This publication has been discontinued on July 14, 2012.
Introduction
Abstract
This report includes details on 140 emerging medical technology companies
that: have presented at a Q1 2011 Elsevier/Medtech Insight In3
investor/partnering conference; have presented at a Q1 2011 LSI Emerging
Medical Technologies Spotlight meeting; or have been identified by LSI' s
in-house research team in Q1 2011. Two- to three-page executive summaries are
provided on most of the companies.
Executive summaries typically include:
Company Contact Information
Company Overview (structure, size, year founded, etc.)
Competitive Landscape
Technological Advantage
Stage of Development
Target Markets
Financial Summary and Sales Forecasts
Financing & Partnering Needs
IP Position & Status
Management Team
Exit Strategy
More
All companies include technology, market(s), key executive, and contact
information.
Coverage includes innovations in a broad spectrum of medical technology areas including:
5 Aesthetics/Dermatology Companies
33 Biomaterials Companies
6 Biotechnology/Cell Therapy Companies
24 Cardiovascular Companies
6 Dental Companies
23 Diagnostics Companies
19 Drug Delivery Companies
11 Endocrine Companies
8 Gastroenterology Companies
8 Gynecology/Women' s Health Companies
10 Imaging Companies
9 Neurology Companies
16 Oncology Companies
12 Ophthalmology Companies
14 Orthopedics Companies
5 Pain Management Companies
17 Patient Monitoring/Management Companies
8 Respiratory Companies
13 Spine Companies
9 Surgery Companies
13 Urology Companies
17 Vascular Companies
7 Wound Management Companies
**Some of the content in this report is generated from LSI' s exclusive license
agreement with Elsevier/Medtech Insight to reproduce content from their In3
conferences. ***Coverage of companies from Q1 2011 is included in this report.
Table of Contents
Table of Contents
BRIEF TECHNOLOGY DESCRIPTIONS FOR COMPANIES COVERED
1-Trans-nasal catheter for real-time imaging of atrial fibrillation (AF)
ablation procedures; 2-Intra-cardiac catheter for real-time image guidance of
percutaneous valve and other structural heart repair procedures;
3-High-definition intravascular ultrasound (IVUS) system, with near-OCT image
resolution; and 4-Image-guided, endoventricular injection catheter for stem
cell and/or biological agent therapy for congestive heart failure (CHF)
1-A long-term cardiac rhythm monitor and 2-A disposable
electrocardiography (ECG) monitor for use for up to 30 days
1-Adult stem cell collection and storage, 2-VSEL(TM) (very small
embryonic-like) stem cells for tissue regeneration, 3-Contract cell
manufacturing for clients around the world, Progenitor Cell Therapy,
4-Therapeutics such as a T-cell regulatory technology to treat disorders of
the immune system, 5-A wound healing technology that uses autologous bone
marrow-derived stem cells, 6-An autologous bone marrow-derived cell line
selected to treat damaged heart muscle following AMI
1-Biochemical sensing technologies for continuous glucose monitoring and
2-Drug-delivery devices for osteoporosis management
1-Biopsy needles with enhanced ultrasound visualization,
2-Microencapsulated tissue markers, 3-Devices for the local, accurately
positioned, chemoablative treatment of soft tissue cancers
1-Deep brain stimulator (DBS) to treat movement disorders, 2-A hybrid
auditory implant (HAI) to treat severe hearing loss
1-Effective cryosurgical tool that is simple and safe to use without
cryogenic gasses or liquids for all medical office skin lesion removal needs,
2-Cervical freeze attachment for gynecology use, 3-Third-generation technology
to accommodate cryosurgical treatments for prostate, liver & renal cancers and
cardiac aberrant foci ablation
1-Non-invasive in vitro diagnostic (IVD) blood test for the detection
and/or monitoring of 14 different types of cancer, 2-Combination Immunogene
Therapy (CIT) technology that could lead to a vaccine or possibly treat those
already diagnosed with cancer
3-D full-breast ultrasound imaging device for the detection of benign or
malignant masses
510(k) cleared device using acoustic reflectometry to continuously monitor
breathing tubes for placement, movement, and obstruction, enabling adverse
event prevention
A business and technology research & development platform, dedicated to
delivering innovative solutions for the musculoskeletal disorders industry
A handheld breath analyzer for the measurement of fat metabolism
A handheld device for the as-needed treatment of allergic rhinitis
A low-cost, clip-on eye-piece for mobile phones that mimics and replaces
the expensive laser-based Shack-Hartmann wavefront aberrometers to diagnose
the most common refractive eye disorders: myopia (nearsightedness),
hypermetropia (farsightedness), astigmatism, and presbyopia (age-related
visual impairment)
A medical implant surface technology company focused on the design and
manufacturing of proprietary and cellular-friendly interbody fusion devices
for the spine
A minimally invasive, green, laser-based technology for the treatment of
benign prostatic hyperplasia (BPH), as an alternative to traditional TURP
surgery
A non-invasive, automatic analyzer that uses measurements of sweat gland
activity to determine whether a patient is at risk for diabetes
A non-invasive, portable device that treats glioblastomas with electrical
fields
A percutaneous implant for mitral valve repair
A Peripheral Nerve Stimulation (PNS) system for patients suffering from
severe, intractable pain
A point-of-care diagnostic system for rapid, sensitive, quantitative
biomarker panels that delivers laboratory-quality results in a clinic or
doctor' s office, within minutes
A removable surgical implant to improve vision loss resulting from
presbyopia
A revolutionary device that will facilitate broad implementation of
extracorporeal CO2 removal and oxygen supplementation resulting in the
avoidance of airway intubation, sedation, and invasive mechanical ventilation
A safe, simple, and cost-effective solution that will revolutionize the
vascular anastomosis procedure
A self-contained, leadless electrode and an independent miniature
pacemaker for the left side of the heart, based on a novel micro-generator
that harvests energy from the movement of the heart
A small, injectable ophthalmic implant containing multiple,
laser-activated reservoirs designed for the on-demand, physician-controlled
release of ocular drug therapies to the back of the eye
A thrombectomy catheter for peripheral artery disease (PAD) that features
a rotating, extending tip
A unique Sharklet-patterned urinary catheter that will reduce
catheter-associated urinary tract infections (CAUTIs)
A unique, non-invasive tool for the analysis of muscle function to assist
in the evaluation and treatment of neck and back injuries and illnesses
A vertebral restoration system that uses spine-specific osteogenic
biomaterials to restore vertebral stability
A wearable product that uses Touch Activated Phlebotomy (TAP) technology
to reduce the inconvenience of blood sampling and facilitate simpler diagnoses
A wireless, remote-controlled unit targeting tissue expansion for breast
reconstruction
A wireless, touch-screen insulin pump featuring a blood glucose meter,
food library, and an activity monitor
Advanced long-term hemodialysis and peritoneal dialysis catheters
Advanced surgical devices for ear, nose, and throat (ENT) surgery
An artificial silicone microchip, which stimulates retinal cones and rods
to restore retinal function
An automated, continuous glucose monitor for bedside use in intensive and
critical care
An elegant, user-friendly alternative to traditional eye dropper bottles
that will allow multi-dose of preservative-free ophthalmic formulations
An expandable, funnel-shaped cannula for the removal of intravascular
material during extracorporeal circulation
An implantable, bionic retina for patients with degenerative retinal
diseases
Anatomically appropriate orthopedic implants, unique instrumentation, and
biologics for pediatric and small stature patients
Anti-infective compounds designed to mimic host defense proteins, but with
completely synthetic/non-peptide backbones, for serious, life-threatening,
acute disorders
Atherosclerotic plaque dissolution through chemical means for treating
occlusive and non-occlusive atherosclerotic disease that may reduce the need
for permanent implants like drug-eluting stents (DES), while also potentially
addressing plaque instability
Best-in-class platform to optimize genes and proteins in human therapeutics
Biocellulose technology that eliminates the
risks/complications/limitations inherent in animal, human, and synthetic
biomaterials
Biocompatible and biodegradable synthetic scaffold to aid soft tissue
regeneration of the anterior cruciate ligament (ACL) of the knee
Blood tests for the early detection of breast cancer, ovarian cancer, lung
cancer, Alzheimer' s, and other serious diseases where significant unmet
clinical needs exist
Capsule-based hydrogels to reduce food intake in obese patients
Cloud/web-based medical imaging data management software and
infrastructure as services - to replace picture archiving communication system
(PACS) at a significantly reduced cost
Compact, home-based device for male fertility assessment
Continuous glucose monitoring system using an intravascular, optical
fluorescence-based sensor to support clinical implementation of tight glycemic
control (TGC) in the intensive care unit (ICU)
Device for dry powder pulmonary delivery to treat patients with
Parkinson¥' s disease
Device for the early detection, assessment, and monitoring of mild
perceptual impairment (MPI), an early indicator of mild cognitive impairment
Device providing sustained intravesical drug delivery for the treatment of
Overactive Bladder (OAB), Interstitial Cystitis (IC), and other bladder
conditions
Device that delivers iron transdermally for patients with iron-deficiency
anemia
Device that prepares 10 million micro-droplets per hour for use in drug
discovery, genomics, molecular epidemiology, and proteomics
Device-based technology with an anti-inflammatory therapeutic platform to
appreciably widen the present window of treatment for ischemic stroke to 12-18
hours
Devices for arthroscopy, hip, knee, and spine surgery, in addition to
radiofrequency identification (RFID) tracking technology
Dynamic and intelligent optics for use in spectacle lenses for the
correction of presbyopia
Effective and convenient phototherapy system available for in-home
treatment of scalp/small-area psoriasis and other photo-responsive skin
diseases
Effective antimicrobial coatings and compounds that are broad-spectrum and
fast-acting against clinically relevant pathogens, including multi-drug
resistant strains such as MRSA
Electro-grafting coating technology for implantable biomedical
applications; used for the fast healing post drug-eluting-stent (DES)
implantation (avoiding late stage thrombosis)
Ellanse, the first dermal filler family offering a complete customized
solution in medical aesthetics
Endovascular device targeting the treatment of abdominal aortic aneurysms
(AAAs)
Fish-skin-derived tissue regeneration technology for chronic wounds and
hernia repair that improves upon current human and porcine technologies
through improved economics & clinical performance, reduced disease transfer
risk, and absence of cultural constraints on usage
Fluorescent markers/optical sensors that provide an accurate and rapid
determination of kidney function
Full Sense(TM) Bariatric Device which is implanted and extracted via
endoscopy and causes satiety leading to weight loss
Functional optical imaging technology for the early diagnosis and guided
treatment of blinding retinal diseases and diseases of other organs of the
body; it is the only optical imaging approach that allows visualization of the
capillaries, non-invasively (without any contrast agent)
Grafts for small diameter (less than 5mm) artificial blood vessels in both
peripheral and coronary applications
Handheld device for monitoring chronic disease home-care patients using a
single drop of blood
Hand-held ultrasound tool that displays a see-through image in the medical
practitioner' s line of sight, at the patient' s skin surface
High-durability tissue heart valves for transcatheter and surgical
implantation with percutaneously-exchangeable leaflets for lifetime service
without anti-coagulation therapy
HistoScanning(TM) is an innovative imaging-based modality available in the
Tissue Characterization market; the only one offering accurate 3D detection
and localization of cancer lesions
Image-guided interventional endoscopy products
Imaging systems enabling the examination of epithelial tissues in the
bladder, cervix, colon, esophagus, lung, oral cavity, and stomach
Imaging systems for the non-invasive, in vivo detection of cancerous and
pre-cancerous lesions
Implantable device to treat epilepsy by anticipating seizures and
delivering intracranial drugs
Implantable hearing device that provides extraordinary acoustic
performance in a completely invisible device
Implantable neurostimulation system for the treatment of obstructive sleep
apnea (OSA)
Implantable pacing and defibrillation device that detects the early onset
of atrial fibrillation and chronic heart failure and delivers targeted
medications
Incubator with 12 fully owned portfolio companies and 20+ fully owned
pipeline technologies, driven by unmet market need
Incubator with over 100 highly novel medical technology inventions
spanning most medical markets
Injectable, synthetic bone subsitutes
Innovative hydrogel technology for tissue repair including cartilage,
bone, and dermal of the knee, wrist, elbow, shoulder, and ankle
Innovative, compact, non-invasive systems for the early detection of skin,
lung, colon, and cervical cancers
Less invasive technologies and a more effective option for Primary Open
Angle Glaucoma patients
Medical image viewing solution that enables physicians to access/view
critical patient images/information from anywhere, without compromising the
security/privacy of the data
Microwave-based soft tissue ablation
Minimally invasive catheter-based system that safely, rapidly, and
effectively removes thrombus and restores blood flow in the peripheral
vasculature utilizing ultrasound energy to destroy clots, without harming
adjacent healthy tissue or generating dangerous emboli
Minimally invasive interstitial laser therapy (ILT) as an alternative to
lumpectomy
Minimally invasive orthopedic device for the treatment of hip pain
Minimially invasive percutaneous implantable cardioverter defibrillator
(PICD) for the treatment of cardiac arrhythmias
Modular, powered, proprietary articulating technology for endoscopes and
laparoscopes, enabling surgical safety, flexibility, and procedural innovations
Next-generation extracellular matrix (ECM) products for advanced wound
healing and tissue regeneration, with improved handling, strength,
resorbability, and infection control over existing products
Next-generation medical devices with anti-fouling surface modifications
that reduce the risk of complications over long durations
Next-generation, cost-effective ophthalmic implants made from STAR(R)
biomaterial that will help patients suffering from glaucoma and corneal
blindness
Non-invasive device using muscular counter pulsation (MCP) technology for
the treatment of acute and chronic heart failure (CHF) in a clinical,
ambulatory, or at-home setting
Non-invasive devices for continuous real-time evaluation of hemodynamic
changes
Non-invasive method for detecting the presence of a right-to-left cardiac
shunt (i.e., PFO) to enable medical treatment and/or closure before the
occurrence of a debilitating or life-threatening stroke or heart attack
Non-invasive ultrasound device for the treatment of glaucoma
Non-invasive, controlled, and sustained release back-of-the-eye
therapeutics for sight-threatening diseases such as: severe uveitis, diabetic
macular edema, and age-related macular degeneration (AMD)
Non-invasive, rapid assessment of dP/dt in Cardiac Resynchronization
Therapy (CRT) for lead placement, lead optimization, and monitoring
Novel bioresorbable regenerative scaffolds that provide 3D architecture
for enhanced tissue repair
Novel implantable ultrasound flow-measuring devices with flow data
wirelessly transmitted from within the body
Novel, implantable cardiovascular device
Off-the-shelf implantable allograft tissue to support peripheral nerve
repair and regeneration
Percutaneous vertebral augmentation (PVA) system for controlling bone
cement delivery and leakage during spinal surgery
Percutaneously-inserted interspinous process fusion cages that provide for
stabilization of the spine
Permanent, catheter-based implant that reduces mitral regurgitaiton by
reshaping the mitral valve
Physical and chemical resurfacing of orthopedic implants and stents which
allows for drug elution without the use of a binding polymer
Portable and advanced point-of-care diagnostics equipment
Portable pediatric vision-screening device for early diagnosis of serious
vision abnormalities
Pressure-controlled Intermittent Coronary Sinus Occlusion (PICSO) device
for acute coronary syndrome (ACS) and heart failure patients
Proprietary medical devices and patient interfaces for the enhancement of
patient safety through capnography monitoring
Radiofrequency (RF)-based detection systems to reduce the risk of retained
surgical sponges
Radiofrequency (RF)-based device for the treatment of congestive heart
failure (CHF)
Remote (wireless) continuous EEG (cEEG) brain monitoring of critical care
patients that significantly reduces mortality rates, improves patient
outcomes, and saves millions of dollars in patient care expense
Remotely controlled percutaneous catheter system for use in a wide range
of interventional applications
Repair and regeneration technology platforms designed to mend and regrow
hard tissue (such as bone) and soft tissue (such as cartilage)
Revolutionary portable device to provide easy and efficient screening
methods for early detection of age-related macular degeneration, diabetic
maculopathy, and other types of retinal disease in the human eye
Spine implant system that stabilizes and restores the spinal anatomy of
persons that have suffered a vertebral compression facture (VCF)
StimBrace addresses osteoarthritic knee pain by intelligently
strengthening leg muscles to stabilize and brace the knee during real-world use
Sutureless, anastomotic connectors to provide a controlled method of
joining vessels
Synthetic cartilage technology for joint repair
Technology for nurses/pharmacy technicians/emergency responders to more
safely and effectively vaccinate the public in the event of a biological or
viral pandemic
Technology that combines diagnostic imaging and therapeutic laser into one
device enabling image-guided navigation when performing retina laser
procedures, with the potential to reduce: treatment time, retreatment rates,
and risk of complications
Technology to embed Nitric Oxide (NO), part of the innate immune system,
into polymer medical devices to make them antimicrobial without the issues of
antibiotic resistance
Teraherz-based, real-time, video-rate imaging system
The first robotic system capable of offering full force-reflection to
laparoscopic surgeons in any surgical practice
The NuLens(TM) Dynacurve IOL is an implantable, flexible lens that changes
it curvature in response with the movements of the eyes accommodative muscle
system
The only device enabling simultaneous, non-invasive, and continuous
measurement of blood flow and oxygen saturation
The only minimally invasive cure for spinal stenosis that maintains the
natural dynamics of the spine
Thrombectomy catheters for patients with peripheral artery disease (PAD)
Two clinically proven lumbar, motion-preservation spinal implants that
offer surgeons: 1-a lumbar joint replacement that has provided superior
treatment over fusion and disc replacement, for patients with degenerative
lumbar joint disease and 2-a posterior dynamic stabilization system used to
restabilize the spine after surgery for spinal stenosis, as an alternative to
lumbar fusion
Unique, patented, activated collagen, CellerateRX(R) for the expanding
diabetes and greater woundcare markets
Vital signs monitoring device for use as an early congestive heart failure
(CHF) crisis indicator at home, to avoid acute/expensive hospitalizations
Whole-body imaging technology for orthopedic applications
Wireless, implantable heart device that allows Congestive Heart Failure
(CHF) patients to monitor data using a handheld instrument
World' s smallest leg compression device for the prevention of deep vein
thrombosis (DVT) in surgical patients, as a safe and effective alternative to
Lovenox, for a significantly reduced price
