Triple Analysis: Breast Cancer, Apoptosis and Protein Kinase Inhibitors

This triple analysis focuses on cancer drug development strategies in Breast Cancer and by the two mechanism/target/effect areas of Apoptosis and Protein Kinase Inhibitors. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Part I: Breast Cancer

• 5.1. The Scope of this Report
• 6. Consider the Therapeutic Target Among Breast Cancer Drugs for the Highest Therapeutic Outcome and Return on Investment (234 Drug Targets)
• 7. Emerging New Products to Established Ones: Drug Target Strategies of Breast Cancer Drugs by their Highest Stage of Development (223 Drug Target Strategies and 470 Drugs)
• 8. Compound Strategies at Work: Competitive Benchmarking of Breast Cancer Drugs by Compound Strategy (8 Compound Strategies)
• 9. Pipeline and Portfolio Planning: Competitive Benchmarking of the Breast Cancer Drug Pipeline by Investigator (247 Investigators and 470 Drugs)
• 10. Disclaimer

• Figures: Includes 8 Figures
• Tables: Includes 309 Tables
• Total Number of Pages: 1,755

Part II: Apoptosis

• 5.1. The Scope of this Report
• 6. Consider the Therapeutic Target Among Apoptotic Drugs in Oncology for the Highest Therapeutic Outcome and Return on Investment (181 Drug Targets)
• 7. Emerging New Products to Established Ones: Drug Target Strategies of Apoptotic Drugs in Oncology by their Highest Stage of Development (157 Drug Target Strategies and 234 Drugs)
• 8. Compound Strategies at Work: Competitive Benchmarking of Apoptotic Cancer Drugs by Compound Strategy(7 Compound Strategies)
• 9. Selecting Indication for Apoptotic Drugs in Oncology (69 Cancer Indications)
• 10. Pipeline and Portfolio Planning: Competitive Benchmarking of the Apoptotic Drug Pipeline in Oncology by Investigator (158 Investigators and 234 Drugs)
• Disclaimer
• 11. Drug Index
• 12. Company Index

• Figures: Includes 7 Figures
• Tables: Includes 315 Tables
• Total Number of Pages: 1,617

Part III: Protein Kinase Inhibitors

• 5.1. The Scope of this Report
• 6. Consider the Therapeutic Target Among Protein Kinase Drugs in Oncology for the Highest Therapeutic Outcome and Return on Investment (183 Drug Targets)
• 7. Emerging New Products to Established Ones: Drug Target Strategies of Protein Kinase Drugs in Oncology by their Highest Stage of Development (278 Drug Target Strategies and 648 Drugs)
• 8. Compound Strategies at Work: Competitive Benchmarking of Protein Kinase Cancer Drugs by Compound Strategy (8 Compound Strategies)
• 9. Selecting Indication for Protein Kinase Drugs in Oncology (70 Cancer Indications)
• 10. Pipeline and Portfolio Planning: Competitive Benchmarking of the Protein Kinase Drug Pipeline in Oncology by Investigator (212 Investigators and 648 Drugs)
• 11. Disclaimer

• Figures: Includes 8 Figures
• Tables: Includes 389 Tables
• Total Number of Pages: 2,940

This Report Includes the Following Companies:

• 4SC
• A&G Pharmaceutical
• AB Science
• Abbott
• Abiogen
• Acceleron Pharma
• Access
• ACT Biotech
• Adherex
• Advanced Life Sciences
• Advanomics
• Advaxis
• Advenchen
• AEgera
• AEterna Zentaris
• Affibody
• Affimed Therapeutics
• Aida Pharmaceuticals
• Aileron Therapeutics
• Alchemia
• Alethia Biotherapeutics
• Allist Pharmaceuticals
• Allos Therapeutics
• Allostera
• Alnis Biosciences
• Alnylam
• AlphaVax
• Alseres Pharmaceuticals
• Ambit Biosciences
• Ambrilia Biopharma
• Amgen
• Amphora
• Anadys Pharmaceuticals
• Anaphore
• Anavex Life Sciences
• AngioChem
• Ansaris
• Antisoma
• Aphios
• Apogee Biotechnology
• Apogenix
• ApopLogic Pharmaceuticals
• Ariad
• Arno Therapeutics
• ArQule
• Array BioPharma
• Ascend Therapeutics
• Ascenta Therapeutics
• Ascepion Pharmaceuticals
• Astellas
• Astex Pharmaceuticals
• Astex Therapeutics
• AstraZeneca
• Attenuon
• AVI BioPharma
• Avila Therapeutics
• Basilea Pharmaceutica
• Bavarian Nordic
• Bayer
• Benitec
• Berkeley Lab
• Beta Pharma
• Betagenon
• Bio-Path Holdings
• BioAlliance Pharma
• BioAxone
• Biocad
• Biogen Idec
• BioInvent
• BioLineRx
• BioMarin
• Biomas
• Bionovo
• BioSante
• Biotecnol
• Biotica Technology
• BioVex
• Boehringer Ingelheim
• Bristol-Myers Squibb
• BTG
• Callisto Pharmaceuticals
• Cambrex
• CanBas
• Cancer Research Technology
• Catalyst Biosciences
• CDG Therapeutics
• Cel-Sci
• Celera
• Celgene
• Cell Therapeutics
• CellCeutix
• Celldex Therapeutics
• Celleron
• Celltrion
• Celsion
• Celtic Pharma
• Center of Molecular Immunology
• Cephalon
• CerRx
• ChemoCentryx
• Chemokine Therapeutics
• Chiesi
• Chlorogen
• Chong Kun Dang
• Chroma Therapeutics
• Circadian Technologies
• Cleveland BioLabs
• Clinical Data
• CombinatoRx
• CompleGen
• Compugen
• CoNCERT Pharmaceuticals
• Coronado Biosciences
• Critical Outcome Technologies
• Curis
• Cyclacel
• Cylene Pharmaceuticals
• Cynvec
• CytImmune Sciences
• Cytochroma
• Cytokine PharmaSciences
• Cytokinetics
• Cytopia
• CytRx
• Daewoong
• Daiichi Sankyo
• Dainippon Sumitomo Pharma
• Debiopharm
• Deciphera Pharmaceuticals
• Dendreon
• DeveloGen
• DiaMedica
• Domainex
• Dong-A
• Dongkook Pharm
• Douglas
• Dyax
• ECI
• Eisai
• Elara Pharmaceuticals
• Eleos
• ElexoPharm
• Eli Lilly
• Emergent BioSolutions
• Endoceutics
• Enkam Pharmaceuticals
• EntreMed
• Enzon
• Epeius Biotechnologies
• EpiCept
• Epizyme
• Erimos
• Esperance Pharmaceuticals
• Etubics
• Eucodis
• Exelixis
• Expression Drug Designs
• Formula Pharmaceuticals
• Fresenius
• Galapagos
• Galectin Therapeutics
• Galena Biopharma
• Genentech
• Generex
• Genmab
• Genta
• GenVec
• Gerolymatos
• Geron
• Gilead Sciences
• GlaxoSmithKline
• GlycoGenesys
• Glycotope
• GlyTag
• Got-a-Gene
• GPC Biotech
• Gradalis
• Green Cross
• Hanmi
• Harbor BioSciences
• Heidelberg Pharma
• Hoffmann-La Roche
• Hospira
• Human Genome Sciences
• Hutchison China MediTech
• Hypha Discovery
• Idera Pharmaceuticals
• ImClone Systems
• Immunocore
• ImmunoFrontier
• ImmunoGen
• Immunomedics
• ImmuPharma
• Immutep
• Incozen Therapeutics
• Incyte Corporation
• Inex
• Infinity Pharmaceuticals
• Inhibiton Therapeutics
• Innate Pharma
• InNexus Biotechnology
• Inovio
• Insmed
• Insys Therapeutics
• Intarcia Therapeutics
• Intellikine
• Intezyne Technologies
• Intradigm
• Introgen Therapeutics
• Ipsen
• Isis Pharmaceuticals
• ISU ABXIS
• Jina Pharmaceuticals
• Johnson & Johnson
• Kadmon
• KAI Pharmaceuticals
• KaloBios
• Kalypsys
• Karus Therapeutics
• Keryx Biopharmaceuticals
• Kiadis
• Kinex
• Kirin Pharma
• KuDOS
• Kyowa Hakko Kirin
• Leo
• Lexicon Pharmaceuticals
• Ligand
• Lorus Therapeutics
• MacroGenics
• Marillion Pharmaceuticals
• Marina Biotech
• MaxoCore Pharmaceuticals
• Meda
• Medarex
• MediGene
• MedImmune
• Mediolanum
• Medisyn Technologies
• Menarini
• Merck & Co
• Merck KGaA
• Merrimack
• MetaMol Theranostics
• MethylGene
• Micromet
• Mitsubishi Tanabe Pharma
• Molecular LogiX
• Mologen
• Myrexis
• Nano Terra
• Nektar Therapeutics
• Nemod Biotherapeutics
• Nereus Pharmaceuticals
• Nerviano Medical Sciences
• Neurocrine Biosciences
• NexGenix Pharmaceuticals
• NexusPharma
• NicOx
• Nidus Laboratories
• NIH
• Nimbus Discovery
• Nippon Kayaku
• Nippon Shinyaku
• Non-industrial source
• Novacea
• NovaLead
• Novartis
• Novelix
• Novogen
• Oasmia
• Oncalis
• OncoGenex Pharmaceuticals
• Oncolix
• OncoMune
• Onconova
• OncoTherapy Science
• Oncothyreon
• Oncozyme Pharma
• Orion Pharma
• OSI Pharmaceuticals
• Oxford BioMedica
• OXiGENE
• Pacific Biotech
• Paladin Labs
• PanaGin
• Pantarhei Bioscience
• Pathway Therapeutics
• Patrys
• Peregrine Pharmaceuticals
• Pfizer
• Pharmacyclics
• PharmaGap
• PharmaMar
• Pharmexa
• Pharminox
• PheneX
• Philogen
• Phoenix Biotechnology
• PHusis Therapeutics
• Pieris
• Pierre Fabre
• Piramal
• PIramed
• Portola Pharmaceuticals
• Proacta
• Progenics Pharmaceuticals
• ProMetic Life Sciences
• ProStrakan
• Provid
• PTC Therapeutics
• QLT
• Quantum Pharmaceuticals
• R&R
• Radient Pharmaceuticals
• Raptor Pharmaceutical
• Ras Therapeutics
• Reata Pharmaceuticals
• Receptor BioLogix
• Regeneron
• Regulon
• RESprotect
• Rexahn
• Rigel
• Rosetta Genomics
• Samtheo Biopharma
• Samyang
• Sanofi
• Santaris Pharma
• Sareum
• Savient Pharmaceuticals
• SBI Biotech
• SBIO
• Scancell
• Schering-Plough
• Seattle Genetics
• SEEK
• Selvita
• Semafore Pharmaceuticals
• Senesco Technologies
• Sentinel Oncology
• SGX Pharmaceuticals
• Shenogen
• Sigma-Tau
• Silence Therapeutics
• Sirnaomics
• SRI International
• Sun Pharma Advanced Research
• Sunesis
• SuperGen
• Supratek Pharma
• Swedish Orphan Biovitrum
• Switch Pharma
• SymBio Pharmaceuticals
• Symbiotec
• Symphogen
• Synageva BioPharma
• Synta Pharmaceuticals
• Taiho
• Taiwan Liposome Company
• Takeda
• Tamir Biotechnology
• Tapestry Pharmaceuticals
• TapImmune
• Targa Therapeutics
• TargeGen
• Tau Therapeutics
• TauTaTis
• Taxolog
• TCD Pharma
• Tekmira Pharmaceuticals
• Telik
• TetraLogic Pharmaceuticals
• Teva
• Thallion Pharmaceuticals
• Therion Biologics
• Theryte
• Tigris Pharmaceuticals
• to-BBB
• ToolGen
• TopoTarget
• Tracon Pharmaceuticals
• Tragara Pharmaceuticals
• Transgene
• TransTech Pharma
• Trion Pharma
• UCB
• UMN Pharma
• Vaccinex
• ValiRx
• VasGene Therapeutics
• Vaxon Biotech
• VBL Therapeutics
• Velacor Therapeutics
• Verastem
• Vernalis
• Vertex Pharmaceuticals
• Vical
• Wilex
• Vion Pharmaceuticals
• VioQuest
• Viragen
• Viralytics
• ViroMed
• ViroTarg
• VM Discovery
• Wyeth
• Xcovery
• Xencor
• Xerion
• Xoma
• Yakult Honsha
• YM BioSciences
• Zensun
• Zenyaku Kogyo
• Zydus Cadila

A Shortlist of Drugs Included are:

• 131I-tositumomab
• 177-Lu-AMBA
• 17s-hydroxysteroid dehydrogenase-1 inhibitors
• 2-methoxyestradiol
• 2aG4-IL-2 fus protein + PS MAb
• 4-hydroxytamoxifen
• 5-FU
• 852A
• 9-aminocamptothecin
• AB-16B5
• abiraterone acetate
• ABT-510
• AC-480
• ACC inhibitor
• acolbifene
• adecatumumab
• aderbasib
• Adva-27a
• AE-37
• AEE-788
• AEG-35156
• AEZS-108
• AF-802
• afatinib
• aflibercept
• AFM-21
• AG-1
• agatolimod
• aglycon protopanaxadiol
• alvespimycin hydrochloride
• alvocidib
• amatuximab
• AME-133
• AMG-386
• amonafide dihydrochloride
• amonafide malate
• amrubicin hydrochloride
• amuvatinib
• anastrozole
• androgen receptor antagonist
• angiopep+paclitaxel
• Angiozyme
• annamycin
• anti-C35 MAb
• anti-HER-2/neu antisense
• anti-HER2 MAb
• anti-HER2neu scFv
• anti-Hsp90-alpha MAbs
• anti-PCDGF MAbs
• anticancers
• antiestrogen
• apatinib
• APG-101
• apricoxib
• AR-002
• AR-004
• AR-42
• AR-7BD-33-11A
• ARC-100
• ARQ-197
• ARQ-621
• ARRY-380
• arzoxifene hydrochloride
• AS-101
• AS-1402
• AS-1411
• ASP-08126
• AT-7519
• AT-9283
• atamestane
• ATN-224
• atrasentan
• Auto TAG vaccine
• AUY-922
• AVE-1642
• AVI-4126
• avorelin
• AVX-701
• axitinib
• AZD-1480
• AZD-4547
• AZD-4877
• AZD-4992
• AZD-8055
• AZD-8931
• bafetinib
• BAL-27862
• banoxantrone
• barasertib
• bardoxolone methyl
• becatecarin
• belinostat
• bevacizumab
• BEZ-235
• BGT-226
• BI-811283
• BIBF-1120
• BIW-8556
• BMN-673
• BMS-599626
• BMS-690514
• BMS-753493
• BMS-754807
• BMS-777607
• BN-107
• bortezomib
• bosutinib
• brca2
• breast cancer therapy
• breast cancer vaccine
• BreMel/TNF-alpha
• BrevaRex MAb
• brivanib alaninate
• brivudine
• BZL-101
• CAB-051
• Cabozantinib
• CAL-101
• cancer therapy (1)
• cancer therapy (2)
• canertinib dihydrochloride
• canfosfamide hydrochloride
• capecitabine
• carbetocin
• catumaxomab
• CBP-501
• CC-223
• CDX-1307
• CEA cancer vaccine
• cediranib
• celecoxib
• cenersen
• cetuximab
• CGX-0682
• CH-4986399
• CHF-4227
• cilengitide
• cintredekin besudotox
• cixutumumab
• clofarabine
• CNF-2024
• conatumumab
• contusugene ladenovec
• CP-724714
• crizotinib
• crolibulin
• CTCE-9908
• CTP-37
• CUDC-101
• custirsen
• CVac
• CX-4945
• CYN-101
• D-3263
• dabigatran etexilate
• dacomitinib
• dalotuzumab
• danusertib
• dasatinib
• daunorubicin
• denosumab
• Diflomotecan
• dinaciclib
• docetaxel (1)
• docetaxel (2)
• docetaxel (3)
• docetaxel (4)
• docetaxel (5)
• docetaxel MAb
• dovitinib lactate
• doxifluridine
• doxorubicin (1)
• doxorubicin (10)
• doxorubicin (11)
• doxorubicin (2)
• doxorubicin (3)
• doxorubicin (4)
• doxorubicin (5)
• doxorubicin (6)
• doxorubicin (7)
• doxorubicin (8)
• doxorubicin (9)
• doxorubicin citrate
• dulanermin
• DXL-702
• E-75
• E39
• ECI-301
• elomotecan
• elsamitrucin
• emepepimut-S
• endostatin
• endoxifen
• eniluracil
• ENMD-2076
• entinostat
• enzastaurin hydrochloride
• EP-100
• epirubicin
• epothilone D
• erlotinib
• ERR antagonists
• ertumaxomab
• estetrol
• estrogen inhibitors
• everolimus
• exatecan mesylate
• exemestane
• Exherin
• exisulind
• EZH2
• F16-IL2
• fadrozole
• FASN inhibitors
• figitumumab
• flt-4 kinase inhibitors
• foretinib
• formestane (1)
• formestane (2)
• fosbretabulin tromethamine
• fosfluridine tidoxil
• fostamatinib disodium
• FPI-01
• fulvestrant
• fusion toxins
• Galactomycin-UCLT
• galarubicin hydrochloride
• ganitumab
• gataparsen
• GDC-0980
• gefitinib
• gimatecan
• glembatumumab vedotin
• GlyB4
• golnerminogene pradenovec
• goserelin
• goserelin acetate ER
• GPR40 antagonists
• GSK-1059615
• GSK-2118436
• GSK-2130579A
• GSK-2302024A
• GT-111
• GVAX
• HAS2 inhibitor
• HE-3235
• Her-2/Neu peptides
• HER2 vaccine
• her2/neu antigen
• Her2/neu gene therapy
• huBrE-3 tiuxetan
• HuMax-Her2
• HuMax-VEGF
• ibritumomab tiuxetan
• IC-83
• icotinib hydrochloride
• icrucumab
• idronoxil
• IGF-1 receptor inhibitor
• IGN-101
• IKKe/TBK1 inhibitor
• imatinib mesilate
• imetelstat
• IMGN-388
• immunogene therapy
• IMO-2055
• IMP-321
• Imuteran
• INCB-028060
• indisulam
• ING-1
• ingenol mebutate
• INGN-225
• INGN-241
• inherbins
• iniparib
• INNO-206
• INSM-18
• interferon (s1a)
• interleukins
• IPH-3102
• ipilimumab
• IPP-204106
• irinotecan
• irinotecan hydrochloride
• irosustat
• ispinesib mesylate
• JI-101
• JMR-132
• kahalalide F
• KD032
• KW-2170
• KX2-391
• labetuzumab
• labetuzumab-SN-38
• lapatinib ditosylate
• lapuleucel-T
• larotaxel
• lasofoxifene
• lenvatinib
• leptin antagonists
• lestaurtinib
• letrozole
• leucine-doxorubicin
• leuprorelin
• linifanib
• linsitinib
• LipoVIL12
• litronesib
• lonafarnib
• lonaprisan
• LOR-2040
• Lovaxin B
• lumiliximab
• LY-2090314
• LY-2157299
• MAGH-22
• mapatumumab
• masitinib
• MDX-1140
• ME-103
• MEDI-547
• Mesd-based peptides
• MetXia
• MGCD-265
• MGN-1601
• MGN-1703
• midostaurin
• milataxel
• mitoxantrone
• MK-1775
• MK-2206
• MKC-1
• MLN-8237
• MM-111
• MM-121
• mocetinostat
• MORAb-004
• motesanib diphosphate
• motexafin gadolinium
• MP-529
• MS-209
• MT-110
• MUC-1 vaccine
• MVA-BN Her-2 vaccine
• Nab-docetaxel
• navitoclax
• neratinib
• nilotinib
• nimotuzumab
• NK-012
• NL-0031
• nolatrexed dihydrochloride
• noscapine
• NPB-001-056
• NXD-30001
• OB-cadherin antibodies
• obinutuzumab
• oblimersen sodium
• OCM-111
• OCM-8054
• OCM-8224
• OGX-225
• OGX-427
• olaparib
• ON-01910
• ON-045270
• onartuzumab
• Onco-L TCS
• Oncohist
• oncolytic viruses
• OSI-027
• OSI-7904L
• osteolytic disease therapy
• Osteopontin-c inhibitor
• OTS-102
• P276-00
• paclitaxel (1)
• paclitaxel (10)
• paclitaxel (11)
• paclitaxel (12)
• paclitaxel (13)
• paclitaxel (14)
• paclitaxel (2)
• paclitaxel (3)
• paclitaxel (4)
• paclitaxel (5)
• paclitaxel (6)
• paclitaxel (7)
• paclitaxel (8)
• paclitaxel (9)
• paclitaxel polyglumex
• paclitaxel-DHA
• PankoPep
• panobinostat
• PANVAC-VF
• PAT-SC1
• patupilone
• pazopanib hydrochloride
• PBI-1402
• PCI-24781
• PD-0325901
• PD-0332991
• pegdinetanib
• pelitinib
• pemetrexed disodium
• pentamidine isethionate
• peptidomimetics
• perifosine
• pertuzumab
• PHA-848125AC
• PhG-alpha-1
• pixantrone
• PKI-179
• PKI-587
• plitidepsin
• ponatinib
• pralatrexate
• Prolanta
• Prolanta ER
• prostate cancer therapy
• PRX-321
• PSK-3668
• PTC-299
• PX-104.1
• PX-12
• PX-866
• quarfloxacin
• quinacrine
• quizartinib dihydrochloride
• R-(-)-gossypol
• R-763
• radiotherapeutic
• RAF-265
• raloxifene hydrochloride
• ramucirumab
• regorafenib
• retaspimycin
• Reximmune-C
• Rexin-G
• RG-1507
• RG-7321
• rhErbB3-f
• ridaforolimus
• rilotumumab
• rinfabate
• romidepsin
• RR-310
• rubitecan
• ruxolitinib
• RX-0201-N
• S1P3 inhibitor
• sabarubicin
• sagopilone
• SAR-566658
• saracatinib
• SBC-202
• Sch-57050
• SCH-900776
• SEL-24-1
• seliciclib
• selumetinib
• semaxanib
• seocalcitol
• SERM + toxin
• SF-1126
• simotaxel
• sipuleucel-T
• siRNA gp96 therapy
• sirolimus
• SM3
• SN-38 (1)
• SN-38 (2)
• SNG-163
• SNG-8023
• SNG-8038
• sorafenib tosylate
• SPC-2968
• SPC-2996
• SR-13668
• SR-16157
• SR-31747
• s-lapachone
• STA-9090
• steroid sulfatase inhibitor
• STP-503
• SU-14813
• SU-6668
• sunitinib malate
• survivin-2B
• Symadex
• talmapimod
• talminogene laherparepvec
• tamoxifen (1)
• tamoxifen (2)
• tamoxifen, oral liquid
• tandutinib
• tanespimycin
• tariquidar
• TAS-108
• tegafur + uracil
• telatinib
• telomerase vaccine
• temsirolimus
• Tenarad
• terameprocol
• TG-4010
• thiocoraline
• thymectacin
• tigapotide triflutate
• tigatuzumab
• tipifarnib
• tivozanib
• TL-32711
• TLK-58130
• TLN-4601
• TNF + paclitaxel
• TNF-alpha
• toremifene citrate
• trastuzumab (1)
• trastuzumab (2)
• trastuzumab (3)
• trastuzumab emtansine
• trastuzumab-MMAE conjugate
• tremelimumab
• triapine
• triciribine phosphate
• trilostane
• triptorelin pamoate
• TroVax
• TRU-016
• TS-1
• TTL-2019
• TTL-3101
• UCN-01
• V-930
• V935
• vandetanib
• varlitinib
• vatalanib
• veliparib
• vemurafenib
• vismodegib
• VM-206
• volasertib
• vosaroxin
• VS-4718
• VS-507
• VS-5095
• VX-001
• WX-671
• WX-UK1
• XL-147
• XL-281
• XL-413
• XL-647
• XL-765
• Y-90-labetuzumab
• YM-155
• Zemab
• zibotentan
• ZYC-300