This publication has been discontinued on July 23, 2012.
Introduction
Abstract
This report presents a comprehensive analysis of the German molecular
diagnostics market, including:
Major issues pertaining to the German molecular diagnostics laboratory
practice, as well as key economic, regulatory, demographic, social and
technological trends with significant market impact during the next ten years.
An extensive review of DNA probe and biochip technologies, test formats,
detection methodologies, trends in testing automation and amplification
methods.
Ten-year test volume and reagent sales forecasts for the following
categories:
Infectious Diseases
Genetic Diseases
Cancer
Paternity Testing/HLA Typing
Forensic Testing
Review of testing methodologies an instrumentation technologies.
Feature comparison of automated and semiautomated analyzers.
Sales and market shares of leading suppliers.
Over 60 specific opportunities for molecular diagnostic instruments, test
systems, IT and auxiliary products.
Profiles of major suppliers, and emerging market entrants, including their
sales, product portfolios, marketing tactics, technological know-how, new
products in R&D, collaborative arrangements and business strategies.
Alternative market penetration strategies.
Potential market entry barriers and risks.
Business planning issues and concerns.
Contains: 850 pages and 36 tables.
Table of Contents
Table of Contents
Introduction
Worldwide Market And Technology Overview
A. DNA Sequencing
1. Introduction
2. Sequencing Methods
3. Autoradiography
4. The Human Genome Project
5. Sequencing Automation
6. Image Scanners
7. Fluorescent Detection
8. Gene Profiling
9. Gene Expression
10. Polymorphism Screening
11. Protein Interaction Networks
B. DNA And RNA Probe Technology
1. Basic Principles
2. Probe Preparation
3. The DNA Probe Test
a. Sample Preparation
b. Hybridization
c. Separation
d. Detection/Measurement
4. Test Formats
a. Filter Hybridization
b. Southern Blot
c. Northern Blot
d. In Situ Hybridization
e. Others
5. Labeling Techniques
6. Amplification Methods
Polymerase Chain Reaction
Temperature Cyclers
PCR Variations
Immuno-PCR
QC-PCR
DAP-PCR
Strand Displacement Activation
TMA
Ligase Chain Reaction
Branched DNA
Hybridization Protection Assay
Nucleic-Acid Sequence-Based Amplification
Self-Sustained Sequence Replicase
Others
Ampliprobe
CAR
CAS
CPT
Dendritic Polymer Technology
ISO-CR
LAT
Probe Networks
RAMP
Repair Chain Reaction
Rolling Circles
Sequence Independent Gene Amplification
Sequence Initiation Reaction
SISPA
Solid Phase Amplification
C. Detection Technologies
1. Radioactive Methods
a. Overview
b. Major Isotopes
P-32
S-35
H-3
I-125
2. Non-Isotopic Methods
a. Enzymatic Labels
b. Chemical Labeling
Indirect Chemical Labeling
Direct Chemical Labeling
c. Fluorescence
d. Chemiluminescence
e. Electrical Conductivity
D. Instrumentation Review
1. Abbott LCx
2. Beckman Coulter/Biomek FK
3. Becton Dickinson SDA
4. Bio-Rad GeneScope
5. Gen-Probe Tigris
6. Roche Cobas Amplicor
7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
Liquid Transportation and Mixing
Separation
Reaction
Detection
F. Pharmacogenomics
G. Major Applications
1. Microbiology/Infectious Diseases
a. Overview
b. Major Infectious Diseases
AIDS
PStructure and Composition
PClassification
PAIDS Origins
PAnimal Lentivirus Systems
PVirus Receptors
PHIV Infections in Humans
Pathogenesis and Pathology
PCD4T Lymphocytes and Memory Cells
PMonocytes and Macrophages
PLymphoid Organs
PNeural Cells
PViral Coinfections
Clinical Findings
PPlasma Viral Load
PPediatric AIDS
Neurologic Disease
Opportunistic Infections
Cancer
PImmunity
Virus Isolation
Serology
Viral Nucleic Acid/Antigen Detection
PEpidemiology
Worldwide Spread of AIDS
United States
Routes of Transmission
PDNA Probes
Overview
Quantitative PCR
In Situ PCR
Needed Improvements
PViral Load/Drug Resistance Testing
PGenotype and Phenotype Testing
PBlood Banking Considerations
Adenovirus
PBackground
PDiagnostic Tests
PVaccines and Drugs
PAdeno-Associated Viruses (AAV)
Anthrax/Bacillus Anthracis
PBackground
PDiagnostic Tests
PVaccines and Drugs
Babesiosis
PBackground
BEA and Other Bartonella Diseases
PBackground
PDiagnostic Tests
PVaccines and Drugs
Chagas Disease
PBackground
Campylobacter
PBackground
PDiagnostic Tests
Culture Identification
PVaccines and Drugs
Chlamydia
PBackground
Chlamydia psittaci
Chlmaydia pneumoniae
Chlamydia trachomatis
PDiagnostic Tests
PVaccines and Drugs
Creutzfeldt-Jakob's Disease
PBackground
PBlood Transmission
PDiagnostic Tests
PMajor Commercial and Academic Players
Bayer
Disease Sciences/Bio Tec Global
Imperial College School of Medicine
Ortho-Clinical Diagnostics
Pall
ProMetic Life Sciences
Proteome Sciences/Idexx
Q-One Biotech
Serono
U.S. Agricultural Research Service
PDrugs
PVaccines
Cytomegalovirus
PBackground
Chorioretinitis
Gastrointestinal
Central Nervous System Disease
PDiagnostic Tests
PVaccines and Drugs
Ebola Virus
PBackground
Epidemiology
Clinical Syndromes
PDiagnostic Tests
PVaccines and Drugs
EchoVirus
PBackground
Acute Aseptic Meningitisis
Encephalitis
Exanthems
Respiratory Disease
Myopericarditis
Neonatal Infections
PDiagnostic Tests
PVaccines and Drugs
Encephalitis
PBackground
PDiagnostic Tests
PVaccines and Drugs
Enteroviruses
PBackground
PDiagnostic Tests
Viral Isolation and Identification
Antibody Tests
PVaccines and Drugs
Epstein-Barr Virus
PBackground
PDiagnostic Tests
PVaccines and Drugs
Gonorrhea
PBackground
PDiagnostic Tests
PVaccines and Drugs
Hepatitis
PHepatitis A
PHepatitis B
Structure and Composition
Replication
PHepatitis C
PHepatitis D (Delta)
PHepatitis E
PHepatitis G
PHepatitis Infections Pathology
PClinical Findings
PLaboratory Tests
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
PVirus-Host Immune Reactions
PEpidemiology
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D (Delta)
PVaccines and Drugs
Herpes Simplex Virus
PBackground
PDiagnostic Tests
PVaccines and Drugs
Legionella
PBackground
PDiagnostic Tests
PVaccines and Drugs
Lyme Disease
PBackground
Clinical Description
Clinical Case Definition
Laboratory Criteria for Diagnosis
Case Classification
PDiagnostic Tests
PVaccines and Drugs
Malaria
Mycoplasma
PBackground
Ureaplasma Urealyticum & Mycoplasma Hominis
PDiagnostic Tests
PVaccines and Drugs
Papillomaviruses/HPV
PBackground
HPV in Cancer
Cervical Neoplasm
PDiagnostic Tests
PVaccines and Drugs
Prevention
Parvovirus B19
PBackground
Microbiology
Epidemiology
Clinical Syndromes
Erythema Infectiosum (Slapped Cheek)
Adult Polyarthropathy
Transient Aplastic Crisis
Transient Pancytopenia
Red Cell Aplasia in Immunocompromised
Perinatal Infections
PDiagnostic Test
PVaccines and Drugs
Pneumonia
PBackground
PDiagnostic Tests
PVaccines and Drugs
Polyomaviruses
PBackground
PDiagnostic Tests
PVaccines and Drugs
Salmonellosis
PBackground
PDiagnostic Tests
PVaccines and Drugs
Shigellosis
PBackground
PDiagnostic Tests
PVaccines and Drugs
Streptococci
PBackground
PDiagnostic Tests
PVaccines and Drugs
Group A Streptococci
Group B Streptococci
Toxoplasmosis
PBackground
PDiagnostic Tests
PVaccines and Drugs
Tuberculosis
PBackground
PDiagnostic Tests
Microscopic Characteristics
Cultural Characteristics
Skin Tests
MDRTB
PVaccines and Drugs
West Nile Virus
PBackground
Clinical Syndromes
PDiagnostic Tests
PVaccines and Drugs
Yersinia
PBackground
PDiagnostic Tests
PVaccines and Drugs
c. Antibiotic Susceptibility
2. Cancer Testing
a. Overview
b. Major Cancer Types
Prostate
Lung
Colon and Rectum
Breast
Skin
Uterine
Leukemia
Oral
c. Oncogenes
Abl/abl-bcr
AIB1
BCL-2
BRCA1
CD44
C-fos
C-myb
C-myc
CYP17
Erb-B
HPC1
N-myc
P40
P51
P53
PIK3CA
PTI-1
Ras
Reg
Sis
Src
3. Genetic Diseases
a. Overview
b. Nucleic Acid Amplification
c. Chromosome Imaging
d. Genomics Technologies
e. Proteomics Technologies
f. Current Pharmacogenomic Tests
g. Future Pharmacogenomic Testing
h. Major Diseases
Achondroplasia
Autosomal Dominant Polycystic Kidney Disease
Cancer
Cosmetogenomics
Cystic Fibrosis
Down's Syndrome
Duchenne and Becker Muscular Dystrophy
Factor V (Leiden)
Factor IX Deficiency
Fragile X Syndrome
Heart Disease
Hemochomatosis
Hemophilia
Huntington's Disease
Maternal-Fetal Incompatibility
Multiple Endocrine Neoplasia
Phenylketonuria (PKU)
Polycystic Kidney Disease (PKD)
Prenatal Screening
Retinitis Pigmentosa
Retinoblastoma
Sickle Cell Anemia
Spinal Muscular Atrophy
Vitamin B12 Metabolism
i. Social Issues and Concerns
4. Forensic Testing
a. Overview
b. Multilocus and Single Locus Probes
Multilocus Probes
Single Locus Probes
PCR and RFLP
c. The FBI
d. DNA Profile Data Banks
U.S.A.
U.K.
e. Judicial Implementation
f. Major Crime Categories
g. Factors Contributing to the DNA Probe Market Expansion
Technology Availability
Use of Hair as Evidence
h. Wildlife Forensics
5. Paternity Testing/HLA Typing
6. Other Applications
a. Disease Susceptibility Testing
b. Cardiovascular Diseases
c. Diabetes
d. Alzheimer's Disease
e. Periodontal Disease
f. Plasma Purification
g. Organ Transplantation
h. Water Contamination
i. Other
H. Competing/complementing Technologies
1. Monoclonal Antibodies/Immunoassays
2. RNA Probes
3. Two-Dimensional Electrophoresis
4. Flow Cytometry
Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers' Sales And Market Shares
Major Product Development Opportunities
A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products
Design Criteria For Decentralized Testing Products
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types Of Distributors
7. Market Segmentation
Potential Market Entry Barriers And Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
Competitive Profiles
Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group
Appendixes
Appendix I: Major Universities and Research Centers Developing Molecular
Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates
List of Tables
Major Companies Developing or Marketing AIDS Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other
Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other
Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular
Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And
Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic
And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic
And Other Direct Identification Tests
Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For
Genetic Diseases
Summary Table Germany, Molecular Diagnostics Test Volume And Sales
Forecast by Major Application
Germany, Laboratories Performing DNA Sequencing by Market Segment
Germany, Molecular Diagnostics Market Potential Laboratory Universe by
Market Segment
Germany, Molecular Diagnostics Test Volume Forecast By Major Application
Germany, Major Infectious Disease Molecular Diagnostics Test Volume
Forecast
