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Market Research Report

Cell-based Assays: Technologies and Global Markets

Published by BCC Research Product code 196807
Published Content info 242 Pages
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Cell-based Assays: Technologies and Global Markets
Published: November 6, 2018 Content info: 242 Pages
Description

Report Highlights:

The global market for cell-based assays should grow from $20.1 billion in 2018 to $32.7 billion by 2023 at a compound annual growth rate (CAGR) of 10.2% from 2018 through 2023.

The global market for drug discovery for validating drug targets/lead profiling assays should grow from $14.4 billion in 2018 to $23.6 billion by 2023 at a CAGR of 10.4% from 2018 through 2023.

The global market for basic research for understanding cell signaling and function should grow from $2.0 billion in 2018 to $3.5 billion by 2023 at a CAGR of 12.1% from 2018 through 2023.

Report Scope:

This report is an update of an earlier report of the same title. It reviews global markets and new developments for cell-based assays and forecasts trends for the use of these assays for drug discovery, safety and toxicology through 2023. The report includes details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market. Statistical information on the prevalence of types of cancers worldwide is also included.

The report also details current issues and trends affecting the industry, as well as costs and factors that have an impact on demand. It covers products in development, new technologies, trends, and alliances and mergers. The report offers market data by segment and region and discusses market trends with respect to drivers, restraints and opportunities.

Report Includes:

  • 23 data tables and 48 additional tables
  • Detailed overview of the global market for cell-based assays within the industry
  • Analyses of global market trends with data from 2017, estimates for 2018, and projections of compound annual growth rates (CAGRs) through 2023
  • Details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market
  • Regional dynamics of cell-based assays covering North America, Europe and other emerging economies
  • Examination of the cell-based assays available and currently being used, new developments, spending trends, and revenue prospects for cell-based assays in the pharmaceutical industry
  • Discussion of current issues and trends affecting the industry, as well as costs and factors that have an impact on demand
  • Coverage of major issues involved in the research and development (R&D) of more effective cell-based approaches for drug discovery
  • Company profiles of major players in the industry including Beckman Coulter, DiscoverX, PerkinElmer, Life Technologies and Promega Corp.
Table of Contents
Product Code: BIO080D

Table of Contents

Chapter 1: Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Scope of the Report
  • Intended Audience
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • BCC Custom Research
  • Related BCC Research Reports

Chapter 2: Summary and Highlights

Chapter 3: Overview

  • Introduction
  • Drug Discovery
  • High-content Screening
  • Data Analysis
  • Overview: Cell-based Assay
  • Tools for Drug Discovery
    • High-content Screening
    • Cell-based Screening
    • Proliferation Assays
    • Proof of Concept for Cell-based Assays
    • Cell-based Assays and Technology Trends
  • Advancements in Cell-based Assays
    • Novel Cell-based Assay Using Organoids, Scaffolds/Hydrogels and Organs-on-a-Chip
    • Spheroids for Drug Development
    • Label-free Cell-based Assay Technology Using Biolayer Interferometry
    • Lineage Sequencing for Mutational Analysis and Cancer-based Studies
    • Evaluation of Hantavirus Replication Using In-cell Western Assay
    • Quantitative Cell-based Assay Using a High-content Analysis Platform
    • High-throughput Single-cell Transcriptome Sequencing
    • Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy
    • G Protein-coupled Receptors
    • Luciferase-based High-throughput Screening Assay
    • Functionally Relevant Morphological Profiling for Mesenchymal Stromal Cells

Chapter 4: Assays for Drug Discovery

  • Cell-based Approaches for ADME/Tox Screening
    • Market Opportunities
    • ADME and Toxicity Screening
    • Multiplexed Cell-based Assays
    • High-throughput Imaging-based Platform for Cell-based Assays
    • Cell Assays in Today's Drug Discovery Process
    • Label-free Cellular Assays: The Relevant Future of Drug Discovery
  • Conclusion

Chapter 5: Cell-based Assays: Current Technologies

  • Factors in Cell-based Assay Development
  • Reporter Gene Technology
  • Cell-based Assays for Studying Protein-Protein Interactions
  • Cell-based Protein-fragment Complementation Assays
  • Measuring Calcium Signaling
  • Cell-based Label-free Approaches
  • Automation and Miniaturization
  • Cell Patterning
  • Cell-based Assays and Physiological Relevance
  • Cell-based Assays and Multiplexing
    • Developing Reporter Assays
    • Reporter Assays and Multiplexing
  • Ultrahigh-throughput Screening
  • Development of the PathHunter Assay
  • High-content Screening Technology
    • Imaging Cells for Cell-based Assays
    • Microscopic Visualization of Cells
    • Quantum Dots
    • Label-free Imaging
  • Investigational New Studies in Drug Development
    • Role of ADME in Drug Design
  • Prodrug Strategies
  • Molecular Modeling
  • Summary
    • Limitations of Cell-based Assays in the Risk Assessment Process
    • Bottlenecks in Cell-based Screening
    • Methods to Improve Throughput in Cell-based Assays
  • New Technologies
    • DataChip
    • BIND Technology
    • Miniaturization of Biological Assays
    • Microfluidic Cell Culture Systems for Drug Research
  • Conclusion

Chapter 6: Commercialization of Cell-based Assays

  • Role of Cell-based Assays
    • Drug Discovery and Cell-based Assays
    • Opportunities for Market Adoption
    • Measuring Cell Proliferation
    • Companies Offering Cell Proliferation Assays
    • Move Toward Therapies with Stem and Immune Cells
    • Cell-based Screening Assays
    • Orphan Receptors
  • Summary

Chapter 7: Global Cell-based Assay and Instrumentation Market

  • Current Market Overview
  • Cell-based Assays
  • Cell-based Assay Market
    • Market Dynamics
    • Market Drivers
    • Cell-based Assays for Preclinical Development
  • Cell Biology Reagents
  • High-throughput Screening
    • Advantages of HTS Assays
    • Major Drivers
  • Drug Discovery Technology Market
  • Market for Life Sciences Tools and Reagents
  • Cell Culture Market
    • Cell Culture Reagent Market
  • Global Market for Cell Culture Reagents
    • Three-dimensional Cell Culture Market
  • Cell-based Assay Market Growth
    • Market Demand
  • Cell-based Assays: Basic Research
  • Market for Cellular Assays in Basic Research
    • Cell Proliferation Fluorescence Assay
    • In Vitro Toxicity Testing
    • In Vitro Skin Irritation Testing
  • ADME and Toxicology Market
    • In Vitro Predictive Toxicology
  • Cell-based Assays for Drug Discovery
  • ADME Toxicology Testing Market
    • DiscoverX
    • ADME Tools and Technologies
    • ADME Studies for FDA Submissions
    • Market Players
    • New Developments
    • In Vitro Inflammation Models
    • Multiplex Assays for GPCR Signaling
  • Types of Cell-based Assays
    • HCS Market Drivers
    • High-Content Screening Kits
  • High-Content Screening Instrumentation Market
    • Flow Cytometers
  • Label-free Detection Market
  • Microplate Instrumentation and Supplies
  • Challenges of Cell-based Assays
  • Future of Cell-based Assays
  • Cell-based Assays for Research Purposes
    • G Protein-Coupled Receptors
  • GPCRs: A Potent Class of Drug Targets
    • GPCR Drugs
    • Developments
  • Cell-based Assays: Screening Ion Channels
  • Label-free Detection
  • Companies
    • Thermo Fisher
    • CellSensor
    • LanthaScreen
    • Molecular Devices
  • Conclusion

Chapter 8: Global Markets

  • Global Market Overview
  • Global Market for Cell-based Assays
    • Cell-based Assays in Leading Emerging Markets
  • Summary
  • North American Market
    • U.S. Market
  • European Market
  • Drug Discovery in Emerging Economies
    • Drug Discovery in India and China
  • Advances in Cell-based Assays
    • Contract Research Organizations and Cell-based Assays
    • Outlook

Chapter 9: Company Profiles

  • ACEA BIOSCIENCES
  • BD BIOSCIENCES
  • BECKMAN COULTER
  • CELLULAR DYNAMICS INTERNATIONAL
  • CALIPER LIFE SCIENCES
  • CELSIS IN VITRO TECHNOLOGIES (CELSIS IVT)
  • CISBIO BIOASSAYS
  • DISCOVERX CORP.
  • EMD MILLIPORE
  • ENZO LIFE SCIENCES
  • ENDONOVO THERAPEUTICS
  • EVOTEC AG
  • GE HEALTHCARE
  • HEMOGENIX
  • LIFE TECHNOLOGIES
  • LONZA
  • MOLECULAR DEVICES (DANAHER)
  • ONCOLMMUNIN
  • ORIGENE TECHNOLOGIES
  • PERKINELMER
  • PROMEGA CORP.
  • ROCHE GROUP
  • STEMCELLS INC.
  • THERMO FISHER SCIENTIFIC
  • TTP LABTECH
  • VIVO BIOSCIENCES
  • VITRO BIOPHARMA

Chapter 10: Legal Aspects of Cell-based Assays

  • Intellectual Property Landscape for Cell-based Assays
    • Recent News, Alliances and Mergers
    • Summary and Outlook

Chapter 11: Appendix: Bibliography

List of Tables

  • Summary Table: Global Market for Cell-based Assays, by Segment, Through 2023
    • Table 1: Estimated U.S. Medical and Health Research Expenditures and Percentage of Total Spending at Academic and Research Institutions
    • Table 2: Uses of Cell-based Assays by Area
    • Table 3: Types of Cell-based Assays
    • Table 4: Apoptotic Markers
    • Table 5: Proof of Concept for Cell-based Assays
    • Table 6: Global Market for Cell-based Assays, Through 2023
    • Table 7: Materials and Manufacturers of Hydrogels, by Type
    • Table 8: Minimum Requirements for Organ-on-a-Chip Units, by Type
    • Table 9: HCS Instrumentation Available in the Market, by Company
    • Table 10: HCS Informatics Tools Available in the Market, by Application
    • Table 11: Selected High-throughput Instruments Available in the Market
    • Table 12: Biological Assay Systems for the Evaluation of Cytochrome P450 Enzyme Isoforms
    • Table 13: Types of Hepatocyte Assay Systems
    • Table 14: Types of ADME Assays
    • Table 15: Common Types of Toxicity Assays
    • Table 16: Traditional Methods of ADME/Tox Testing
    • Table 17: Conventional In vitro ADME/Tox Screening Methods
    • Table 18: Applications of Label-free Assays
    • Table 19: Factors for Cell-based Assay Development
    • Table 20: Approaches to Cell-based Systems for Drug Screening
    • Table 21: List of Current Confocal HCS Platforms
    • Table 22: Widefield HCS Platforms, by Type
    • Table 23: List of Studies for Filing an Investigational New Drug Application
    • Table 24: List of Studies for Clinical Filings
    • Table 25: List of Existing Cell-based Assay Technologies
    • Table 26: Biological Applications for High-Content Analysis
    • Table 27: Global Market for Cell Biology Reagents and Tools, Through 2023
    • Table 28: Global Market for High-throughput Screening, Through 2023
    • Table 29: Key Companies for High-throughput Screening Technologies
    • Table 30: Global Market for Drug Discovery Technologies, Through 2023
    • Table 31: Key Companies for Drug Discovery Technologies
    • Table 32: Global Market for Tools and Reagents Used in Life Sciences Research, Through 2023
    • Table 33: Global Market for Cell Culture, Through 2023
    • Table 34: Cell Culture Reagent Types
    • Table 35: Global Market for Cell Culture Reagents, Through 2023
    • Table 36: U.S. Market for Cell Culture, Through 2023
    • Table 37: Global Market for 3D Cell Culture, Through 2023
    • Table 38: 3D Cell Culture Technologies
    • Table 39: Key Companies in Cell-based Assays
    • Table 40: Cell-based Assay Market Segments
    • Table 41: Global Market for Cell-based Assays, Through 2023
    • Table 42: Limitations of Cell-based Assays
    • Table 43: Global Market for Cell-based Assays Used in Basic Research, Through 2023
    • Table 44: Areas Using In Vitro Toxicology Testing
    • Table 45: Global Market for 3D Cell Culture, Through 2023
    • Table 46: Global Market for Specialized Cell-based Assays Used in Drug Discovery, Through 2023
    • Table 47: In Vitro Predictive Toxicology Assays
    • Table 48: 3D Microtissue and Spheroid Models
    • Table 49: Global Market for ADME Assays, Through 2023
    • Table 50: List of Key Companies in ADME Assays
    • Table 51: Major Companies in the High-Content Screening Market
    • Table 52: Products Offered by Molecular Devices
    • Table 53: High-content Screening System Platforms
    • Table 54: Millipore Product Applications
    • Table 55: Global Market for High-Content Screening Instruments, Through 2023
    • Table 56: Key Flow Cytometry Companies
    • Table 57: Assay Methods Used to Study GPCRs
    • Table 58: GPCR Primary Screening Assays
    • Table 59: Key GPCR Targeting Drugs
    • Table 60: Key Companies with GPCR Products
    • Table 61: Omeros' GPCRs and Their Indications
    • Table 62: Thermo Fisher's Products
    • Table 63: Thermo Fisher's Cell-based Technologies
    • Table 64: Key Growth Drivers of the Cell-based Assay Market
    • Table 65: Global Market for Cell-based Assays, by Region, Through 2023
    • Table 66: North American Market for Cell-based Assays, Through 2023
    • Table 67: U.S. Market for Cell-based Assays, Through 2023
    • Table 68: European Market for Cell-based Assays, Through 2023
    • Table 69: Chinese Market for Drug Discovery Outsourcing, Through 2023
    • Table 70: Indian Market for Drug Discovery Products, Through 2023

List of Figures

  • Summary Figure: Global Market for Cell-based Assays, by Segment, 2017-2023
    • Figure 1: Projected Global Aging Population (60 Years and Above), 1990-2100
    • Figure 2: Drug Discovery Process Steps
    • Figure 3: Global Market for Cell-based Assays, 2017-2023
    • Figure 4: Process Flow for Patient-derived Organoid Cell Assay
    • Figure 5: Basic Architecture of Organ-on-a-Chip Systems
    • Figure 6: Shares of Approved Drugs with Unique GPCRs, 2017
    • Figure 7: Cell Viability and Kinase Assays Used to Measure Change in ATP Levels
    • Figure 8: Shares of Common Diseases Registered for Mesenchymal Stromal Cell-based Therapy, 2016
    • Figure 9: Global Market for Cell Biology Reagents and Tools, 2017-2023
    • Figure 10: Global Market for Drug Discovery Technologies, 2017-2023
    • Figure 11: Global Market for Tools and Reagents Used in Life Sciences Research, 2017-2023
    • Figure 12: Global Market for Cell Culture, 2017-2023
    • Figure 13: Global Market for Cell Culture Reagents, 2017-2023
    • Figure 14: U.S. Market for Cell Culture, 2017-2023
    • Figure 15: Global Market for 3D Cell Culture, 2017-2023
    • Figure 16: Global Market for Cell-based Assays, 2017-2023
    • Figure 17: Global Market for Cell-based Assays Used in Basic Research, 2017-2023
    • Figure 18: Global Market for 3D Cell Culture, 2017-2023
    • Figure 19: Global Market for Specialized Cell-based Assays Used in Drug Discovery, 2017-2023
    • Figure 20: Phase Transition Success Rates and Likelihood of Approval from Phase I for all Diseases, all Modalities, 2005-2016
    • Figure 21: Global Market for ADME Assays, 2017-2023
    • Figure 22: Global Market for High-Content Screening Instruments, 2017-2023
    • Figure 23: Global Market for Cell-based Assays, by Region, 2017-2023
    • Figure 24: North American Market for Cell-based Assays, 2017-2023
    • Figure 25: U.S. Market for Cell-based Assays, 2017-2023
    • Figure 26: European Market for Cell-based Assays, 2017-2023
    • Figure 27: Chinese Market for Drug Discovery Outsourcing, 2017-2023
    • Figure 28: Indian Market for Drug Discovery Products, 2017-2023
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