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2012 Japan Molecular Diagnostics Market Outlook: Growth Opportunities and Strategies

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This publication has been discontinued on July 23, 2012.

Abstract

Description

This report presents a comprehensive analysis of the Japanese molecular diagnostics market, including:

  • Major issues pertaining to the Japanese molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
  • An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
  • Ten-year test volume and reagent sales forecasts for the following categories:
    • Infectious Diseases
    • Genetic Diseases
    • Cancer
    • Paternity Testing/HLA Typing

Forensic Testing

  • Review of testing methodologies an instrumentation technologies.
  • Feature comparison of automated and semiautomated analyzers.
  • Sales and market shares of leading suppliers.
  • Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
  • Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
  • Alternative market penetration strategies.
  • Potential market entry barriers and risks.
  • Business planning issues and concerns.

Contains 860 pages and 36 tables

Table of Contents

Introduction

Worldwide Market And Technology Overview

A. DNA Sequencing

  • 1. Introduction
  • 2. Sequencing Methods
  • 3. Autoradiography
  • 4. The Human Genome Project
  • 5. Sequencing Automation
  • 6. Image Scanners
  • 7. Fluorescent Detection
  • 8. Gene Profiling
  • 9. Gene Expression
  • 10. Polymorphism Screening
  • 11. Protein Interaction Networks

B. DNA And RNA Probe Technology

  • 1. Basic Principles
  • 2. Probe Preparation
  • 3. The DNA Probe Test
    • a. Sample Preparation
    • b. Hybridization
    • c. Separation
    • d. Detection/Measurement
  • 4. Test Formats
    • a. Filter Hybridization
    • b. Southern Blot
    • c. Northern Blot
    • d. In Situ Hybridization
    • e. Others
  • 5. Labeling Techniques
  • 6. Amplification Methods
    • Polymerase Chain Reaction
      • Temperature Cyclers
      • PCR Variations
        • Immuno-PCR
        • QC-PCR
        • DAP-PCR
    • Strand Displacement Activation
    • TMA
    • Ligase Chain Reaction
    • Branched DNA
      • Hybridization Protection Assay
    • Nucleic-Acid Sequence-Based Amplification
    • Self-Sustained Sequence Replicase
    • Others
      • Ampliprobe
      • CAR
      • CAS
      • CPT
      • Dendritic Polymer Technology
      • ISO-CR
      • LAT
      • Probe Networks
      • RAMP
      • Repair Chain Reaction
      • Rolling Circles
      • Sequence Independent Gene Amplification
      • Sequence Initiation Reaction
      • SISPA
      • Solid Phase Amplification

C. Detection Technologies

  • 1. Radioactive Methods
    • a. Overview
    • b. Major Isotopes
      • P-32
      • S-35
      • H-3
      • I-125
  • 2. Non-Isotopic Methods
    • a. Enzymatic Labels
    • b. Chemical Labeling
      • Indirect Chemical Labeling
      • Direct Chemical Labeling
    • c. Fluorescence
    • d. Chemiluminescence
    • e. Electrical Conductivity

D. Instrumentation Review

  • 1. Abbott LCx
  • 2. Beckman Coulter/Biomek FK
  • 3. Becton Dickinson SDA
  • 4. Bio-Rad GeneScope
  • 5. Gen-Probe Tigris
  • 6. Roche Cobas Amplicor
  • 7. Tecan LS Series

E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip

  • Liquid Transportation and Mixing
  • Separation
  • Reaction
  • Detection

F. Pharmacogenomics

G. Major Applications

1. Microbiology/Infectious Diseases

  • a. Overview
  • b. Major Infectious Diseases

* AIDS

  • Structure and Composition
  • Classification
  • AIDS Origins
  • Animal Lentivirus Systems
  • Virus Receptors
  • HIV Infections in Humans
    • Pathogenesis and Pathology
  • CD4T Lymphocytes and Memory Cells
  • Monocytes and Macrophages
  • Lymphoid Organs
  • Neural Cells
  • Viral Coinfections
    • Clinical Findings
  • Plasma Viral Load
  • Pediatric AIDS
    • Neurologic Disease
    • Opportunistic Infections
    • Cancer
  • Immunity
    • Virus Isolation
    • Serology
    • Viral Nucleic Acid/Antigen Detection
  • Epidemiology
    • Worldwide Spread of AIDS
    • United States
    • Routes of Transmission
  • DNA Probes
    • Overview
    • Quantitative PCR
    • In Situ PCR
    • Needed Improvements
  • Viral Load/Drug Resistance Testing
  • Genotype and Phenotype Testing
  • Blood Banking Considerations

* Adenovirus

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs
  • Adeno-Associated Viruses (AAV)

* Anthrax/Bacillus Anthracis

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Babesiosis

  • Background

* BEA and Other Bartonella Diseases

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Chagas Disease

  • Background

* Campylobacter

  • Background
  • Diagnostic Tests
    • Culture Identification
  • Vaccines and Drugs

* Chlamydia

  • Background
    • Chlamydia psittaci
    • Chlmaydia pneumoniae
    • Chlamydia trachomatis
  • Diagnostic Tests
  • Vaccines and Drugs

* Creutzfeldt-Jakob's Disease

  • Background
  • Blood Transmission
  • Diagnostic Tests
  • Major Commercial and Academic Players
    • Bayer
    • Disease Sciences/Bio Tec Global
    • Imperial College School of Medicine
    • Ortho-Clinical Diagnostics
    • Pall
    • ProMetic Life Sciences
    • Proteome Sciences/Idexx
    • Q-One Biotech
    • Serono
    • U.S. Agricultural Research Service
  • Drugs
  • Vaccines

* Cytomegalovirus

  • Background
    • Chorioretinitis
    • Gastrointestinal
    • Central Nervous System Disease
  • Diagnostic Tests
  • Vaccines and Drugs

* Ebola Virus

  • Background
    • Epidemiology
    • Clinical Syndromes
  • Diagnostic Tests
  • Vaccines and Drugs

* EchoVirus

  • Background
    • Acute Aseptic Meningitisis
    • Encephalitis
    • Exanthems
    • Respiratory Disease
    • Myopericarditis
    • Neonatal Infections
  • Diagnostic Tests
  • Vaccines and Drugs

* Encephalitis

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Enteroviruses

  • Background
  • Diagnostic Tests
    • Viral Isolation and Identification
    • Antibody Tests
  • Vaccines and Drugs

* Epstein-Barr Virus

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Gonorrhea

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Hepatitis

  • Hepatitis A
  • Hepatitis B
    • Structure and Composition
    • Replication
  • Hepatitis C
  • Hepatitis D (Delta)
  • Hepatitis E
  • Hepatitis G
  • Hepatitis Infections Pathology
  • Clinical Findings
  • Laboratory Tests
    • Hepatitis A
    • Hepatitis B
    • Hepatitis C
    • Hepatitis D
    • Hepatitis E
  • Virus-Host Immune Reactions
  • Epidemiology
    • Hepatitis A
    • Hepatitis B
    • Hepatitis C
    • Hepatitis D (Delta)
  • Vaccines and Drugs

* Herpes Simplex Virus

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Legionella

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Lyme Disease

  • Background
    • Clinical Description
    • Clinical Case Definition
    • Laboratory Criteria for Diagnosis
    • Case Classification
  • Diagnostic Tests
  • Vaccines and Drugs

* Malaria

* Mycoplasma

  • Background
    • Ureaplasma Urealyticum & Mycoplasma
  • Hominis
  • Diagnostic Tests
  • Vaccines and Drugs

* Papillomaviruses/HPV

  • Background
    • HPV in Cancer
    • Cervical Neoplasm
  • Diagnostic Tests
  • Vaccines and Drugs
    • Prevention

* Parvovirus B19

  • Background
    • Microbiology
    • Epidemiology
    • Clinical Syndromes
    • Erythema Infectiosum (Slapped Cheek)
    • Adult Polyarthropathy
    • Transient Aplastic Crisis
    • Transient Pancytopenia
    • Red Cell Aplasia in Immunocompromised
    • Perinatal Infections
  • Diagnostic Test
  • Vaccines and Drugs

* Pneumonia

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Polyomaviruses

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Salmonellosis

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Shigellosis

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Streptococci

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs
    • Group A Streptococci
    • Group B Streptococci

* Toxoplasmosis

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs

* Tuberculosis

  • Background
  • Diagnostic Tests
    • Microscopic Characteristics
    • Cultural Characteristics
    • Skin Tests
    • MDRTB
  • Vaccines and Drugs

* West Nile Virus

  • Background
    • Clinical Syndromes
  • Diagnostic Tests
  • Vaccines and Drugs

* Yersinia

  • Background
  • Diagnostic Tests
  • Vaccines and Drugs
  • c. Antibiotic Susceptibility

2. Cancer Testing

  • a. Overview
  • b. Major Cancer Types
    • Prostate
    • Lung
    • Colon and Rectum
    • Breast
    • Skin
    • Uterine
    • Leukemia
    • Oral
  • c. Oncogenes
    • Abl/abl-bcr
    • AIB1
    • BCL-2
    • BRCA1
    • CD44
    • C-fos
    • C-myb
    • C-myc
    • CYP17
    • Erb-B
    • HPC1
    • N-myc
    • P40
    • P51
    • P53
    • PIK3CA
    • PTI-1
    • Ras
    • Reg
    • Sis
    • Src

3. Genetic Diseases

  • a. Overview
  • b. Nucleic Acid Amplification
  • c. Chromosome Imaging
  • d. Genomics Technologies
  • e. Proteomics Technologies
  • f. Current Pharmacogenomic Tests
  • g. Future Pharmacogenomic Testing
  • h. Major Diseases
    • Achondroplasia
    • Autosomal Dominant Polycystic Kidney Disease
    • Cancer
    • Cosmetogenomics
    • Cystic Fibrosis
    • Down's Syndrome
    • Duchenne and Becker Muscular Dystrophy
    • Factor V (Leiden)
    • Factor IX Deficiency
    • Fragile X Syndrome
    • Heart Disease
    • Hemochomatosis
    • Hemophilia
    • Huntington's Disease
    • Maternal-Fetal Incompatibility
    • Multiple Endocrine Neoplasia
    • Phenylketonuria (PKU)
    • Polycystic Kidney Disease (PKD)
    • Prenatal Screening
    • Retinitis Pigmentosa
    • Retinoblastoma
    • Sickle Cell Anemia
    • Spinal Muscular Atrophy
    • Vitamin B12 Metabolism
  • i. Social Issues and Concerns

4. Forensic Testing

  • a. Overview
  • b. Multilocus and Single Locus Probes
    • Multilocus Probes
    • Single Locus Probes
    • PCR and RFLP
  • c. The FBI
  • d. DNA Profile Data Banks
    • U.S.A.
    • U.K.
  • e. Judicial Implementation
  • f. Major Crime Categories
  • g. Factors Contributing to the DNA Probe Market Expansion
    • Technology Availability
    • Use of Hair as Evidence
  • h. Wildlife Forensics

5. Paternity Testing/HLA Typing

6. Other Applications

  • a. Disease Susceptibility Testing
  • b. Cardiovascular Diseases
  • c. Diabetes
  • d. Alzheimer's Disease
  • e. Periodontal Disease
  • f. Plasma Purification
  • g. Organ Transplantation
  • h. Water Contamination
  • i. Other

H. Competing/complementing Technologies

  • 1. Monoclonal Antibodies/Immunoassays
  • 2. RNA Probes
  • 3. Two-Dimensional Electrophoresis
  • 4. Flow Cytometry

Japan

  • A. Executive Summary
  • B. Business Environment
  • C. Market Structure
  • D. Market Size, Growth And Major Suppliers'Sales And Market Shares

Major Product Development Opportunities

  • A. Instrumentation
  • B. Reagent Kits and Test Systems/panels
  • C. Computers, Software and Automation
  • D. Auxiliary Products

Design Criteria For Decentralized Testing Products

  • Alternative Market Penetration Strategies
  • A. Internal Development
  • B. Collaborative Arrangements
  • C. University Contracts
  • D. Distribution Strategies For Decentralized Testing Markets
    • 1. Marketing Approaches
    • 2. Product Complexity
    • 3. Customer Preference
    • 4. Established Suppliers
    • 5. Emerging Suppliers
    • 6. Major Types Of Distributors
    • 7. Market Segmentation

Potential Market Entry Barriers And Risks

  • A. Market Maturity
  • B. Cost Containment
  • C. Competition
  • D. Technological Edge And Limitations
  • E. Patent Protection
  • F. Regulatory Constraints
  • G. Decentralized Testing Market Challenges

Competitive Profiles

  • Abbott
  • Affymetrix
  • Agilent
  • Applied Gene Technologies
  • Arca
  • Beckman Coulter/Danaher
  • Becton Dickinson
  • Biokit
  • BioMerieux
  • Bio-Rad
  • Biotest
  • Caliper
  • Cepheid
  • Decode
  • Diadexus
  • Eiken
  • Enzo
  • Exact Sciences
  • Fujirebio
  • Gen-Probe
  • Hologic
  • Illumina
  • Innogenetics/Solvay
  • Kreatech
  • Li-Cor Biosciences
  • Life Technologies
  • Monogram Biosciences
  • Myriad Genetics
  • Nanogen/Elitech
  • Novartis
  • Orchid CellMark
  • Ortho-Clinical Diagnostics
  • Proteome Sciences
  • Qiagen
  • Roche
  • Scienion
  • Sequenom
  • Shimadzu
  • Siemens
  • Sierra Molecular
  • Takara Bio
  • Tecan Group

Appendixes

Appendix I: Major Universities and Research Centers

  • Developing Molecular Diagnostic
  • Technology

Appendix II: Glossary of Terms

Appendix III: Currency Exchange Rates

List of Tables

  • Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
  • Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests
  • Oncogenes Potential Application in Cancer Diagnosis
  • Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
  • Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases
  • Summary Table Japan, Molecular Diagnostics Test Volume And Sales Forecast by Major Application
  • Japan, Laboratories Performing DNA Sequencing by Market Segment
  • Japan, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment
  • Japan, Molecular Diagnostics Test Volume Forecast By Major Application
  • Japan, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
  • Japan, Infectious Disease Screening NAT Volume Forecast
  • Japan, Molecular Diagnostics Market Forecast By Major Application
  • Japan, Infectious Disease Screening Nat Reagent Market Forecast by Test
  • Japan, Molecular Diagnostics Market By Major Supplier
  • Japan, HIV/Hepatitis NAT Market Reagent Sales by Major Supplier
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