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PUBLISHER: AVICENNE | PRODUCT CODE: 1279924

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PUBLISHER: AVICENNE | PRODUCT CODE: 1279924

The Worldwide Orthopedic & Spine Contract Manufacturing Market Report 2022-2027 and Top 100 Supplier Profiles, 12th Edition

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PAGES: 400+ Pages, 1000+ Exhibits, 100+ Company Profiles
DELIVERY TIME: 1-2 business days
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New updates:

  • Complete overview of the orthopedic end-user market: markets, prices, players, strategic trends & moves
  • Spine, Trauma, extremities and shoulder contract manufacturing, detailed and separate analyses
  • Inflation: Impact on the contract manufacturing business and the orthopedic end-user market
  • 3D printing for orthopedics: Contract manufacturing & in-house market sizes and forecasts
  • MDR: Decreased competitiveness of the European orthopedic industry, scenarios of short and long terms impact on the players
  • Robotics for orthopedics: Penetration of robotics for players like Stryker, Zimmer-Biomet, Depuy-Synthes, Think Surgical, etc.
  • Chrome Cobalt: What are the alternatives and when will they be available?
  • A plethora of strategic information on the Top 100 contract manufacturers, with 125 profiles - included those of acquired companies

Overview:

This report contains 400+ pages and 1 000+ exhibits and 100+ company profiles. It detailed the worldwide orthopedic Contract Manufacturing market and analysis for the following segments:

  • Forging: Hip stem, hip cup, femoral knee, tibial knee, shoulder stem, shoulder glenoïd, LF plates, LC plates
  • Casting: Femoral knee, tibial knee, hip cup, hip stem
  • Hip machining and finishing: Stem, cup, head, liner
  • Knee machining and finishing: Insert, tibial, femoral components
  • Shoulder machining and finishing: Stem, glenoïd, other parts
  • Spine machining and finishing: Lumbar Universal Systems, spine plates, spine screws and cages
  • Trauma machining and finishing: Plates, screws, nails, intramedullary hip screws, compression hip screws.....
  • Extremities machining and finishing: Foot plates, foot screws, hand, wrist & elbow plates, hand, wrist & elbow screws.....
  • Instrument machining and finishing: Hip, knee, spine, trauma, shoulder, extremities
  • Cases and trays: Hip, knee, spine, trauma
  • Coating: Stem, cup, femoral, tibial components
  • Ceramics: Femoral heads, cup liners
  • Marking, packaging and sterilization: Hip, knee, spine, trauma.

This report provides also details and analysis for the following segments:

  • By OEM orders
  • By services & products offered for all segments & sub-segments (volume, value)
  • By Contract Manufacturing market share & player details:
  • Implants: Tecomet, Orchid, Viant, Lisi, Avalign, Marle, Norman Noble, PCC, Paragon, Mediliant Group, etc. (70+ companies mentioned)
  • Instruments: Tecomet, Viant, Intech, Avalign, Autocam Medical, Norwood, Orchid, Lisi, Tegra, etc. (45+)
  • Cases & trays: Tecomet, Paragon, Viant, Avalign, Medin, Intech, RMS, Inomed, etc. (20+)
  • Coating: Orchid, Lincotek, Viant, DOT, APS Materials, Terolab, Medical, Medicoat, etc.
  • Ceramics: Ceramtec, Coorstek, Kyocera, Metoxit, etc.
  • 3D Printing: Stryker, Zimmer Biomet, Lima, Adler, Lincotek, Cretex, Avalign as well as Arcam, EOS, Concept Laser, SLM, 3D Systems, Renishaw, etc.
  • Packaging: Amcor, Oliver, Millstone, Nelipack, etc.
  • Sterilization: Steris, Sterigenics, Ionisos, etc.
  • Orthobiologics: Heraeus, RTI surgical, Biocomposites, Tecres, Bonesupport, Teknimed Subiton, etc.
  • Raw materials, Peek, Polyethylene UHMW: Invibio, Solvay, Evonik, PPD Meditech, etc.
    • Top 100 players with market share in each segment
    • Orthopedics Additive Manufacturing market analysis: users, suppliers, products focused on & forecasts
Product Code: CM 12-2023

Table of Contents

Purpose of the Survey and Methodology

Synopsis & Executive summary

  • Segmentation
  • Worldwide Orthopedic market in 2022: by product & by player
  • Worldwide Orthopedic market in 2022: Majors Vs challengers
  • Worldwide Orthopedic market in 2022: life cycle of orthopedic products and forecasts for 2027
  • Orthopedic Contract Manufacturing value chain
  • Contract Manufacturing market & trends: Forging
  • Contract Manufacturing market & trends: Casting
  • Contract Manufacturing market & trends: Instrument machining
  • Contract Manufacturing market & trends: Instruments is a highly fragmented market
  • Contract Manufacturing market & trends: Coating
  • Contract Manufacturing market & trends: Cases & trays
  • Contract Manufacturing market & trends: Ranking of top players
  • Orthopedic Contract Manufacturing market & trends: Top20, Top 21-100 and top 101 -1 000 distribution of revenues
  • Orthopedic Contract Manufacturing market & trends: consolidation by acquisition - Forecasts by service for 2027
  • The Orthopedics Contract Manufacturing market is growing faster than In-house manufacturing
  • Orthopedic Contract Manufacturing market & trends: Additive Manufacturing for hip, knee, knee, shoulder& trauma
  • Orthopedic Contract Manufacturing market & trends: Additive Manufacturing for spine & Additive Manufacturing machines in 2022 and usage forecasts

I - Orthopedic environment

  • Contract Manufacturing market value chain
  • Orthopedics Macro environment: Political, Economical, social/culture, technological, environment, legal & regulatory
  • Market Drivers
  • Global population growth 1950-2050 and people over 65
  • The market drivers
    • Demographic & Economic
    • Orthopedics is generally risk-averse with few disruptive innovations, many small incremental innovations
    • Innovation and new products pull the market
    • Innovative surgeons are looking for new products, % of the surgeons by category in each type of country
    • Product Mix pulls the market up
  • The market limiters
    • Regulatory & Certification
    • Reimbursement and pricing regulation
    • MDR (Medical Device Regulation): Impact in Europe
    • A product's CE marked under MDD will remain valid for about 5 years, which will necessitate a mandatory request for validation under MDR, backed clinical studies, before the MDD expiry date: details
    • Hip Price trends in Europe show regular decrease
    • Knee Price trends in Europe show regular decrease
    • Reimbursement price decreases are not frequent, hence they have been manageable over the long term
    • Hip ASP erosion in developed countries
    • Hip average price trend in Europe 2003-2022: France, Germany, UK, Italy, Average Europe
    • Reimbursement HIP average price* trend in Europe (€), including country disparities
    • Group purchasing in Germany, France and Italy
    • The orthopedic sales channels

II - Worldwide orthopedic & spine market; players, drivers & limiters and forecasts 2022 - 2027

  • Orthopedics Ecosystem
  • Worldwide orthopedic markets in 2022 by product
  • The Worldwide orthopedics market: Growth 2000 - 2010 CAGR, 2010 - 2015 CAGR, 2015 - 2019 CAGR & 2015 - 2022 CAGR
  • Worldwide implants market in 2022 by value (B$): Knee, hip, spine and by area, USA, Europe, Row
  • Worldwide implants market knee, hip & spine in 2022 by value (BUS$)
  • Worldwide implants market Trauma, shoulder & Extremities in 2022 by value (BUS$)
  • Hip & Knee sales per area: USA, Europe, Japan, Australia, Korea & Row
  • Ratio for 10,000 inhabitants & growth by area (2022)
  • Worldwide orthopedic market in 2022: competition
  • Worldwide competition by product in 2022: Market share
  • Three types of Challengers competing with the Majors
  • The challengers gained market share continuously: 2016-2017-2018-2019-2020-2021-2022 and hip, knee, spine & trauma
  • Challengers have continuously gained market share (2013-2022) except in 2020 due to Covid impact
  • Top 4 vs. Challengers for hip & knee worldwide markets: Majors have no growth while challengers are growing fast
  • Hip, knee & shoulder challengers are growing faster than the market average
  • Spine challengers are grabbing market share from the Majors and emerging as top players with revenues ranging from US$0.5B - US$1B
  • Spine: Worldwide market shares 2012-2022: Majors limit market share losses by buying rivals
  • Trauma: Worldwide player market shares, 2016-2022
  • Hip Europe market share 2012-2022: Depuy Synthes, Zimmer Biomet, Stryker, Smith & Nephew & other
  • Knee Europe market share 2012-2022: Depuy Synthes, Zimmer Biomet, Stryker, Smith & Nephew & other
  • Majors Vs Challengers : Revenues CAGR, market share
  • Majors Vs Challengers: 2022 picture
  • Challengers growing Vs majors
  • Reasons why Challengers are growing faster than Majors (except during Covid crisis)
  • Orthopedic is generally risk-averse with few disruptive innovations, many small incremental innovations, almost all of them coming from small players.
  • Product Mix pulls the market: Total hip trends 2006-2026 (by volume) / Cemented, Cementless & Hybrid
  • The revision driver: more and more people have more than one implant during their lifetime / Hip implant trends 2006-2026 (by volume)
  • Bearing trends in Total hip market Europe example
  • Dual mobility cups: Europe 2022 (by volume)
  • Total knee market in 2022 (in volume): From fixed to mobile bearing and back to fixed, the pathways of innovation
  • Knee: Europe implant market in 2022 (by value): Total Vs. Partial Vs. Revision
  • Shoulder implant market: Europe 2022 (by volume): Standard Vs. Reversed
  • Hip ASP erosion in developed countries 2012-2022
  • Knee ASP erosion in developed countries 2012-2022
  • Forecast Price erosion 2022-2027: USA, Australia, Japan, Europe
  • Hip Europe market share 2012-2022
  • Knee Europe market share 2012-2022
  • The life cycle of orthopedic products: Growth forecasts by 2027 for hip, knee, spine, extremities
  • Worldwide orthopedic market forecasts 2000-2027 for hip, knee, extremities, shoulder, trauma, spine, orthobiologics & Others
  • Summary: Orthopedic market

III - Worldwide orthopedic & spine Contract Manufacturing market, OEM strategies, Contract Manufacturers position, market share and forecasts to 2027

  • Contract Manufacturing market value chain: Major OEMs have a different outsourcing strategy Vs Challengers. Challengers outsource almost all their products.
  • Zimmer Biomet: main facilities details
  • OEM contract manufacturing strategy: Zimmer Biomet
  • OEM contract manufacturing strategy: Stryker
  • OEM contract manufacturing strategy: Depuy Synthes
  • OEM contract manufacturing strategy: Smith & Nephew
  • OEM contract manufacturing needs: Medtronic
  • OEM contract manufacturing needs: Challengers
  • Contract Manufacturing process segmentation & raw materials: 14 segments & 70 sub-segments
  • Forging Contract Manufacturing market 2022
  • Forging Contract Manufacturing market 2012-2027 by product
  • Forging Contract Manufacturing market share in 2022: Tecomet, Marle, Orchid, Lisi, PMP, etc.
  • Forging Contract Manufacturing market: OEMs relationships with their suppliers
  • Casting Contract Manufacturing market 2022
  • Casting Contract Manufacturing market 2012-2027 by product
  • Casting Contract Manufacturing market share in 2022: Orchid, PCC, Marle, Lincotek, Tecomet, etc.
  • Casting Contract Manufacturing market: OEMs relationships with their suppliers
  • Hip machining & finishing Contract Manufacturing market 2022
  • Hip machining & finishing Contract Manufacturing market 2012-2027 by product
  • Knee machining & finishing Contract Manufacturing market 2022
  • Knee machining & finishing Contract Manufacturing market 2012-2027 by product
  • Shoulder machining & finishing Contract Manufacturing market 2022
  • Shoulder machining & finishing Contract Manufacturing market 2012-2027 by product
  • Spine implants machining & finishing Contract Manufacturing market 2022
  • Spine implants machining & finishing Contract Manufacturing market 2012-2027
  • Trauma implants machining & finishing Contract Manufacturing market 2022
  • Trauma implants machining & finishing Contract Manufacturing market 2012-2027
  • Extremities implants machining & finishing Contract Manufacturing market 2022
  • Extremities implants machining & finishing Contract Manufacturing market 2012-2027
  • Spine, Trauma, Extremities & Shoulder Contract Manufacturing market 2022-2027
  • Player market shares: Spine, Trauma, Extremities & Shoulder contract manufacturing in 2022
  • What are orthopedic instruments for knee, hip, spine, trauma, shoulder & extremities?
  • Knee orthopedic instruments: functional segmentation
  • Knee orthopedic instrument segmentation: 150 to 200 pieces
  • Hip orthopedic instrument segmentation: 80 to 150 pieces
  • Spine instruments: 30 to 50 pieces
  • Spine orthopedic instruments - product segmentation
  • Trauma instruments segmentation: 10 to 20 pieces
  • The Major OEMs have a different outsourcing strategy Vs the challengers. The challengers outsource almost all their instruments
  • Instruments life cycle: New OEM projects lead to instruments set manufacturing. When an OEM postpones the launch of its new projects (for example during the 2008 & 2011 crisis & during Covid 19), it also drastically reduces its instruments manufacturing
  • Cutting tools: Single-use trend: Single-use is a pressing demand from surgeons
  • Cutting tools: Single-use trend: Single-use is growing rapidly in the US and Europe
  • Instruments Contract Manufacturing market 2022
  • Instruments Contract Manufacturing market 2012-2027 by product
  • Instruments Contract Manufacturing market share in 2022: Tecomet, Intech, Jabil, Paragon, etc.
  • Orthopedic robotic market in 2022: MAKO from Stryker, ROSA from Zimmer Biomet, OMNIlife science-Corin, TANVI, Navio of Smith, Mazor from Medtronic and Velys from Depuy Synthes
  • Mako's acquisition by Stryker boosted the orthopedic robotic market and have a huge impact on instruments market
  • Orthopedic robotics surgeries: Stryker open the mass market, Smith & Nephew, Zimmer Biomet, Depuy and many others have followed
  • Robotic assisted surgeries: USA is by far the leading country for Robotics usage. 2014-2025 procedures by robotic systems
  • What are orthopedic cases & trays?
  • Cases & trays Contract Manufacturing market 2022
  • Cases & trays Contract Manufacturing market 2012-2027 by product
  • Cases & trays Contract Manufacturing top 15 market share in 2022: Tecomet, VIANT, Paragon, Avalign, etc.
  • Ceramics Contract Manufacturing market 2022
  • Ceramics Contract Manufacturing market 2012-2027 by product
  • Ceramics Contract Manufacturing market share in 2022: Ceramtec, Coorstek, Kyocera, etc.
  • Coating Contract Manufacturing
  • Coating Contract Manufacturing market 2022
  • Coating Contract Manufacturing market 2012-2027 by product
  • Coating Contract Manufacturing market share in 2022: Orchid, Lincotek, DOT, Viant, APS Materials, etc.
  • MPS Contract Manufacturing market 2022
  • Marking Packaging & Sterilization -MPS - Contract Manufacturing market 2012-2026 by product
  • Contract Manufacturing market value chain
  • Contract Manufacturers worldwide orthopedics revenues in 2022 (in MUS$)
  • CMO top players: 2017-2022 main M&A activity
  • Contract Manufacturing competitor ranking & dispersion
  • Orthopedic Contract Manufacturing concentration by acquisition
  • Contract Manufacturing industry needs more concentration
  • More outsourcing is a heavy trend for all the orthopedic companies: Outsourcing rate
  • Continuous trend: OEM facility disinvestments occur when there are opportunities to sell to a large and reliable player, who can guarantee supply security
  • Depuy Synthes - Jabil: strategic deal to disinvest 14 facilities: initial road map
  • JABIL Healthcare profile
  • OEM facility disinvestments: huge impact of Depuy Synthes - Jabil deal for 2019-2020
  • More outsourcing is a heavy trend for all the orthopedic companies
  • The risk of moving to LLC by 2026
  • Contract Manufacturing price range dashboard
  • Orthopedics Contract Manufacturing market is growing faster than In-house manufacturing
  • Contract Manufacturing market is growing at a higher rate than the orthopedic market
  • Contract Manufacturing market historical revenues & forecasts (MUS$): 2012-2027

IV - 3D Printing in Orthopedics / Orthobiologics / Cobalt Chrome...

  • 3D Printing & Trabecular in Orthopedics
  • 3D Printing history in Orthopedics
  • Story of Zimmer and Trabecular Tantalum
  • Zimmer, Trabecular Metal related implants
  • 3D Printing Manufacturing: Technologies and major competitors, EOS, SLM Solutions, Concept Laser (GE), Arcam (GE), Others
  • Arcam EBM installed base for orthopedic industry: Lima
  • Beijing AK MEDICAL EBM Installed base
  • Illustrative build-up speed and resolution of selected Metal 3D Printing systems: EBM Vs Selective Laser Melting
  • Smith & Nephew usage of 3D Printing for customized cutting blocks
  • Stryker's History of 3D Printing: STRYKER, to build a 3D printing manufacturing facility for more than $400 million
  • Stryker's current products made by 3D printing: Knee, cages, other
  • Depuy Spine usage of 3D Printing for prototyping of complex surgical tools
  • Depuy Synthes has acquired 3D Printing technology from Tissue Regeneration Systems Inc.
  • XILLOC invested usage for Cranio-Maxillofacial applications
  • Equipment suppliers for Orthopedics, Installed base per customer and per supplier: EOS, ARCAM (GE), CONCEPT LASER (GE), SLM Solutions, 3D Systems, Trumpf and their customers
  • Addressable market should increase with lower 3D Printing cost: cost and complexity curve linked with addressable market
  • Additive Manufacturing is attractive for reconstructive implants
  • Number of implants produced using 3D Printing: Zimmer Biomet, Lima, Exactech, Adler Ortho
  • FDA clearance for medical devices using 3D Printing in USA
  • 3D Printing in 2022
  • 3D Printing impact on forging, casting & machining of implants
  • Cages Raw Materials in the five main European countries: Peek, Titanium Vs 3D Printing
  • Is 3D Printing the right option for the implant Contract Manufacturing business? Analysis for implants, standard cages, special cages and customized implants
  • Is Additive Manufacturing the right option for the instruments Contract Manufacturing business? Analysis of customized cutting guides and complex instruments
  • Analysis of one of the most advanced Contract Manufacturers in 3D Printing
  • Lincotek 3D Printing activity details
  • Major Contract Manufacturers: 3D Printing investments and strategies; Tecomet, Orchid, Lincotek, Marle, and many others
  • 3D Printing for orthopedics: Executive summary
  • Use of antibiotics for orthopedic cements: Need for cements with new antibiotics
  • Synthetic or natural bone substitutes, allografts, must satisfy many needs: injectable substitutes or more abundant allografts
  • Top bone grafts on the market: injectables and antibiotics are the main drivers
  • Cobalt Chrome is today used in many orthopedic products: femoral part of the knee, the cup in dual mobility and some hip heads, etc.. In 2017, the European Union recommends the classification of Cobalt as Carcinogenic, Mutagenic and Reprotoxic (CMR). In May 2025, a new decision will be taken on the classification of Cobalt. Substitutes exist today and other projects are underway to develop alternative materials to Cobalt Chrome.

V - Impact of Covid-19 & Inflation

  • COVID-19: timeline of a Pandemic
  • The impact of Covid-19 on the Orthopedics Market
  • Bearing in mind that during the 2008 financial crisis, growth in orthopedics was merely slowed down implants and contract manufacturers largely held their ground
  • The world economy will experience the worst recession with the Great Lockdown (2020) since the Great Depression (1930s) but the recovery was fortunately very quick.
  • Growth projections: the COVID-19 health crisis will have a severe impact on economic activity in 2020
  • Latest World Economic Outlook: the COVID-19 pandemic will severely impact growth across all regions - Update July 2021
  • During the 2008 financial crisis, growth in orthopedics was merely slowed down implants and contract manufacturers largely held their ground
  • What is the forecast for 2020 for the world economy and the orthopedic industry? Even the International Monetary Fund has said that forecasts have become very dicey and a grey area
  • The world economy will experience the worst recession since the Great Depression (1930s)
  • Growth projections: the COVID-19 health crisis will have a severe impact on economic activity in 2020
  • Latest World Economic Outlook: the COVID-19 pandemic will severely impact growth across all regions
  • The "Covid-19 effect": orthopedic sales decline, Zimmer Biomet: Q1 2020 net sales decreased in %
  • The "Covid-19 effect": orthopedic sales decline, DEPUY SYNTHES Q1 2020 sales decrease: trauma is less impacted
  • The "Covid-19 effect": orthopedic sales decline, Medtronic Q4 (January-March) sales decrease mainly in USA
  • The "Covid-19 effect": orthopedic sales decline, STRYKER Q1 2020 April sales decreased in %
  • The "Covid-19 effect": orthopedic sales decline, Smith & Nephew Q1 2020 sales decreased in %
  • Forecasts of the main players, % of loose of their 2020 revenues from orthopedics due to the impact of Covid-19
  • Orthopedic activity in China recovered in April, while European and US activity collapsed.
  • According to the forecasts of the main players, they will lose a small part of their 2020 revenues from orthopedics due to the impact of Covid-19: details
  • The "Covid-19 effect": orthopedic companies sales decline in 2020
  • The "Covid-19 effect": country impact for 2020 - USA & Europe
  • Covid-19 impact on Orthopedic players
  • The "Covid-19 effect" on the Contract manufacturing market in 2020
  • Covid-19 impact on US Orthopedic players
  • The Majors, which accounted for 65% of the market in 2020, have not all recovered the 2019 level by the first half of 2021. We believe that by the end of 2021, the Majors will not reach the 2019 level and the two years of lost growth.
  • A part of the challengers (> $100M in revenue) have returned to double-digit growth, others continue to suffer
  • Worldwide orthopedic market forecasts 2000-2026
  • Contribution to year-on year CPI (Consumer Price Index) inflation in the G7 countries
  • Impact of inflation on the end-user market and on contract manufacturing (1/2)
  • Impact of inflation on the end-user market and on contract manufacturing (2/2)
  • FX rate variation from January 2018 to September 2022: The Euro has devalued by almost 20% Vs the US Dollar!
  • Impact of exchange rate fluctuations on the major orthopedic companies: the Majors are impacted in terms of their revenues in Europe! Production will tend to relocate within Europe or to ROW
  • Impact of exchange rate fluctuations on orthopedic contract manufacturers: Majors contract manufacturers are negatively impacted on their share of sales in Europe
  • The Orthopedics Contract Manufacturing market is growing faster than In-house manufacturing 2000-2027
  • The Orthopedics Contract Manufacturing market is growing faster than In-house manufacturing 2012-2022

VI - Contract manufacturing competitor ranking, Top 100 profiles and SWOT analysis of the leaders

Example of profiles:

Appendices

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