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Market Research Report

Dravet Syndrome (DS) - Epidemiology Forecast to 2028

Published by DelveInsight Business Research LLP Product code 905934
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Dravet Syndrome (DS) - Epidemiology Forecast to 2028
Published: August 1, 2019 Content info: 87 Pages
Description

DelveInsight's 'Dravet Syndrome (DS)- Epidemiology Forecast to 2028' report delivers an in-depth understanding of the disease, historical & forecasted epidemiology of Dravet Syndrome in the United States, EU5 (Germany, Spain, Italy, France and United Kingdom),Japan, Australia and Austria.

Geography Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain and the United Kingdom)
  • Japan
  • Australia
  • Austria

Study Period: 2017-2028

Dravet Syndrome Epidemiology

The Dravet Syndrome (DS) epidemiology division provide the insights about historical and current patient pool and forecasted trend for every 9 major countries. The epidemiology data for Dravet Syndrome are studied through all possible division to give a better understanding about the Disease scenario in 9MM. It also helps to recognize the causes of current and forecasted trends by exploring numerous studies, survey reports and views of key opinion leaders.

Dravet Syndrome Epidemiology Segmentation

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (total incident population, incidence of Dravet Syndrome by Mutation Class, incidence of Dravet Syndrome by Mutation Type, seizure associated cases, gender-specific incident cases and age-specific incident cases) scenario of Dravet Syndrome (DS) in the 9MM covering United States, EU5 countries (Germany, Spain, Italy, France and United Kingdom) and Japan from 2017-2028.

The DelveInsight report also provides the epidemiology trends observed in the 9MM during the study period, along with the assumptions undertaken. The calculated data are presented with relevant tables and graphs to give a clear view of the epidemiology at first sight.

According to DelveInsight, the total number of incident cases of Dravet Syndrome (DS) in 9 MM was found to be 36301, in the year 2017.

Report Scope

  • The report covers detailed overview of Dravet Syndrome explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns
  • The report provides the insight about the historical and forecasted patient pool of Dravet Syndrome in 9 major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK),Japan, Australia and Austria
  • The Report assesses the disease risk and burden and highlights the unmet needs of the disease
  • The Report helps to recognize the growth opportunities in the 9MM with respect to the patient population
  • The report provides the segmentation of the disease epidemiology by incidence of DS, incidence of Dravet Syndrome by Mutation Class, incidence of Dravet Syndrome by Mutation Type, seizure associated cases, gender-specific incident cases and age-specific incident cases in 9MM

Key strengths

  • 10 Year Forecast of Dravet Syndrome epidemiology
  • 9MM Coverage
  • Total Prevalent Cases of DS
  • Prevalent Cases according to segmentation: Incidence, Mutation Types, Mutation Class, Age Groups, Severity and segments based gender.
  • Diagnosed cases of DS

Key assessments

  • Patient Segmentation
  • Disease Risk & Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population
Table of Contents
Product Code: DIEI0372

Table of Contents

1. Key Insights

2. Dravet Syndrome Market Overview at a Glance

  • 2.1. Market Share (%) Distribution of Dravet Syndrome in 2017
  • 2.2. Market Share (%) Distribution of Dravet Syndrome in 2028

3. Dravet Syndrome: Disease Background and Overview

  • 3.1. Introduction
  • 3.2. Clinical Features of Dravet Syndrome
    • 3.2.1. Epilepsy
    • 3.2.2. Cognition
    • 3.2.3. Movement disorders
    • 3.2.4. Sudden Death
  • 3.3. Genetics of Dravet Syndrome
    • 3.3.1. Sodium Channel a1 Subunit Gene (SCN1A) and its association with Dravet Syndrome
    • 3.3.2. Functional aspects of voltage gate sodium channel mutations
    • 3.3.3. Detection of SCN1A mutations
    • 3.3.4. Inheritance mode and pattern
    • 3.3.5. Dravet Syndrome without SCN1A Alterations
  • 3.4. Signs and Symptoms of Dravet Syndrome
  • 3.5. Pathophysiology
  • 3.6. Diagnosis of Dravet Syndrome
    • 3.6.1. Differential diagnosis

4. Epidemiology and Patient Population

  • 4.1. Key Findings
  • 4.2. Total Incidence of Dravet Syndrome in 9MM

5. Country Wise-Epidemiology of Dravet Syndrome

6. United States

  • 6.1. Assumptions and Rationale
  • 6.2. Incident Population of Dravet Syndrome
  • 6.3. Mutations associated with Dravet Syndrome
    • 6.3.1. Incidence of Dravet Syndrome by Mutation Class
    • 6.3.2. Incidence of Dravet Syndrome by Mutation Type
  • 6.4. Seizure associated cases of Dravet Syndrome
  • 6.5. Gender specific Incidence of Dravet Syndrome
  • 6.6. Age specific Incidence of Dravet Syndrome
  • 6.7. Mortality associated with Dravet Syndrome

7. EU-5

  • 7.1. Assumptions and Rationale

8. Germany

  • 8.1. Incident Population of Dravet Syndrome
  • 8.2. Mutations associated with Dravet Syndrome
    • 8.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 8.2.2. Incidence of Dravet Syndrome by Mutation Type
  • 8.3. Seizure associated cases of Dravet Syndrome
  • 8.4. Gender specific Incidence of Dravet Syndrome
  • 8.5. Age specific Incidence of Dravet Syndrome
  • 8.6. Mortality associated with Dravet Syndrome

9. France

  • 9.1. Incident Population of Dravet Syndrome
  • 9.2. Mutations associated with Dravet Syndrome
    • 9.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 9.2.2. Incidence of Dravet Syndrome by Mutation Type
  • 9.3. Seizure associated cases of Dravet Syndrome
  • 9.4. Gender specific Incidence of Dravet Syndrome
  • 9.5. Age specific Incidence of Dravet Syndrome
  • 9.6. Mortality associated with Dravet Syndrome

10. Italy

  • 10.1. Incident Population of Dravet Syndrome
  • 10.2. Mutations associated with Dravet Syndrome
    • 10.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 10.2.2. Incidence of Dravet Syndrome by Mutation Type
  • 10.3. Seizure associated cases of Dravet Syndrome
  • 10.4. Gender specific Incidence of Dravet Syndrome
  • 10.5. Age specific Incidence of Dravet Syndrome
  • 10.6. Mortality associated with Dravet Syndrome

11. Spain

  • 11.1. Incident Population of Dravet Syndrome
  • 11.2. Mutations associated with Dravet Syndrome
    • 11.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 11.2.2. Incidence of Dravet Syndrome by Mutation Type.
  • 11.3. Seizure associated cases of Dravet Syndrome
  • 11.4. Gender specific Incidence of Dravet Syndrome
  • 11.5. Age specific Incidence of Dravet Syndrome
  • 11.6. Mortality associated with Dravet Syndrome

12. United Kingdom

  • 12.1. Incident Population of Dravet Syndrome
  • 12.2. Mutations associated with Dravet Syndrome
    • 12.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 12.2.2. Incidence of Dravet Syndrome by Mutation Type
  • 12.3. Seizure associated cases of Dravet Syndrome
  • 12.4. Gender specific Incidence of Dravet Syndrome
  • 12.5. Age specific Incidence of Dravet Syndrome
  • 12.6. Mortality associated with Dravet Syndrome

13. Austria

  • 13.1. Incident Population of Dravet Syndrome
  • 13.2. Mutations associated with Dravet Syndrome
    • 13.2.1. Incidence of Dravet Syndrome by Mutation Class
    • 13.2.2. Incidence of Dravet Syndrome by Mutation Type
  • 13.3. Seizure associated cases of Dravet Syndrome
  • 13.4. Gender specific Incidence of Dravet Syndrome
  • 13.5. Age specific Incidence of Dravet Syndrome
  • 13.6. Mortality associated with Dravet Syndrome

14. Japan

  • 14.1. Assumptions and Rationale
  • 14.2. Incident Population of Dravet Syndrome
  • 14.3. Mutations associated with Dravet Syndrome
    • 14.3.1. Incidence of Dravet Syndrome by Mutation Class
    • 14.3.2. Incidence of Dravet Syndrome by Mutation Type
  • 14.4. Seizure associated cases of Dravet Syndrome
  • 14.5. Gender specific Incidence of Dravet Syndrome
  • 14.6. Age specific Incidence of Dravet Syndrome
  • 14.7. Mortality associated with Dravet Syndrome

15. Australia

  • 15.1. Assumptions and Rationale
  • 15.2. Incident Population of Dravet Syndrome
  • 15.3. Mutations associated with Dravet Syndrome
    • 15.3.1. Incidence of Dravet Syndrome by Mutation Class
    • 15.3.2. Incidence of Dravet Syndrome by Mutation Type
  • 15.4. Seizure associated cases of Dravet Syndrome
  • 15.5. Gender specific Incidence of Dravet Syndrome
  • 15.6. Age specific Incidence of Dravet Syndrome
  • 15.7. Mortality associated with Dravet Syndrome

16. Appendix

17. Report Methodology

  • 17.1. Sources Used

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

List of Tables

  • Table 1: Stages of Dravet Syndrome
  • Table 2: Genetic background of Dravet syndrome
  • Table 3: Total Incident Population of Dravet Syndrome in 9MM (2017-2028)
  • Table 4: Incident Population of Dravet Syndrome in the United States (2017-2028)
  • Table 5: Mutation positive cases of Dravet Syndrome in the United States (2017-2028)
  • Table 6: Incidence of Dravet Syndrome by Mutation Class in the United States (2017-2028)
  • Table 7: Incidence of Dravet Syndrome by Mutation Type in the United States (2017-2028)
  • Table 8: Seizure associated cases of Dravet Syndrome in the United States (2017-2028)
  • Table 9: Gender specific Incidence of Dravet Syndrome in the United States (2017-2028)
  • Table 10: Age specific Incidence of Dravet Syndrome in the United States (2017-2028)
  • Table 11: Number of Deaths Associated with Dravet Syndrome in the United States (2017-2028)
  • Table 12: Incident Population of Dravet Syndrome in Germany (2017-2028)
  • Table 13: Mutation positive cases of Dravet Syndrome in Germany (2017-2028)
  • Table 14: Incidence of Dravet Syndrome by Mutation Class in Germany (2017-2028)
  • Table 15: Incidence of Dravet Syndrome by Mutation Type in Germany (2017-2028)
  • Table 16: Seizure associated cases of Dravet Syndrome in Germany (2017-2028)
  • Table 17: Gender specific Incidence of Dravet Syndrome in Germany (2017-2028)
  • Table 18: Age specific Incidence of Dravet Syndrome in Germany (2017-2028)
  • Table 19: Number of Deaths Associated with Dravet Syndrome in Germany (2017-2028)
  • Table 20: Incident Population of Dravet Syndrome in France (2017-2028)
  • Table 21: Mutation positive cases of Dravet Syndrome in France (2017-2028)
  • Table 22: Incidence of Dravet Syndrome by Mutation Class in France (2017-2028)
  • Table 23: Incidence of Dravet Syndrome by Mutation Type in France (2017-2028)
  • Table 24: Seizure associated cases of Dravet Syndrome in France (2017-2028)
  • Table 25: Gender specific Incidence of Dravet Syndrome in France (2017-2028)
  • Table 26: Age specific Incidence of Dravet Syndrome in France (2017-2028)
  • Table 27: Number of Deaths Associated with Dravet Syndrome in France (2017-2028)
  • Table 28: Incident Population of Dravet Syndrome in Italy (2017-2028)
  • Table 29: Mutation positive cases of Dravet Syndrome in Italy (2017-2028)
  • Table 30: Incidence of Dravet Syndrome by Mutation Class in Italy (2017-2028)
  • Table 31: Incidence of Dravet Syndrome by Mutation Type in Italy (2017-2028)
  • Table 32: Seizure associated cases of Dravet Syndrome in Italy (2017-2028)
  • Table 33: Gender specific Incidence of Dravet Syndrome in Italy (2017-2028)
  • Table 34: Age specific Incidence of Dravet Syndrome in Italy (2017-2028)
  • Table 35: Number of Deaths Associated with Dravet Syndrome in Italy (2017-2028)
  • Table 36: Incident Population of Dravet Syndrome in Spain (2017-2028)
  • Table 37: Mutation positive cases of Dravet Syndrome in Spain (2017-2028)
  • Table 38: Incidence of Dravet Syndrome by Mutation Class in Spain (2017-2028)
  • Table 39: Incidence of Dravet Syndrome by Mutation Type in Spain (2017-2028)
  • Table 40: Seizure associated cases of Dravet Syndrome in Spain (2017-2028)
  • Table 41: Gender specific Incidence of Dravet Syndrome in Spain (2017-2028)
  • Table 42: Age specific Incidence of Dravet Syndrome in Spain (2017-2028)
  • Table 43: Number of Deaths Associated with Dravet Syndrome in Spain (2017-2028)
  • Table 44: Incident Population of Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 45: Mutation positive cases of Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 46: Incidence of Dravet Syndrome by Mutation Class in the United Kingdom (2017-2028)
  • Table 47: Incidence of Dravet Syndrome by Mutation Type in the United Kingdom (2017-2028)
  • Table 48: Seizure associated cases of Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 49: Gender specific Incidence of Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 50: Age specific Incidence of Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 51: Number of Deaths Associated with Dravet Syndrome in the United Kingdom (2017-2028)
  • Table 52: Incident Population of Dravet Syndrome in Austria (2017-2028)
  • Table 53: Mutation positive cases of Dravet Syndrome in Austria (2017-2028)
  • Table 54: Incidence of Dravet Syndrome by Mutation Class in Austria (2017-2028)
  • Table 55: Incidence of Dravet Syndrome by Mutation Type in Austria (2017-2028)
  • Table 56: Seizure associated cases of Dravet Syndrome in Austria (2017-2028)
  • Table 57: Gender specific Incidence of Dravet Syndrome in Austria (2017-2028)
  • Table 58: Age specific Incidence of Dravet Syndrome in Austria (2017-2028)
  • Table 59: Number of Deaths Associated with Dravet Syndrome in Austria (2017-2028)
  • Table 60: Incident Population of Dravet Syndrome in Japan (2017-2028)
  • Table 61: Mutation positive cases of Dravet Syndrome in Japan (2017-2028)
  • Table 62: Incidence of Dravet Syndrome by Mutation Class in Japan (2017-2028)
  • Table 63: Incidence of Dravet Syndrome by Mutation Type in Japan (2017-2028)
  • Table 64: Seizure associated cases of Dravet Syndrome in Japan (2017-2028)
  • Table 65: Gender specific Incidence of Dravet Syndrome in Japan (2017-2028)
  • Table 66: Age specific Incidence of Dravet Syndrome in Japan (2017-2028)
  • Table 67: Number of Deaths Associated with Dravet Syndrome in Japan (2017-2028)
  • Table 68: Incident Population of Dravet Syndrome in Australia (2017-2028)
  • Table 69: Mutation positive cases of Dravet Syndrome in Australia (2017-2028)
  • Table 70: Incidence of Dravet Syndrome by Mutation Class in Australia (2017-2028)
  • Table 71: Incidence of Dravet Syndrome by Mutation Type in Australia (2017-2028)
  • Table 72: Seizure associated cases of Dravet Syndrome in Australia (2017-2028)
  • Table 73: Gender specific Incidence of Dravet Syndrome in Australia (2017-2028)
  • Table 74: Age specific Incidence of Dravet Syndrome in Australia (2017-2028)
  • Table 75: Number of Deaths Associated with Dravet Syndrome in Australia (2017-2028)

List of Figures

  • Figure 1: Schematic representation of clinical manifestations of Dravet syndrome
  • Figure 2: Differential diagnosis of Dravet syndrome in the course of the disease
  • Figure 3: Total Incident Population of Dravet Syndrome in 9 MM (2017-2028)
  • Figure 4: Incident Population of Dravet Syndrome in the United States (2017-2028)
  • Figure 5: Mutation positive cases of Dravet Syndrome in the United States (2017-2028)
  • Figure 6: Incidence of Dravet Syndrome by Mutation Class in the United States (2017-2028)
  • Figure 7: Incidence of Dravet Syndrome by Mutation Type in the United States (2017-2028)
  • Figure 8: Seizure associated cases of Dravet Syndrome in the United States (2017-2028)
  • Figure 9: Gender specific Incidence of Dravet Syndrome in the United States (2017-2028)
  • Figure 10: Age specific Incidence of Dravet Syndrome in the United States (2017-2028)
  • Figure 11: Number of Deaths Associated with Dravet Syndrome in the United States (2017-2028)
  • Figure 12: Incident Population of Dravet Syndrome in Germany (2017-2028)
  • Figure 13: Mutation positive cases of Dravet Syndrome in Germany (2017-2028)
  • Figure 14: Incidence of Dravet Syndrome by Mutation Class in Germany (2017-2028)
  • Figure 15: Incidence of Dravet Syndrome by Mutation Type in Germany (2017-2028)
  • Figure 16: Seizure associated cases of Dravet Syndrome in Germany (2017-2028)
  • Figure 17: Gender specific Incidence of Dravet Syndrome in Germany (2017-2028)
  • Figure 18: Age specific Incidence of Dravet Syndrome in Germany 2017-2028)
  • Figure 19: Number of Deaths Associated with Dravet Syndrome in Germany (2017-2028)
  • Figure 20: Incident Population of Dravet Syndrome in France (2017-2028)
  • Figure 21: Mutation positive cases of Dravet Syndrome in France (2017-2028)
  • Figure 22: Incidence of Dravet Syndrome by Mutation Class in France (2017-2028)
  • Figure 23: Incidence of Dravet Syndrome by Mutation Type in France (2017-2028)
  • Figure 24: Seizure associated cases of Dravet Syndrome in France (2017-2028)
  • Figure 25: Gender specific Incidence of Dravet Syndrome in France (2017-2028)
  • Figure 26: Age specific Incidence of Dravet Syndrome in France (2017-2028)
  • Figure 27: Number of Deaths Associated with Dravet Syndrome in France (2017-2028)
  • Figure 28: Incident Population of Dravet Syndrome in Italy (2017-2028)
  • Figure 29: Mutation positive cases of Dravet Syndrome in Italy (2017-2028)
  • Figure 30: Incidence of Dravet Syndrome by Mutation Class in Italy (2017-2028)
  • Figure 31: Incidence of Dravet Syndrome by Mutation Type in Italy (2017-2028)
  • Figure 32: Seizure associated cases of Dravet Syndrome in Italy (2017-2028)
  • Figure 33: Gender specific Incidence of Dravet Syndrome in Italy (2017-2028)
  • Figure 34: Age specific Incidence of Dravet Syndrome in Italy (2017-2028)
  • Figure 35: Number of Deaths Associated with Dravet Syndrome in Italy (2017-2028)
  • Figure 36: Incident Population of Dravet Syndrome in Spain (2017-2028)
  • Figure 37: Mutation positive cases of Dravet Syndrome in Spain (2017-2028)
  • Figure 38: Incidence of Dravet Syndrome by Mutation Class in Spain (2017-2028)
  • Figure 39: Incidence of Dravet Syndrome by Mutation Type in Spain (2017-2028)
  • Figure 40: Seizure associated cases of Dravet Syndrome in Spain (2017-2028)
  • Figure 41: Gender specific Incidence of Dravet Syndrome in Spain (2017-2028)
  • Figure 42: Age specific Incidence of Dravet Syndrome in Spain (2017-2028)
  • Figure 43: Number of Deaths Associated with Dravet Syndrome in Spain (2017-2028)
  • Figure 44: Incident Population of Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 45: Mutation positive cases of Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 46: Incidence of Dravet Syndrome by Mutation Class in the United Kingdom (2017-2028)
  • Figure 47: Incidence of Dravet Syndrome by Mutation Type in the United Kingdom (2017-2028)
  • Figure 48: Seizure associated cases of Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 49: Gender specific Incidence of Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 50: Age specific Incidence of Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 51: Number of Deaths Associated with Dravet Syndrome in the United Kingdom (2017-2028)
  • Figure 52: Incident Population of Dravet Syndrome in Austria (2017-2028)
  • Figure 53: Mutation positive cases of Dravet Syndrome in Austria (2017-2028)
  • Figure 54: Incidence of Dravet Syndrome by Mutation Class in Austria (2017-2028)
  • Figure 55: Incidence of Dravet Syndrome by Mutation Type in Austria (2017-2028)
  • Figure 56: Seizure associated cases of Dravet Syndrome in Austria (2017-2028)
  • Figure 57: Gender specific Incidence of Dravet Syndrome in Austria (2017-2028)
  • Figure 58: Age specific Incidence of Dravet Syndrome in Austria (2017-2028)
  • Figure 59: Number of Deaths Associated with Dravet Syndrome in Austria (2017-2028)
  • Figure 60: Incident Population of Dravet Syndrome in Japan (2017-2028)
  • Figure 61: Mutation positive cases of Dravet Syndrome in Japan (2017-2028)
  • Figure 62: Incidence of Dravet Syndrome by Mutation Class in Japan (2017-2028)
  • Figure 63: Incidence of Dravet Syndrome by Mutation Type in Japan (2017-2028)
  • Figure 64: Seizure associated cases of Dravet Syndrome in Japan (2017-2028)
  • Figure 65: Gender specific Incidence of Dravet Syndrome in Japan (2017-2028)
  • Figure 66: Age specific Incidence of Dravet Syndrome in Japan (2017-2028)
  • Figure 67: Number of Deaths Associated with Dravet Syndrome in Japan (2017-2028)
  • Figure 68: Incident Population of Dravet Syndrome in Australia (2017-2028)
  • Figure 69: Mutation positive cases of Dravet Syndrome in Australia (2017-2028)
  • Figure 70: Incidence of Dravet Syndrome by Mutation Class in Australia (2017-2028)
  • Figure 71: Incidence of Dravet Syndrome by Mutation Type in Australia (2017-2028)
  • Figure 72: Seizure associated cases of Dravet Syndrome in Australia (2017-2028)
  • Figure 73: Gender specific Incidence of Dravet Syndrome in Australia (2017-2028)
  • Figure 74: Age specific Incidence of Dravet Syndrome in Australia (2017-2028)
  • Figure 75: Number of Deaths Associated with Dravet Syndrome in Australia (2017-2028)
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