Competitor Analysis: Tau and Amyloid Beta Targeted Therapy of Alzheimer's Disease published by La Merie Publishing in August, 2010. This report consists of 105 Pages and the price starts from US $ 890.
Abstract
The present Competitive Intelligence Report about Tau and Amyloid Beta
Targeted Therapy of Alzheimer' s Disease provides a competitor evaluation in
the field of therapeutic vaccines, antibodies and small molecules targeting
Tau and/or Amyloid Beta for treatment of Alzheimer' s disease as of August
2010. Purchase of the downloadable pdf report includes a 6-month online access
to the data of the report and any updates since the publication date.
Credentials to access the database will be sent by e-mail and allow online
work with the project data to print or export an individual report.
One of the main pillars of current drug discovery and development activities
in the pharmaceutical industry for Alzheimer' s disease is prevention of the
accumulation of misfolded proteins, i.e. amyloid beta and tau. At present, the
majority of approaches are directed to the amyloidogenic pathway. Amyloid beta
peptides derive from amyloid precursor protein (APP) by proteolytic cleavage
by beta secretase and gamma secretase.
Thus, inhibitors of beta secretase (or beta-site APP-cleaving enzyme, BACE-1)
are a main area of drug discovery complicated by the substate diversity of
BACE-1 and the need to pass the blood-brain barrier (BBB) which explains that
only very few inhibitors entered clinical development with no compound in
phase III, but many ongoing discovery programs. The first representative of
the class of inhibitors and modulators of gamma secretase has entered phase
III but the studies recently failed to meet the efficacy endpoint and even
worsened the clinical outcomes in the studies. It remains to be seen whether
follower programs in clinical phases I and II will suffer the same fate or can
be differentiated from Lilly' s semagacestat. Most of the gamma secretase
inhibitors in development are Notch-sparing molecules, thereby avoiding
typical side effects of the Notch signaling pathway, e-g. gastrointestinal and
hematological toxicities.
Increasing the activy of alpha secretase is another means to reduce the
activity of beta secretase. A number of compounds with different primary
mechanisms of action are in clinical and preclinical development.Strong
efforts are made by the industry in immunotherapy against amyloid beta to
inhibit generation of toxic amyloid beta aggregates and remove soluble and
aggregated amuyloid beta. At least eight therapeutic vaccines against amyloid
beta are under clinical investigation and more candidates are in preclinical
R&D stages. Passive immunotherapy with therapeutic antibodies against amyloid
beta has already reached phase III testing in clinical studies. Ten antibody
projects are in clinical or IND enabling study phases and more than ten
candidates in preclinical stages. Intravenous infusion of human-plasma derived
immunoglobulin preparations which contain naturally occurring plyclonal
anti-amyloid beta antibodies are also in advanced clinical testing.
Another approach is the development of CNS-bioavailable compounds that inhibit
amyloid beta aggregation or disintegrate amyloid beta oligomeric species
without being toxic or immunogenic. The second generation of such molecules
has at least ten representatives in clinical studies up to phase II.
The cytoplasmic protein Tau has recently gained much interest as a target for
new therapies of Alzheimer' s disease where it is abnormally phosphorylated
resulting in the generation of neurofibrillary tangles (aggregates) toxic to
neurons. The main tau-targeted approaches include molecules inhibiting
hyperphosphorylation and molecules that inhibit tau aggregation or promote
aggregate disassembly. Only a few molecules have reached clinical stages, but
strong research efforts are undertaken to come up with more clinical
candidates.
The report includes a compilation of currently active projects in research and
development of vaccines, antibodies, small molecules, proteins and peptides
targeting Tau and/or the amyloid beta pathway. In addition, the report lists
company-specific R&D pipelines of Tau and Amyloid Beta Targeted Therapeutics
for Alzheimer' s disease. Competitor projects are listed in a tabular format
providing information on:
- Drug Codes,
- Target / Mechanism of Action,
- Class of Compound,
- Company
- Product Category
- Indication,
- R&D Stage and
- additional comments with a hyperlink leading to the source of information.
Report Statistics
- Pages: 105
- Release Date: August of 2010
- Format: PDF
Table of Contents
1. Tau Targeted Therapy
- Tau Aggregation Inhibitors
- Tau Phosphorylation Inhibitors
- Microtubule Stabilizers
- Tau Immunotherapy
- Dual Tau & Amyloid Beta or Other Tau Targeted Therapy
2. Amyloid Beta Imaging
3. Amyloid Beta Immunotherapy (Amyloid Beta Clearance)
- IV Immune Globulins (IVIG)
- Passive Amyloid Beta Immunotherapy
- Active Amyloid Beta Immunotherapy
4. Prevention of Amyloid Beta Production
- Beta Secretase Inhibitors & Modulators
- Gamma Secretase Inhibitors
- Gamma Secretase Modulators
- Dual α & γ Secretase Inhibitors & Other Amyloid Production
Inhibitors
5. Alpha Secretase Activation (Non-Amyloidogenic Pathway of APP Processing)
- Alpha7 Nicotinic Acetylcholine Receptor (NAChR) Agonists
- GABA-A Receptor Modulation, 5-HT4 Receptor Agonism and Other α
Secretase Activators
6. Amyloid Beta Aggregation Reduction and Aggregate Removal
Corporate Anti-Infective Antibody Portfolios and R&D Pipelines
- Abbott
- Abiogen Pharma
- Ablynx
- AC Immune
- Actelion
- Acumen Therapeutics
- Affitech
- Affiris
- Alzprotect
- Amgen
- Archer Pharmaceuticals
- ArmaGen Technologies
- Astellas Pharma
- Astex Therapeutics
- AstraZeneca
- Avid Radiopharmaceuticals
- Axon Neuroscience
- Baxter
- Bayer Schering Pharma
- Bellus Health
- BioArctic Neuroscience
- Biogen Idec
- Boehringer Ingelheim
- Bristol-Myers Squibb
- Bruin Pharma
- Cellzome
- Chiesi Farmaceutici
- CoMentis
- Critical Outcome Technologies
- Cytos Biotechnology
- D-Pharm
- Delenex
- Diamedica
- DNAVEC
- Eisai
- Elan
- Eli Lilly
- EnVivo Pharmaceuticals
- Evotec
- ExonHit Therapeutics
- Galantos
- Galapagos
- GE Healthcare
- GlaxoSmithKline
- Grifols
- Humanetics Pharmaceuticals
- Immuno-Biological Laboratories
- Intellect Neurosciences
- Johnson & Johnson (Cilag-Janssen, Ortho-McNeil)
- Kinexis
- Lay Line Genomics
- Ligand Pharmaceuticals
- Link Medicine Corp.
- Lundbeck
- Medivir
- Memory Pharmaceuticals
- Merck & Co
- Merz Pharmaceuticals
- Mindset Pharmaceuticals
- Mitsubishi Tanabe Pharmaceutical
- NasVax
- Neurimmune Therapeutics
- NeuroGenetic Pharmaceuticals
- Noscira
- Novartis
- Octapharma
- Pfizer
- Prana Biotechnology
- Proteotech
- QR Pharma
- Roche (Genentech)
- Samaritan Pharmaceuticals
- Sanofi-Aventis
- Senexis
- Siena Biotech
- Takeda Pharmaceutical Co.
- TauRx Pharmaceuticals
- Transition Therapeutics
- TransTech Pharma
- United Biomedical
- Virionics
- Vitae Pharmaceuticals
- Xytis
