PUBLISHER: DelveInsight | PRODUCT CODE: 1125997
PUBLISHER: DelveInsight | PRODUCT CODE: 1125997
DelveInsight's "Cholangiocarcinoma (CCA) - Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Cholangiocarcinoma, historical and forecasted epidemiology as well as the Cholangiocarcinoma market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
The Cholangiocarcinoma market report provides current treatment practices, emerging drugs, cholangiocarcinoma market share of the individual therapies, current and forecasted cholangiocarcinoma market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current cholangiocarcinoma treatment practice/algorithm, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Study Period: 2019-2032.
The DelveInsight's Cholangiocarcinoma epidemiology report gives a thorough understanding of Cholangiocarcinoma. Cholangiocarcinoma is a type of cancer that forms in the slender tubes (bile ducts) that carry the digestive fluid bile. Bile ducts connect your liver to your gallbladder and to your small intestine. Cholangiocarcinoma (CCA) tumors can arise from anywhere in the biliary tract and may be difficult to identify based on histopathologic analysis alone. CCA can be anatomically differentiated into intrahepatic CCA (ICC) and extrahepatic CCA (ECC).
Early research on the genetic pathophysiology of CCAs concentrated on determining the carcinogenic function of certain genes, which were frequently discovered to be mutated in other cancers or altered by copy number changes. Studies have demonstrated that the genetic profiles of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma are diverse; in fact, 50% of patients have actionable mutations such as FGFR, IDH1, HER2, and BRAF.
For a definitive diagnosis, patients usually undergo endoscopic retrograde cholangiopancreatography and procedures such as cytology, brushing, FISH (fluorescence in situ hybridization)-polisomy, biopsy, ultrasonography, choledochoscopy, cholangioscopy, chromoendoscopy, confocal endoscopy, narrow-band imaging. MRI, CT, endoscopic ultrasonography, or 18FDG PET-CT cannot definitively demonstrate the stricture's neoplastic nature.
Unfortunately, the outlook is bleak. Most patients have an advanced or incurable illness when they are diagnosed, leaving systemic therapy as their sole choice for treatment. It is generally known that subgroups vary in their tumor biology and clinical presentation in addition to their varied etiological sources. Surgery may be curative for individuals with resectable illness when they first arrive, although these patients make up a small percentage with substantial recurrence rates. Additionally, the recurrence patterns often prohibit additional curative resection.
The best method for extending survival is still total surgical resection (R0); however, disease recurrence is not unheard of. Furthermore, patient comorbidities sometimes precluded surgical intervention, even if it could technically be done. Therefore, in order to increase survival in such a population, reduced morbidity interventional procedures must be developed.
Surgery with complete resection represents the only treatment for CCA with curative intent. Other treatment approaches may include liver transplantation which is associated with rapid tumor recurrence and low survival, and it has historically not been recommended as a treatment for unresectable CCA. Chemotherapy for patients presenting with unresectable or metastatic CCA, systemic chemotherapy remains the mainstay palliative treatment modality, and the role of adjuvant chemotherapy is not clearly defined in CCA, but for patients with local recurrence after resectioning pCCA, chemotherapy has been recommended.
The Cholangiocarcinoma epidemiology division provides insights about historical and current Cholangiocarcinoma patient pool and forecasted trends for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This report also provides the diagnosed patient pool and their trends along with assumptions undertaken.
The disease epidemiology covered in the report provides historical as well as Cholangiocarcinoma epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032.
In the year 2021, the total diagnosed incident cases of CCA were 46,466 in the 7MM which are expected to grow during the study period, i.e., 2019-2032.
The disease epidemiology covered in the report provides historical as well as forecasted Cholangiocarcinoma epidemiology [segmented as Total Diagnosed-incidence Cases of Cholangiocarcinoma, Total Type-specific Cases of Cholangiocarcinoma, Total Age-specific Cases of Cholangiocarcinoma, Total Stage-specific Cases of Cholangiocarcinoma, Total Mutation-specific Cases of Cholangiocarcinoma, and Total Treated Cases (across lines) of Cholangiocarcinoma] in the 7MM covering the United States, EU-5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.
The epidemiology segment also provides the Cholangiocarcinoma epidemiology data and findings across the United States, EU-5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
According to the DelveInsight, in the year 2021, the total diagnosed incident cases of CCA were 10,034 in the United States which are expected to grow during the study period, i.e., 2019-2032.
The highest number of total incident cases of CCA was observed in Italy among the EU5 countries with 6,489 cases in 2021 which are expected to grow during the study period, i.e., 2019-2032.
In the year 2021, the total diagnosed incident cases of CCA were 16,004 in Japan which are expected to grow during the study period, i.e., 2019-2032.
The drug chapter segment of the Cholangiocarcinoma report encloses the detailed analysis of Cholangiocarcinoma marketed drugs and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Cholangiocarcinoma clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
The report provides the details of the emerging therapies under the late and mid-stage of development for Cholangiocarcinoma treatment.
The Cholangiocarcinoma (CCA) market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Cholangiocarcinoma market trends by analyzing the impact of current therapies on the market, unmet needs, and demand for better technology.
This segment gives a thorough detail of Cholangiocarcinoma market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
According to DelveInsight, the Cholangiocarcinoma market in 7MM is expected to witness a major change in the study period 2019-2032.
The Cholangiocarcinoma market size in the 7MM is expected to change during the study period 2019-2032. The therapeutic market of Cholangiocarcinoma in the seven major markets is expected to increase during the study period (2019-2032). In 2021, the total market size of Cholangiocarcinoma was USD 786.1 million which is expected to rise during the study period (2019-2032).
The total market size of Cholangiocarcinoma in the United States accounted for USD 237.3 million in 2021 which is expected to rise during the study period (2019-2032).
In EU-5, the total market size of Cholangiocarcinoma was USD 326 million in 2021, which is expected to rise during the study period (2019-2032).
In Japan, the total market size of Cholangiocarcinoma was USD 165.5 million in 2021, which is expected to rise during the study period (2019-2032).
This section focuses on the rate of uptake of the potential drugs recently launched in the Cholangiocarcinoma market or expected to get launched in the market during the study period 2019-2032. The analysis covers Cholangiocarcinoma market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs, and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
The report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Cholangiocarcinoma key players involved in developing targeted therapeutics.
The report covers detailed information on collaborations, acquisition, and merger, licensing patent details, and other information for Cholangiocarcinoma emerging therapies.
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In a report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
To keep up with current market trends, we take KOLs and SMEs ' opinions working in the Cholangiocarcinoma domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Cholangiocarcinoma market trends. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.
We perform Competitively and Market Intelligence analysis of the Cholangiocarcinoma (cUTI) Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.