• Japanese
  • Korean
  • Chinese
Cover Image

Cell Culture: The Market for Media, Sera and Reagents

The growth in biopharmaceuticals is creating an unprecedented increase in demand for cell culture products. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques. This Kalorama Information report, Cell Culture; The Market for Media, Sera and Reagents, analyzes the world market for media, sera and reagents and the major trends and drivers. It is the fifth time Kalorama Information has looked at this market since 2007.

As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals. The report contains market size projections, product offerings of major companies, current culture practice trends and company market share. The report focuses on three segments of the cell culture market

Media Market

Different kinds of cells require different types of media. Serum based media are widely used to grow a broad range of animal cell types and cell lines such as Chinese hamster ovaries (CHO) or murine myeloma cells (NS0) cells. This report provides market size and forecast to 2019 for the following categories of media:

  • Animal-Free Media
  • Serum-Free Media
  • Chemically Defined Media

Sera Market

Serum has traditionally been used as the major supplement to cell culture media. Serum is a complex mix of albumins, growth factors and growth inhibitors. Serum is one of the most important components of cell culture media and serves as a source for amino acids, proteins, vitamins (particularly fat-soluble vitamins such as A, D, E, and K), carbohydrates, lipids, hormones, growth factors, minerals, and trace elements. This report provides market size and forecast to 2019 for the following categories of sera:

  • Newborn Calf
  • Other Bovine
  • Fetal Bovine Serum
  • Other Sera

Reagents Market

Cultured cells require a sterile environment and a supply of nutrients for growth. An alternative to purchasing prepared defined media, is to purchase reagents and other cell culture components to create an optimum environment for a particular cell line. Biological reagents are an intrinsic component in every research laboratory and research project. This report provides market size and forecast to 2019 for the following categories of reagents:

  • Buffers and Salt Solution
  • Cytokines and Growth Factors
  • Cell Dissociation Reagents
  • Others

Eleven cell culture-derived biopharmaceutical drugs were launched in the US and European markets in 2014. Biopharmaceuticals (recombinant proteins, monoclonal antibody and nucleic acid-based products) represent the fastest growing sector in the pharmaceutical industry. Driving the extraordinary interest in biopharmaceuticals is the ability of these large proteins to target diseases in a very specific manner, thus maximizing efficacy while minimizing side effects. The report discusses key market drivers and restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production. It also discusses late-breaking trends such as 3D cell Culture. In addition, the report reviews the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems.

Country Cell Culture Markets

A global report, market estimates for the overall cell culture market are segmented by geography. The report offers the following regions/countries:

  • North America
  • UK/Ireland
  • Rest of Europe
  • Asia
  • China
  • Japan
  • Singapore/Malaysia
  • Rest of World

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.

Companies Profiled in This Report Include:

  • Advanced Biotechnologies, Inc.
  • Affymetrix, Inc.
  • AMRESCO, Inc.
  • Analytical Biological Services Inc.
  • Atlanta Biologicals, Inc.
  • Athena Enzyme Systems
  • BD Biosciences
  • Bioreclamation Inc
  • Cell Essentials, Inc.
  • CellGenix Technologie Transfer GmbH
  • ClonTech Laboratories, inc.
  • Corning Life Sciences
  • EMD Millipore
  • GE Healthcare Life Sciences
  • Gemini Bio-Products
  • invitria
  • Irvine Scientific
  • J R Scientific, Inc.
  • Life Technologies
  • Lonza Bioscience
  • MP Biomedicals
  • Novozymes Biopharma US Inc
  • PromoCell GmbH
  • Quality Biological, Inc.
  • SBH Sciences
  • Selexis SA
  • SeraCare Life Sciences, Inc.
  • Sera Laboratories International Ltd
  • Sigma-Aldrich
  • Stemcell Technologies Inc.
  • Thermo Fisher Scientific, Inc.
  • Tico Europe
  • Wisent Bioproducts

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

  • Scope and Methodology
  • Cells for Biopharmaceutical Production
    • Bacteria and Yeasts Systems
    • Animal Cell Systems
    • Insect Cell Systems
  • Cell Lines and Cell Banks
  • Fermentors and Bioreactors
    • Stirred-tank Reactors
    • Airlift Fermentors
    • Packed Bed Reactors
    • Hollow-fiber Reactor
    • Single-use Disposable Systems
    • Perfusion Bioreactor
  • Fermentation Processes
    • Batch and Fed-Batch Fermentation
    • Suspended vs. Anchored Cells
    • Microencapsulation
  • Advancement In Cell Culture Techniques: 3d Cell Culture
    • Growing cells in three dimensional systems
  • Cell Culture Environment
  • Functions and Components of Basal Media
    • pH and Osmotic Pressure
    • Energy Sources
    • Nutrients
    • Cell Culture Media
    • Lysogeny broth (LB)
    • Classical Media
    • Serum-free Media
    • Protein-free Media
    • Chemically Defined Media
    • Specialty Media
  • Sera
  • Reagents
  • Shifting Towards Non-animal Derived Reagents
  • Addressing Reagent Safety Issues
    • Global Cell Culture Market
  • Cell Culture Market and Forecast
  • Current and Future Trends

CHAPTER TWO: INTRODUCTION

  • Growing Demand for Biopharmaceuticals
  • Biopharmaceutical Growth Increases Demand for Cell Culture Products
  • A Brief History of Biotechnology
  • Science of Genetic Manipulation
  • Biopharmaceutical Market and Production
    • Biopharmaceutical Production
  • Top Selling Biopharmaceuticals in 2012, 2013 and 2014
  • FDA-approved Biopharmaceuticals
  • Upstream Bioprocessing: Cell Culture Expression Systems
  • Cells for Biopharmaceutical Production
    • Bacteria and Yeasts Systems
    • Animal Cell Systems
    • Insect Cell Systems
  • Advantages/Disadvantages of Cell Culture Systems
  • Cell Lines and Cell Banks
  • Biopharmaceuticals Produced from Cell Culture
  • Cell Culture Practices/Guidelines
  • Validation of Facilities
  • Maintaining Sterilization Standards

CHAPTER THREE: TECHNOLOGY

  • Introduction and Overview
  • Milestones in Cell Culture Development
  • Cell Lines for Bioproduction
  • Predominant Cell Lines
    • Chinese Hamster Ovary (CHO)
    • SP2/0, and NS0
    • HEK 293 and PER. C6
  • Sources: Largest Collections of Cell Lines
  • Bioreactors
  • Types of Bioreactors/Fermentors
    • Stirred-tank Reactors
    • Airlift Fermentors
    • Packed Bed Reactors
    • Hollow-fiber Reactor
    • Single-use/Disposable Systems
    • Perfusion Bioreactor
  • Fermentation Processes
  • Batch and Fed-Batch Fermentation
  • Suspended vs. Anchored Cells
  • Microencapsulation
  • Advancement In Cell Culture Techniques: 3d Cell Culture
    • Growing Cells in Three Dimensional Systems
  • Functions and Components of Basal Media
    • pH and Osmotic Pressure
    • Energy Sources
    • Nutrients
  • Cell Culture Media
  • Types of Media
    • Lysogeny broth (LB)
    • Classical Media
    • Serum-free Media
    • Protein-free Media
    • Chemically Defined Media
    • Specialty Media
  • Sera
  • Sources of Sera
  • Bovine Serum Safety Issues and Regulations
  • Shift to Serum-free Media
  • Reagents
  • Major Types of Biologic Reagents
    • Amino Acids
    • Growth Factors and Cytokines
    • Albumin
    • Transferrin
    • Thrombin
    • Growth Supplements
    • Protease Inhibitor
    • Attachment Factors
  • Shifting Towards Non-animal Derived Reagents
  • Addressing Reagent Safety Issues

CHAPTER FOUR: CELL CULTURE MARKET

  • Overview
  • Cell Culture Market
    • Market Drivers
    • Cell Culture Market Forecast
  • Global Cell Culture Market Share, by Region
    • Global Market Share, by Region, 2014 and 2019
  • Asia Pacific Region Gaining Market Share
    • Singapore: Fastest Growing Region
  • Market Segment Analysis
  • Media
    • Percentage of Market by Media Type
    • Advantages and Disadvantages of Using Serum
    • Liquid Versus Powdered Media
  • Sera
  • Reagents
  • Reagent Types
    • Cytokines and growth factors
    • Cell Dissociation Reagents
    • Buffers and Salt Solutions
    • Other Reagents
  • Cell Culture Supplier Market Share
  • Market Leaders in Cell Culture, 2014
  • Current and Future rends
  • Shift to Serum-free and Animal Product-free Media
  • Cell Culture-based Vaccine Production
    • Cell Culture-based Seasonal Vaccines
  • Stem Cell Research Driving Cell Culture Market
    • Sigma-Aldrich
    • ThermoFisher Scientific
    • Lonza Bioscience
    • EMD Millipore
    • BD Bioscience
  • Impact of Generic Biopharmaceuticals on Cell Culture Market

CHAPTER FIVE: COMPANY PROFILES

  • Advanced Biotechnologies, Inc.
    • History and Lines of Business
    • Cell Culture Products and Services
  • Affymetrix, Inc
    • History and Lines of Business
    • Cell Culture Products, Reagents and Biochemicals
  • AMRESCO, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Analytical Biological Services Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Atlanta Biologicals, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Athena Enzyme Systems
    • History and Lines of Business
    • Cell Culture Products
  • BD Biosciences
    • History and Lines of Business
    • Cell Culture Products
  • Bioreclamation Inc
    • History and Lines of Business
    • Cell Culture Products
  • Cell Essentials, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • CellGenix Technologie Transfer GmbH
    • History and Lines of Business
    • Cell Culture Products and Services
  • ClonTech Laboratories, inc.
    • History and Lines of Business
    • Cell Culture Products
  • Corning Life Sciences
    • History and Lines of Business
    • Cell Culture Products
  • EMD Millipore
    • History and Lines of Business
    • Cell Culture Products
  • GE Heathcare Live Sciences
    • History and Lines of Business
    • Cell Culture Products
  • Gemini Bio-Products
    • History and Lines of Business
    • Cell Culture Products
  • invitria
    • History and Lines of Business
    • Cell Culture Products
  • Irvine Scientific
    • History and Lines of Business
    • Cell Culture Products
  • J R Scientific, Inc.
    • History and Development
    • Cell Culture Products
  • Life Technologies
    • History and Lines of Business
    • Cell Culture Products
  • Lonza Bioscience
    • History and Lines of Business
    • Cell Culture Products and Services
  • MP Biomedicals
    • History and Lines of Business
    • Cell Culture Products
  • Novozymes Biopharma US Inc
    • History and Lines of Business
    • Cell Culture Products
  • PromoCell GmbH
    • History and Lines of Business
    • Cell Culture Products
  • Quality Biological, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • R&D Systems, Inc
    • History and Lines of Business
    • Cell Culture Products
  • SBH Sciences
    • History and Lines of Business
    • Cell Culture Products
  • Selexis SA
    • History and Lines of Business
    • Cell Culture Products and Technology
  • SeraCare Life Sciences, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Sera Laboratories International Ltd
    • History and Lines of Business
    • Cell Culture Products
    • Product Categories
  • Sigma-Aldrich
    • History and Lines of Business
    • Cell Culture Products
  • Stemcell Technologies Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Thermo Fisher Scientific, Inc.
    • History and Lines of Business
    • Cell Culture Products
  • Tico Europe
    • History and Lines of Business
    • Cell Culture Products
  • Wisent Bioproducts
    • History and Lines of Business
    • Cell Culture Products

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

  • Exhibit 1-1: Global Cell Culture Market, 2009-2019
  • Exhibit 1-2: Cell Culture Global Market Share, 2014 (North America, UK/Ireland, Rest of Europe,
  • China, Japan, Korea, Singapore/Malaysia, ROW)

CHAPTER TWO: INTRODUCTION

  • Exhibit 2-1: Top Selling Biological Drugs in 2012 and 2013
  • Exhibit 2-2: Top Selling Biological Drugs in 2014
  • Exhibit 2-3: FDA Biopharmaceutical Product Approvals, 2013
  • Exhibit 2-4: FDA Biopharmaceutical Product Approvals, 2014
  • Exhibit 2-5: Approximate times from Introduced Gene to Protein Production at Useable Levels
  • Exhibit 2-6: Disadvantages/Advantages of Cell Culture Systems
  • Exhibit 2-7: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells

CHAPTER THREE: TECHNOLOGY

  • Table 3-1: Five Types of 3D Cell Culture Methods
  • Exhibit 3-2: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma,Myeloma and CHO cell lines

CHAPTER FOUR: MARKET ANALYSIS

  • Exhibit 4-1: Global Cell Culture Market, 2009-2019
  • Exhibit 4-2: Cell Culture Global Market Share, by Region, 2014 (North America, UK/Ireland, Rest of
  • Europe, China, Japan, Korea, Singapore/Malaysia, ROW)
  • Exhibit 4-3: Cell Culture Global Market Share, by Region, 2019
  • Exhibit 4-4: Global Market Share, 2014 and 2019
  • Exhibit 4-5: Global Cell Culture Market by Segment Media, Sera and Reagents, 2009-2019
  • Exhibit 4-6 Media Sales, 2014-2019
  • Exhibit 4-7 Market Share, by Media Type, 2014 (Animal-Free, Serum-Free, Chemically Defined)
  • Exhibit 4-8: Market Share, by Media Type, 2019 (Animal-Free, Serum-Free, Chemically Defined)
  • Exhibit 4-10: Sera Sales, 2009-2019
  • Exhibit 4-11: Market Share by 2014 by Sera Type(Newborn Calf, Other Bovine, Other Sera, Fetal Bovine Serum)
  • Exhibit 4-12: Reagent Sales, 2009-2019
  • Table 4-13: Market Share by Reagent Type, 2014 (Buffers and Salt Solution, Cytokines and Growth Factors, Cell Dissociation Reagents, Buffers and Salt Solutions, Others)
  • Exhibit 4-14: Cell Culture Company Market Share 2014
Show More
Pricing
  • Int'l: +1-860-674-8796
  • TollFree(US): +1-866-353-3335
  • Europe: +32-2-535-7543
  • Asia: +65-6223-2436
Back to Top