Global Capillary Electrophoresis Market - 2021-2028

Capillary Electrophoresis Market. Overview

The capillary electrophoresis market. The size was valued at US$ XX billion in 2020 and is estimated to reach US$ XX billion by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).

Capillary electrophoresis is a technique that separates ions analytically based on their electrophoretic mobility using an applied voltage. It is used most predominately because it gives faster results and provides separation with high-resolution. Over a large range of detection methods available,this is a useful technique.

Capillary Electrophoresis Market. Dynamics

The rising incidence of cancer disease will drive the capillary electrophoresis market. Growing research and development will drive the market in the forecast period.

The rising incidence of cancer disease will drive the capillary electrophoresis market

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020.

The key to the effective treatment of cancer is its early diagnosis. The detection of cancer biomarkers plays a critical role in cancer early diagnosis and classification and staging tumor progression, or assessment prognosis and treatment response. Various molecular diagnostic techniques have been developed for cancer biomarker studies, with many of the more effective approaches requiring a separation step before detection. Capillary electrophoresis (CE) can perform rapid and efficient separation with small samples, which is well-suited to analyze both small- and macro- molecule biomarkers in complex samples. CE has different separation modes and can couple different detectors into various platforms, such as conducting studies on DNA/ RNA point mutation, protein misexpression, and metabolite abnormality. Disease diagnosis using capillary electrophoresis methods has the advantages of high efficiency, high throughput, and high speed. Coupled with the different nucleic acid detection strategies, it overcomes the drawbacks of traditional identification methods, precluding many types of false-positive and negative results.

Growing research and development will drive the market in the forecast period

Capillary electrophoresis plays a critical role in the development of DNA analysis technologies. It's the best method of choice for DNA analysis techniques commonly used for sequencing, sizing, and aptamer discovery, and affinity studies. As novel approaches emerge, capillary electrophoresis techniques evolve from development stages to validated and applied methods. Still, the development of techniques to better understand separations in a capillary, such as artificial matrices, suggests that optimization of capillary electrophoresis methods will continue to be pivotal in expanding the field of DNA analysis.

It has become an established method because of its wide recognition as an analytical technique of choice in numerous analytical laboratories, academic and industrial sectors. The most important CE applications are pharmaceutical and biochemical research and quality control.

The limitations of capillary electrophoresis and the presence of alternative technologies will hamper the market

The short light path leading to a decrease in sensitivity, need of sample concentration/clean-up for sensitivity, protein adsorption on the walls causing decreased resolution, lack of different types of commercial detectors, and lack of instruments designed specifically for routine clinical use all these limitations will hamper the capillary electrophoresis market.

Denaturing and reducing sodium dodecyl sulfate PAGE (SDS-PAGE) with a discontinuous buffer system is the most widely used electrophoresis technique and separates proteins primarily by mass. Nondenaturing PAGE, also called native-PAGE, separates proteins according to their mass/charge ratio.

COVID-19 Impact Analysis

Capillary electrophoresis is a powerful separation tool with a wide range of analytes for diverse applications and is compatible with various detection methods. It has been used for research purposes during COVID-19 and hence might see a rise in its market.

Capillary Electrophoresis Market. Segment Analysis

Automatic capillary electrophoresis systems will dominate the capillary electrophoresis market

Capillary electrophoresis allows to automate the analysis of a wide range of compounds, including peptides, proteins, nucleic acids, oligonucleotides, and pharmaceuticals.

On November 1, 2019, Sebia got FDA approval for CAPI 3 IMMUNOTYPING. The CAPI 3 IMMUNOTYPING kit is designed to detect and characterize monoclonal proteins (immunotyping) in human urine and serum with the CAPILLARYS 3 instrument SEBIA, for capillary electrophoresis. The CAPILLARYS 3 instrument performs all procedural sequences automatically to obtain a protein profile for qualitative analysis. Each urine or serum sample is mixed with individual antisera that are specific against gamma (IgG), alpha (Ig A), and mu (Ig M) heavy chains, and kappa (free and bound) light chains and lambda (free and bound) light chains, respectively.

The capillary gel electrophoresis segment will dominate the market

Capillary Gel Electrophoresis (CGE) is an analytical separation method where charged molecules are separated in capillaries filled with porous gel matrix. Because of its advantages it is an adaptation of the traditional slab gel electrophoresis to the capillary electrophoresis (CE) method. Capillary Gel Electrophoresis is used to separate large biological molecules like protein, DNA, and RNA.

Capillary gel separations show to be three times faster, with better resolution (2.4 x) and higher separation efficiency (5.4 x) than a conventional automated slab gel DNA sequencing instrument. Agreement of measured values for velocity, resolution, and separation efficiency with theory predicts further improvements will result from increased electric field strengths (higher voltages and shorter capillaries). It has many advantages, such as automation, high separation efficiency, on-capillary detection, anticonvective nature of the capillary, and array dimension (multi capillary system).

Pharmaceutical and biotechnology companies segment will dominate the market

Capillary electrophoresis (CE) has a significant role in drug discovery and manufacturing processes. It can grow further due to new developments that can provide highly sensitive and high throughput analysis. CE is important for quality control of pharmaceutical entities and products (e.g., qualitative and quantitative analyses, purity testing, chiral purity, and related substance and stoichiometric determination). Quantitative analysis is mainly determined by comparing the mobility or migration time of the compounds of interest with those of the standards. Quantitative analysis is calculated from the peak height or peak area based on a standard calibration curve. Purity testing is usually required for drugs with low stability, whereas the determination of related substances is essential to ensure that precursors or reagents from synthesis processes do not exceed limits.

Capillary electrophoresis (CE) is a versatile micro/macro analytical technique gaining worldwide usage for the analysis and separation of ionic substances. It captured the attention of those working in a variety of fields focused on biologically active molecules. Its appealing characteristics include precise and unprecedented mass sensitivity, automated electrophoretic separation of microvolume samples with relatively short analysis times. Analyses of a diverse spectrum of analytes, ranging from small organic ions to macromolecular protein complexes and DNA are the further characteristics of this technology . Recent CE research and development, while combining some of the most robust aspects of traditional electrophoresis, chromatography, and capillary technology focused on avenues leading to improving detection, understanding and employing the basic chemistry of CE vis-a-vis new applications.

Capillary Electrophoresis Market. Geographical Analysis

North America region will dominate the capillary electrophoresis market

Rising research in the field of genomics and drug discovery. And increasing funding by the government for research projects will drive the market in this region.

The US leads in discovering approved drugs by a wide margin (118 out of the 252 drugs). Traditionally, the U.S is viewed as the leader in biotechnology innovation. Over 1,200 biotech companies employ around 200,000 workers in fields ranging from human product development to food and agriculture services. The region with leading innovative and research biopharmaceutical companies is represented by Pharmaceutical Research and Manufacturers of America (PhRMA). It is devoted to developing and discovering medicines that enable patients to healthier,live longer and more productive lives.Hence, increased research and development in this region will drive the market.

Capillary Electrophoresis Market. Competitive Landscape

Major key players in the capillary electrophoresis market are Agilent Technologies Inc., SEBIA, Thermo Fisher Scientific, LONZA, Teledyne Technologies Incorporated, Bio-Rad Laboratories, Harvard Bioscience, LABGENE Scientific SA., Helena Laboratories Corporation, Biotron Healthcare, QIAGEN, VWR International, LLC, TBG Diagnostics LTD., Shimadzu Corporation, Beckman Coulter, Inc., MERCK KGAA, Analytik Jena AG, Prince Technologies, Syngene, AB Sciex, and Lumex Instruments

Capillary Electrophoresis Market. Key Companies to Watch

Thermo Fisher Scientific

Overview: Globally, Thermo Fisher Scientific Inc. is the leader in serving science, with revenues of more than $24 billion and around 70,000 employees all over the world. Their mission is to enable customers to make the world cleaner,healthier and safer. They help their customers accelerate life sciences research, improve patient diagnostics, deliver medicines, solve complex analytical challenges to market and increase laboratory productivity. Through their premier brands Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, and Unity Lab Services they offer a combination of unmatched innovative technologies, comprehensive services and purchasing convenience.

Product Portfolio: The company comprises of Analytical Instruments, Laboratory Supply Chain Programs and eCommerce, Laboratory Equipment, Lab Services, Specialty Diagnostics, Life Sciences, Pharma Services, and CDMO

Key Development: On June 7, Thermo Fisher Scientific, the world leader in serving science, and Advanced Electrophoresis Solutions Ltd (AES), specialists in protein imaging technologies, today announced an agreement to combine essential protein separation techniques with mass spectrometry (MS) to advance therapeutic protein development through streamlined characterization.

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• Visualize the composition of the Capillary Electrophoresis Market. segmentation By Product type, By Mode and End-User type of packaging highlighting the key commercial assets and players.
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The Capillary Electrophoresis Market. report would provide an access to an approx. 60 market data table, 50 figures and 200 pages.

Target Audience

• Service Providers/ Buyers
• Industry Investors/Investment Bankers
• Education & Research Institutes
• Research Professionals
• Emerging Companies
• Manufacturers

Market Segmentation

Capillary Electrophoresis Market. - By Product type

• Automatic capillary electrophoresis systems
• Semi-automatic capillary electrophoresis systems

Capillary Electrophoresis Market. - By Mode

• capillary gel electrophoresis (CGE)
• Capillary zone electrophoresis (CZE)
• Capillary electro chromatography (CEC)

Capillary Electrophoresis Market. - By End-User

• Pharmaceutical and biotechnology companies
• Research organizations and institutes
• Others

Capillary Electrophoresis Market. - By Region

• North America
• Europe
• South America
• Asia Pacific
• Middle East and Africa