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Market Research Report

Keratoconus - Epidemiology Forecast to 2030

Published by DelveInsight Business Research LLP Product code 963742
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Keratoconus - Epidemiology Forecast to 2030
Published: October 14, 2020 Content info: 100 Pages
Description

DelveInsight's 'Keratoconus (KC) - Epidemiology Forecast - 2030' report delivers an in-depth understanding of the disease, historical and forecasted Keratoconus (KC) epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

Keratoconus (KC) Understanding

Keratoconus (KC) also known as the conical cornea, is an eye (ocular) disorder characterized by progressive thinning and changes in the shape of the cornea. The cornea is the thin, clear outer layer of the eye and is normally dome-shaped. Slowly progressive thinning of the cornea causes a cone-shaped bulge to develop towards the center of the cornea in the areas of greatest thinning. Affected individuals develop a blurry or distorted vision, sensitivity to light (photophobia), and additional vision problems. KC has different types based on the shape and location of the thinned cornea. These types include nipple, oval, keratoglobus, and D-shaped KC.

Generally, KC is first diagnosed in young people at puberty or in their late teens. The exact cause of KC is unknown. There are many theories based on research and its association with other conditions such as allergies and genetic causes; however, no one theory explains it all, and it may be caused by a combination of things.

In its earliest stages, KC is known to cause slight blurring and distortion of vision and increased sensitivity to glare and light; these symptoms usually appear in the late teens or early 20s. It may progress for 10-20 years and then slow in its progression. Each eye may be affected differently.

The specific underlying mechanism(s) responsible for KC are not fully understood. Most cases appear to occur randomly for unknown reasons (sporadically). However, a positive family history of KC has been established in some cases. Most researchers believe that multiple, complex factors are required for the development of KC, including both genetic and environmental factors.

Keratoconus (KC) Epidemiology Perspective by DelveInsight

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Population of Keratoconus (KC), Severity-specific Distribution of Keratoconus (KC) and Age-specific Distribution of Keratoconus (KC) in the 7MM market covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2017 to 2030.

Keratoconus (KC) Detailed Epidemiology Segmentation

  • The total diagnosed prevalent population of KC in the seven major markets was estimated to be 1,602,427 in 2017.
  • The diagnosed prevalent cases of KC, in the United States, were found to be 550,047 in 2017.
  • In 2017, the mild, moderate and severe type of KC, in the United States, were found to be 121,010, 313,527, and 115,510, respectively.
  • It was found that in the United States, the maximum number of cases of KC was found in the age group of 30-39 with 181,515 cases in 2017, while the lowest number of cases were found in the age group ≥60 with 16,501 cases in 2017.
  • In the EU5 countries, the diagnosed prevalence of KC was found to be maximum in Germany, with 218,772 cases, followed by Italy with 171,676 cases in 2017. The least number of cases were found in Spain, with 105,463 cases in 2017.
  • In Japan, the diagnosed prevalence of KC was anticipated to be 240,591 in 2017.

Scope of the Report:

  • The report covers the descriptive overview of Keratoconus (KC), explaining its causes, signs and symptoms, pathophysiology.
  • The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan.
  • The report assesses the disease risk and burden and highlights the unmet needs of Keratoconus (KC).
  • The report provides the segmentation of the disease epidemiology for the 7MM by Total Diagnosed Prevalent Population of Keratoconus (KC), Severity-specific Distribution of Keratoconus (KC) and Age-specific Distribution of Keratoconus (KC).

Report Highlights:

  • Eleven Year Forecast of Keratoconus (KC)
  • 7MM Coverage
  • Total Diagnosed Prevalent Population of Keratoconus (KC)
  • As per DelveInsight's analysis, KC, based on its severity, can be categorized into three types, namely, mild, moderate and severe.
  • Delvelnsight has also analysed age-specific data of KC, according to which the overall diagnosed population of KC can be segmented into separate age groups, namely, <20, 20-29, 30-39, 40-49, 50-59, and ≥60. Further analysis of this data suggests that KC is more prevalent among the 30-39 age group.
  • The current treatment option for KC includes Intrastromal corneal ring segments (ICRS), Corneal reshaping and Cross-Linking (CXL) along with Riboflavin solutions + UV Light, Keratoplasty and Others (Antihistamine/mast cell-stabilizing topical medications, antihistamines, mast cell stabilizers, nonsteroidal anti-inflammatory (NSAID)).
  • The emerging pipeline of KC market possess only one therapy, namely, IVMED-80 Eye Drop, which is being developed by iVeena Delivery Systems. It is non-surgical, non-UV light treatment for medical cross-linking of the cornea. This therapy is currently in its phase I/II clinical developmental stage.

Key Questions Answered

  • What is the disease risk, burden and unmet needs of Keratoconus (KC)?
  • What is the historical Keratoconus (KC) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
  • What would be the forecasted patient pool of Keratoconus (KC) at the 7MM level?
  • What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Keratoconus (KC)?
  • Out of the above-mentioned countries, which country would have the highest prevalent population of Keratoconus (KC) during the forecast period (2020-2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2020-2030)?

Reasons to buy:

The Keratoconus (KC) report will allow the user to -

  • Develop business strategies by understanding the trends shaping and driving the 7MM Keratoconus (KC) market.
  • Quantify patient share distribution in the 7MM for Keratoconus (KC).
  • The Keratoconus (KC) epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
  • The Keratoconus (KC) epidemiology model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the eleven-year forecast period using reputable sources.

Key Assessments

  • Patient Segmentation
  • Disease Risk and Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population

Geographies Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2017-2030

Table of Contents
Product Code: DIEI0431

Table of Contents

1 Key Insights

2 Keratoconus (KC) Overview at a Glance

3 Executive Summary of Keratoconus (KC)

4 Disease Background and Overview: Keratoconus (KC)

  • 4.1 Introduction
  • 4.2 Types of KC
    • 4.2.1 Shape-based differentiation
    • 4.2.2 Severity- based differentiation
    • 4.2.3 Index-based differentiation
  • 4.3 Causes
  • 4.4 Signs and Symptoms
  • 4.5 Pathology
  • 4.6 Histopathology
    • 4.6.1 Epithelium
    • 4.6.2 Basement membrane
    • 4.6.3 Nerve fibers
    • 4.6.4 Bowman's layer
    • 4.6.5 Stroma
  • 4.7 Diagnosis
    • 4.7.1 Eye refraction
    • 4.7.2 Slit-lamp examination
    • 4.7.3 Keratometry
    • 4.7.4 Corneal Topography
    • 4.7.5 Corneal Tomography
    • 4.7.6 Keratoconus indices
    • 4.7.7 The Belin Ambrosio Enhanced Ectasia Display (BAD)
    • 4.7.8 Holladay 6 map display
    • 4.7.9 Corneal pachymetry
    • 4.7.10 Automated detection program for subclinical KC
    • 4.7.11 Corneal biomechanics
  • 4.8 Differential Diagnosis

5 Epidemiology and Patient Population

  • 5.1 Key Findings
  • 5.2 Total Diagnosed Prevalent Population of Keratoconus in the 7MM

6 Country-wise Epidemiology of Keratoconus

  • 6.1 United States
    • 6.1.1 Assumptions and Rationale
    • 6.1.2 Total Diagnosed Prevalent Population of Keratoconus in the United States
    • 6.1.3 Severity-specific Distribution of Keratoconus in the United States
    • 6.1.4 Age-specific Distribution of Keratoconus in the United States
  • 6.2 EU5 Countries
    • 6.2.1 Assumptions and Rationale
  • 6.3 Germany
    • 6.3.1 Total Diagnosed Prevalent Population of Keratoconus in Germany
    • 6.3.2 Severity-specific Distribution of Keratoconus in Germany
    • 6.3.3 Age-specific Distribution of Keratoconus in Germany
  • 6.4 France
    • 6.4.1 Total Diagnosed Prevalent Population of Keratoconus in France
    • 6.4.2 Severity-specific Distribution of Keratoconus in France
    • 6.4.3 Age-specific Distribution of Keratoconus in France
  • 6.5 Italy
    • 6.5.1 Total Diagnosed Prevalent Population of Keratoconus in Italy
    • 6.5.2 Severity-specific Distribution of Keratoconus in Italy
    • 6.5.3 Age-specific Distribution of Keratoconus in Italy
  • 6.6 Spain
    • 6.6.1 Total Diagnosed Prevalent Population of Keratoconus in Spain
    • 6.6.2 Severity-specific Distribution of Keratoconus in Spain
    • 6.6.3 Age-specific Distribution of Keratoconus in Spain
  • 6.7 United Kingdom
    • 6.7.1 Total Diagnosed Prevalent Population of Keratoconus in the United Kingdom
    • 6.7.2 Severity-specific Distribution of Keratoconus in the United Kingdom
    • 6.7.3 Age-specific Distribution of Keratoconus in the United Kingdom
  • 6.8 Japan
    • 6.8.1 Assumptions and Rationale
    • 6.8.2 Total Diagnosed Prevalent Population of Keratoconus in Japan
    • 6.8.3 Severity-specific Distribution of Keratoconus in Japan
    • 6.8.4 Age-specific Distribution of Keratoconus in Japan

7 Appendix

  • 7.1 Bibliography
  • 7.2 Report Methodology

8 DelveInsight Capabilities

9 Disclaimer

10 About DelveInsight

List of Tables

  • Table 1 Summary of KC, Market, Epidemiology and Key Events (2017-2030)
  • Table 2 Amsler-Krumeich Classification for grading KC
  • Table 3 ABCD Grading System for classifying KC
  • Table 4 Total Diagnosed Prevalent Population of Keratoconus in the 7MM (2017-2030)
  • Table 5 Total Diagnosed Prevalent Population of Keratoconus in the United States (2017-2030)
  • Table 6 Severity-specific Distribution of Keratoconus in the United States (2017-2030)
  • Table 7 Age-specific Distribution of Keratoconus in the United States (2017-2030)
  • Table 8 Total Diagnosed Prevalent Population of Keratoconus in Germany (2017-2030)
  • Table 9 Severity-specific Distribution of Keratoconus in Germany (2017-2030)
  • Table 10 Age-specific Distribution of Keratoconus in Germany (2017-2030)
  • Table 11 Total Diagnosed Prevalent Population of Keratoconus in France (2017-2030)
  • Table 12 Severity-specific Distribution of Keratoconus in France (2017-2030)
  • Table 13 Age-specific Distribution of Keratoconus in France (2017-2030)
  • Table 14 Total Diagnosed Prevalent Population of Keratoconus in Italy (2017-2030)
  • Table 15 Severity-specific Distribution of Keratoconus in Italy (2017-2030)
  • Table 16 Age-specific Distribution of Keratoconus in Italy (2017-2030)
  • Table 17 Total Diagnosed Prevalent Population of Keratoconus in Spain (2017-2030)
  • Table 18 Severity-specific Distribution of Keratoconus in Spain (2017-2030)
  • Table 19 Age-specific Distribution of Keratoconus in Spain (2017-2030)
  • Table 20 Total Diagnosed Prevalent Population of Keratoconus in the United Kingdom (2017-2030)
  • Table 21 Severity-specific Distribution of Keratoconus in the United Kingdom (2017-2030)
  • Table 22 Age-specific Distribution of Keratoconus in the United Kingdom (2017-2030)
  • Table 23 Total Diagnosed Prevalent Population of Keratoconus in Japan (2017-2030)
  • Table 24 Severity-specific Distribution of Keratoconus in Japan (2017-2030)
  • Table 25 Age-specific Distribution of Keratoconus in Japan (2017-2030)

List of Figures

  • Figure 1 Total Diagnosed Prevalent Population of Keratoconus in the 7MM (2017-2030)
  • Figure 2 Total Diagnosed Prevalent Population of Keratoconus in the United States (2017-2030)
  • Figure 3 Severity-specific Distribution of Keratoconus in the United States (2017-2030)
  • Figure 4 Age-specific Distribution of Keratoconus in the United States (2017-2030)
  • Figure 5 Total Diagnosed Prevalent Population of Keratoconus in Germany (2017-2030)
  • Figure 6 Severity-specific Distribution of Keratoconus in Germany (2017-2030)
  • Figure 7 Age-specific Distribution of Keratoconus in Germany (2017-2030)
  • Figure 8 Total Diagnosed Prevalent Population of Keratoconus in France (2017-2030)
  • Figure 9 Severity-specific Distribution of Keratoconus in France (2017-2030)
  • Figure 10 Age-specific Distribution of Keratoconus in France (2017-2030)
  • Figure 11 Total Diagnosed Prevalent Population of Keratoconus in Italy (2017-2030)
  • Figure 12 Severity-specific Distribution of Keratoconus in Italy (2017-2030)
  • Figure 13 Age-specific Distribution of Keratoconus in Italy (2017-2030)
  • Figure 14 Total Diagnosed Prevalent Population of Keratoconus in Spain (2017-2030)
  • Figure 15 Severity-specific Distribution of Keratoconus in Spain (2017-2030)
  • Figure 16 Age-specific Distribution of Keratoconus in Spain (2017-2030)
  • Figure 17 Total Diagnosed Prevalent Population of Keratoconus in the United Kingdom (2017-2030)
  • Figure 18 Severity-specific Distribution of Keratoconus in the United Kingdom (2017-2030)
  • Figure 19 Age-specific Distribution of Keratoconus in the United Kingdom (2017-2030)
  • Figure 20 Total Diagnosed Prevalent Population of Keratoconus in Japan (2017-2030)
  • Figure 21 Severity-specific Distribution of Keratoconus in Japan (2017-2030)
  • Figure 22 Age-specific Distribution of Keratoconus in Japan (2017-2030)
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