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Market Research Report

Global Breast Cancer Liquid Biopsy Market - 2020-2027

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Global Breast Cancer Liquid Biopsy Market - 2020-2027
Published: May 10, 2021 Content info: 180 Pages
Description

Market Overview

The global breast cancer liquid biopsy market size was worth US$ XX billion in 2018 and is estimated to reach US$ XX billion by 2027, growing at a CAGR of XX % during the forecast period (2020-2027).

A biopsy is a tissue or cell sample that is taken from any part of the patient's body and examined in the lab to detect cancer. Liquid biopsy offers a real-time approach for the treatment of breast cancer. It is used for the collection and analysis of a sample of blood taken from the patient. Liquid biopsy uses body fluids as a sample for analysis, primarily blood. It analyses the presence of tumor cell-derived biomarkers such as circulating tumor cells, cell-free DNA (cfDNA) and their cargo proteins, and circulating cell-free RNA (cfRNA). A liquid biopsy is a non-invasive, simple, and cost-effective diagnostic tool for cancer. The number of circulating biomarkers differ among cancer patients and healthy individuals. Therefore, these circulating biomarkers act as an essential tool for early diagnosis and monitoring of disease progression in advanced cancer stages to analyze the heterogeneity of tumor cells. Moreover, the breast cancer liquid biopsy test detects epidermal growth factor receptor (EGFR) gene mutations that support clinicians to choose the proper breast cancer treatment at the right time. Breast cancer is considered the second most common malignancy in the world, and therefore, liquid biopsy is an important tool for breast cancer diagnosis and determination.

Market Dynamics

The global breast cancer liquid biopsy market growth is driven by the increasing prevalence of breast cancer cases, increase in demand for non-invasive procedures, growing awareness about cancer, increase in health care expenditure, and initiatives and measures taken by government and global health organizations. Moreover, increased intensive research and development in the field of cancer, technological advancements, and an increase in demand toward personalized medicine are key factors to drive the growth of the market.

Increasing prevalence of breast cancer cases, is expected to drive the global Breast cancer liquid biopsy market growth.

The incidence of breast cancers is proliferating. According to the World Health Organization (WHO) scenario, breast cancer is the second most cancer occurring among women. It affects nearly 2.1 million women each year. The American Cancer Society's estimates for breast cancer in the United States for 2021 are that about 281,550 new cases of invasive breast cancer will be diagnosed in women. According to Breast Cancer Care, WA Incorporated in 2019; an estimated 19,371 Australian women were diagnosed with the breast cancer or approximately 53 each day, which accounts for roughly 14% of all new breast cancer cases are diagnosed; furthermore, according to Cancer Research UK, breast cancer is the most common cancer in United Kingdom, accounting for nearly 15% of all the new cancer cases.

Initiative programs undertaking by the government to improve clinical awareness among the common people, is expected to drive the global Breast cancer liquid biopsy market growth.

By Indian Cancer Society: Cancer Awareness Campaign 2019

The campaign is called "Raho cancer se do Kadam aage,"aims to create cancer awareness amongst the population of India. It is essential to destroy the myths that people wrongly believe, inform them about the signs and symptoms and the importance of screening for early detection. It is also essential to follow a healthy lifestyle, and sharing survivor stories give hope and confidence.

National Comprehensive Cancer Control Program. More than 98,000 people have been involved in cancer coalitions, and Sixty-nine cancer plans have been created and updated.

National Breast and Cervical Cancer Early Detection Program (NBCCEDP). Through the NBCCEDP, CDC helping low-income, uninsured, and underinsured women to gain access to frequent breast and cervical cancer screening, diagnostic, and treatment services. . During 2016-2017, about 5.3% of U.S. women were eligible for this program, breast cancer screening services, and the program served 15.0% of qualified women.

High cost of treatment in low- income countries is likely to hinder the market growth

Health-care expenditure for breast cancer is quite high. It has been estimated that by 2035, the United States will spend approximately between 3.6 and 7.6 trillion dollars on patients with the breast cancer. With low-income countries providing only 20% of health insurance reimbursements, it is becoming difficult for people to afford the bills and opt for minimally invasive surgeries. For instance, as per the National Library of Medicine, the Procedure-related costs were $368.5 and the incremental treatment cost with liquid biopsy was US $7,333.17.

COVID-19 Impact Analysis

The COVID-19 pandemic has negatively impacted healthcare systems globally and also on the market growth. According to the Centers for Disease Control and Prevention (CDC) and many medical professional organizations recommended that cancer screening and other health prevention services, along with elective surgeries, be postponed unless the risks outweighed the benefits and secure the hospital infrastructure for the treatment of COVID-19 patients. Thus, the COVID-19 pandemic has impacted the On-going clinical trials too. However, the situation is expected to improve gradually.

Segment Analysis

Based on the Product Type, the global Breast Cancer Liquid Biopsy market is segmented into Reagents and Kits, Instruments, Others.

Reagents and Kits segment accounts the largest market share among all the segments.

Reagents are playing a vital role in the In-vitro cancer diagnostics market. It includes chemical, biological, or immunological components, solutions, or preparations intended by the manufacturer to be used during the in-vitro diagnosis process. Increase in number of breast cancer liquid biopsy test procedures, surge in demand for reagent kits, increase in breast cancer liquid biopsy reagent kit approvals. For instance, On November 9, 2019, Lexent Bio signed a partnership with Illumina, Inc. to develop a next-generation sequencing IVD kit to diagnose cancer. In September 2019, Sysmex Inostics announced the launch of "SafeSEQ" liquid biopsy panels for breast and head & neck cancer, along with the availability of the "SafeSEQ Rapid Custom Development" program designed for identification and analysis of circulating tumor DNA. The test has been optimized to offer highest levels of accuracy, and sensitivity in different biopsy processes.

Instruments

The instrument segment is expected grow slowly, advanced instruments and rapid testing tools are driving the segment. For instance, BioNTech Diagnostics GmbH develops and manufactures the biomarker-based in vitro diagnostic devices (IVDD) like MammaTyper for Invasive breast cancer is under clinical trials.

Based on the circulating biomarkers, the global Breast Cancer Liquid Biopsy market is segmented into circulating tumor cells (CTC's), circulating cell-free DNA (cfDNA), extracellular vesicles, and other circulating biomarkers.

The circulating cell-free DNA segment is expected to grow at the fastest CAGR during the forecast period (2020-2027). The Circulating cell-free DNA (cfDNA) in plasma offers a non-invasive approach to monitor tumor molecular profiling in real-time at multiple time points, detect emerging genomic alterations associated with drug resistance, and clarify cancer prognosis and diagnosis of cancer recurrence or progression. Many companies offer cfDNA based products for use in research purposes. For instance, Hilden, Germany-based Qiagen, offers the QIAamp circulating nucleic acid kit used in a column-based method to isolate cfDNA from plasma and serum. Genomics for Life Pty Ltd is a Queensland, Australia-based company that offers genetic testing for cfDNA from blood samples. It is a major private-sector company that provides cfDNA-based testing services in Australia.

Based on End-Users, the global Breast Cancer Liquid Biopsy market is segmented into Reference laboratories, Hospitals and Physician laboratories, and Others

The reference laboratories segment accounts the largest share of the global breast cancer liquid biopsy market. Reference laboratories are well-equipped large laboratories. This is due to a rise in the number of liquid biopsy test samples received by reference laboratories for genetic testing.

Geographical Analysis

North America region holds the largest share in the global breast cancer liquid biopsy market. This is primarily due to rising incidences of breast cancer and the growing demand for non-invasive treatment in this region. According to the National Breast Cancer Foundation of the United States, in 2019, 62% of breast cancer cases were diagnosed at a localized stage. Female breast cancer represented approximately 15.2% of all new cancer cases in the United States. In the United States, Biocept, a molecular oncology diagnostics company, offers advanced methods for detecting circulating cancer cells (CTCs) and oncogene mutation fragments (ctDNA) in the blood. This allows CLIA-certified and CAP-accredited laboratories to perform predictive biomarker testing and provide the most up-to-date biomarker status from a non-invasive patient blood sample in breast cancer diagnosis up opportunities in breast cancer liquid biopsy.

The Asia Pacific is expected to be the fastest-growing market over the forecast period owing to increasing prevalence rate, increasing focus on preventive care, and government initiatives promoting technological innovations.

Competitive Landscape

The global breast cancer liquid biopsy market is quite competitive with some key competitors like QIAGEN, F. Hoffmann-La Roche Ltd, Bio-Rad Laboratories Inc, Janssen Diagnostics, Guardant Health, Inc, Myriad Genetics, Adaptive Biotechnologies, Epic Sciences, Fluxion Biosciences, Inc and Illumina, Inc. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, contributing to the market's growth globally. For instance, In January 2021, Biodesix announced an agreement with HiberCell to conduct further development of an enzyme-linked immunosorbent assay (ELISA) as a companion diagnostic test.

QIAGEN

Overview: QIAGEN, founded in 1984, is a German provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. Currently, 5,300 employees. Founded by the three young scientists, Metin Colpan, Karsten Henco, and Jurgen Schumacher, and their doctoral supervisor Detlev Riesner, their goal was to establish a research outfit supplying products for molecular biological research. In 2004, QIAGEN's QIAamp became the world's first standalone product for sample preparation to receive the CE-mark. In 2007, QIAGEN merged with Digene Corp., creating the market and technology leader in molecular diagnostics. In 2018, Collaborations with more than 25 pharmaceutical and biotech companies to develop companion and complementary diagnostics to guide clinical decision-making solidified QIAGENs leading position in precision medicine.

Product Portfolio: The company portfolio includes Oncology, Liquid Biopsy, Infectious disease, Next-generation sequencing, Molecular biology research, Genomic services, Digital PCR.

Key developments:

Two new FDA-approved tests are added to QIAGEN's companion diagnostic portfolio: The therascreen PIK3CA RGQ PCR Kit aids in identifying patients eligible for a new breast cancer therapy developed by Novartis and the therascreen FGFR RGQ RT-PCR Kit identifies urothelial cancer patients for Janssen Biotech's newly approved FGFR kinase inhibitor.

Why Purchase the Report?

  • Visualize the composition of the global breast cancer liquid biopsy market segmentation by product type, by circulating biomarkers, by end-users, by region.
  • Identify commercial opportunities in global breast cancer liquid biopsy market by analyzing trends and co-development deals.
  • Excel data sheet with thousands of data points of global breast cancer liquid biopsy market - level 4/5 segmentation.
  • PDF report with the most relevant analysis cogently put together after exhaustive qualitative interviews and in-depth market study.
  • Product mapping in excel for the key product of all major market players

The global breast cancer liquid biopsy market report would provide an access to an approx. 61 market data table, 50 figures and 300 pages.

Target Audience

  • Service Providers/ Buyers
  • Industry Investors/Investment Bankers
  • Education & Research Institutes
  • Research Professionals
  • Emerging Companies
  • Manufacturers
Table of Contents

Table of Contents

1. Global Breast Cancer Liquid Biopsy Market Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Global Breast Cancer Liquid Biopsy Market - Market Definition and Overview

3. Global Breast Cancer Liquid Biopsy Market - Executive Summary

  • 3.1. Market Snippet by Product Type
  • 3.2. Market Snippet by Circulating Biomarkers
  • 3.3. Market Snippet by End User
  • 3.4. Market Snippet by Region

4. Global Breast Cancer Liquid Biopsy Market - Market Dynamics

  • 4.1. Market Impacting Factors
  • 4.2. Drivers
    • 4.2.1. Increasing prevalence of Breast cancer cases
    • 4.2.2. Initiative programs undertaking by the government to improve clinical awareness among the common people.
  • 4.3. Restraints:
    • 4.3.1. High cost of treatment in low-income countries
  • 4.4. Opportunity
  • 4.5. Impact Analysis

5. Global Breast Cancer Liquid Biopsy Market - Industry Analysis

  • 5.1. Porter's Five Forces Analysis
  • 5.2. Supply Chain Analysis
  • 5.3. Pricing Analysis
  • 5.4. Regulatory Analysis
  • 5.5. Reimbursement Analysis
  • 5.6. Unmet Needs

6. Global Breast Cancer Liquid Biopsy Market - COVID-19 Analysis

  • 6.1. Analysis of Covid-19 on the Market
    • 6.1.1. Before COVID-19 Market Scenario
    • 6.1.2. Present COVID-19 Market Scenario
    • 6.1.3. After COVID-19 or Future Scenario
  • 6.2. Pricing Dynamics Amid Covid-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. Global Breast Cancer Liquid Biopsy Market - By Product Type

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type Segment
    • 7.1.2. Market Attractiveness Index, By Product Type
  • 7.2. Reagents & Kits*
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis, and Y-o-Y Growth Analysis (%)
  • 7.3. Instruments

8. Global Breast Cancer Liquid Biopsy Market - By Circulating Biomarkers

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 8.1.2. Market Attractiveness Index, By Circulating Biomarkers
  • 8.2. Circulating cell-free DNA (cfDNA)*
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis, and Y-o-Y Growth Analysis (%)
  • 8.3. Circulating tumor cells (CTC's)
  • 8.4. Extracellular vesicles, and
  • 8.5. Other circulating biomarkers

9. Global Breast Cancer Liquid Biopsy Market - By End users

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End users
    • 9.1.2. Market Attractiveness Index, By End users
  • 9.2. Reference Laboratories*
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis, and Y-o-Y Growth Analysis (%)
  • 9.3. Hospital and Physician Laboratories
  • 9.4. Others

10. Global Breast Cancer Liquid Biopsy Market - By Region

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Region
    • 10.1.2. Market Attractiveness Index, By Region
  • 10.2. North America
    • 10.2.1. Introduction
    • 10.2.2. Key Region-Specific Dynamics
    • 10.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type
    • 10.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 10.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-Users
    • 10.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.2.6.1. U.S.
      • 10.2.6.2. Canada
      • 10.2.6.3. Mexico
  • 10.3. Europe
    • 10.3.1. Introduction
    • 10.3.2. Key Region-Specific Dynamics
    • 10.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type
    • 10.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 10.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-Users
    • 10.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.3.6.1. Germany
      • 10.3.6.2. U.K.
      • 10.3.6.3. France
      • 10.3.6.4. Italy
      • 10.3.6.5. Spain
      • 10.3.6.6. Rest of Europe
  • 10.4. South America
    • 10.4.1. Introduction
    • 10.4.2. Key Region-Specific Dynamics
    • 10.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type
    • 10.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 10.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-Users
    • 10.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.4.6.1. Brazil
      • 10.4.6.2. Argentina
      • 10.4.6.3. Rest of South America
  • 10.5. Asia Pacific
    • 10.5.1. Introduction
    • 10.5.2. Key Region-Specific Dynamics
    • 10.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type
    • 10.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 10.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-Users
    • 10.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.5.6.1. China
      • 10.5.6.2. India
      • 10.5.6.3. Japan
      • 10.5.6.4. Australia
      • 10.5.6.5. Rest of Asia Pacific
  • 10.6. Middle East and Africa
    • 10.6.1. Introduction
    • 10.6.2. Key Region-Specific Dynamics
    • 10.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Type
    • 10.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Circulating Biomarkers
    • 10.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-Users
    • 10.6.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country

11. Global Breast Cancer Liquid Biopsy Market - Competitive Landscape

  • 11.1. Competitive Scenario
  • 11.2. Market Positioning/Share Analysis
  • 11.3. Mergers and Acquisitions Analysis

12. Global Breast Cancer Liquid Biopsy Market- Company Profiles

  • 12.1. QIAGEN*
    • 12.1.1. Company Overview
    • 12.1.2. Product Portfolio and Description
    • 12.1.3. Key Highlights
    • 12.1.4. Financial Overview
  • 12.2. F. Hoffmann-La Roche Ltd,
  • 12.3. Bio-Rad Laboratories Inc,
  • 12.4. Janssen Diagnostics,
  • 12.5. Guardant Health, Inc,
  • 12.6. Myriad Genetics,
  • 12.7. Adaptive Biotechnologies,
  • 12.8. Epic Sciences,
  • 12.9. Fluxion Biosciences, Inc and
  • 12.10. Illumina, Inc

LIST NOT EXHAUSTIVE

13. Global Breast Cancer Liquid Biopsy Market - Premium Insights

14. Global Breast Cancer Liquid Biopsy Market - DataM

  • 14.1. Appendix
  • 14.2. About Us and Services
  • 14.3. Contact Us
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