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DNA sequencing: technologies, markets and companies

This report briefly reviews basics of human genome variations, development of sequencing technologies, and their applications. Current large and small sequencers are described as well as companies developing them. Various applications of sequencing are described including those for genetics, medical diagnostics, drug discovery and cancer. Next generation sequencing technologies, both second and third generations, are reviewed. Companies developing software for analysis of sequencing data are also included. Selected academic institutes conducting research in sequencing are also listed.

Current market is mostly for research applications and future markets will be other applications related to healthcare. The value of DNA sequencer market in 2013 is described with estimates for 2018 and 2023. Various methods and factors on which market estimates depend are described briefly. Markets are tabulated according to geographical areas as well as applications. Small sequencers form the basis of SWOT (strengths, weaknesses, opportunities, threats) analysis. Several marketing strategies have been outlined.

The report includes profiles of 117 companies involved in sequencing and their 118 collaborations. The report text is supplementd by 39 tables, 13 figures and 370 selected references to the literature.

Table of Contents

0. Executive Summary

1. Introduction

  • Definition and scope of sequencing
  • Historical aspects of sequencing
  • Basics of molecular biology
  • Variations in the human genome
  • Impact of sequencing on healthcare

2. DNA Sequencing Technologies

  • Introduction
  • Limitations of sequencing methods and measures to remedy them
  • Emerging sequencing technologies
  • Chemical DNA sequencing
  • Second generation sequencers
  • Future prospects of next generation sequencing

3. Role of Bioinformatics in Sequencing

  • Introduction
  • Growth of the sequencing database
  • Sequencing data storage
  • Bioinformatics challenges of new sequencing technology
  • Construction of libraries for NGS
  • Bioinformatic tools for analysis of genomic sequencing data
  • Accessing DNA sequence information
  • Analysis of genomic variation by sequencing of large populations
  • Human gene connectome
  • Funding of research for interpretation of sequencing data
  • Future challenges for managing sequencing data

4. Comparative Analysis of Sequencing Technologies

  • General findings of the study
  • Third generation large sequencers
  • Third generation small sequencers
  • The ideal small sequencer
  • SWOT analysis of small sequencers
  • Concluding remarks on SWOT analysis

5. Sequencing for Research

  • Introduction
  • Applications in basic research
  • Sequencing of human genomes
  • Sequencing genomes of non-human primates
  • Sequencing genomes of other organisms
  • Applications in drug discovery and development
  • Sequencing projects supported by US Government
  • 1000 Genomes Project
  • Human Variome Project
  • Academic centers conducting research on sequencing

6. Applications of Sequencing in Healthcare

  • Introduction
  • Applications of sequencing in molecular diagnostics
  • Applications of sequencing in oncology
  • Sequencing in genetic disorders
  • Sequencing for HLA typing
  • Sequencing for study of the human immune system
  • Sequencing in neurological and psychiatric disorders
  • Sequencing in cardiovascular disorders
  • Sequencing genomes of microbes
  • Population targeted sequencing studies
  • Sequencing in aging research
  • Next generation sequencing and pharmaceutical industry
  • Role of sequencing in personalized medicine
  • Current status and future prospects of clinical applications of NGS

7. Markets for Sequencers

  • Introduction
  • Methods used for estimation of sequencer markets
  • Currently marketed sequencers
  • Academic and research markets for sequencing
  • Factors affecting future development of sequencing markets
  • Marketing potential for sequencers
  • Challenges to developing market for sequencers
  • Recommendations

8. Companies Involved in Sequencing

  • Introduction
  • Major players in sequencing
  • Profiles of companies involved in sequencing
  • Collaborations

9. References

Tables and Figures

Note: The Table of Contents has Been Edited for Brevity. For a Complete List of Tables and Figures Please Request a Free Sample.

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