The growth in biopharmaceuticals is creating an unprecedented increase in
demand for cell culture products. Cell culture techniques have been used in
biological sciences for more than 50 years; however, cell culture techniques
have been applied to production systems for only about 26 years. The cell
culture industry, which began in the late 1980s from the utilization of
recombinant DNA technology and cell hybridization, is today a major
underpinning of the biopharmaceutical market.
The choice of cells to use in biopharmaceutical production depends on a number
of factors, some technical and some economic. Bacteria and yeast, for
instance, are relatively simple to grow. Each cell of a bacterium or yeast is
an independent organism capable of its own metabolism. Yeasts and bacteria
have fairly simple nutritional needs and grow well suspended in a liquid
medium, as well as in large fermentors.
This report is focused on cell culture used in the research and production of
biopharmaceuticals. In the pharmaceutical industry, cell culture is a major
foundation of biopharmaceutical development, bioprocessing and manufacturing.
Biopharmaceutical products are developed from large, complex protein
molecules, which require equally complex manufacturing methods and an array of
analytical techniques. As growing cells for biopharmaceutical production is
slow, expensive and complicated, optimizing cell culture development is of
paramount concern to companies developing biopharmaceuticals. Forecasts and
current market sizing are provided in three specific segments:
Media,
Sera, and
Reagents
In addition to a thorough discussion of the technologies and techniques
currently employed and emerging in the cell culture area, Kalorama's
exhaustive report provides specific information on:
Market Size, of the Cell Culture Media Segment Market, Sera Segment
Market and Reagent Segment Market through 2017
Market Share Estimate for Animal-Derived, Component Free Media
Market Share Estimate for Serum-Free Media
Market Share Estimate for Chemically-Defined Media
Competitive Market Share by leading supplier as of 2012
Estimated Market by Region (North America, Europe, Asia U.S.)
Key Market Drivers and Restraints for suppliers, including
discussions of biopharmaceutical pipelines, biomedical R&D directions, and the
future of transgenic plant and animal production.
Review of the various expression systems (Bacteria, Yeast, Insect,
and Mammal) and the biopharmaceutical product manufactured by these systems
The report contains a discussion of the preferences in media types
vying for dominance in the market, including the following:
ADCF - animal derived component free media
CD - chemically defined media
CSFM - complete serum free medium
PF - protein free media
SF - serum free media
SFM - serum free medium
The report also contains a discussion of Major Trends Impacting the
Market: stem cell research (including plans of major companies), cell
culture-based vaccine Production and generic biopharmaceuticals and
Profiles of Leading Suppliers and information about M&A activities in
recent years
The information for this report was gathered using both primary and secondary
research including comprehensive research of secondary sources such as company
literature, databases, investment reports, and medical and business journals.
Telephone interviews and email correspondence were the primary method of
gathering information. For the purpose of this study Kalorama Information
conducted interviews with key industry officials, consultants, and government
personnel. These sources were the primary basis in gathering information
specifically relating to revenue and market share data presented in this
report. Specific interviews with pharmaceutical company and cell culture
supply company representatives included marketing directors, division
managers, and product representatives.
Table of Contents
Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
Scope and Methodology
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Cell Lines and Cell Banks
Fermentors and Bioreactors
Stirred-tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-Fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environment
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-free Media
Chemically Defined Media
Specialty Media
Sera
Reagents
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
World Cell Culture Market
Cell Culture Market and Forecast
Current And Future Trends
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
Growing Demand for Biopharmaceuticals
Biopharmaceutical Market
Development of Biopharmaceuticals
Biopharmaceutical Growth Increases Demand for Cell Culture Products
A Brief History of Biotechnology
Science of Genetic Manipulation
From Petri Dish to Biopharmaceutical
Upstream Bioprocessing: Cell Culture Expression Systems
Cells for Biopharmaceutical Production
Bacteria and Yeasts Systems
Animal Cell Systems
Insect Cell Systems
Advantages/Disadvantages of Cell Culture Systems
Cell Lines and Cell Banks
Biopharmaceuticals Produced from Cell Culture
Cell Culture Practices and Regulatory Guidelines
Validation of Facilities
Maintaining Sterilization Standards
CHAPTER THREE: CELL CULTURE TECHNOLOGY
Introduction and Overview
Milestones in Cell Culture Development
Cell Lines for Bioproduction
Predominant Cell Lines
Chinese Hamster Ovary (CHO)
SP2/0, and NS0
HEK 293 and PER. C6
Sources: Largest Collections of Cell Lines
Fermentors and Bioreactors
Types of Bioreactors/Fermentors
Stirred-tank Reactors
Airlift Fermentors
Packed Bed Reactors
Hollow-fiber Reactor
Disposable Systems
Fermentation Processes
Batch and Fed-Batch Fermentation
Suspended vs. Anchored Cells
Microencapsulation
Cell Culture Environment
Functions and Components of Basal Media
pH and Osmotic Pressure
Energy Sources
Nutrients
Cell Culture Media
Types of Media
Lysogeny broth (LB)
Classical Media
Serum-free Media
Protein-free Media
Chemically Defined Media
Specialty Media
Sera
Sources of Sera
Bovine Serum Safety Issues and Regulations
Shift to Serum-free Media
Reagents
Major Types of Biologic Reagents
Amino Acids
Growth Factors and Cytokines
Albumin
Transferrin
Thrombin
Growth Supplements
Protease Inhibitor
Attachment Factors
Shifting Towards Non-animal Derived Reagents
Addressing Reagent Safety Issues
CHAPTER FOUR: CELL CULTURE MARKET CURRENT AND FUTURE TRENDS
Overview
Cell Culture Market
Market Drivers
Cell Culture Market Forecast
Market Segment Analysis
Media
Sera
Reagents
Cell Culture Suppliers' Market Share
Current And Future Trends
Shift to Serum-free and Animal Product-free Media
Concomitant Need for Animal-derived Media
Cell Culture-based Vaccine Production
Cell Culture-based Vaccine on Market
Stem Cell Research Driving Cell Culture Market
Life Technologies
Sigma-Aldrich
ThermoFisher Scientific
Lonza Bioscience
EMD Millipore
BD Bioscience
Impact of Generic Biopharmaceuticals on Cell Culture Market
CHAPTER FIVE: COMPANY PROFILES
Advanced Biotechnologies, Inc.
History and Lines of Business
Cell Culture Products and Services
Affymetrix, Inc.
History and Lines of Business
Cell Culture Products, Reagents and Biochemicals
Molecular Biology Enzymes
Molecular Biology Kits and Reagents
Purification
Biochemicals
PCR Reagents
Panomics Quantitative Assays
eBioscience Immunology Reagents
Financial Information
AMRESCO, Inc.
History and Lines of Business
Cell Culture Products
Analytical Biological Services Inc.
History and Lines of Business
Cell Culture Products
Mammalian Cell Culture
Cell in Microtiter Plates for HTS
Primary Cultures
Insect Cell Culture
Athena Enzyme Services
History and Lines of Buiness
Cell Culture Products
Atlanta Biologicals, Inc.
History and Lines of Business
Cell Culture Products
Animal & Human Sera
Media & Balanced Salts
Supplements & Reagents
Cell Separation Products
Athena Enzyme Systems
History and Lines of Business
Cell Culture Products
Expression Media
Cell Culture Products
Custom Cell Culture Media
Enzyme Assays
BD Biosciences
History and Lines of Business
Cell Culture Products
Clinical and Clinical Research Reagents, which include:
Exhibit 4-2 Cell Culture World Market Share, by Region, 2012
Exhibit 4-3 World Cell Culture Market by Segment: Media, Sera and
Reagents, 2005-201571
Exhibit 4-4 Breakout of Media Market (Serum-Free, CD, ADCF)
Exhibit 4-5 Cell Culture Market Share, 2012
Cell Culture: The Market for Media, Sera and Reagents, 5th Edition published by Kalorama Information in April 24, 2013. This report consists of 152 Pages and the price starts from US $ 3995.
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