Global Pellagra Treatment Market - 2022-2029

Market Overview

The global pellagra treatment market size was valued at US$ XX million in 2021 and is estimated to reach US$ XX million by 2029, growing at a CAGR of XX % during the forecast period (2022-2029).

Pellagra is a disease caused by a dietary deficiency in niacin (one of the B complex vitamins) or tryptophan (an amino acid).

Market Dynamics

The factors influencing the global pellagra treatment market are the increasing research and development and the increasing prevalence of pellagra.

The increasing research and development is expected to drive the market growth in the forecast period

Pellagra is a disease caused by a dietary deficiency in niacin (one of the B complex vitamins) or tryptophan (an amino acid). The triad of dermatitis, diarrhea, and dementia are the classic clinical features of pellagra, though most people do not have all three. Headache, irritability, poor concentration, apathy and confusion, vertigo, myoclonus, tremor, rigidity, weakness, dysphagia, seizures, and various psychiatric symptoms are all examples of neurologic abnormalities. Patients become disoriented, confused, and delirious as pellagra progresses, then stuporous and comatose, and finally die.

Pellagra can occur in people with Crohn's disease due to niacin deficiency caused by malabsorption and tryptophan wastage combined with increased 5-hydroxyindoleacetic acid excretion in the urine. Pellagra has been linked to infectious colitis and malabsorption caused by intestinal bacterial overgrowth. Niacin, also known as vitamin B3, is a generic name for two compounds: nicotinamide and nicotinic acid. It is required for carbohydrate, fat, protein, alcohol metabolism, drug and reactive oxygen species detoxification, cell signaling, and DNA repair. Niacin-rich foods include tuna fish, chicken, beef, peanuts, mushroom, avocado, and green peas, with recommended daily intakes of 14 mg. At the same time, HIV patients are expected to have higher niacin requirements. Moreover, the WHO recommends taking at least 300 mg nicotinamide in an oral divided daily dose for 3-4 weeks to treat pellagra. Niacin-induced flushing necessitates the use of nicotinamide. General malnutrition and cachexia may necessitate the use of additional dietary supplements.

Limitations associated with pellagra treatment are expected to hamper the market growth

Niacin is probably safe for most people when taken by mouth. Niacin can cause a flushing reaction, a common minor side effect. Side effects include burning, tingling, itching, redness of the face, arms, chest, and headaches. Starting with small doses of niacin and taking 325 mg of aspirin before each dose of niacin can help to reduce the flushing reaction. This reaction usually subsides as the body adjusts to the medication. Alcohol can exacerbate the flushing reaction. When taking niacin, one should stay away from large amounts of alcohol. Concerns have been raised about the risk of stroke in people who take niacin. According to one large study, people who took high doses of niacin had a two-fold higher risk of stroke than those who did not take niacin.

COVID-19 Impact Analysis

Countries worldwide went into lockdown early in the COVID-19 pandemic, shutting down or reducing transport within and between them. This impacted medicine manufacturing, supply, and distribution, causing global medicines supply chain bottlenecks. Some medicines used in COVID-19 patients have also seen an increase in demand. For instance, niacin is a component of NAD and NADP, important during chronic systemic inflammation. Increased levels of NAD+ are required to treat a wide range of pathophysiological conditions because it acts as a coenzyme in various metabolic pathways. NAD+ is produced in the early stages of inflammation and has immunomodulatory properties, lowering pro-inflammatory cytokines such as IL-1, IL-6, and TNF-.According to new research, targeting IL-6 may help control the inflammatory storm in COVID-19 patients. Niacin could be used as an adjunct treatment for COVID-19 patients because of its lung-protective and immune-strengthening properties. Hence, covid-19 is expected to positively impact the market with the rise in demand for niacin.

Segment Analysis

Primary pellagra is expected to dominate the market growth

Diets low in niacin or tryptophan cause primary pellagra. Because tryptophan is converted to niacin in the body, a lack of it can result in a niacin deficiency. Primary pellagra is common in developing countries where corn (maize) is a major food source or aftermath of long-term disasters such as famine or war. Corn is high in niacin, but it is locked up in a bound form that can only be accessed with alkaline solutions, and corn proteins are low in tryptophan. Pellagra is still endemic in India, China, and parts of Africa.

Dietary and lifestyle changes and a niacin or nicotinamide supplement treat primary pellagra. Nicotinamide is another form of Vitamin B3 used to treat pellagra in its early stages. When a disease is detected early on, it is possible to recover completely within a few days of starting treatment. On the other hand, skin improvement may take some time (usually a few months). When pellagra is left untreated, it can lead to death in as little as 4-5 years.

Geographical Analysis

North America region is expected to hold the largest market share in the global pellagra treatment market

The growing prevalence of pellagra and increasing research and development in this region is expected to drive the market growth.

Pellagra (a niacin deficiency disease) claimed more than 100,000 lives in the United States alone, affecting more than 3 million people. Pellagra reached epidemic proportions in the American South in the early 1900s. Pellagra infected over 3 million Americans during that time, resulting in over 100,000 deaths, but the epidemic ended after dietary niacin fortification. Hence, with pellagra's increasing prevalence, the demand for its treatment increased. And is expected to boost the market growth in North America region.

Competitive Landscape

With mergers, acquisitions, and product launches, the global pellagra treatment market is moderately competitive. Some of the key players in the market are DSM, Merck KGaA, Foodchem International Corporation, Jubilant Life Sciences Limited, Western Drugs Ltd., Lasons, Bazayan & Co, Resonance Specialties Limited, Veer-Chemie

Western Drugs Ltd.

Overview: Western Drugs Ltd. is a leading manufacturer of Niacin (Nicotinic Acid) and Niacinamide. The company was founded in 1989 and is headquartered in India.

Product Portfolio: Vitamin B3 Niacin (Nicotinic Acid) is a nutrient additive used in food, feed, and pharmaceutical/nutritional products. It is an essential B complex vitamin, also known as Vitamin B3, with various uses. It is available in powder and granular form.

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