Market Research Report
Hypoparathyroidism - Market Insight, Epidemiology And Market Forecast - 2032
|Hypoparathyroidism - Market Insight, Epidemiology And Market Forecast - 2032|
DelveInsight Business Research LLP
Content info: 140 Pages
Delivery time: 2-10 business days
DelveInsight's 'Hypoparathyroidism -Market Insights, Epidemiology, and Market Forecast-2032' report deliver an in-depth understanding of the Hypoparathyroidism , historical and forecasted epidemiology as well as the Hypoparathyroidism market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.
The Hypoparathyroidism market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Hypoparathyroidism market size from 2019 to 2032. The Report also covers current Hypoparathyroidism treatment practice, market drivers, market barriers, SWOT analysis, reimbursement, and market access, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Hypoparathyroidism (hypoPTH) is a rare condition in which the parathyroid glands fail to produce sufficient amounts of parathyroid hormone or lacks biological activity. The parathyroid glands are part of the endocrine system-the network of glands that secrete hormones into the bloodstream, where they travel to various body areas. These hormones regulate the chemical processes (metabolism) that influence various organs and activities within the body. Hormones are involved in numerous vital processes, including regulating heart rate, body temperature, blood pressure, cell differentiation and growth, and modulation of several metabolic processes. Parathyroid hormone (along with vitamin D and the hormone calcitonin, which is produced by the thyroid gland) plays a role in regulating the levels of calcium and phosphorus in the blood and in determining bone growth and bone cell activity. Due to a deficiency of the parathyroid hormone, individuals may exhibit abnormally low levels of calcium in the blood (hypocalcemia) and high levels of phosphorus (hyperphosphatemia).
A diagnosis of hypoPTH is made based upon the identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests. Blood tests can reveal abnormal levels of calcium, phosphorus, magnesium, creatinine, and intact parathyroid hormone. Urine tests can reveal if the body is excreting too much calcium.
In addition, the Food and Drug Administration (FDA) has approved the use of the synthetic parathyroid hormone teriparatide as a diagnostic agent to distinguish hypoPTH from pseudohypoparathyroidism.
Additional tests may be performed to detect complications that may be associated with hypoPTH. For example, an electrocardiogram, a test that records the heart's electrical activity, can reveal arrhythmias that are sometimes associated with low calcium levels and hypoPTH. An ophthalmologic exam should also be done to check for cataracts.
Unlike most other hormonal deficits, hypoPTH is not treated with replacing the missing hormone, parathyroid hormone (PTH).
Currently, the standard treatment consists of activated vitamin D (calcitriol) and calcium supplements. Some people may also need magnesium supplementation. Conventional therapy requires many pills taken throughout the day.
Diet recommendations usually include eating foods high in calcium, such as dairy products, breakfast cereals, fortified orange juice, and green, leafy vegetables, or avoiding foods high in phosphorus, such as meat, poultry, fish, nuts, whole grains, and beans. Conventional therapy with vitamin D and calcium may lead to a buildup of calcium in the kidneys. This buildup may lead to problems, including kidney stones and deposits of calcium, reduced kidney function, tissue damage, or even kidney failure. In January 2015, the US Food and Drug Administration approved PTH 1-84 for adult hypoPTH patients who do not respond well to standard treatment as an add-on to that treatment
The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Cases of Hypoparathyroidism, Diagnosed Prevalent Cases of Hypoparathyroidism, Gender-specific Diagnosed Prevalent Cases of Hypoparathyroidism, Type-specific Diagnosed Prevalent Cases of Hypoparathyroidism, Cause-specific Diagnosed Prevalent Cases of Hypoparathyroidism and Age-specific Diagnosed Prevalent Cases of Hypoparathyroidism scenario in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2019 to 2032.
The epidemiology segment also provides the Hypoparathyroidism epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
TransCon PTH is an investigational prodrug of parathyroid hormone (PTH) and is under development as a once-daily hormone replacement therapy. It is designed to restore physiologic levels of PTH for 24 h each day. The company believes that this therapy can address both the short-term symptoms and long-term complications of hypoparathyroidism (HP).
The company's goal is to provide a PTH replacement therapy that normalizes serum and urinary calcium, as well as serum phosphate levels, and improves the quality of life. In September 2020, the company submitted an amendment to IND to initiate PaTHway, a global Phase III clinical trial evaluating the safety, tolerability, and efficacy of the therapy in adults with HP following discussions with FDA and European regulatory authorities. In addition, the company is planning to conduct a Phase III study in Japan designed to evaluate the safety, tolerability, and efficacy of the therapy
EB612, an oral human parathyroid hormone (1-34) (PTH), the parathyroid glands are part of the endocrine system, a network of glands that secrete hormones into the bloodstream, which then travel to various areas of the body. PTH (along with vitamin D and the hormone calcitonin, which the thyroid gland produces) plays a role in regulating the levels of calcium and phosphorus in the blood. Due to a deficiency of PTH, individuals may exhibit abnormally low levels of calcium in the blood (hypocalcemia) and high levels of phosphorus (hyperphosphatemia). The common practice in treating these patients is with calcium and Vitamin D supplements at high doses in addition to other various drugs to treat the symptoms
Hypoparathyroidism is a rare condition in which the parathyroid glands fail to produce sufficient amounts of parathyroid hormone or the parathyroid hormone produced lacks biological activity. The parathyroid glands are part of the endocrine system, the network of glands that secrete hormones into the bloodstream, where they travel to various areas of the body. The severity of the condition can range from mild symptoms such as a tingling or numbness in the fingers, toes, or around the lips (paresthesias) to severe muscle cramps and muscle spasms.
The treatment of hypoparathyroidism is directed toward the specific symptoms that are apparent in each individual and the lab tests. Treatment is aimed at raising calcium levels high enough to provide symptom relief without causing abnormally high levels of calcium in the blood (hypercalcemia) or the urine (hypercalciuria). The specific therapies used may vary depending upon the disease severity, the specific symptoms present, an individual's age and overall health, personal preference, and additional factors.
Oral calcium supplements can increase calcium levels in the blood. However, at high doses, calcium supplements can cause gastrointestinal side effects, such as constipation, in some people. There are several different types of calcium supplements available. Some brands may work better for certain people. High doses of vitamin D, generally in the form of calcitriol, can help the body absorb calcium and eliminate phosphorus. Another form of vitamin D that may be used is ergocalciferol or cholecalciferol. Outside the US, doctors use alpha calcidol. Ergocalciferol and cholecalciferol have a longer duration of action than calcitriol or alpha calcidol because the former two forms of vitamin D are stored in the body for long times.
If the magnesium level is low and the patient experiences symptoms of hypoparathyroidism, the doctor may recommend taking a magnesium supplement. If the calcium levels remain low even with treatment, thiazide diuretics can help decrease the amount of calcium lost through the urine. However, some people with hypoparathyroidism, including people who inherited the condition, should not take thiazide diuretics.
Some individuals, especially those with severe symptoms due to low blood calcium levels, may require immediate relief through intravenous calcium therapy, even if their calcium levels are only mildly reduced. Intravenous therapy means that a substance (e.g., calcium) is delivered into the bloodstream through an injection or infusion directly into a vein.
Furthermore, some may be encouraged to make dietary changes to help treat their condition. Affected individuals may be encouraged to eat foods high in calcium, such as dairy products, breakfast cereals, and fortified orange juice, and green, leafy vegetables.
This section provides the total Hypoparathyroidism market size and; market size by therapies in the United States.
The total Hypoparathyroidism market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.
The total Hypoparathyroidism market size and market size by therapies in Japan are provided.
This section focuses on the rate of uptake of the potential drugs recently launched in the Hypoparathyroidism market or expected to get launched in the market during the study period 2019-2032. The analysis covers the Hypoparathyroidism market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs, and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.
The report covers the detailed information of collaborations, acquisition, and merger, licensing, and patent details for Hypoparathyroidism emerging therapies.
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
We perform competitive and market Intelligence analysis of the Hypoparathyroidism market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.