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Next Generation Sequencing: Opportunities, Trends and World Market

Abstract

This report is about the fast-growing worldwide market for next-generation sequencing (NGS) tools and services. NGS systems makers are effectively driving down the cost of sequencing a human genome. Once the cost of full genome sequencing drops to $1,000 or less, scientists will be able sequence human genomes at the massive scale needed to better understand human variation and help open the gateway to personalized medicine. New NGS markets in medical, agriculture, bio-fuels, forensics, or others will emerge.

This must-have report discusses its interesting topics with key findings. Within a short time, the commercial NGS systems have seen a rapid uptake as these systems have been deployed into large genome centers, non-profit institutes, cancer research centers, drug makers, diagnostics firms and service providers worldwide. The report estimates that the total NGS tools and service market will reach $1.3 billion in 2011 and grow at a high double digit growth rate over the next 5-years. The report shows that various NGS systems are available to fill nearly every customer need, from high production volumes, to small scale, or to special niches.

The study reviews the technologies that these new NGS machines use and what kinds of applications and research projects that the scientists are doing. The report discusses government research grants and private initiatives. The report studies NGS service providers that outsource to pharma and biotech companies or other customers because the technologies might help them become more productive faster. Service providers such as Complete Genomics, GATC, PerkinElmer and others are convenient resources.

Takeda Pacific offers this report in an interactive PDF format. The interactive feature uses hyperlinks that enable the reader to click the mouse to jump from Table of Contents items to sections inside the report. The hyperlinks also allow the reader to click on links to Internet information.

This report is for business executives, entrepreneurs, venture capitalists, investors, product managers, research managers, business development managers, government officials and other decision makers. The research study discusses NGS products and services from Illumina, Life Technologies, Roche 454, Helicos Biosciences, Ion Torrent, Pacific Biosciences, Oxford Nanopore Technologies, and others.

The report uses 61 figures and tables to illustrate the findings. The study features convenient tables that help the reader scan the details of key trends, market segmentation, forecasts, M&As, alliances, grant funding, patents and so forth. The study profiles the activities of 19 companies.

About Takeda Pacific

Analysts at Takeda Pacific developed this report. The company provides business consulting that focuses on facilitating business development and market research projects. The business projects may involve European, Japanese and North American Life Science companies. Since it' s founding in late 1992, TP has reviewed or analyzed thousands of life Science and technology firms for its clients. Takeda Pacific has produced numerous industry reports about emerging pharma, biotech, medical devices and technology companies and markets.Takeda Pacific also offers follow-up consulting or custom research consulting to assist in your business development or benchmarking, market assessment projects.

Report Statistics

  • Date Published: May 2011
  • Authors: Jay K. Myers, Paula Mitchell Myers
  • Total Number of Pages: 161 (can be printed; fully searchable PDF format)

Table of Contents

1. Next-Gen. Sequencing (NGS) Market Landscape

  • CE and NGS for Life Science Research
    • Genome Sequencing Equipment Systems
      • Sanger-based CE Sequencing Systems
  • NGS Systems In Development
    • Bioinformatics Software
    • Genome Sequencing Organizations
    • IT Infrastructure and Applications
    • Others
  • NGS Applications & Projects for R&D
    • Academic Life Science Applications
    • Research Sequencing Applications
    • Pharma/ Biotech Drug Discovery/ Diagnostics R&D
    • Clinical Diagnostic Applications and Projects
    • Public Health Applications
    • Emerging ‘Personal Genomics' Applications
    • Agricultural/ Veterinary/Bio-energy Applications
    • Metagenomics Applications
    • Other Related Applications

2. Technology Developments in NGS

  • The Emergence of Next-Generation DNA Sequencing Technology Initiatives
    • The NIH Launched its Initiative for Sequencing the Genome for $1,000 or Less
    • The Archon X PRIZE for Genomics: $10 Million Goes to...
  • Developing Near Term and Emerging NGS Technologies
    • Near-Term Goal: Driving to a Low-Cost Genome
    • $1,000 Genome Time Line

3. Commercializing NGS Technologies

  • Commercial NGS Technologies for the Sub-$10,000 Genome
    • Sample Preparation
    • Sequencing
    • Data Analysis
    • Roche/ 454 Life Sciences, Inc. GS FLX and GS Junior.
    • Illumina, Inc. HiSeq, Genome Analyzer llx and MiSeq
    • Life Technologies SOLiD and Ion Torrent PGM
    • Danaher Motion Polonator G.007 - Open Source Polony Sequencing System
    • Helicos BioSciences Inc. , HeliScope, A 3G Platform Tha. Uses Single-Molecule Sequencing
  • Emerging Nanopore and 3G Technologies fo. Low-Cost Genome Sequencing
    • Pacific BioSciences, Inc. Real Time Single-Molecule Sequencing
    • Oxford Nanopore Technologies, Ltd. . BASE"! Technology

4. Major Alliances, M&As & Patents

  • Summary of Key Alliances and M&As
    • Definitions of Alliance and M&A Deal Types
    • Highlights of Key Alliances and M&As
    • Data Tables for Alliances and M&As
  • IP, Business Development and Challenges
    • Summary of Key Patents Involving Sequencing Technologies
    • The Business Value of IP
    • IP Challenges

5. Next-Generation Sequencing (NGS) Tools & Service Market Size

  • The Total Worldwide Market Size, 2010-2015
  • NGS Market Size by Products & Services
    • Methodology and Definitions
      • Market Segmentation
      • Estimating Unit Shipments and Revenues
  • NGS Tools & Service Market By Major Product & Service Segments
    • NGS Tools & Service Market By Major Product & Service Segments & Revenues
    • NGS Tools & Service Market By Major Product & Service Segment Shares
    • NGS Equipmen. & Consumables Market Segment by Subsegments & Revenues
    • NGS Equipmen. & Consumables Market by Subsegments & Market Shares
    • NGS Equipment Units Shipped Each Year and Estimated NGS Installed Base
    • The NGS Equipment and Consumables Market by Top Vendors, Revenues & Market Shares
    • The IT. Storage Tech., NGS BioInfo & Software Market Segment By Subsegments & Revenues
    • The Commercial NGS Service Provider Market Segment by Top Vendors & Revenues
  • NGS Tools & Service Market by Major NGS Application Segments
  • NGS Tools & Service Market by Customer Segments
  • NGS Tools & Service Market by WW Regions

6. Conclusions and New Business Opportunities

  • NGS Opportunities and Challenges
    • The Human Genome Project
    • Cumulative Advances in Technology Enabled NGS Developments
    • Driving to the $1,000 Genome and Beyond
    • The X PRIZE for Genomics Fosters Race to Reach the $10,000 Genome
    • Key M&As Enabled Commercial Next-Gen. Sequencing Platforms
    • Barriers to Market Entry Are Getting More Challenging
    • Enormous Amounts of NGS Data Challenge Researchers
    • Personal Genomics Hits Challenges
    • Famous Individuals and Their Genomes
    • Government Regulators
    • Clinical Sequencing for Diagnostic & Therapy Guidance
  • Some Hot Development Areas in NGS
    • NGS Systems May Replace CE Sequencing and Enable New Applications
    • Automated Sample Preparation
    • Capture Microarrays & DNA Preparation for Targeted and Exome Sequencing
  • Large-Scale International Sequencing Projects Use NGS
    • Scientists Want to Sequence 100,000' s of Humans to Enable Personal Medicine
    • The 1,000 Genomes Project
    • Human Microbiome Project
    • The Cancer Genome Atlas (US)
    • The Wellcome Trust Sanger Institute' s Cancer Genome Project
  • NGS Business Opportunities
    • Opportunities or Implications for the US
    • Opportunities or Implications for Europe
    • Opportunities or Implications for Japan and Asia

7. Profiles of Companies in Next Generation Sequencing

  • 23andMe, Inc.
  • 454 Life Sciences (Roche)
  • Affymetrix, Inc.
  • BioTeam, Inc.
  • DeCODE genetics, Inc.
  • DNASTAR, Inc.
  • GATC Biotech AG
  • Genomatix Software GmbH
  • GenomeQuest, Inc.
  • Helicos Biosciences Corporation
  • Illumina, Inc.
  • Intelligent Bio-Systems, Inc.
  • Knome, Inc.
  • Life Technologies, Inc.
  • NABsys, Inc.
  • Navigenics, Inc.
  • Oxford Nanopore Technologies Ltd.
  • Pacific Biosciences, Inc.
  • SeqWright, Inc.

8. Appendix

  • Glossary
  • Key Genome Sequencing Centers
  • Interesting Blogs Supporting NGS
  • Key Patents
  • About Takeda Pacific
  • About the Authors

LIST OF TABLES

  • Table 1. Sequencer Vendor Provided Software
  • Table 2. Selected Commercial Software
  • Table 3. Selected Open Source Short-Read Assembly Software
  • Table 4. Next-Generation Sequencing Tech. Grants Awarded FY 2004
  • Table 5. Next-Generation Sequencing Tech. Grants Awarded FY 2005
  • Table 6. Next-Generation Sequencing Tech. Grants Awarded FY 2006
  • Table 7. Next-Generation Sequencing Tech. Grants Awarded FY 2007
  • Table 8. Next-Generation Sequencing Tech. Grants Awarded FY 2008
  • Table 9. Next-Generation Sequencing Tech. Grants Awarded FY 2009
  • Table 10. Next-Generation Sequencing Tech. Grants Awarded FY 2010
  • Table 11. Competing Teams for the X PRIZE for Genomics
  • Table 12. Summary of Key Alliances and M&As, Mar/2005 to Jun/2008
  • Table 13. Key Alliances Jan-Jun 2008
  • Table 14. Key Alliances Jan-Dec 2007
  • Table 15. Key Alliances Jan-Dec 2006
  • Table 16. Key Alliances Mar-Dec 2005
  • Table 17. NGS Related US Patents Issued to Orgs., 2007 to May/2008
  • Table 18. Key Acquisitions in Next-Generation Sequencing.
  • Table 19. Total NGS Tools & Service Market 2010-2015
  • Table 20. NGS Tools & Service Market By Major Product & Service Segment & Revenues
  • Table 21. NGS Tools & Service Market by Segments & Shares
  • Table 22. NGS Equipmen. & Consumables Market by Subsegments & Revenues $M
  • Table 23. NGS Equipmen. & Consumables Market by Subsegments & Market Share %
  • Table 24. NGS Equipment Units Shipped Each Year and Estimated Installed Base
  • Table 25. NGS Equipment & Consumables Market Segment By Top NGS Vendors & Revenues to 2015
  • Table 26. NGS Equipment & Consumables Segment By Top NGS Vendors and Projected Market Shares %
  • Table 27. IT. Storage Tech., NGS BioInfo. & Software Market By Subsegments & Revenues
  • Table 28. IT. Storage Tech., NGS BioInfo. & Software Market Subsegments & Market Shares %
  • Table 29. Commercial NGS Service Provider Market by Revenues
  • Table 30. Commercial NGS Service Provider Market by Top 15 Vendors & Revenues to 2015
  • Table 31. NGS Tools & Service Market By Application Segments
  • Table 32. NGS Tools & Services Market By Applications Market Share %
  • Table 33. NGS Tools & Service Market By Customer Segments by Spending $M
  • Table 34. NGS Tools & Service Market By Customer Type Spen. and Market Share %
  • Table 35. NGS Tools & Service Market By WW Regions & Revenues
  • Table 36. Applications Unique to Next-Generation Sequencers
  • Table 37. Capture Arrays & DNA Sample Preparation for Targeted/ Exome NGS
  • Table 38. Opportunities or Implications for the US
  • Table 39. Opportunities or Implications for Europe
  • Table 40. Opportunities or Implications for Japan and Asia
  • Table 41. Large International Genome Sequencing Centers
  • Table 42. Blogs and Communities Supporting NGS
  • Table 43. Recent Patents for Genome Sequencing

LIST OF ILLUSTRATIONS

  • Figure 1. Cost of Sequencing a Full Genome
  • Figure 2. The NGS Tools and Service Market Landscape
  • Figure 3. Roche/ 454 GS FLX DNA Sequencer
  • Figure 4. Illumina Genome Analyzers
  • Figure 5. The Life Technologies 5500xl, 5500 SOLiD and Ion Torrent Sequencing Systems
  • Figure 6. The Danaher Polonator G.007
  • Figure 7. Helicos HeliScope Sequencer
  • Figure 8. Simultaneous & Continuous Excitation & Detection in a ZMW
  • Figure 9. Pacific BioSciences Sequencing instrument
  • Figure 10. Exonuclease Nanopore DNA Sequencing Method
  • Figure 11. The Oxford Nanopore GridION Flexible Deployment Scale
  • Figure 12. Total NGS Tools & Service Market 2010-2015
  • Figure 13. NGS Tools & Service Market By Major Product & Service Segments & Revenues
  • Figure 14. NGS Tools & Service Market By Segment Shares
  • Figure 15. NGS Equipment & Consumables Market Segment By NGS Vendors & Revenues to 2015
  • Figure 16. NGS Tools & Service Market By Application Segments
  • Figure 17. NGS Tools & Service Market By Customer Segments
  • Figure 18. NGS Tools & Service Market By WW Regions
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