PUBLISHER: DelveInsight | PRODUCT CODE: 1226669
PUBLISHER: DelveInsight | PRODUCT CODE: 1226669
DelveInsight's 'Lipodystrophy - Market Insights, Epidemiology, and Market Forecast-2032' report delivers an in-depth understanding of Lipodystrophy historical and forecasted epidemiology as well as the Lipodystrophy market trends in the United States, EU4 (Germany, France, Italy and Spain), the UK, and Japan.
The Lipodystrophy market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Lipodystrophy market size. The report also covers Lipodystrophy procedure, SWOT analysis, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Study Period: 2019-2032.
Lipodystrophy is a medical condition characterized by complete or partial loss of adipose tissue. Not infrequently, lipodystrophy occurs in combination with the pathological accumulation of adipose tissue at distinct anatomical sites. Patients with lipodystrophy exhibit numerous metabolic complications, which indicate the importance of adipose tissue as an active endocrine organ. The total amount and the appropriate distribution of adipose tissue depots contribute to the metabolic state. Genetic and molecular research has improved our understanding of the mechanisms underlying lipodystrophy. Circulating hormones secreted by the adipose tissue, such as leptin and adiponectin, are greatly reduced in distinct subpopulations of patients with lipodystrophy. This finding rationalizes the use of these adipokines or agents that increase their circulating levels, such as peroxisome proliferator-activated receptor ? (PPAR?) agonists, for therapeutic purposes. Other novel therapeutic approaches, including growth hormone and growth hormone-releasing factors, are also being studied as potential additions to the therapeutic armamentarium. New insights gained from research and clinical trials could potentially revolutionize the management of this difficult-to-treat condition.
Lipodystrophies are categorized according to both the etiology (congenital or acquired) and the pattern of adipose tissue loss, which can be either generalized (affecting the whole body) or partial (affecting specific body regions).
Congenital generalized lipodystrophy (CGL), or Berardinelli¬-Seip syndrome, is a rare autosomal recessive disorder that is characterized by a near total lack of body adipose tissue. Approximately 250 cases of CGL have been described in the literature. This syndrome is ubiquitous in all geographic regions, with the highest frequency reported in Brazil.
CGL occurs most frequently in instances of parental consanguinity and is diagnosed soon after birth. Despite voracious appetites and accelerated linear growth rates, children with cGl demonstrate markedly reduced subcutaneous adiposity. CGL is also associated with diabetes mellitus, hypertriglyceridemia, hepatic steatosis, cirrhosis, acromegaloid features, and acanthosis nigricans. Cardiomyopathy, mild mental retardation, advanced bone age, cervical spine instability, and muscular weakness have also been reported. Reproductive function is severely impaired in women but usually unaffected in men. Females are commonly present with clitoromegaly, hirsutism, amenorrhea or irregular menstrual cycles, and ovarian cysts. Finally, levels of leptin and adiponectin, hormones produced in adipose tissue, are low in both sexes.
Acquired generalized lipodystrophy, or Lawrence-Seip syndrome, shares many features with CGL, including severely reduced subcutaneous adiposity, insulin resistance or diabetes mellitus, acanthosis nigricans, hypertriglyceridemia, hepatic steatosis, hypoleptinemia, and hypoadiponectinemia. In addition to reduced subcutaneous adiposity, adipose tissue is reduced in the palms, soles, and intra-abdominal areas.
The epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Cases of Lipodystrophy, Subtype-specific Cases of Lipodystrophy, Gender-specific Cases of Lipodystrophy covering the United States, the EU4 (Germany, France, Italy, Spain), UK and Japan from 2019 to 2032.
WAYLIVRA (volanesorsen), an antisense oligonucleotide inhibitor of apolipoprotein CIII (apoCIII) mRNA, is being developed by Ionis Pharmaceuticals through its subsidiary company, Akcea Therapeutics to treat familial partial lipodystrophy (FPL). Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective, progressive body fat loss (adipose tissue) from various body areas. Individuals with FPL often have reduced subcutaneous fat in the arms and legs, and the head and trunk regions may or may not have fat loss.
Mibavademab (REGN 4461) is a leptin receptor (LEPR) agonist antibody developed by Regeneron pharmaceuticals to treat generalized lipodystrophy. The drug is currently in Phase II clinical trials conducted on patients with generalized lipodystrophy and familial partial lipodystrophy.
Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for glucose reabsorption in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies, for managing type 2 diabetes mellitus. Upon oral administration, empagliflozin selectively and potently inhibits SGLT2 in the kidneys, suppressing glucose reabsorption in the proximal tubule. Inhibition of SGLT2 increases urinary glucose excretion by the kidneys, resulting in a reduction of plasma glucose levels in an insulin-independent manner.
Lipodystrophy includes a heterogeneous group of rare diseases characterized by different amounts of adipose tissue loss and several metabolic complications, including hypertriglyceridemia, steatohepatitis, and insulin resistance that may lead to severe morbidity and, sometimes, mortality. Therefore, therapy for lipodystrophy primarily consists of a conventional approach that involves standard treatments of metabolic abnormalities. Because lipodystrophy is heterogeneous, various therapeutic approaches are available, each of which has a different efficacy based on the type of illness and the patient's unique appearance. Lipodystrophy treatment aims to improve both the metabolic issues and pathological alterations in adipose tissue distribution.
The standard clinical treatment of lipodystrophy include lifestyle modification, the use of oral and injectable diabetes medications and insulin (also includes concentrated formulations), lipid-lowering drugs, and other medications to treat complications of lipodystrophy.
Lipodystrophy syndromes are characterized by various and severe metabolic complications, treatment of which is challenging. Since standard therapies often lack sufficient metabolic regulation - leptin replacement therapy with metreleptin, a recombinant leptin analog - is needed. Metreleptin therapy has been approved by the FDA and EMA, respectively, for patients with GL and both GL and PL. Patients with GL commonly benefit from therapy with metreleptin, which is generally used as an adjunct to diet, physical activity, and other standard treatments for metabolic abnormalities. For a subgroup of patients with PL, metreleptin may be a suitable treatment option, while it might not represent an adequate therapy for others. Additional studies on metabolic pathways are necessary for these patients to develop novel therapeutic strategies.
This section provides the total Lipodystrophy market size and market size by therapies in the United States.
The total Lipodystrophy market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.
The total Lipodystrophy market size and market size by therapies in Japan are provided.
This section focuses on the rate of uptake of the potential drugs recently launched in the Lipodystrophy market or expected to get launched in the market during the study period 2019-2032. The analysis covers the Lipodystrophy market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, and reasons behind the maximal use of new drugs, and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
The report provides insights into different therapeutic candidates in Phase II and Phase III stage. It also analyzes key players involved in developing targeted therapeutics.
The report covers detailed information on collaborations, acquisitions, merger, licensing, and patent details for Lipodystrophy emerging therapies.
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
We perform competitive market Intelligence analysis of the Lipodystrophy market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.