PUBLISHER: DelveInsight | PRODUCT CODE: 1048311
PUBLISHER: DelveInsight | PRODUCT CODE: 1048311
DelveInsight's, "Antisense Oligonucleotide Therapeutics - Pipeline Insight, 2022" report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Antisense Oligonucleotide Therapeutics pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Antisense Oligonucleotide Therapeutics Understanding
Antisense Oligonucleotide Therapeutics: Overview
Antisense oligonucleotide (ASOs) are small-sized single-stranded nucleic acids that offer advantages over siRNAs in terms of targeting both nuclear and cytoplasmic located lncRNAs. Antisense oligonucleotide-based therapeutics involves downregulation of gene expression. Antisense oligonucleotides (AOs) are a class of synthetic nucleic acid molecules that are capable of regulating gene expression through binding to premature or mature messenger RNA (mRNA) targets. Antisense oligonucleotides (ASOs), known as genetic materials, are promising agents used in the regulation of unsuitable expression of genes in pathological situations by the specific inhibition of expression of their mRNA targets. By capitalizing "antisense" DNA approach, the overexpressed proteins can be blocked in several diseases such as cancer, neurological diseases, cardiovascular diseases, inflammation and autoimmune diseases, infectious diseases, etc. ASOs are emerging as a class of therapeutics with high potential to treat diseases affecting the CNS.
Antisense Oligonucleotide Therapeutics Emerging Drugs Chapters
This segment of the Antisense Oligonucleotide Therapeutics report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Antisense Oligonucleotide Therapeutics Emerging Drugs
Cobitolimod is a Toll-like receptor 9 (TLR9) agonist that can provide an anti-inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis. Cobitolimod is a DNA-based ImmunoModulatory Sequence (DIMS) that is administered locally inside the large intestine, where it binds to Toll-like receptor 9 (TLR9) present inside immune cells as well as on the surface of epithelial cells. Cobitolimod is a first in class treatment that can provide a local anti-inflammatory effect, which can lead to healing of the mucosa and improvement of clinical symptoms. Cobitolimod is has a very limited systemic absorption. US Food and Drug Administration (FDA) has granted orphan-drug designation for the drug candidate cobitolimod for treatment of ulcerative colitis in pediatric patients.
Prexigebersen (previously BP 100-1-01) is a neutral-charge, liposomal-delivered antisense cancer drug. It is designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2). Bio-Path is currently evaluating prexigebersen in Phase II program for the treatment of acute myeloid leukemia (AML). Prexigebersen has received orphan drug designation from the FDA and from the European Medicines Agency for AML.
Further product details are provided in the report……..
Antisense Oligonucleotide Therapeutics: Therapeutic Assessment
This segment of the report provides insights about the different Antisense Oligonucleotide Therapeutics drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 15+ key companies which are developing the Antisense Oligonucleotide Therapeutics. The companies which have their Antisense Oligonucleotide Therapeutics drug candidates in the most advanced stage, i.e. Phase III include, InDex Pharmaceuticals.
DelveInsight's report covers around 15+ products under different phases of clinical development like
Antisense Oligonucleotide Therapeutics pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
Antisense Oligonucleotide Therapeutics: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Antisense Oligonucleotide Therapeutics therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Antisense Oligonucleotide Therapeutics drugs.
Key Questions
Current Scenario and Emerging Therapies:
Key Players
Key Products
Introduction
Executive Summary
Antisense Oligonucleotide Therapeutics: Overview
Pipeline Therapeutics
Therapeutic Assessment
Antisense Oligonucleotide Therapeutics - DelveInsight's Analytical Perspective
In-depth Commercial Assessment
Antisense Oligonucleotide Therapeutics Collaboration Deals
Late Stage Products (Phase III)
Cobitolimod: InDex Pharmaceuticals
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Prexigebersen: Bio-Path Holdings
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
ION 736: Ionis Pharmaceuticals/AstraZeneca
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
NT0100: NeuBase Therapeutics
Drug profiles in the detailed report…..
Inactive Products
Antisense Oligonucleotide Therapeutics Key Companies
Antisense Oligonucleotide Therapeutics Key Products
Antisense Oligonucleotide Therapeutics- Unmet Needs
Antisense Oligonucleotide Therapeutics- Market Drivers and Barriers
Antisense Oligonucleotide Therapeutics- Future Perspectives and Conclusion
Antisense Oligonucleotide Therapeutics Analyst Views
Antisense Oligonucleotide Therapeutics Key Companies
Appendix