PUBLISHER: DelveInsight | PRODUCT CODE: 1226618
PUBLISHER: DelveInsight | PRODUCT CODE: 1226618
"WAYLIVRA Market Drug Insight and Market Forecast - 2032" report provides comprehensive insights about WAYLIVRA for Severe Hypertriglyceridemia (SHTG) in the five major markets. A detailed picture of the WAYLIVRA for severe hypertriglyceridemia in the 5MM, i.e., EU4 (Germany, France, Italy, and Spain) and the United Kingdom for the study period 2019 -2032 is provided in this report along with a detailed description of the WAYLIVRA for severe hypertriglyceridemia. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the WAYLIVRA market forecast analysis for severe hypertriglyceridemia in the 5MM, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in severe hypertriglyceridemia.
WAYLIVRA (Volanesorsen) is a self-administered, subcutaneous injection with a prefilled syringe with dosage for one-time use. It is indicated as an adjunct to diet in adult patients with genetically confirmed familial chylomicronemia syndrome (FCS) and at high risk for pancreatitis, in whom response to diet and triglyceride-lowering therapy has been inadequate.
WAYLIVRA, along with a low-fat diet, is used to reduce triglyceride blood levels in patients with FCS that has been confirmed by genetic testing. It is only given to patients in whom other medicines to reduce triglycerides have not worked and are at high risk of developing pancreatitis.
Prior to initiating WAYLIVRA, secondary causes of hypertriglyceridemia (e.g., uncontrolled diabetes, hypothyroidism) should be excluded or appropriately addressed. The recommended starting dose is 285 mg in 1.5 mL injected subcutaneously once weekly for three months. Following three months, dose frequency should be reduced to 285 mg every two weeks. However, treatment should be discontinued in patients with a reduction in serum triglycerides below 22.6 mmol/L after three months on volanesorsen 285 mg weekly.
After six months of treatment with volanesorsen, an increase of dose frequency to 285 mg weekly should be considered if the response has been inadequate in terms of serum triglyceride reduction as evaluated by the supervising-experienced specialist and in the condition that platelet counts are in the normal range. Patients should be re-down titrated to 285 mg every two weeks if the higher 285 mg once weekly dose does not provide significant additional triglyceride reduction after nine months.
The active substance in WAYLIVRA, volanesorsen, is an antisense oligonucleotide, a very short piece of synthetic RNA (a type of genetic material). It has been designed to block the production of a protein that slows down the breakdown of fats called apolipoprotein C-III. By blocking the production of this protein, the medicine reduces the level of triglycerides in the blood and, as a result, fat accumulation in the body, which is expected to reduce the risk of pancreatitis.
The report provides insights into:
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.
WAYLIVRA Analytical Perspective by DelveInsight
This report provides a detailed market assessment of WAYLIVRA for severe hypertriglyceridemia in the five major markets, i.e., EU4 (Germany, France, Italy and Spain) and the United Kingdom. This segment of the report provides forecasted sales data from 2023 to 2032.
The report provides the clinical trials information of WAYLIVRA for severe hypertriglyceridemia covering trial interventions, trial conditions, trial status, start and completion dates.
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