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Drug Delivery in Cancer - technologies, markets and companies

Notes

Drug delivery strategies vary according to the type and location of cancer. This report will provide an in-depth analysis of innovative cancer therapies as well as methods of delivery.

Drug delivery remains a challenge in management of cancer. Approximately 12.5 million new cases of cancer are being diagnosed worldwide each year and considerable research is in progress for drug discovery for cancer. Cancer drug delivery is no longer simply wrapping up cancer drugs in a new formulations for different routes of delivery. The focus is on targeted cancer therapy. The newer approaches to cancer treatment not only supplement the conventional chemotherapy and radiotherapy but also prevent damage to normal tissues and prevent drug resistance.

Innovative cancer therapies are based on current concepts of molecular biology of cancer. These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. Important methods of immunotherapy in cancer involve use of cytokines, monoclonal antibodies, cancer vaccines and immunogene therapy.

Several innovative methods of drug delivery are used in cancer. These include use of microparticles as carriers of anticancer agents. These may be injected into the arterial circulation and guided to the tumor by magnetic field for targeted drug delivery. Polyethylene glycol (PEG) technology has been used to overcome some of the barriers to anticancer drug delivery. Encapsulating anticancer drugs in liposomes enables targeted drug delivery to tumor tissues and prevents damage to the normal surrounding tissues. Monoclonal antibodies can be used for the delivery of anticancer payloads such as radionucleotides, toxins and chemotherapeutic agents to the tumors.

Drug delivery strategies vary according to the type and location of cancer. Role of drug delivery in the management of cancers of the brain, the bladder, the breast, the ovaries and the prostate are used as examples to illustrate different approaches both experimental and clinical. Biodegradable implants of carmustine are already used in the treatment of malignant brain tumors.

The market value of drug delivery technologies and the anticancer drugs are difficult to separate. Cancer market estimates from 2012-2022 are given according to organs involved and the types of cancer as well as according to technologies. Distribution of the into major regions is also described.

Profiles of 226 companies involved in developing innovative cancer therapies and methods of delivery are presented along with their 254 collaborations. The bibliography contains over 650 publications that are cited in the report.The report is supplemented with 66 tables and 10 figures.

Table of Contents

Part - I: Technologies & Markets

0. Executive Summary

1. Introduction to cancer therapy

  • Molecular biology of cancer
  • Cancer biomarkers
  • Cancer proteomics
  • Limitations of genomics and proteomics for understanding cancer
  • Cancer microenvironment
  • Epidemiology of cancer
  • Current management of cancer
  • Basics of drug delivery in cancer
  • Methods of assessing drug delivery in cancer

2. Innovative treatments for cancer

  • Introduction
  • Selective estrogen receptor modulators
  • Antiangiogenic strategies for cancer
  • Bacterial anticancer agents
  • Innovations in cell therapy for cancer
  • Cancer immunotherapy
  • Innovative methods of radiation delivery
  • Ion channels and transporters in cancer
  • Irreversible electroporation
  • Methods to overcome multidrug resistance (MDR)
  • Targeted cancer therapies
  • Enhancing the effects of radiation and chemotherapy

3. Drug delivery systems for cancer

  • Introduction
  • Routes of drug delivery in cancer
  • Innovative formulations for drug delivery in cancer
  • Nanobiotechnology-based drug delivery for cancer
  • Polyethylene glycol technology
  • Single-chain antibody-binding protein technology
  • Vesicular systems for drug delivery in cancer
  • Liposomes for anticancer drug delivery
  • Pharmacosomes for controlled anticancer drug delivery
  • Emulsion formulations of anticancer drugs
  • Albumin-based drug carriers
  • Anticancer drugs that bind to tumors
  • Monoclonal antibodies
  • Monoclonal T cell receptor technology
  • Radioactive materials for diagnosis and targeted therapy of cancer
  • Strategies for drug delivery in cancer

4. Delivery of Biological Therapies for Cancer

  • Introduction
  • Antisense therapy
  • RNA interference
  • DNA interference
  • Cancer gene therapy
  • Cell therapy for cancer
  • Cancer vaccines

5. Delivery strategies according to cancer type and location

  • Introduction
  • Bladder cancer
  • Brain tumors
  • Breast Cancer
  • Cancer of the cervix and the uterus
  • Colorectal cancer
  • Cancer of the liver
  • Gastrointestinal cancer
  • Leukemia
  • Malignant melanoma
  • Nasopharangeal carcinoma
  • Neuroblastoma
  • Non-Hodgkin's lymphoma
  • Non-small cell lung cancer
  • Ovarian cancer
  • Pancreatic cancer
  • Prostate cancer

6. Cancer drug delivery markets

  • Introduction
  • Market forecasts 2012-2022
  • Market share according to cancer drug delivery technologies
  • Strategic aspects of cancer drug delivery
  • Unmet needs in cancer drug delivery
  • Future prospects of cancer drug delivery

7. References

Tables and Figures

Note: The Table of Contents has Been Edited for Brevity. For a Complete List of Tables and Figures Please Request a Free Sample.

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