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Personalized Medicine - scientific & commercial aspects

Notes

This report describes the latest concepts of development of personalized medicine based on pharmacogenomics, pharmacogenetics, pharmacoproteomics, and metabolomics. The bibliography contains over 630 selected publications cited in the report.

The aim of personalized medicine or individualized treatment is to match the right drug to the right patient and, in some cases, even to design the appropriate treatment for a patient according to his/her genotype. This report describes the latest concepts of development of personalized medicine based on pharmacogenomics, pharmacogenetics,pharmacoproteomics, and metabolomics. Basic technologies of molecular diagnostics play an important role, particularly those for single nucleotide polymorphism (SNP) genotyping. Diagnosis is integrated with therapy for selection of the treatment as well for monitoring the results. Biochip/microarray technologies are also important and finally bioinformatics is needed to analyze the immense amount of data generated by various technologies.

Various technologies are integrated to develop personalized therapies for specific therapeutic areas described in the report. Examples of this are genotyping for drug resistance in HIV infection, personalized therapy of cancer, antipsychotics for schizophrenia, antidepressant therapy, antihypertensive therapy and personalized approach to neurological disorders. Although genotyping is not yet a part of clinically accepted routine, it is expected to have this status by the year 2016.

Ethical issues are involved in the development of personalized medicine mainly in the area of genetic testing. These along with social issues and consideration of race in the development of personalized medicine are discussed. Regulatory issues are discussed mainly with reference to the FDA guidelines on pharmacogenomics.

Table of Contents

Part I

0. Executive Summary 21

1. Basic Aspects 23

2. Molecular Diagnostics in Personalized Medicine 49

3. Pharmacogenetics 123

4. Pharmacogenomics 159

5. Role of Pharmacoproteomics 173

6. Role of Metabolomics in Personalized Medicine 179

7. Personalized Biological Therapies 185

8. Personalized Medicine in Major Therapeutic Areas 191

9. Personalized Therapy of Cancer 267

10. Development of Personalized Medicine 385

11. Ethical, Legal and Regulatory Aspects of Personalized Medicine 445

12. Commercial Aspects of Personalized Medicine 465

13. References 485

Part II

14. Companies Involved in Developing Personalized Medicine 5

Part I

Tables and Figures

Note: The Table of Contents has Been Edited for Brevity. For a Complete List of Tables and Figures Please Request a Free Sample.

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