market Analysis
    • Current and Future Analysis
      • Pharmaceutical Companies Opt for Cell-Based Assays in Drug Discovery
      • Rising Number of Drug Targets Surge Demand for Cell-Based Assays
      • GPCR Targets to Drive Growth in Functional Cell Assay Market
      • Cell Growth-Based Assay Kits Market Makes Progress
      • Cell Death Based Assays: Efficiency Improvements in Development Programs Favor Growth
      • Cell-based Assays Represent the Primary Drug Discovery Tool in HTS Laboratories
      • Advances in Technology, Identification Methods, and Lab Disciplines in CBA Market
      • Regulatory Requirements in Cell-Based Assays Market
      • Validation Assays for Compliance with ICH Guidelines
      • Outsourcing of Validation Studies to CTOs
      • Growth of European Drug Discovery CRO Market: Opportunities for CBA Market
      • Clinical Trials Market in Europe
      • Competitive Landscape
    • Product Launches
    • Strategic Corporate Developments
    • Focus on Select Players
  • B. Market Analytics
    • Table 25: European Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 26: European Historic Review for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 27: European 15-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
    • Table 28: European Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 29: European Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 30: European 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

4. REST OF WORLD

  • A. Market Analysis
    • Current and Future Analysis
      • Emerging Nations Capitalize on the Outsourcing Trend
      • China
      • Life Sciences Market in China Continues to Thrive Despite Recession
      • China Emerges as the Major Outsourcer for Drug Discovery
      • China Begins Implementation of GLP Standard
      • Use of Non-Human Primates- A Key Feature of Chinese Pharmaceutical Sector
      • Going Ahead
      • India
      • A Thriving Clinical Trials Market
    • Table 31: Cost of Conducting Clinical Trials: India Vs. US (In US$ Million) (includes corresponding Graph/Chart)
    • Strategic Corporate Developments
  • B. Market Analytics
    • Table 32: Rest of World Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 33: Rest of World Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 34: Rest of World 15-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)
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