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1008538

Global Patient Derived Xenograft (PDX) Models Market - 2021-2028

Published: | DataM Intelligence | 180 Pages | Delivery time: 2 business days

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Global Patient Derived Xenograft (PDX) Models Market - 2021-2028
Published: June 1, 2021
DataM Intelligence
Content info: 180 Pages
Delivery time: 2 business days
  • Description
  • Table of Contents

Market Overview

The global patient derived xenograft (PDX) models market size was valued US$ XX billion in 2020 and is estimated to reach US$ XX billion by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).

Patient-derived xenografts (PDX) are models of cancer where the cells or tissue of a patient's tumor are embedded into an immune deficient or humanized mouse. PDX models resemble human tumor biology allowing for natural cancer sequence and offer the most translational research model for estimating efficacy.

Market Dynamics

The major factors driving the growth of this market are the growing demand for personalized medicine, continuous support for cancer research from the public and private sectors, and growth in the number of R&D activities in the pharmaceutical industry.

The growing demand for personalized medicine will drive the market growth

Personalized medicine is developing tailored medicines to provide individualized medication and care based on individual and genetic variations. These medicines are produced through the use of animal models. In this process, immunodeficient models are revamped with human tissues, and the disease expressed is recorded. It is followed by employing the model with drugs/gene therapeutics to find the most suitable medication, thus generating suitable or personalized medicines.

The development of therapeutics for key disorders such as cancer has attracted significant attention. Presently, cancer is a significant burden on the healthcare sector across the world. As per the data published by GLOBOCAN in 2020, it is expected that 19.3 million cases and 10 million cancer deaths occurred in 2020. In vivo and in vitro strategies are being developed to fight the rising prevalence of cancer and offer efficient treatments to patients. A significant advancement in this regard is the development of PDX models, as they have imminent high power for the efficacy of standard and novel anti-cancer therapeutics. Owing to this convenience, these models are frequently being used in preclinical studies.

Rising demand for humanized PDX models is driving the market growth

Immunodeficient mice are now reconstituted with bone marrow or peripheral blood cells and patient tumor implants to generate humanized xenograft models. These models present a valuable stage to study the participation of xenogeneic immune cells in the overall anti-tumor immunity. They also help study immunotherapy drugs aimed at mobilizing the effector arm of the immune system. However, in humanized xenografts, there is a potential risk of graft versus host disease. Therefore the limitation can be mitigated by keeping the experimental setup and analysis to a reasonable time frame of 6-10 weeks.

However, these models are not fitting for evaluating stroma-tumor interactions, majorly accountable for tumor growth and progression in a patient. Humanized PDX models help surmount these issues and are gaining demand in the market.

For instance, in September 2018, JSR Corporation company announced addition of PDX models of prostate cancer to its product portfolio.

High cost of personalized PDX models will hamper the market growth in the forecast period

Howevwer, for building the personalized PDX models, a patient's tumor is embedded and grown in various immunocompromised models. It is then stored, fragmented, and inserted again in a more extensive set of models treated with different drugs and drug combinations. After analyzing the cost of building and maintaining these models, coupled with the necessity of expensive drugs in these models, PDX experiments will cost thousands of dollars, even in the case of a particular patient. Moreover, using PDX models in government-funded research can also be cost-prohibitive. These factors are limiting the adoption of PDX models market across the globe.

Industry Analysis

PEST Analysis:

COVID-19 Impact Analysis

The COVID-19 pandemic has impacted the healthcare systems globally and also has a notable impact on the market. PDX models market is negatively impacted by COVID 19 pandemic due to decreased productivity in life science organizations associated with country-wise lockdowns, the interruption of clinical trials, and decreased pharma R&D deals in therapeutic areas.

For instance, As per the GEP Worldwide, it is estimated that more than 1,200 clinical trials over the globe were interrupted by June 2020. Nearly 61% of clinical trials were disrupted due to the delay of patient enrolment. Trials including respiratory disease, ID/anti-infectives, oncology, and cardiovascular disease were the hard-hit during this time. The market is propelled to grow at a steady rate after the situation gets normal.

Segment Analysis

Mice model segment is expected to grow at the fastest CAGR during the forecast period (2021-2028)

The mice model are expected to account for the largest share of the market. Mice models are small animal models for several infectious disorders, including Zika virus, hepatitis B virus (HBV), hepatitis C virus (HCV), and cytomegalovirus (CMV), among others. Therefore certain mice models are widely used for various viral investigations in pre-clinical studies.

For instance, in March 2019, the National Institute of Allergy and Infectious Diseases funded projects to conduct detailed characterization, direct comparisons, and additional humanized immune system (HIS) mouse models. The increasing need to evaluate the outcomes of drugs on humans coupled with a growing focus on analyzing human-specific infections, treatments, and immune responses fosters the development and use of humanized mice models.

Major companies are concentrating on developing their product portfolios by new launches. For instance, in July 2019, Taconic Biosciences launched the first commercially available diet-induced NASH rodent model. This new model will keep researchers months of preparation and expedite the clinical development of NASH therapy to treat liver failure.

Thus, the mice model segment is expanding, increasing R&D activities in the pharmaceutical industry.

Respiratory tumor model segment are expected to dominate the patient derived xenograft (PDX) models market, by tumor type, during the forecast period

The respiratory tumor model segment is anticipated to grow at a faster pace in the forecast period. The key constituents contributing to the segment's growth include increasing research activities in oncology and the increasing focus of market players on generating lung cancer PDX models, and the increasing number of cancer cases.

As per WHO, cancer is the second principal cause of death globally and is accountable for 9.6 million deaths in 2018. Many companies focus on producing breakthrough products to tackle chronic diseases to keep their competitive edge and penetrate new regional markets. Additionally, funding for companies associated with cancer research is anticipated to boost the market.

Geographical Analysis

North America region holds the largest market share in the global Patient derived xenograft (PDX) models market

North America region dominates the global patient-derived xenograft (PDX) models market estimated for the largest market share in 2020, owing to a surge in funding and awareness among patients about personalized medication. Patient-derived tumor xenografts are perceived as very suitable preclinical cancer models. According to the American Cancer Society, there were 1,735,350 new cases of cancer diagnosed in the United States in 2018. Also, in 2018, the National Institute of Cancer expands the repository of cancer investigation models to incorporate more research models.

As per the American Cancer Society's estimation, the new lung cancer cases in the United States for 2018 were around 234,030, and about 154,050 deaths were expected due to lung cancer. In the United States, lung cancer survival has been improved, and the incidence of localized lung cancer has increased.

Market players are involved in product launch, product trials pipelines, product approvals and acquisitions. For instance, In November 2019, Envigo acquired the assets of the research models business unit of Horizon Discovery Group plc

Hence, the North American region is expected to grow faster due to rising preclinical activities by pharmaceutical companies and rising cancer research in this region.

Competitive Landscape

The patient derived xenograft (PDX) models market is moderately competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Charles River Laboratories, Envigo, JSR Corporation (Crown Bioscience Inc.), Champions Oncology, Inc., EPO Berlin-Buch GmbH, Hera BioLabs, Horizon Discovery Group plc, WuXi AppTec, BEIJING IDMO Co. Ltd., Shanghai ChemPartner Co., Ltd. among others. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the patient derived xenograft (PDX) models market globally.

Patient Derived Xenograft (PDX) Models Market Key Companies to Watch

Charles River Laboratories

Overview: Charles River Laboratories International, Inc. is an American pharmaceutical company specializing in various preclinical and clinical laboratory, gene therapy and cell therapy services for the Pharmaceutical, Medical Device and Biotechnology industries. It also supplies assorted biomedical products and outsourcing services for research and development in the pharmaceutical industry (for example, contract research organization services) and offers support in basic research, drug discovery, safety and efficacy, clinical support, and manufacturing.

Product Portfolio: The company offers research models & services, discovery services, preclinical cro services for safety assessment, and laboratory sciences among others.

Key Development: In 2019, Charles River Laboratories renewed its online Tumor Model Compendium by combining 79 new patient-derived xenografts, ten new cell line-derived xenografts, and 36 new cell line models for several cancer types including anal, colon, lung, and renal cancer, as well as leukemia and melanoma.

Why Purchase the Report?

  • Visualize the composition of the patient derived xenograft (PDX) models market segmentation by type, tumor type, application and end user highlighting the key commercial assets and players.
  • Identify commercial opportunities in patient derived xenograft (PDX) models market by analyzing trends and co-development deals.
  • Excel data sheet with thousands of data points of patient derived xenograft (PDX) models market - level 4/5 segmentation.
  • PDF report with the most relevant analysis cogently put together after exhaustive qualitative interviews and in-depth market study.
  • Product mapping in excel for the key product of all major market players

The global patient derived xenograft (PDX) models market report would provide an access to an approx. 61 market data table, 52 figures and 200 pages.

Target Audience

  • Service Providers/ Buyers
  • Industry Investors/Investment Bankers
  • Education & Research Institutes
  • Research Professionals
  • Emerging Companies
  • Manufacturers

Market Segmentation

Global Patient Derived Xenograft (PDX) Models Market - By Type

  • Mice Model
  • Rats Model

Global Patient Derived Xenograft (PDX) Models Market - By Tumor Type

  • Gastrointestinal Tumor Model
  • Gynecological Tumor Model
  • Respiratory Tumor Model
  • Other Tumor Model

Global Patient Derived Xenograft (PDX) Models Market - By Application

  • Preclinical Drug Development
  • Biomarker Analysis
  • Basic Cancer Research

Global Patient Derived Xenograft (PDX) Models Market - By End User

  • Pharmaceutical & Biotechnology Companies
  • Contract Research Organizations (CROs)
  • Academic & Research Institutions
  • Others

Global Patient Derived Xenograft (PDX) Models Market - By Region

  • North America
  • South America
  • Europe
  • Asia
  • Middle East & Africa

Table of Contents

1. Global Patient Derived Xenograft (PDX) Models Market Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Global Patient Derived Xenograft (PDX) Models Market - Market Definition and Overview

3. Global Patient Derived Xenograft (PDX) Models Market - Executive Summary

  • 3.1. Market Snippet by Type
  • 3.2. Market Snippet by Tumor Type
  • 3.3. Market Snippet by Application
  • 3.4. Market Snippet by End User
  • 3.5. Market Snippet by Region

4. Global Patient Derived Xenograft (PDX) Models Market - Market Dynamics

  • 4.1. Market Impacting Factors
    • 4.1.1. Drivers
      • 4.1.1.1. The growing demand for personalized medicine will drive the market growth
      • 4.1.1.2. Rising demand for humanized PDX models is driving the market growth
    • 4.1.2. Restraints:
      • 4.1.2.1. High cost of personalized PDX models will hamper the market growth in the forecast period
    • 4.1.3. Opportunity
    • 4.1.4. Impact Analysis

5. Global Patient Derived Xenograft (PDX) Models Market - Industry Analysis

  • 5.1. Porter's Five Forces Analysis
  • 5.2. Supply Chain Analysis
  • 5.3. Pricing Analysis
  • 5.4. Regulatory Analysis
  • 5.5. Reimbursement Analysis
  • 5.6. Unmet Needs

6. Global Patient Derived Xenograft (PDX) Models Market - COVID-19 Analysis

  • 6.1. Analysis of Covid-19 on the Market
    • 6.1.1. Before COVID-19 Market Scenario
    • 6.1.2. Present COVID-19 Market Scenario
    • 6.1.3. After COVID-19 or Future Scenario
  • 6.2. Pricing Dynamics Amid Covid-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. Global Patient Derived Xenograft (PDX) Models Market - By Type

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type Segment
    • 7.1.2. Market Attractiveness Index, By Type Segment
  • 7.2. Mice Model*
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 7.3. Rats Model

8. Global Patient Derived Xenograft (PDX) Models Market - By Tumor Type

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 8.1.2. Market Attractiveness Index, By Tumor Type
  • 8.2. Gastrointestinal Tumor Model*
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 8.3. Gynecological Tumor Model
  • 8.4. Respiratory Tumor Model
  • 8.5. Other Tumor Model

9. Global Patient Derived Xenograft (PDX) Models Market - By Application

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 9.1.2. Market Attractiveness Index, By Application
  • 9.2. Preclinical Drug Development*
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 9.3. Biomarker Analysis
  • 9.4. Basic Cancer Research

10. Global Patient Derived Xenograft (PDX) Models Market - By End User

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User Segment
    • 10.1.2. Market Attractiveness Index, By End User Segment
  • 10.2. Pharmaceutical & Biotechnology Companies *
    • 10.2.1. Introduction
    • 10.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 10.3. Contract Research Organizations (CROs)
  • 10.4. Academic & Research Institutions
  • 10.5. Others

11. Global Patient Derived Xenograft (PDX) Models Market - By Region

  • 11.1. Introduction
    • 11.1.1. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
    • 11.1.2. Market Attractiveness Index, By Region
  • 11.2. North America
    • 11.2.1. Introduction
    • 11.2.2. Key Region-Specific Dynamics
    • 11.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 11.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 11.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 11.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
    • 11.2.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 11.2.7.1. U.S.
      • 11.2.7.2. Canada
      • 11.2.7.3. Mexico
  • 11.3. Europe
    • 11.3.1. Introduction
    • 11.3.2. Key Region-Specific Dynamics
    • 11.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 11.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 11.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 11.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
    • 11.3.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 11.3.7.1. Germany
      • 11.3.7.2. U.K.
      • 11.3.7.3. France
      • 11.3.7.4. Italy
      • 11.3.7.5. Spain
      • 11.3.7.6. Rest of Europe
  • 11.4. South America
    • 11.4.1. Introduction
    • 11.4.2. Key Region-Specific Dynamics
    • 11.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 11.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 11.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 11.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
    • 11.4.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 11.4.7.1. Brazil
      • 11.4.7.2. Argentina
      • 11.4.7.3. Rest of South America
  • 11.5. Asia Pacific
    • 11.5.1. Introduction
    • 11.5.2. Key Region-Specific Dynamics
    • 11.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 11.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 11.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 11.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
    • 11.5.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 11.5.7.1. China
      • 11.5.7.2. India
      • 11.5.7.3. Japan
      • 11.5.7.4. Australia
      • 11.5.7.5. Rest of Asia Pacific
  • 11.6. Middle East and Africa
    • 11.6.1. Introduction
    • 11.6.2. Key Region-Specific Dynamics
    • 11.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Type
    • 11.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tumor Type
    • 11.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 11.6.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User

12. Global Patient Derived Xenograft (PDX) Models Market - Competitive Landscape

  • 12.1. Key Developments and Strategies
  • 12.2. Company Share Analysis
  • 12.3. Product Benchmarking
  • 12.4. Key Companies to Watch
  • 12.5. Company with disruptive technology
  • 12.6. Start Up Companies

13. Global Patient Derived Xenograft (PDX) Models Market- Company Profiles

  • 13.1. Charles River Laboratories*
    • 13.1.1. Company Overview
    • 13.1.2. Product Portfolio and Description
    • 13.1.3. Key Highlights
    • 13.1.4. Financial Overview
  • 13.2. Envigo
  • 13.3. JSR Corporation (Crown Bioscience Inc.)
  • 13.4. Champions Oncology, Inc.
  • 13.5. EPO Berlin-Buch GmbH
  • 13.6. Hera BioLabs
  • 13.7. Horizon Discovery Group plc
  • 13.8. WuXi AppTec
  • 13.9. BEIJING IDMO Co. Ltd.
  • 13.10. Shanghai ChemPartner Co., Ltd..

LIST NOT EXHAUSTIVE

14. Global Patient Derived Xenograft (PDX) Models Market - DataM

  • 14.1. Appendix
  • 14.2. About Us and Services
  • 14.3. Contact Us