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PUBLISHER: Bizwit Research & Consulting LLP | PRODUCT CODE: 1251573

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PUBLISHER: Bizwit Research & Consulting LLP | PRODUCT CODE: 1251573

Global Targeted Sequencing and Resequencing Market Size study & Forecast, by Technology by Type, by Application, by End-use and Regional Analysis, 2022-2029

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Global Targeted Sequencing and Resequencing Market is valued at approximately USD 4.1 billion in 2021 and is anticipated to grow with a healthy growth rate of more than 22.59% over the forecast period 2022-2029. Targeted Sequencing is a method of detecting unusual variants in a certain set of genes whereas, Resequencing is a method in which a subset of genes is isolated and sequenced. Targeted Sequencing and Resequencing are the methods used for the sequencing of a portion of a person's genome to look for sequence discrepancies between that person and the species' typical genome. Shotgun and high throughput are the two main types of DNA sequencing. Targeted sequencing and resequencing are used for the detection of mutations in DNA caused by various congenital diseases. In comparison to WGS and other survey methods, it provides a proper analysis of the results and prevents the erroneous interpretation of sequencing data. Cost-saving advantages of full genome sequencing, increasing R&D investments in the pharmaceutical industry, advantages of amplicon sequencing and targeted gene panels and Technological advancements in sequencing technology are the factors driving the major market growth.

According to the National Library of Medicine, full genome sequencing costs about $10 million in 2007. Since then, sequencing prices have decreased rapidly, and it is expected that the $1000 genome will soon become a reality. Additionally, in 2019, R&D expenditures in the pharmaceutical business were $83 billion. Particularly, between 2015 and 2019, investment in pharmaceutical R&D surged by about 50%. Increasing R&D investments leads to the development of innovative Sequencing and Resequencing techniques. Cost-saving advantages of full genome sequencing and increasing research and development investments in the pharmaceutical industry are the major factors driving the growth of the market. Other components driving market increase are the advantages of amplicon sequencing and targeted gene panels and Technological advancements in sequencing technology. Furthermore, emerging digital next-generation sequencing technology and advancements to perform sequencing in less time are the factors creating major market opportunities in the forecast period. However, the high cost of maintaining Targeted Sequencing and Resequencing stifles market growth throughout the forecast period of 2022-2029.

The key regions considered for the Global Targeted Sequencing And Resequencing Market study includes Asia Pacific, North America, Europe, Latin America, and Rest of the World. North America dominated the market in terms of revenue, owing to the dominance of market players, increasing advancements in technology, and the region's increasing development of sequencing capabilities. Asia Pacific is expected to grow with the highest CAGR during the forecast period, owing to factors such as increasing investments in research & development, the prevalence of advanced technology for drug development and discovery, and the geographic expansion of key players.

Major market players included in this report are:

  • Illumina, Inc.
  • F. Hoffmann-La Roche Ltd
  • Agilent Technologies Inc.
  • GATC Biotech Ag
  • Oxford Nanopore Technologies
  • Thermo Fisher Scientific, Inc.
  • DNASTAR Inc.
  • QIAGEN
  • BGI
  • Perkin Elmer, Inc.

Recent Developments in the Market:

  • In January 2021, Illumina announced several collaborations between Merck, Myriad Genetics, Kura Oncology, and Bristol Myers Squibb that support the company's goal of creating standardized, widely available tools for precision oncology.
  • In Aug 2022, The Medical Device Innovation Consortium (MDIC) introduced Somatic Reference Samples (SRS), an initiative to improve NGS-based cancer diagnosis by validating and developing public genomic datasets and therapeutically relevant samples.

Global Targeted Sequencing And Resequencing Market Report Scope:

  • Historical Data 2019-2020-2021
  • Base Year for Estimation 2021
  • Forecast period 2022-2029
  • Report Coverage Revenue forecast, Company Ranking, Competitive Landscape, Growth factors, and Trends
  • Segments Covered Technology, Type, Application, End-use, Region
  • Regional Scope North America; Europe; Asia Pacific; Latin America; Rest of the World
  • Customization Scope Free report customization (equivalent up to 8 analyst's working hours) with purchase. Addition or alteration to country, regional & segment scope*

The objective of the study is to define market sizes of different segments & countries in recent years and to forecast the values to the coming years. The report is designed to incorporate both qualitative and quantitative aspects of the industry within countries involved in the study.

The report also caters detailed information about the crucial aspects such as driving factors & challenges which will define the future growth of the market. Additionally, it also incorporates potential opportunities in micro markets for stakeholders to invest along with the detailed analysis of competitive landscape and Technology offerings of key players. The detailed segments and sub-segment of the market are explained below:

By Technology:

  • Sequencing
  • Re-sequencing

By Type:

  • DNA
  • RNA

By Application:

  • Clinical Application
  • Plant & animal sciences
  • Drug development
  • Others

By End-use:

  • Hospitals & clinics
  • Academic Research
  • Others

By Region:

  • North America
  • U.S.
  • Canada
  • Europe
  • UK
  • Germany
  • France
  • Spain
  • Italy
  • ROE
  • Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • South Korea
  • RoAPAC
  • Latin America
  • Brazil
  • Mexico
  • Rest of the World

Table of Contents

Chapter 1. Executive Summary

  • 1.1. Market Snapshot
  • 1.2. Global & Segmental Market Estimates & Forecasts, 2019-2029 (USD Billion)
    • 1.2.1. Targeted Sequencing And Resequencing Market, by Region, 2019-2029 (USD Billion)
    • 1.2.2. Targeted Sequencing And Resequencing Market, by Technology, 2019-2029 (USD Billion)
    • 1.2.3. Targeted Sequencing And Resequencing Market, by Type, 2019-2029 (USD Billion)
    • 1.2.4. Targeted Sequencing And Resequencing Market, by Application, 2019-2029 (USD Billion)
    • 1.2.5. Targeted Sequencing And Resequencing Market, by End-use, 2019-2029 (USD Billion)
  • 1.3. Key Trends
  • 1.4. Estimation Methodology
  • 1.5. Research Assumption

Chapter 2. Global Targeted Sequencing and Resequencing Market Definition and Scope

  • 2.1. Objective of the Study
  • 2.2. Market Definition & Scope
    • 2.2.1. Scope of the Study
    • 2.2.2. Industry Evolution
  • 2.3. Years Considered for the Study
  • 2.4. Currency Conversion Rates

Chapter 3. Global Targeted Sequencing and Resequencing Market Dynamics

  • 3.1. Targeted Sequencing and Resequencing Market Impact Analysis (2019-2029)
    • 3.1.1. Market Drivers
      • 3.1.1.1. Decreasing cost of full genome sequencing
      • 3.1.1.2. increasing R&D investments in the pharmaceutical industry
    • 3.1.2. Market Challenges
      • 3.1.2.1. High Cost of maintaining Targeted Sequencing and Resequencing technology
    • 3.1.3. Market Opportunities
      • 3.1.3.1. Emerging digital next-generation sequencing technology
      • 3.1.3.2. Advancements to perform sequencing in less time.

Chapter 4. Global Targeted Sequencing and Resequencing Market Industry Analysis

  • 4.1. Porter's 5 Force Model
    • 4.1.1. Bargaining Power of Suppliers
    • 4.1.2. Bargaining Power of Buyers
    • 4.1.3. Threat of New Entrants
    • 4.1.4. Threat of Substitutes
    • 4.1.5. Competitive Rivalry
  • 4.2. Futuristic Approach to Porter's 5 Force Model (2019-2029)
  • 4.3. PEST Analysis
    • 4.3.1. Political
    • 4.3.2. Economical
    • 4.3.3. Social
    • 4.3.4. Technological
  • 4.4. Investment Adoption Model
  • 4.5. Analyst Recommendation & Conclusion
  • 4.6. Top investment opportunity
  • 4.7. Top winning strategies

Chapter 5. Risk Assessment: COVID-19 Impact

  • 5.1. Assessment of the overall impact of COVID-19 on the industry
  • 5.2. Pre COVID-19 and post COVID-19 Market scenario

Chapter 6. Global Targeted Sequencing And Resequencing Market, by Technology

  • 6.1. Market Snapshot
  • 6.2. Global Targeted Sequencing And Resequencing Market by Technology, Performance - Potential Analysis
  • 6.3. Global Targeted Sequencing And Resequencing Market Estimates & Forecasts by Technology 2019-2029 (USD Billion)
  • 6.4. Targeted Sequencing And Resequencing Market, Sub Segment Analysis
    • 6.4.1. Sequencing
    • 6.4.2. Re-sequencing

Chapter 7. Global Targeted Sequencing And Resequencing Market, by Type

  • 7.1. Market Snapshot
  • 7.2. Global Targeted Sequencing And Resequencing Market by Type, Performance - Potential Analysis
  • 7.3. Global Targeted Sequencing And Resequencing Market Estimates & Forecasts by Type 2019-2029 (USD Billion)
  • 7.4. Targeted Sequencing And Resequencing Market, Sub Segment Analysis
    • 7.4.1. DNA
    • 7.4.2. RNA

Chapter 8. Global Targeted Sequencing And Resequencing Market, by Application

  • 8.1. Market Snapshot
  • 8.2. Global Targeted Sequencing And Resequencing Market by Application, Performance - Potential Analysis
  • 8.3. Global Targeted Sequencing And Resequencing Market Estimates & Forecasts by Application 2019-2029 (USD Billion)
  • 8.4. Targeted Sequencing And Resequencing Market, Sub Segment Analysis
    • 8.4.1. Clinical Application
    • 8.4.2. Plant & animal sciences
    • 8.4.3. Drug development
    • 8.4.4. Oyhers

Chapter 9. Global Targeted Sequencing And Resequencing Market, by End-use

  • 9.1. Market Snapshot
  • 9.2. Global Targeted Sequencing And Resequencing Market by End-use, Performance - Potential Analysis
  • 9.3. Global Targeted Sequencing And Resequencing Market Estimates & Forecasts by End-use 2019-2029 (USD Billion)
  • 9.4. Targeted Sequencing And Resequencing Market, Sub Segment Analysis
    • 9.4.1. Hospitals & Clinics
    • 9.4.2. Academic ResearchOthers

Chapter 10. Global Targeted Sequencing And Resequencing Market, Regional Analysis

  • 10.1. Targeted Sequencing And Resequencing Market, Regional Market Snapshot
  • 10.2. North America Targeted Sequencing And Resequencing Market
    • 10.2.1. U.S. Targeted Sequencing And Resequencing Market
      • 10.2.1.1. Technology breakdown estimates & forecasts, 2019-2029
      • 10.2.1.2. Type breakdown estimates & forecasts, 2019-2029
      • 10.2.1.3. Application breakdown estimates & forecasts, 2019-2029
      • 10.2.1.4. End-use breakdown estimates & forecasts, 2019-2029
    • 10.2.2. Canada Targeted Sequencing And Resequencing Market
  • 10.3. Europe Targeted Sequencing And Resequencing Market Snapshot
    • 10.3.1. U.K. Targeted Sequencing And Resequencing Market
    • 10.3.2. Germany Targeted Sequencing And Resequencing Market
    • 10.3.3. France Targeted Sequencing And Resequencing Market
    • 10.3.4. Spain Targeted Sequencing And Resequencing Market
    • 10.3.5. Italy Targeted Sequencing And Resequencing Market
    • 10.3.6. Rest of Europe Targeted Sequencing And Resequencing Market
  • 10.4. Asia-Pacific Targeted Sequencing And Resequencing Market Snapshot
    • 10.4.1. China Targeted Sequencing And Resequencing Market
    • 10.4.2. India Targeted Sequencing And Resequencing Market
    • 10.4.3. Japan Targeted Sequencing And Resequencing Market
    • 10.4.4. Australia Targeted Sequencing And Resequencing Market
    • 10.4.5. South Korea Targeted Sequencing And Resequencing Market
    • 10.4.6. Rest of Asia Pacific Targeted Sequencing And Resequencing Market
  • 10.5. Latin America Targeted Sequencing And Resequencing Market Snapshot
    • 10.5.1. Brazil Targeted Sequencing And Resequencing Market
    • 10.5.2. Mexico Targeted Sequencing And Resequencing Market
  • 10.6. Rest of The World Targeted Sequencing And Resequencing Market

Chapter 11. Competitive Intelligence

  • 11.1. Top Market Strategies
  • 11.2. Company Profiles
    • 11.2.1. Illumina, Inc.
      • 11.2.1.1. Key Information
      • 11.2.1.2. Overview
      • 11.2.1.3. Financial (Subject to Data Availability)
      • 11.2.1.4. Product Summary
      • 11.2.1.5. Recent Developments
    • 11.2.2. F. Hoffmann-La Roche Ltd
    • 11.2.3. Agilent Technologies Inc.
    • 11.2.4. GATC Biotech Ag
    • 11.2.5. Oxford Nanopore Technologies
    • 11.2.6. Thermo Fisher Scientific, Inc.
    • 11.2.7. DNASTAR Inc.
    • 11.2.8. QIAGEN
    • 11.2.9. BGI
    • 11.2.10. Perkin Elmer, Inc.

Chapter 12. Research Process

  • 12.1. Research Process
    • 12.1.1. Data Mining
    • 12.1.2. Analysis
    • 12.1.3. Market Estimation
    • 12.1.4. Validation
    • 12.1.5. Publishing
  • 12.2. Research Attributes
  • 12.3. Research Assumption

LIST OF TABLES

  • TABLE 1. Global Targeted Sequencing And Resequencing Market, report scope
  • TABLE 2. Global Targeted Sequencing And Resequencing Market estimates & forecasts by Region 2019-2029 (USD Billion)
  • TABLE 3. Global Targeted Sequencing And Resequencing Market estimates & forecasts by Technology 2019-2029 (USD Billion)
  • TABLE 4. Global Targeted Sequencing And Resequencing Market estimates & forecasts by Type 2019-2029 (USD Billion)
  • TABLE 5. Global Targeted Sequencing And Resequencing Market estimates & forecasts by Application 2019-2029 (USD Billion)
  • TABLE 6. Global Targeted Sequencing And Resequencing Market estimates & forecasts by End-use 2019-2029 (USD Billion)
  • TABLE 7. Global Targeted Sequencing And Resequencing Market by segment, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 8. Global Targeted Sequencing And Resequencing Market by region, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 9. Global Targeted Sequencing And Resequencing Market by segment, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 10. Global Targeted Sequencing And Resequencing Market by region, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 11. Global Targeted Sequencing And Resequencing Market by segment, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 12. Global Targeted Sequencing And Resequencing Market by region, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 13. Global Targeted Sequencing And Resequencing Market by segment, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 14. Global Targeted Sequencing And Resequencing Market by region, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 15. Global Targeted Sequencing And Resequencing Market by segment, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 16. Global Targeted Sequencing And Resequencing Market by region, estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 17. U.S. Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 18. U.S. Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 19. U.S. Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 20. Canada Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 21. Canada Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 22. Canada Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 23. UK Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 24. UK Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 25. UK Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 26. Germany Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 27. Germany Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 28. Germany Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 29. France Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 30. France Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 31. France Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 32. Italy Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 33. Italy Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 34. Italy Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 35. Spain Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 36. Spain Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 37. Spain Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 38. RoE Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 39. RoE Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 40. RoE Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 41. China Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 42. China Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 43. China Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 44. India Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 45. India Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 46. India Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 47. Japan Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 48. Japan Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 49. Japan Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 50. South Korea Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 51. South Korea Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 52. South Korea Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 53. Australia Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 54. Australia Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 55. Australia Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 56. RoAPAC Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 57. RoAPAC Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 58. RoAPAC Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 59. Brazil Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 60. Brazil Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 61. Brazil Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 62. Mexico Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 63. Mexico Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 64. Mexico Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 65. RoLA Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 66. RoLA Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 67. RoLA Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 68. Row Targeted Sequencing And Resequencing Market estimates & forecasts, 2019-2029 (USD Billion)
  • TABLE 69. Row Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 70. Row Targeted Sequencing And Resequencing Market estimates & forecasts by segment 2019-2029 (USD Billion)
  • TABLE 71. List of secondary sources, used in the study of global Targeted Sequencing And Resequencing Market
  • TABLE 72. List of primary sources, used in the study of global Targeted Sequencing And Resequencing Market
  • TABLE 73. Years considered for the study
  • TABLE 74. Exchange rates considered

List of tables and figures and dummy in nature, final lists may vary in the final deliverable

LIST OF FIGURES

List of figures

  • FIG 1. Global Targeted Sequencing And Resequencing Market, research methodology
  • FIG 2. Global Targeted Sequencing And Resequencing Market, Market estimation techniques
  • FIG 3. Global Market size estimates & forecast methods
  • FIG 4. Global Targeted Sequencing And Resequencing Market, key trends 2021
  • FIG 5. Global Targeted Sequencing And Resequencing Market, growth prospects 2022-2029
  • FIG 6. Global Targeted Sequencing And Resequencing Market, porters 5 force model
  • FIG 7. Global Targeted Sequencing And Resequencing Market, pest analysis
  • FIG 8. Global Targeted Sequencing And Resequencing Market, value chain analysis
  • FIG 9. Global Targeted Sequencing And Resequencing Market by segment, 2019 & 2029 (USD Billion)
  • FIG 10. Global Targeted Sequencing And Resequencing Market by segment, 2019 & 2029 (USD Billion)
  • FIG 11. Global Targeted Sequencing And Resequencing Market by segment, 2019 & 2029 (USD Billion)
  • FIG 12. Global Targeted Sequencing And Resequencing Market by segment, 2019 & 2029 (USD Billion)
  • FIG 13. Global Targeted Sequencing And Resequencing Market by segment, 2019 & 2029 (USD Billion)
  • FIG 14. Global Targeted Sequencing And Resequencing Market, regional snapshot 2019 & 2029
  • FIG 15. North America Targeted Sequencing And Resequencing Market 2019 & 2029 (USD Billion)
  • FIG 16. Europe Targeted Sequencing And Resequencing Market 2019 & 2029 (USD Billion)
  • FIG 17. Asia pacific Targeted Sequencing And Resequencing Market 2019 & 2029 (USD Billion)
  • FIG 18. Latin America Targeted Sequencing And Resequencing Market 2019 & 2029 (USD Billion)
  • FIG 19. Global Targeted Sequencing And Resequencing Market, company Market share analysis (2021)

List of tables and figures and dummy in nature, final lists may vary in the final deliverable

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