Developmental and Epileptic Encephalopathies (DEE) - Epidemiology Forecast - 2032

DelveInsight's "Developmental and Epileptic Encephalopathy - Epidemiology Forecast to 2032" report delivers an in-depth understanding of the DEE, historical and forecasted epidemiology as well as the DEE market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

Geographies Covered

• The United States

• EU5 (Germany, France, Italy, Spain, and the United Kingdom)

• Japan

Study Period: 2019-2032.

Developmental and Epileptic Encephalopathy Disease Understanding and Treatment Algorithm

Developmental and Epileptic Encephalopathy (DEE) refers to a group of severe epilepsies that are characterized both by seizures, which are often drug-resistant, as well as encephalopathy, which is a term used to describe significant developmental delay or even loss of developmental skills. The syndromes of epileptic encephalopathies with onset in the neonatal period, infancy, and early childhood include early myoclonic encephalopathy, Ohtahara syndrome, West syndrome, Dravet syndrome (severe myoclonic epilepsy in infancy), Lennox-Gastaut syndrome (LGS), Landau-Kleffner syndrome (LKS), Epilepsy with continuous spike-and-waves during slow-wave sleep, Doose Syndrome (myoclonic atonic epilepsy), CDKL5 deficiency disorder (CDD), Tuberous sclerosis complex (TSC), SCN8A-DEE, and KCNQ2-DEE.

DEE Diagnosis

The diagnosis of these epileptic encephalopathies begins with an EEG which should include both the sleep and wake states. Moreover, Brain computed tomography (CT) scanning, and more specifically, magnetic resonance imaging (MRI) is also indicated. These should be performed before steroid treatment, which may lead to apparent atrophy on the CT or MRI scan.

Treatment

The approach to the treatment of epileptic encephalopathy has some of the general principles and approach to pediatric epilepsy treatment. The most appropriate anti-epileptic treatment is selected based on the type of epilepsy syndrome. Antiseizure medications includes clobazam, vigabatrin, zonisamide, phenobarbital, benzodiazapines, vigabatrin, and others are used for treatment of DEE. Steroids therapies, vagus nerve stimulation, ketogenic diet and epilepsy surgery are also used for management of DEE.

DEE Epidemiology

The DEE epidemiology division provides insights about historical and current DEE patient pool and forecasted trends for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight's report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by, diagnosed prevalent cases of DEE in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan market from 2019 to 2032.

Country Wise- DEE Epidemiology

This section provides glimpse of the DEE epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

• The total diagnosed prevalent cases of DEE in the 7MM were 302,897 in 2021, growing at a CAGR of 0.31% during the study period (2019-2032).

• Epidemiology assessed for the condition showed that the US, in 2021, accounted for approximately 129,437 diagnosed prevalent cases of DEE.

• Among the EU-5 countries in 2021, Germany had the highest diagnosed prevalent population of DEE with 21,041 cases, followed by France (17,258) and UK (16,381). In contrast, Spain had the lowest cases (11,743) in 2021.

• Japan accounted for 23,798 diagnosed prevalent DEE cases in 2021.

• LGS accounted for the highest number of diagnosed prevalent cases in 7MM. 79,396 cases, were observed in 2021 which are expected to increase by 2032.

• In EU5 countries, the diagnosed prevalent cases of Tuberous sclerosis complex were highest in Germany with 4,651 in 2021.

Scope of the Report:

• The Developmental and Epileptic Encephalopathies (DEE) report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns

• The Developmental and Epileptic Encephalopathies (DEE) Epidemiology Report and Model provide an overview of the global trends of Developmental and Epileptic Encephalopathies (DEE) in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan)

• The report provides insight into the historical and forecasted patient pool of Developmental and Epileptic Encephalopathies (DEE) in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan

• The report helps recognize the growth opportunities in the 7MM for the patient population

• The report assesses the disease risk and burden and highlights the unmet needs of Developmental and Epileptic Encephalopathies (DEE)

• The report provides the segmentation of the Developmental and Epileptic Encephalopathies (DEE) epidemiology

Report Highlights:

• 11-year Forecast of Developmental and Epileptic Encephalopathies (DEE) epidemiology

• 7MM Coverage

• Prevalent and Diagnosed Cases of Developmental and Epileptic Encephalopathies (DEE)

• Cases of Developmental and Epileptic Encephalopathies (DEE) by Mutation Types

• Developmental and Epileptic Encephalopathies (DEE) Cases associated with Clinical Manifestations

KOL views

We interview, KOLs and SME's opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered

• What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Developmental and Epileptic Encephalopathies (DEE)?

• What are the key findings pertaining to the Developmental and Epileptic Encephalopathies (DEE) epidemiology across 7MM and which country will have the highest number of patients during the forecast period (2019-2032)?

• What would be the total number of patients of Developmental and Epileptic Encephalopathies (DEE) across the 7MM during the forecast period (2019-2032)?

• Among the EU5 countries, which country will have the highest number of patients during the forecast period (2019-2032)?

• At what CAGR the patient population is expected to grow in 7MM during the forecast period (2019-2032)?

• What is the disease risk, burden and unmet needs of Developmental and Epileptic Encephalopathies (DEE)?

• What are the currently available treatments of Developmental and Epileptic Encephalopathies (DEE)?

Reasons to buy:

The Developmental and Epileptic Encephalopathies (DEE) Epidemiology report will allow the user to -

• Develop business strategies by understanding the trends shaping and driving the global Developmental and Epileptic Encephalopathies (DEE) market

• Quantify patient populations in the global Developmental and Epileptic Encephalopathies (DEE) market to improve product design, pricing, and launch plans

• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Developmental and Epileptic Encephalopathies (DEE) therapeutics in each of the markets covered

• Understand the magnitude of Developmental and Epileptic Encephalopathies (DEE) population by its epidemiology

• The Developmental and Epileptic Encephalopathies (DEE) Epidemiology Model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources

Key Assessments

• Patient Segmentation
• Disease Risk & Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population