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2014 Strategies for the German Nucleic Acid Testing Market

Highlights

  • Comprehensive 850-page market segmentation analysis of the German NAT market.
  • Major issues pertaining to the German NAT laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next five years.
  • An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
  • Five-year test volume and reagent sales forecasts for the following categories:
                 - Infectious Diseases
                 - Cancer
                 - Forensic Testing
                 - Genetic Diseases
                 - Paternity Testing/HLA Typing
  • Review of testing methodologies and instrumentation technologies.
  • Feature comparison of automated and semiautomated analyzers.
  • Sales and market shares of leading suppliers.
  • Over 60 specific opportunities for NAT instruments, test systems, IT and auxiliary products.
  • Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
  • Alternative market penetration strategies.
  • Potential market entry barriers and risks.
  • Business planning issues and concerns.

Contains 850 pages and 36 tables

Table of Contents

Introduction

Worldwide Market And Technology Overview

A. DNA Sequencing

  • 1. Introduction
  • 2. Sequencing Methods
  • 3. Autoradiography
  • 4. The Human Genome Project
  • 5. Sequencing Automation
  • 6. Image Scanners
  • 7. Fluorescent Detection
  • 8. Gene Profiling
  • 9. Gene Expression
  • 10. Polymorphism Screening
  • 11. Protein Interaction Networks

B. DNA And RNA Probe Technology

  • 1. Basic Principles
  • 2. Probe Preparation
  • 3. The DNA Probe Test
    • a. Sample Preparation
    • b. Hybridization
    • c. Separation
    • d. Detection/Measurement
  • 4. Test Formats
    • a. Filter Hybridization
    • b. Southern Blot
    • c. Northern Blot
    • d. In Situ Hybridization
    • e. Others
  • 5. Labeling Techniques
  • 6. Amplification Methods
    • Polymerase Chain Reaction
      • Temperature Cyclers
      • PCR Variations
        • Immuno-PCR
        • QC-PCR
        • DAP-PCR
    • Strand Displacement Activation
    • TMA
    • Ligase Chain Reaction
    • Branched DNA
      • Hybridization Protection Assay
    • Nucleic-Acid Sequence-Based Amplification
    • Self-Sustained Sequence Replicase
    • Others
      • Ampliprobe
      • CAR
      • CAS
      • CPT
      • Dendritic Polymer Technology
      • ISO-CR
      • LAT
      • Probe Networks
      • RAMP
      • Repair Chain Reaction
      • Rolling Circles
      • Sequence Independent Gene Amplification
      • Sequence Initiation Reaction
      • SISPA
      • Solid Phase Amplification

C. Detection Technologies

  • 1. Radioactive Methods
    • a. Overview
    • b. Major Isotopes
      • P-32
      • S-35
      • H-3
      • I-125
  • 2. Non-Isotopic Methods
    • a. Enzymatic Labels
    • b. Chemical Labeling
      • Indirect Chemical Labeling
      • Direct Chemical Labeling
    • c. Fluorescence
    • d. Chemiluminescence
    • e. Electrical Conductivity

D. Instrumentation Review

  • 1. Abbott LCx
  • 2. Beckman Coulter/Biomek FK
  • 3. Becton Dickinson SDA
  • 4. Bio-Rad GeneScope
  • 5. Gen-Probe Tigris
  • 6. Roche Cobas Amplicor
  • 7. Tecan LS Series

E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip

  • Liquid Transportation and Mixing
  • Separation
  • Reaction
  • Detection

F. Pharmacogenomics

G. Major Applications

1. Microbiology/Infectious Diseases

  • a. Overview
  • b. Major Infectious Diseases
  • * AIDS
    • Structure and Composition
    • Classification
    • AIDS Origins
    • Animal Lentivirus Systems
    • Virus Receptors
    • HIV Infections in Humans
      • Pathogenesis and Pathology
    • CD4T Lymphocytes and Memory Cells
    • Monocytes and Macrophages
    • Lymphoid Organs
    • Neural Cells
    • Viral Coinfections
      • Clinical Findings
    • Plasma Viral Load
    • Table of Contents (continued)
    • Pediatric AIDS
      • Neurologic Disease
      • Opportunistic Infections
      • Cancer
    • Immunity
      • Virus Isolation
      • Serology
      • Viral Nucleic Acid/Antigen Detection
    • Epidemiology
      • Worldwide Spread of AIDS
      • United States
      • Routes of Transmission
    • DNA Probes
      • Overview
      • Quantitative PCR
      • In Situ PCR
      • Needed Improvements
    • Viral Load/Drug Resistance Testing
    • Genotype and Phenotype Testing
    • Blood Banking Considerations
  • * Adenovirus
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
    • Adeno-Associated Viruses (AAV)
  • * Anthrax/Bacillus Anthracis
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Babesiosis
    • Background
  • * BEA and Other Bartonella Diseases
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Chagas Disease
    • Background
    • Table of Contents (continued)
  • * Campylobacter
    • Background
    • Diagnostic Tests
      • Culture Identification
    • Vaccines and Drugs
  • * Chlamydia
    • Background
      • Chlamydia psittaci
      • Chlmaydia pneumoniae
      • Chlamydia trachomatis
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Creutzfeldt-Jakob's Disease
    • Background
    • Blood Transmission
    • Diagnostic Tests
    • Major Commercial and Academic Players
      • Bayer
      • Disease Sciences/Bio Tec Global
      • Imperial College School of Medicine
      • Ortho-Clinical Diagnostics
      • Pall
      • ProMetic Life Sciences
      • Proteome Sciences/Idexx
      • Q-One Biotech
      • Serono
      • U.S. Agricultural Research Service
    • Drugs
    • Vaccines
  • * Cytomegalovirus
    • Background
      • Chorioretinitis
      • Gastrointestinal
      • Central Nervous System Disease
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Ebola Virus
    • Background
      • Epidemiology
      • Clinical Syndromes
    • Table of Contents (continued)
    • Diagnostic Tests
    • Vaccines and Drugs
  • * EchoVirus
    • Background
      • Acute Aseptic Meningitisis
      • Encephalitis
      • Exanthems
      • Respiratory Disease
      • Myopericarditis
      • Neonatal Infections
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Encephalitis
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Enteroviruses
    • Background
    • Diagnostic Tests
      • Viral Isolation and Identification
      • Antibody Tests
    • Vaccines and Drugs
  • * Epstein-Barr Virus
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Gonorrhea
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Hepatitis
    • Hepatitis A
    • Hepatitis B
      • Structure and Composition
      • Replication
    • Hepatitis C
    • Hepatitis D (Delta)
    • Hepatitis E
    • Hepatitis G
    • Hepatitis Infections Pathology
    • Clinical Findings
    • Laboratory Tests
    • Table of Contents (continued)
      • Hepatitis A
      • Hepatitis B
      • Hepatitis C
      • Hepatitis D
      • Hepatitis E
    • Virus-Host Immune Reactions
    • Epidemiology
      • Hepatitis A
      • Hepatitis B
      • Hepatitis C
      • Hepatitis D (Delta)
    • Vaccines and Drugs
  • * Herpes Simplex Virus
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Legionella
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Lyme Disease
    • Background
      • Clinical Description
      • Clinical Case Definition
      • Laboratory Criteria for Diagnosis
      • Case Classification
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Malaria
  • * Mycoplasma
    • Background
      • Ureaplasma Urealyticum & Mycoplasma
    • Hominis
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Papillomaviruses/HPV
    • Background
      • HPV in Cancer
      • Cervical Neoplasm
    • Diagnostic Tests
    • Vaccines and Drugs
    • Table of Contents (continued)
      • Prevention
  • * Parvovirus B19
    • Background
      • Microbiology
      • Epidemiology
      • Clinical Syndromes
      • Erythema Infectiosum (Slapped Cheek)
      • Adult Polyarthropathy
      • Transient Aplastic Crisis
      • Transient Pancytopenia
      • Red Cell Aplasia in Immunocompromised
      • Perinatal Infections
    • Diagnostic Test
    • Vaccines and Drugs
  • * Pneumonia
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Polyomaviruses
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Salmonellosis
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Shigellosis
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Streptococci
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
      • Group A Streptococci
      • Group B Streptococci
  • * Toxoplasmosis
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
    • Table of Contents (continued)
  • * Tuberculosis
    • Background
    • Diagnostic Tests
      • Microscopic Characteristics
      • Cultural Characteristics
      • Skin Tests
      • MDRTB
    • Vaccines and Drugs
  • * West Nile Virus
    • Background
      • Clinical Syndromes
    • Diagnostic Tests
    • Vaccines and Drugs
  • * Yersinia
    • Background
    • Diagnostic Tests
    • Vaccines and Drugs
    • c. Antibiotic Susceptibility

2. Cancer Testing

  • a. Overview
  • b. Major Cancer Types
  • * Prostate
  • * Lung
  • * Colon and Rectum
  • * Breast
  • * Skin
  • * Uterine
  • * Leukemia
  • * Oral
  • c. Oncogenes
    • Abl/abl-bcr
    • AIB1
    • BCL-2
    • BRCA1
    • CD44
    • C-fos
    • C-myb
    • C-myc
    • CYP17
    • Erb-B
    • HPC1
    • N-myc
    • P40
    • P51
    • P53
    • PIK3CA
    • PTI-1
    • Ras
    • Reg
    • Sis
    • Src

3. Genetic Diseases

  • a. Overview
  • b. Nucleic Acid Amplification
  • c. Chromosome Imaging
  • d. Genomics Technologies
  • e. Proteomics Technologies
  • f. Current Pharmacogenomic Tests
  • g. Future Pharmacogenomic Testing
  • h. Major Diseases
    • * Achondroplasia
    • * Autosomal Dominant Polycystic Kidney Disease
    • * Cancer
    • * Cosmetogenomics
    • * Cystic Fibrosis
    • * Down's Syndrome
    • * Duchenne and Becker Muscular Dystrophy
    • * Factor V (Leiden)
    • * Factor IX Deficiency
    • * Fragile X Syndrome
    • * Heart Disease
    • * Hemochomatosis
    • * Hemophilia
    • * Huntington's Disease
    • * Maternal-Fetal Incompatibility
    • * Multiple Endocrine Neoplasia
    • * Phenylketonuria (PKU)
    • * Polycystic Kidney Disease (PKD)
    • * Prenatal Screening
    • * Retinitis Pigmentosa
    • * Retinoblastoma
    • * Sickle Cell Anemia
    • * Spinal Muscular Atrophy
    • * Vitamin B12 Metabolism
  • i. Social Issues and Concerns

4. Forensic Testing

  • a. Overview
  • b. Multilocus and Single Locus Probes
    • * Multilocus Probes
    • * Single Locus Probes
    • * PCR and RFLP
  • c. The FBI
  • d. DNA Profile Data Banks
    • * U.S.A.
    • * U.K.
  • e. Judicial Implementation
  • f. Major Crime Categories
  • g. Factors Contributing to the DNA Probe Market Expansion
    • * Technology Availability
    • * Use of Hair as Evidence
  • h. Wildlife Forensics

5. Paternity Testing/HLA Typing

6. Other Applications

  • a. Disease Susceptibility Testing
  • b. Cardiovascular Diseases
  • c. Diabetes
  • d. Alzheimer's Disease
  • e. Periodontal Disease
  • f. Plasma Purification
  • g. Organ Transplantation
  • h. Water Contamination
  • i. Other

H. Competing/complementing Technologies

  • 1. Monoclonal Antibodies/Immunoassays
  • 2. RNA Probes
  • 3. Two-Dimensional Electrophoresis
  • 4. Flow Cytometry

I. Worldwide Market Overview

  • 1. Business Environment
  • 2. Market Structure
  • 3. Market Size and Growth

Germany

  • A. Executive Summary
  • B. Business Environment
  • C. Market Structure
  • D. Market Size, Growth And Major Suppliers'Sales And Market Shares

Major Product Development Opportunities

  • A. Instrumentation
  • B. Reagent Kits and Test Systems/panels
  • C. Computers, Software and Automation
  • D. Auxiliary Products

Design Criteria For Decentralized Testing Products

Alternative Market Penetration Strategies

  • A. Internal Development
  • B. Collaborative Arrangements
  • C. University Contracts
  • D. Distribution Strategies For Decentralized Testing Markets
    • 1. Marketing Approaches
    • 2. Product Complexity
    • 3. Customer Preference
    • 4. Established Suppliers
    • 5. Emerging Suppliers
    • 6. Major Types Of Distributors
    • 7. Market Segmentation

Potential Market Entry Barriers And Risks

  • A. Market Maturity
  • B. Cost Containment
  • C. Competition
  • D. Technological Edge And Limitations
  • E. Patent Protection
  • F. Regulatory Constraints
  • G. Decentralized Testing Market Challenges

Competitive Profiles

  • Abbott
  • Affymetrix
  • Agilent
  • Applied Gene Technologies
  • Arca
  • Beckman Coulter/Danaher
  • Becton Dickinson
  • Biokit
  • BioMerieux
  • Bio-Rad
  • Biotest
  • Caliper
  • Cepheid
  • Decode
  • Diadexus
  • Eiken
  • Enzo
  • Exact Sciences
  • Fujirebio
  • Gen-Probe
  • Hologic
  • Illumina
  • Innogenetics/Solvay
  • Kreatech
  • Li-Cor Biosciences
  • Life Technologies
  • Monogram Biosciences
  • Myriad Genetics
  • Nanogen/Elitech
  • Novartis
  • Orchid CellMark
  • Ortho-Clinical Diagnostics
  • Proteome Sciences
  • Qiagen
  • Roche
  • Scienion
  • Sequenom
  • Shimadzu
  • Siemens
  • Sierra Molecular
  • Takara Bio
  • Tecan Group

Appendixes

  • Appendix I: Major Universities and Research Centers Developing NAT Technology
  • Appendix II: Glossary of Terms
  • Appendix III: Currency Exchange Rates

List of Tables

  • Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
  • Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
  • Oncogenes Potential Application in Cancer Diagnosis Major Companies Developing or Marketing Cancer NAT Tests
  • Major Companies Developing or Marketing NAT Assays For Genetic Diseases
  • Summary Table Germany, NAT Test Volume And Sales Forecast by Major Application
  • Germany, Laboratories Performing DNA Sequencing by Market Segment
  • Germany, NAT Market Potential Laboratory Universe by Market Segment
  • Germany, NAT Test Volume Forecast By Major Application
  • Germany, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
  • Germany, Infectious Disease Screening NAT Volume Forecast
  • Germany, NAT Market Forecast By Major Application Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
  • Germany, NAT Market by Major Supplier
  • Germany, HIV/Hepatitis NAT Market Reagent Sales by Major Supplier
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