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Market Research Report

The Market for Stem Cell Exosomes

Published by BIOINFORMANT WORLDWIDE, LLC Product code 587814
Published Content info 134 Pages
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The Market for Stem Cell Exosomes
Published: December 15, 2017 Content info: 134 Pages
Description

Although long overlooked, exosomes are rapidly gaining momentum as a novel strategy for accessing the therapeutic effects of stem cells without the risks and difficulties of administering the cells to patients.

Although exosomes were discovered more than 30 years ago, it was not until recently that the scientific community began to give credit to exosomes for a range of promising traits. Ten years ago in 2006, there were only 76 articles published about exosomes on PubMed.gov. Today, there are more than 4,400 articles published about exosomes on PubMed.gov, of which approximately 25% were released in the past year.

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When exosome publications are analyzed, U.S. authors have published approximately 40% of the articles and Chinacomes in second place. When the term "exosome" is searched in the scientific literature, Dr. Susanne Gabrielsson from the Karolinska Institutet in Sweden is the leading author, with 37 articles.


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When the term "extracellular vesicles" is searched, Unicyte AG, a regenerative medicine unit of Fresenius Medical Care, takes the lead. Headquartered in Switzerland, the company has published more than 100 papers on exosomes and extracellular vesicles in combination with Prof. Giovanni Camussi.


On the venture capital front, there has also been a great deal of market activity. In January 2016, Exosome Diagnostics closed $60 million in Series B financing, which it followed in July 2017 with $30 million in Series C financing. Similarly, Codiak Biosciences was launched in 2016 when the MD Anderson Cancer Center joined two venture capital firms to form the company with more than $80 million in series A and B financing. On November 29, 2017, Codiak BioSciences added another $76.5 million in Series C financing. In May 2017, ExCoBio Inc. raised US $11 million in a Series A funding round.

Companies leading the charge in the area of exosome therapeutics include Anjarium Biosciences, Capricor Therapeutics, Codiak Biosciences, Creative Medical Technology Holdings, Everkine Corporation, Evox Therapeutics, Exogenus Therapeutics, Kimera Labs, ReNeuron, and Unicyte AG, a subsidiary of Fresenius Medical Care.

Numerous life science companies have also launched tools and systems to support exosome research, including Beckman Coulter, Exiqon, System Biosciences (SBI), Lonza, Thermo Fisher, Qiagen, ZenBio, and more. In particular, Lonza made aggressive investments in the sector through its May 2017 acquisition of HansaBioMed Life Sciences and investment into Exosomics.

Similarly, techniques for large-scale clinical-grade manufacture of stem cell exosomes is becoming a focal point within the industry, as highlighted by a recent partnership between RoosterBio and Exopharmand Lonza's strategic acquisitions.

Exosome Market Forces

Exosome-related technologies have been developing rapidly over the past few years and substantial growth is expected for the market as they get integrated into the fields of liquid biopsy, precision medicine and regenerative medicine. In particular, cancer derived exosomes influence the invasive potential of cells by regulating angiogenesis, metastasis, and immunity, making them an extremely useful source of biomarkers for use in cancer detection, diagnosis, and therapeutic selection.

While exosomes derived from multiple stem cell types are being explored, mesenchymal stem cell (MSC) derived exosomes are best represented within the scientific literature and global patent activity.

To characterize this rapidly forming marketplace, BioInformant has released a 134 page market report that explores growing demand for exosome therapeutics, diagnostics, research tools, consumer care products, and manufacturing technologies. It also reveals trend rate data for exosome patents, grants, scientific publications, andclinical trials, and present social analytics from Google Trends and Google Adwords.

Claim it to:

  • 1. Identify the five market segments that compose the industry
  • 2. Reveal the market players competing in each niche
  • 3. Identify opportunities for exosome product development
  • 4. Access market size determinations and projections through 2022

Companies Mentioned Include:

  • Anjarium Biosciences
  • Avalon GloboCare Corp.
  • Beckman Coulter
  • Capricor Therapeutics
  • Cavadis B.V.
  • Cell Guidance Systems
  • Codiak Biosciences
  • CosmoBio USA
  • Creative Medical Technologies Holdings
  • Exiqon
  • ExoCoBio Inc.
  • Exerkine Corporation
  • Exopharm
  • Exosome Diagnostics
  • Evox Therapeutics
  • Exogenus Therapeutics
  • Exosome Sciences
  • Exosomics Siena SpA
  • Exostemtech Co. Ltd.
  • Exovita Biosciences
  • Galen Lab Supplies
  • Guangzhou Selaira Stem Cell Technology Co., Ltd
  • HansaBioMed Life Sciences
  • iZon Science
  • Kimera Labs
  • Lonza
  • Miltenyi Biotec
  • Norgen Biotek
  • ReNeuron
  • RoosterBio
  • Unicyte AG
  • ZenBio
Table of Contents

Table of Contents

1. Abstract

2. Research Methodology

  • 2.1. Input Sources
  • 2.2 Research & Analysis Methodologies

3. Report Purpose

  • 3.1. Survey Recent Advancements with Stem Cell Exosomes
  • 3.2. Provide a "Snapshot" of the Global Market for Stem Cell Exosomes
  • 3.3. Assess Opportunities for Commercialization
  • 3.4. Identify Major Market Players and Assess the Competitive Environment
  • 3.5. Identify Existing and Emerging Trends
  • 3.6. Identify Critical Opportunities and Threats within the Marketplace

4. Key Characteristics of Exosomes

5. Types of Stem Cell Derived Exosomes

6. Advantages of Exosomes

7. Therapeutic Effects of Exosomes

  • 7.1. Influencing Growth of Target Cells
  • 7.2. Influencing Phenotype
  • 7.3. Contributing to Cell Fate Decision
  • 7.4. Promote Regeneration
  • 7.5. Immunomodulation
  • 7.6. Anti-inflammatory Effects
  • 7.7. Anti-fibrotic Effects

8. Role of Stem Cell Exosomes in Cancer

  • 8.1. Role in Tumor Angiogenesis
  • 8.2. Role in Tumor Invasion and Metastasis
  • 8.3. Role in Tumor Biomarkers

9. Exosome Characterization

10. Rates of Exosome Scientific Publications (All Cell Types)

  • 10.1. Analysis of Exosome Scientific Publications (All Cell Types)
  • 10.2. Analysis of Stem Cell Exosome Scientific Publications
  • 10.3. Comparison of Scientific Publication Rates for Exosome Synonyms

11. Trend Data

  • 11.1. Grant Funding Analysis
  • 11.2. Patent Analysis
    • 11.2.1. Patents about Stem Cell Exosomes
    • 11.2.2. Patents about Exosomes (Derived from All Cell Types)
  • 11.3. Clinical Trial Analysis 12. Social Analytics

12. Social Analytics

  • 12.1. Marketing Costs for Exosomes - Google Adwords Price-Per-Click (PPC) Analysis
  • 12.2. Top Social Media Articles (Trailing 12 Months)
  • 12.3. Google Trends
  • 12.4. Twitter Data

13. Timeline of Exosome Industry Events

14. Profiles of Companies Developing Exosome Technologies

  • 14.1. Anjarium Biosciences
  • 14.2. Capricor Therapeutics
  • 14.3. Codiak Biosciences
  • 14.4. Creative Medical Technologies Holdings
  • 14.5. Evox Therapeutics
  • 14.6. Exerkine Corporation
  • 14.7. ExoCoBio Inc.
  • 14.8. Exogenus Therapeutics
  • 14.9. Exopharm
  • 14.10. Exosome Diagnostics
  • 14.11. Exosome Sciences
  • 14.12. Exosomics Siena SpA
  • 14.13. Exovita Biosciences
  • 14.14. Kimera Labs
  • 14.15. Lonza
  • 14.16. ReNeuron
  • 14.17. RoosterBio

15. Companies Developing Exosome Research Products

  • 15.1. Market Leaders
  • 15.2. Companies Advertising Exosome Research Products with Google Adwords
  • 15.3. All Companies Offering Exosome Research Products

16. SWOT Analysis (Strengths, Weaknesses, Opportunities, Threats)

  • 16.1. Strengths of Stem Cell Exosome Market
  • 16.2. Weaknesses of Stem Cell Exosome Market
  • 16.3. Opportunities for the Stem Cell Exosome Market
  • 16.4. Threats to Stem Cell Exosome Market

17. Investment Environment

  • 17.1. Traditional Venture Capital Investments
  • 17.2. Other Types of Industry Investment (Partnerships, M&A, Co-Branding)

18. Market Segments

  • 18.1. Research Products
  • 18.2. Diagnostic Tools
  • 18.3. Therapeutics
  • 18.4. Cosmeceuticals
  • 18.5. Manufacturing Services

19. Market Size Determination

  • 19.1. Definitions
  • 19.2 Methodology
  • 19.3 Future Projections by Market Segment

20. Regulatory Oversight of Exosomes

  • 20.1. U.S. Regulation of Stem Cell Exosomes
  • 20.2. 21st Century Cures Act and REGROW Act
  • 20.3. Accelerated Approval Pathways in Japan 20.4. Accelerated Approval Pathways Worldwide

21. Exosome Conferences and Events

22. Conclusions

Appendix A - Exosome Industry Announcements

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