PUBLISHER: DelveInsight | PRODUCT CODE: 1226620
PUBLISHER: DelveInsight | PRODUCT CODE: 1226620
"VERZENIO Drug Insight and Market Forecast - 2032" report provides comprehensive insights about VERZENIO for ER +ve HER2-ve Breast Cancer in the United States. A detailed picture of the VERZENIO for ER+ve HER2-ve Breast Cancer in the United States for the study period 2019-2032 is provided in this report along with a detailed description of the VERZENIO for ER+ve HER2-ve Breast Cancer. The report provides insight about mechanism of action, dosage and administration, as well as research and development activity including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the VERZENIO market forecast, analysis for ER+ve HER2-ve Breast Cancer in the United States, descriptive analysis such as SWOT, analyst views, comprehensive overview of market competitors, and brief about other emerging therapies in ER+ve HER2-ve Breast Cancer.
VERZENIO (Abemaciclib) is indicated for the treatment of women with HR+ in combination with fulvestrant.
It is also used to treat HER2- advanced or metastatic breast cancer with disease progression following endocrine therapy. In addition, it is used as monotherapy for the treatment of adult patients with HR+, HER2- advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting.
Dosage and Administration
Mechanism of Action
Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). These kinases are activated upon binding to D-cyclins. In ER+ breast cancer cell lines, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation.
In vitro, continuous exposure to abemaciclib inhibited Rb phosphorylation and blocked progression from G1 into the S phase of the cell cycle, resulting in senescence and apoptosis. In breast cancer xenograft models, abemaciclib dosed daily without interruption as a single agent or in combination with antiestrogens resulted in a reduction of tumor size.
The report provides insights into:
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.
VERZENIO Analytical Perspective by DelveInsight
This report provides a detailed market assessment of VERZENIO in ER+ve HER2-ve Breast Cancer in the United States. This segment of the report provides forecasted sales data from 2023 to 2032.
The report provides the clinical trials information of VERZENIO in ER+ve HER2-ve Breast Cancer covering trial interventions, trial conditions, trial status, start and completion dates.
Key Questions