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PUBLISHER: Daedal Research | PRODUCT CODE: 1264088

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PUBLISHER: Daedal Research | PRODUCT CODE: 1264088

Global Custom Synthesis & Manufacturing (CSM) Market: Analysis By Application (Pharmaceutical, Agrochemical, and Others), By Region Size and Trends with Impact of COVID-19 and Forecast up to 2028

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The global custom synthesis and manufacturing market was valued at US$271.33 billion in 2022. The market value is expected to reach US$474.94 billion by 2028. Custom synthesis manufacturing (CSM) refers to the process of manufacturing a specific chemical compound, material, or product according to the specific requirements and specifications of a customer. This process involves the synthesis of a desired compound or material that is not readily available in the market or cannot be obtained through standard manufacturing processes.

The contract synthesis and manufacturing (CSM) provides several benefits, including cost-effectiveness, specialization, flexibility, regulatory compliance, and speed to market. Custom Synthesis and Manufacturing (CSM) is on the rise across the world, driven by strong growth in end-use demand, innovators shifting focus to core competencies and outsourcing of production to low manufacturing cost destinations. The CSM market is expected to continue to grow due to the increasing demand for pharmaceuticals, growing complexity of drugs, advancements in technology, increasing patent expiry, and growing trend of green manufacturing. The market is expected to grow at a CAGR of approx. 10% during the forecasted period of 2023-2028.

Market Segmentation Analysis:

By Application: The report provides the custom synthesis and manufacturing market analysis based on applications: Pharmaceutical, Agrochemical, and Others. The pharmaceutical segment held the highest share in the market and is also expected to be the fastest-growing segment in the forecasted period. The pharmaceutical industry requires a wide range of specialty chemicals, intermediates, and APIs (active pharmaceutical ingredients) to develop and manufacture drugs. Many pharmaceutical companies outsource these activities to third-party CROs (contract research organizations) and CMOs (contract manufacturing organizations) to reduce costs and increase efficiency. Thus, the increasing trend of outsourcing is driving market growth.

By Region: The report provides insight into the custom synthesis and manufacturing market based on the regions namely, North America, Asia Pacific, Europe, and the Rest of the World. North America held the highest share of the market The pharmaceutical industry is growing at a consistent pace in North America, with a large number of biotech and pharma companies operating in the region. Morever the US has a large pool of population suffering from health diseases. For instance, according to the article US Health Care from a Global Perspective, 2022, the US has the highest rate of people with multiple chronic conditions and an obesity rate nearly twice the OECD average. Therefore, owing to the high rate of people suffering from chronic diseases along with the increasing health spending contributes to the growth of the pharmaceutical industry. These factors are driving the demand for CSM services.

Asia Pacific is expected to be the fastest-growing region in the forthcoming years. Within Asia Pacific, India provides lucrative opportunities to the overall CSM industry. The main drivers of the Indian CSM market include the rising trend of contract manufacturing of fine chemicals along with niche specialty chemicals in India. Many global companies are preferring investment in contract manufacturing in India. Moreover, market growth is driven by research & development of new molecules/chemistries developed followed by willingness for reduced capital investments in the overall fine chemicals segment.

Market Dynamics:

Growth Drivers: The global custom synthesis and manufacturing market growth is predicted to be supported by numerous growth drivers such as the growing pharmaceutical industry, rising agrochemical industry growth, surging cases of cancer, escalating pharma research and development spending, increasing demand for specialty chemicals, increasing regulatory compliance requirement, increasing outsourcing trend, and many other factors. There are several regulatory compliance requirements that chemical and drug manufacturers must follow to ensure the safety and efficacy of their products. For instance, Good Manufacturing Practice ensures that drugs and APIs are consistently produced and controlled according to quality standards. Regulatory compliance requirements for the manufacturing of chemicals and drugs are becoming increasingly stringent, particularly in developed countries. As a result, many companies are turning to custom synthesis and manufacturing services to ensure compliance with regulations and reduce the risk of non-compliance.

Challenges: However, the market growth would be negatively impacted by various challenges such as cost pressure, talent shortage, etc.

Trends: The market is projected to grow at a fast pace during the forecast period, due to various latest trends such as integration of AI/MI, increasing patent expiry, technological advancement, green manufacturing, increasing role of automation and robotics, etc. When a drug or chemical's patent expires, it opens up opportunities for generic drug manufacturers and other companies to produce and sell the same drug or chemical. This often leads to increased competition, which in turn drives down the price of the drug or chemical. As a result, many pharmaceutical and chemical companies are increasingly turning to custom synthesis and manufacturing services to reduce costs and increase efficiency.

Impact Analysis of COVID-19 and Way Forward:

The COVID-19 pandemic had a mixed impact on the custom synthesis and manufacturing (CSM) market in 2020. On one hand, there was an increased demand for certain pharmaceutical products and ingredients, as well as for diagnostic and testing reagents, which drove growth in the CSM market. On the other hand, disruptions in global supply chains, production shutdowns, and reduced demand for non-essential products due to lockdowns and restrictions imposed by governments worldwide had negatively impacted the market. One of the major impacts of the pandemic on the CSM market has been an increased focus on digitization and automation. Overall, while the pandemic has caused significant disruption in the CSM market, it has also presented opportunities for innovation and growth in the long term.

Competitive Landscape:

The global custom synthesis and manufacturing market is fragmented. The key players in the global custom synthesis and manufacturing market are:

Thermo Fisher Scientific Inc. (Alfa Aesar)

PI Industries Ltd.

Aragen Life Sciences Private Ltd.

Seikagaku Corporation (Dalton Pharma Services)

Navin Fluorine International Ltd. (Manchester Organics Ltd.)

Anupam Rasayan India Ltd.

Divi's Laboratories Ltd.

Taros Chemicals GmbH & Co. KG

Solvias AG

Matrix Fine Chemicals GmbH

Cambrex

Tokyo Chemical Industry Co., Ltd.

Some of the strategies among key players in the market are opening new facilities, mergers, acquisitions, and collaborations. Aragen operationalize cutting-edge formulation manufacturing facility in Hyderabad. The 12,000 square feet new facility would strengthen the company's ability to deliver clinical supplies to customers through the company's integrated drug substance and drug product development and manufacturing. On the other hand, in 2023, Taros Chemicals announced a strategic partnership to provide clients with integrated drug discovery and development services spanning from hit generation to pre-clinical development. Through this unique partnership, global pharmaceutical and biotech companies would now take advantage of a one-stop-shop access to Taros' synthetic and medicinal chemistry expertise covering hit identification, hit to lead and lead optimization as well as drug design and molecular modelling services.

Table of Contents

    1. Executive Summary

    2. Introduction

    • 2.1 Custom Synthesis and Manufacturing (CSM): An Overview
      • 2.1.1 Introduction to Custom Synthesis and Manufacturing (CSM)
      • 2.1.2 Custom Synthesis and Manufacturing Advantages
    • 2.2 Custom Synthesis and Manufacturing Segmentation: An Overview
      • 2.2.1 Custom Synthesis and Manufacturing Segmentation

    3. Global Market Analysis

    • 3.1 Global Custom Synthesis and Manufacturing Market: An Analysis
      • 3.1.1 Global Custom Synthesis and Manufacturing Market: An Overview
      • 3.1.2 Global Custom Synthesis and Manufacturing Market by Value
      • 3.1.3 Global Custom Synthesis and Manufacturing Market by Application (Pharmaceutical, Agrochemical, and Others)
      • 3.1.4 Global Custom Synthesis and Manufacturing Market by Region (North America, Asia Pacific, Europe, and Rest of the World)
    • 3.2 Global Custom Synthesis and Manufacturing Market: Application Analysis
      • 3.2.1 Global Custom Synthesis and Manufacturing Market by Application: An Overview
      • 3.2.2 Global Pharmaceutical Custom Synthesis and Manufacturing Market by Value
      • 3.2.3 Global Agrochemical Custom Synthesis and Manufacturing Market by Value
      • 3.2.4 Global Others Custom Synthesis and Manufacturing Market by Value

    4. Regional Market Analysis

    • 4.1 North America Custom Synthesis and Manufacturing Market: An Analysis
      • 4.1.1 North America Custom Synthesis and Manufacturing Market: An Overview
      • 4.1.2 North America Custom Synthesis and Manufacturing Market by Value
      • 4.1.3 North America Custom Synthesis and Manufacturing Market by Region (US, Canada, and Mexico)
      • 4.1.4 The US Custom Synthesis and Manufacturing Market by Value
      • 4.1.5 Canada Custom Synthesis and Manufacturing Market by Value
      • 4.1.6 Mexico Custom Synthesis and Manufacturing Market by Value
    • 4.2 Asia Pacific Custom Synthesis and Manufacturing Market: An Analysis
      • 4.2.1 Asia Pacific Custom Synthesis and Manufacturing Market: An Overview
      • 4.2.2 Asia Pacific Custom Synthesis and Manufacturing Market by Value
      • 4.2.3 Asia Pacific Custom Synthesis and Manufacturing Market by Region (China, Japan, India, and Rest of the Asia Pacific)
      • 4.2.4 China Custom Synthesis and Manufacturing Market by Value
      • 4.2.5 Japan Custom Synthesis and Manufacturing Market by Value
      • 4.2.6 India Custom Synthesis and Manufacturing Market by Value
      • 4.2.7 India Custom Synthesis and Manufacturing Market by Application Area (Generic Molecules and Patented Molecules)
      • 4.2.8 India Custom Synthesis and Manufacturing Market by Application (Pharmaceutical, Agrochemical, and Others)
      • 4.2.9 India Pharmaceutical Custom Synthesis and Manufacturing Market by Value
      • 4.2.10 India Agrochemical Custom Synthesis and Manufacturing Market by Value
      • 4.2.11 India Others Custom Synthesis and Manufacturing Market by Value
      • 4.2.12 Rest of Asia Pacific Custom Synthesis and Manufacturing Market by Value
    • 4.3 Europe Custom Synthesis and Manufacturing Market: An Analysis
      • 4.3.1 Europe Custom Synthesis and Manufacturing Market: An Overview
      • 4.3.2 Europe Custom Synthesis and Manufacturing Market by Value
      • 4.3.3 Europe Custom Synthesis and Manufacturing Market by Region (Germany, The UK, France, Italy, Spain, and Rest of the Europe)
      • 4.3.4 Germany Custom Synthesis and Manufacturing Market by Value
      • 4.3.5 UK Custom Synthesis and Manufacturing Market by Value
      • 4.3.6 France Custom Synthesis and Manufacturing Market by Value
      • 4.3.7 Italy Custom Synthesis and Manufacturing Market by Value
      • 4.3.8 Spain Custom Synthesis and Manufacturing Market by Value
      • 4.3.9 Rest of Europe Custom Synthesis and Manufacturing Market by Value
    • 4.4 Rest of World Custom Synthesis and Manufacturing Market: An Analysis
      • 4.4.1 Rest of World Custom Synthesis and Manufacturing Market: An Overview
      • 4.4.2 Rest of World Custom Synthesis and Manufacturing Market by Value

    5. Impact of COVID-19

    • 5.1 Impact of COVID-19 on Global Custom Synthesis & Manufacturing Market
    • 5.2 Post COVID-19 Impact on Global Custom Synthesis & Manufacturing Market

    6. Market Dynamics

    • 6.1 Growth Driver
      • 6.1.1 Growing Pharmaceutical Industry
      • 6.1.2 Rising Agrochemical Industry Growth
      • 6.1.3 Increasing Cases of Cancer
      • 6.1.4 Surging Pharma Research and Development Spending
      • 6.1.5 Escalating Demand for Specialty Chemicals
      • 6.1.6 Increasing Regulatory Compliance Requirement
      • 6.1.7 Rising Outsourcing Trend
    • 6.2 Challenges
      • 6.2.1 Cost Pressure
      • 6.2.2 Talent Shortage
    • 6.3 Market Trends
      • 6.3.1 Integration of AI/MI
      • 6.3.2 Increasing Patent Expiry
      • 6.3.3 Technological Advancements
      • 6.3.4 Green Manufacturing
      • 6.3.5 Increasing Role of Automation and Robotics

    7. Competitive Landscape

    • 7.1 India Custom Synthesis and Manufacturing Market: Key Comparison
    • 7.2 Global Agrochemical Players by Market Share

    8. Company Profiles

    • 8.1 Thermo Fisher Scientific Inc. (Alfa Aesar)
      • 8.1.1 Business Overview
      • 8.1.2 Operating Segments
      • 8.1.3 Business Strategy
    • 8.2 PI Industries Ltd.
      • 8.2.1 Business Overview
      • 8.2.2 Revenue by Product
      • 8.2.3 Business Strategy
    • 8.3 Aragen Life Sciences Private Ltd.
      • 8.3.1 Business Overview
      • 8.3.2 Revenue by Region
      • 8.3.3 Business Strategy
    • 8.4 Seikagaku Corporation (Dalton Pharma Services)
      • 8.4.1 Business Overview
      • 8.4.2 Operating Segments
      • 8.4.3 Business Strategy
    • 8.5 Navin Fluorine International Ltd. (Manchester Organics Ltd.)
      • 8.5.1 Business Overview
      • 8.5.2 Revenue by Region
    • 8.6 Anupam Rasayan India Ltd.
      • 8.6.1 Business Overview
      • 8.6.2 Revenue by Business Segment
    • 8.7 Divi's Laboratories Ltd.
      • 8.7.1 Business Overview
      • 8.7.2 Operating Regions
    • 8.8 Taros Chemicals GmbH & Co. KG
      • 8.8.1 Business Overview
      • 8.8.2 Business Strategy
    • 8.9 Solvias AG
      • 8.9.1 Business Overview
      • 8.9.2 Business Strategy
    • 8.10 Matrix Fine Chemicals GmbH
      • 8.10.1 Business Overview
      • 8.10.2 Business Strategy
    • 8.11 Cambrex
      • 8.11.1 Business Overview
      • 8.11.2 Business Strategy
    • 8.12 Tokyo Chemical Industry Co., Ltd.
      • 8.12.1 Business Overview

List of Tables

  • Table 1: List of Active Ingredients Go Off-patent
  • Table 2: India Custom Synthesis and Manufacturing Market: Key Comparison

List of Figures

  • Figure 1: Custom Synthesis and Manufacturing Advantages
  • Figure 2: Custom Synthesis and Manufacturing Segmentation
  • Figure 3: Global Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 4: Global Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 5: Global Custom Synthesis and Manufacturing Market by Application; 2022 (Percentage, %)
  • Figure 6: Global Custom Synthesis and Manufacturing Market by Region; 2022 (Percentage, %)
  • Figure 7: Global Pharmaceutical Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 8: Global Pharmaceutical Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 9: Global Agrochemical Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 10: Global Agrochemical Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 11: Global Others Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 12: Global Others Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 13: North America Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 14: North America Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 15: North America Custom Synthesis and Manufacturing Market by Region; 2022 (Percentage, %)
  • Figure 16: The US Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 17: The US Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 18: Canada Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 19: Canada Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 20: Mexico Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 21: Mexico Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 22: Asia Pacific Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 23: Asia Pacific Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 24: Asia Pacific Custom Synthesis and Manufacturing Market by Region; 2022 (Percentage, %)
  • Figure 25: China Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 26: China Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 27: Japan Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 28: Japan Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 29: India Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 30: India Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 31: India Custom Synthesis and Manufacturing Market by Application Area; 2022 (Percentage, %)
  • Figure 32: India Custom Synthesis and Manufacturing Market by Application; 2022 (Percentage, %)
  • Figure 33: India Pharmaceutical Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 34: India Pharmaceutical Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 35: India Agrochemical Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 36: India Agrochemical Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 37: India Others Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 38: India Others Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 39: Rest of Asia Pacific Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 40: Rest of Asia Pacific Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 41: Europe Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 42: Europe Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 43: Europe Custom Synthesis and Manufacturing Market by Region; 2022 (Percentage, %)
  • Figure 44: Germany Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 45: Germany Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 46: UK Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 47: UK Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 48: France Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 49: France Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 50: Italy Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 51: Italy Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 52: Spain Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 53: Spain Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 54: Rest of Europe Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 55: Rest of Europe Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 56: Rest of World Custom Synthesis and Manufacturing Market by Value; 2018-2022 (US$ Billion)
  • Figure 57: Rest of World Custom Synthesis and Manufacturing Market by Value; 2023-2028 (US$ Billion)
  • Figure 58: Europe Pharmaceutical Sales Per Capita by Region; 2018-2021 (US$)
  • Figure 59: Global Agricultural Chemicals Market Value; 2021-2030 (US$ Billion)
  • Figure 60: The US New Cancer Cases; 2019-2022 (Million)
  • Figure 61: Global Spending on Pharmaceutical Research and Development; 2019-2028 (US$ Billion)
  • Figure 62: Global Specialty Chemicals Industry by Region; 2015-2025 (US$ Billion)
  • Figure 63: Global AI Market Revenue; 2020-2023 (US$ Billion)
  • Figure 64: Global Agrochemical Players by Market Share; 2022 (Percentage, %)
  • Figure 65: Thermo Fisher Scientific Inc. Revenues by Segments; 2022 (Percentage, %)
  • Figure 66: PI Industries Ltd. Revenue by Product; 2022 (Percentage, %)
  • Figure 67: Aragen Life Sciences Private Ltd. Revenue by Region; 2022 (Percentage, %)
  • Figure 68: Seikagaku Corporation Net Sales by Segment; 2022 (Percentage, %)
  • Figure 69: Navin Fluorine International Ltd. Revenue by Region; 2022 (Percentage, %)
  • Figure 70: Anupam Rasayan India Ltd. Revenue by Business Segment; 2022 (Percentage, %)
  • Figure 71: Divi's Laboratories Ltd. Revenue by Region; 2022 (Percentage, %)
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