PUBLISHER: DelveInsight | PRODUCT CODE: 1116916
PUBLISHER: DelveInsight | PRODUCT CODE: 1116916
DelveInsight's, 'Genital Warts (Condyloma Acuminatum)-Market Insights, Epidemiology, and Market Forecast-2032' report delivers an in-depth understanding of the Genital Warts, historical and forecasted epidemiology as well as the Genital Warts market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan, and China.
The Genital Warts market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM+China Genital Warts market size from 2019 to 2032. The Report also covers current Genital Warts treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Study Period: 2019-2032
Human papillomavirus (HPV) is a small, nonenveloped, double-stranded DNA virus. Most of the HPV-related diseases and research are focused on HPV types within the alpha group. Individual types are further classified as high-risk (e.g., HPV16 and 18) and low-risk HPV (e.g., HPV6 and 11) based on oncogenic potential. E6 and E7 are the main oncoproteins, with E6 binding to p53.
Genital warts (also known as anogenital warts, condylomata acuminata, condylomas) are benign proliferative lesions caused by human papillomavirus (HPV) types 6 and 11, which are found in >95% of lesions. Genital warts (GWs) are transmitted by having sexual contact with someone who already has them and may be found on the outside of genitals. Some types, which cause cancer, result in the growth of lesions on a woman's cervix. It is possible to get genital warts, HPV infection, even if they are not visible. Besides, they look like flesh-colored bumps that have a cauliflower-like appearance, and are usually flat, papular, or pedunculated growths on the genital mucosa, occurring in clusters.
Genital Warts Diagnosis
Clinical diagnosis of GW is based on the appearance of warts, whereas histopathological diagnosis is not routinely indicated. Nucleic Acid Amplification Test for HPV DNA is also recommended. Accurate diagnosis is an essential first step in the treatment of GWs. Also, Pap test, HPV tests and newer technologies like Dermatoscopy are being used.
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Genital Warts Treatment
The current options available for the treatment of GWs are primarily centered upon removal of the warty growth rather than elimination of the underlying viral infection. Common treatments include topical therapeutic agents; physical removal of warts with cryotherapy, electrocautery or lasers; or photodynamic therapy along with vaccines. The criteria for warts treatment, developed by the American Academy of Dermatology include: the patient's desire for therapy, symptoms of pain, bleeding, itching or burning; (3) disabling or disfiguring lesions; (4) large numbers or large sizes of lesions; (5) the patient's desire to prevent the spread of warts to unblemished skin of self or others; and (6) an immunocompromised condition.
There are currently three approved vaccines for the prevention of HPV infection, Gardasil (recombinant HPV quadrivalent vaccine, Types 6, 11, 16, and 18; Merck), Gardasil (recombinant HPV nonavalent vaccine; Merck) and Cervarix (recombinant HPV bivalent vaccine, Types 16 and 18; GlaxoSmithKline). The vaccines are prepared from viral proteins but do not contain viral DNA. Therefore, neither vaccine can cause HPV infection. Both vaccines were designed for the prevention of HPV infection and did not treat existing HPV infection or disease. The therapeutic pipeline is active with many novel topical formulations like SB206, VP-102 and others in development.
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The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Incident cases of Genital Warts, Gender-specific Incident Cases of Genital Warts, Age-specific Incident Cases of Genital Warts, and Anatomical Location of GWs in Incident Population in the 7MM+China covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), Japan, and China from 2019 to 2032.
Key Findings
The epidemiology segment also provides the Genital Warts epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan, and China.
The drug chapter segment of the Genital Warts report encloses the detailed analysis of Genital Warts marketed drugs, mid-phase, and late-stage pipeline drugs. It also helps to understand the Genital Warts clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details of each included drug and the latest news and press releases.
Genital Warts Marketed Drugs
Imiquimod: Medicis Pharmaceuticals
Imiquimod (Zyclara/Aldara) is an immune response modifier. It is a prescription medicine used to treat actinic keratosis (a condition caused by extensive sun exposure) on the face and scalp of adults who are over 18 years of age. It is also used to treat genital warts that appear on the outside of the body in adults and children who are at least 12 years old. This medicine is not a cure for genital warts.
Imiquimod, under brand Aldara cream (5%) was approved by FDA in 1997 for the treatment of external genital warts and perianal warts for patients 12 years or older. The drug was manufactured by 3M pharmaceuticals. In 2004, the drug was also approved for biopsy-confirmed, primary superficial basal cell carcinoma. Additionally, the drug was also licensed for Actinic Keratosis by FDA.
European Medicine Agency (EMA) on September 18, 1998, approved the medical use of Imiquimod (5%) whereas it was further accepted by Pharmaceuticals and Medicals Devices Agency of Japan (PMDA) on August 31, 2007.
Products detail in the report…
Veregen (Polyphenon E): Aresus Pharma
Veregen, first drug in its class for the local treatment of genital warts, is based on a defined extract of green tea leaves produced in a complex and specifically developed process. Veregen was the first and is one of the few innovative herbal medicines which were approved by the US Food and Drug Administration (FDA).
Veregen (sinecatechins) ointment, 15% is a botanical drug product for topical use. The drug substance in Veregen is sinecatechins, which is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85-95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg), and some additional minor catechin derivatives, i.e., Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves (MediGene, 2008).
Products detail in the report…
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Genital Warts Emerging Drugs
VP-102: Verrica Pharmaceuticals
VP-102 is a proprietary drug-device combination of 0.7% w/v cantharidin delivered via a single-use precision applicator. The active ingredient, cantharidin, is a naturally occurring vesicant that causes the degradation of desmosomal plaques. It is topical, applied directly to the lesions, and designed to be convenient for both patients and practitioners. Verrica is also advancing its lead product, VP-102, a proprietary topical therapy, in many common skin indications, including molluscum contagiosum and verruca vulgaris (common warts) (Verrica Pharmaceuticals, 2022).
Products detail in the report…
Ranpirnase (RanTop): Tamir Biotechnology
Orgenesis completed its pre-Investigational New Drug ("IND") consultation with the US FDA regarding the development of RanTop® (Ranpirnase topical gel) for the treatment of anogenital warts. The company is on track to start Phase II trials in this indication after completing the FDA pre-IND requests. Two Phase I/IIa trials were previously completed for the treatment of AGW caused by human papillomavirus. In both these trials, Ranpirnase 0.1% gel was applied twice daily to the affected areas for up to 8 weeks. The results demonstrated the product's tolerability and signs of preliminary clinical efficacy (Orgenesis Inc., 2021).
Products detail in the report…
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The current therapeutic options available for the treatment of GW are largely centered upon removal of the warts. There is little evidence to suggest that existing treatments are effective in the long-term eradication of genital warts or that they play any significant role in reducing the relapse rate of disease. A wide range of therapies are presently in use, which are highly variable and can differ dramatically with respect to cost, side-effect profiles, dosing schedules, duration of treatment, and overall effectiveness. The DelveInsight's, market forecast focus on the market revenue generated by pharmacological therapies (including all the currently used chemical therapies) prescribed for the management of genital warts and doesn't comprise the revenue generated by devices &/or surgical procedures (such as Cryotherapy, Electrosurgery, Scissor excision or laser removal of warts) or prophylaxis measures (Gradasil or Cervarix). The market is subdivided bases of mode of treatment that is either Topical or Systemic treatment.
Along with the topical therapies, there are a variety of treatment options for genital warts. No data shows the superiority of one treatment over another. Moreover, few data are available from direct head-to-head comparisons of treatments. It would be beneficial to carry out a high quality study to compare directly the preferred treatment options to make better informed decisions. According to an article by Hoy et al. (2009), it is estimated that treatment regimens involving patient-applied therapies include almost 40% of individuals, and slightly more than one-half of these individuals are treated with physician-applied therapies.
In emerging scenario, companies such as Verrica Pharmaceuticals, Tamir Biotechnology and Novan Inc. are conducting late phase clinical trials for topical treatment of genital warts.
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Key Findings
This section provides the total Genital Warts market size and; market size by therapies in the United States.
The total Genital Warts market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.
The total Genital Warts market size and market size by therapies in Japan are provided.
The total Genital Warts market size and market size by therapies in China are provided.
This section focuses on the rate of uptake of the potential drugs recently launched in the Genital Warts market or expected to get launched in the market during the study period 2019-2032. The analysis covers Genital Warts market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
Genital Warts Development Activities
The report provides insights into different therapeutic candidates in phase II, and phase III stages. It also analyzes key players involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition, and merger, licensing, and patent details for Genital Warts emerging therapies.
Reimbursement Scenario in Genital Warts
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
Competitive Intelligence Analysis
We perform competitive and market Intelligence analysis of the Genital Warts market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.
Key Questions
Market Insights:
Epidemiology Insights:
Current Treatment Scenario, Marketed Drugs, and Emerging Therapies: