Market Research Report
Global Alcohol Dehydrogenase Market - 2021-2028
|Global Alcohol Dehydrogenase Market - 2021-2028|
Published: November 24, 2021
Content info: 180 Pages
Delivery time: 2 business days
The global alcohol dehydrogenase market size was valued at US$ XX million in 2020 and is estimated to reach US$ XX million by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).
Alcohol dehydrogenases are zinc enzymes that catalyze the oxidation of primary and secondary alcohols to the corresponding aldehyde or ketone by transferring a hydride anion to NAD+ and releasing a proton.
The factors driving the market growth are the increasing use of alcohol dehydrogenase for various applications and the adoption of enzyme-based therapies for treatment, diagnosis, and other purposes.
Alcohol dehydrogenases (ADHs) are best known for their roles in ethanol oxidation and elimination. Although less well known, ADHs play an important role in the metabolism of a variety of drugs and metabolites containing alcohol functional groups, including abacavir (HIV/AIDS), hydroxyzine (antihistamine), and ethambutol (antituberculosis). ADHs are made up of seven gene families and several genetic polymorphisms. ADHs are cytosolic enzymes found primarily in the liver and other tissues such as the gastrointestinal tract and adipose tissue. Significant species differences in ADHs include genes, proteins, enzymatic activity, and tissue distribution.
Fomepizole (4-methyl pyrazole) is a nonspecific ADH inhibitor currently being used as an antidote for methanol and ethylene glycol poisoning. Fomepizole can treat intoxication caused by other drugs of abuse by inhibiting ADHs and preventing the formation of toxic metabolites. ADHs can be activated by the farnesoid X receptor (FXR) and other transcription factors. In the clinic, drug-drug interactions for ADHs have been observed between ethanol and therapeutic drugs and between fomepizole and ADH substrates.
Several unfavorable factors are stifling the global alcohol dehydrogenase market's growth. The two main enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase. Another problem associated with ADH is drug addiction, which according to studies, is linked to alcoholism. Although some risk factors are shared by alcoholism and other drug addictions, alcoholism is frequently comorbid with other drug addictions. All of these factors are expected to limit the industry's growth.
Most alcohol is broken down or metabolized by alcohol dehydrogenase, an enzyme found in liver cells (ADH). ADH converts alcohol to acetaldehyde, rapidly degraded by another enzyme, aldehyde dehydrogenase (ALDH). Alcohol consumption is linked to a number of communicable and non-communicable diseases and mental health disorders, making a person more vulnerable to COVID-19. Alcohol, in particular, weakens the immune system and raises the risk of adverse health outcomes. As a result, people should limit their alcohol consumption at all times, especially during the COVID-19 pandemic. Hence, the growth of the alcohol dehydrogenase market is expected to be decreased with the limitation of alcohol consumption during the COVID-19 pandemic
The most fundamental and necessary application of alcohol dehydrogenase is in disease diagnosis. The brain contains alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH). ALDH and alcohol dehydrogenase is also found in brain tumour cells. Furthermore, class I isoenzyme activity was significantly higher in cancer cells than in healthy brain cells. The activity of these enzymes in tumour tissue is reflected in the serum and may be useful in diagnosing brain neoplasms.
Alcohol dehydrogenase is a polymorphic enzyme in multiple isoenzymes classified into several classes and found in various organs. ADH is involved in the metabolism of many biologically important substances, catalyzing the oxidation or reduction of a diverse range of substrates. The best-studied function of ADH is protection against excess ethanol and other exogenous xenobiotics and lipid peroxidation products. Alcohol dehydrogenase isoenzymes are also involved in the metabolism of retinol and serotonin. Cancer tissues have significantly higher total alcohol dehydrogenase activity than healthy organs (e.g., liver, stomach). Changes in the activity of specific ADH isoenzymes in the sera of patients with various cancers (particularly the digestive system) appear to be caused by the release of these isoenzymes from cancer cells. They may serve as markers of this cancer. The presence of specific ADH isoenzymes in the serum may indicate the location of cancer. Alcohol dehydrogenase may also be useful in the detection of non-cancerous liver diseases (e.g., viral hepatitis, non-alcoholic cirrhosis). For instance, ADH and ALDH isoenzymes can be secreted from cancer cells and found in patients' sera, suggesting they could be used in cancer diagnostics. ADH isoenzymes are being studied as tumor markers in various malignant diseases.
Ongoing technological developments, as well as the presence of a more significant number of major key players in this region, Companies are concentrating on the breakdown of potentially harmful alcohols in humans and other species, as well as the development of beneficial aldehyde, ketone, or alcohol groups during the formation of numerous metabolites. Furthermore, rising investments in healthcare facilities across the region are expected to support market growth during the forecast period. For instance, according to CDC in the U.S in 2018, two-thirds (66.3%) of adults aged 18 and up consumed alcohol in the previous year. 5.1 percent of adults aged 18 and up engaged in heavy drinking.
The global alcohol dehydrogenase market is moderately competitive. Established companies and new entrants currently form business strategies such as mergers, acquisitions, product launches, joint ventures, and brand promotions to gain domination in the market. Product research, innovations, technological developments, and technology are all part of the process. Some of the major key players in the market are Sigma-Aldrich, Worthington Biochemical, Alfa Aesar, Roche Diagnostics, MAK WOOD, Inc., OYC Americas, Calzyme Laboratories, Inc., Sisco Research Laboratories Pvt. Ltd.
The global alcohol dehydrogenase market report would provide an access to an approx. 45+ market data table, 40+ figures and 180 pages.
LIST NOT EXHAUSTIVE