Cell and Gene Therapy Market and Deals Analysis, 2023: Financings, Partnering, Mergers and Acquisitions, Tech Transfers, IPOs, and Other Deals

Table of Contents

Chapter 1: Executive Summary

• Introduction
• $40.2 Billion in Funding During 2022
  • Figure 1-1: Total Deals per Month, April 2021-March 2023 (Total count)
  • Figure 1-2: Total Deals per Month by Type, Apr 2021-Mar 2023 [VC/ Private, IPO/FPO/SPAC; and All Other Deals] (Total count)
• Quarterly Funding Amounts
  • Table 1-1: Total Quarterly Funding, by Type, Q1 2021-Q4 2021 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
  • Table 1-2: Total Quarterly Funding, by Type, Q1 2022-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
  • Figure 1-3: Total Quarterly Funding, Q1 2021- Q1 2023 ($M)
  • Figure 1-4: Total Quarterly Funding, by Type, Q1 2021-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] ($M)
• Quarterly Funding Category Shares, Q1 2021 Through Q1 2023
  • Table 1-3: Total Quarterly Funding Share, by Type, 2021 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Table 1-4: Total Quarterly Funding Share, by Type, Q1 2022-Q1 2023 [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Figure 1-5: Q1 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Figure 1-6: Q2 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Figure 1-7: Q3 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Figure 1-8: Q4 2022 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
  • Figure 1-9: Q1 2023 Funding Share, by Type of Funding [M&A; Venture Capital/Private; IPO/FPO; Collab; SPAC; and Strat inv] (%)
• Quarterly Deal Counts by Category, Q1 2021 - Q1 2023
  • Table 1-5: Quarterly Count of Deals, By 2021 Quarter, By Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; Manufacturing, Supply Chain; Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number) (%)
  • Table 1-6: Quarterly Count of Deals, by Quarter Q1 2022-Q1 2023, By Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; Manufacturing, Supply Chain; Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number) (%)
• Growth in Collaborations, Manufacturing/Supply Chain Deals, Licensing, Distribution/ Co-Marketing Highlight Activity in Cell and Gene Therapy
  • Figure 1-10: Most Frequent Types of Deals, by Quarter, by Category [Technology/Research/Strategic Collaboration; Venture Capital/Private Investment; Acquisition, Merger, Strategic Investment; Licensing; Public Offering/SPAC; and Manufacturing, Supply Chain] (Total number)
• A Look at Less Frequent CGT Deal Types
  • Figure 1-11: Lower Frequency Deal Types, by Quarter, by Category [Outreach, Philanthropy, Education; Distribution, Co-Marketing; Spinout, Restructure; Conclude/Terminate Deal; Joint Venture; and Settle Litigation] (total number)
  • Figure 1-12: Merger/ Acquisition Amount, by Quarter [Q1 2021 - Q1 2023] ($M)
  • Figure 1-13: Venture Capital/Private Funding Round Amount, by Quarter [January 2021-January 2022] ($M)
  • Figure 1-14: IPO/FPO Amount, by Quarter [Q1 2021-Q1 2023] ($M)
  • Figure 1-15: SPAC Portion Amount, by Year and Q1 2023 ($M)
• Synopsis of Most Active Deal-Making Companies
  • Table 1-7: Most Active Companies' Deal-Making Rankings, by Category, 2021-Q1 2023 (Rank)
  • Table 1-8: Most Active Companies in Overall Deals, Collaborations
  • Figure 1-16: Most Active Companies in Overall Deals, Collaborations

Chapter 2: Venture Capital & Private Funding

• VC/Private Funding in Flux
  • Figure 2-1: Total Number of VC/ Private Funding Deals by Month, January 2021-March 2023 (Total count)
  • Figure 2-2: Average VC/ Private Funding Round Amount, By Quarter Q1 2021-Q1 2023 ($M)
  • Table 2-1: Regional Venture Capital/Private Funding, by Quarter Q1 2021-Q1 2023, [North America, Europe, APAC, Rest of World] ($M) (%)
  • Figure 2-3: Quarterly Venture Capital/Private Total Funding, Q1 2021- Q1 2023, by Region [North America, Europe, APAC, Rest of World] ($M)
  • Table 2-2: Regional Venture Capital/Private Funding Shares, by Quarter Q1 2021-Q1 2023, [North America, Europe, APAC, Rest of World] (%)
  • Figure 2-4: Regional Venture Capital/Private Funding Shares, by Quarter Q1 2021 Q1 2023, [North America, Europe, APAC, Rest of World] (%)
  • Figure 2-5: Venture Capital/Private Funding Round Amounts, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 2-3: Venture Capital/Private Fundraising Deals, Q1 2023
  • Table 2-4: Venture Capital/Private Fundraising Deals, Q4 2022
  • Table 2-5: Venture Capital/Private, Q3 2022
  • Table 2-6: Venture Capital/Private Fundraising Deals, Q2 2022
  • Table 2-7: Venture Capital/Private Fundraising Deals, Q1 2022

Chapter 3: Strategic Investments

• Strategic Investments in Cell and Gene Therapy
  • Figure 3-1: Total Number of Strategic Investments, By Quarter [Q1 2021-Q1 2023] (Total count)
  • Figure 3-2: Average Strategic Investment Amount, By Quarter [Q1 2021-Q1 2023] ($M)
  • Figure 3-3: Total Strategic Investments, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 3-1: Strategic Investment Total Amounts, Counts, and Averages, by Quarter, Q1 2021 Q1 2023, ($M)
  • Table 3-2: Strategic Investments, January 2021-April 2023
• Most Active Companies
  • Table 3-3: Most Active in Acquisition/Merger/ Strategic Investment
  • Figure 3-4: Most Active in Acquisition/Merger/ Strategic Investment

Chapter 4: IPOs, FPOs, & SPACs

• North America Sees the Majority of Proceeds from IPOs, FPOs, SPACs
  • Figure 4-1: Total Number of IPOs/ FPOs, By Month [Jan 2021-Mar 2023] (Total count)
  • Figure 4-2: Average IPO/ FPO Proceeds, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 4-1: Quarterly IPO/ FPO Total Funding, Q1 2021 Q1 2023, by Region [North America, Europe, APAC] ($M)
  • Figure 4-3: Total IPO/ FPO Funding, By Quarter, by Region [Q1 2021-Q1 2023] ($M)
  • Table 4-2: Regional IPO/ FPO Funding Shares, by Quarter, Q1 2021 Q1 2023, [North America, Europe, APAC] (%)
  • Figure 4-4: Regional IPO/FPO Funding Shares, By Quarter, Q1 2021 Q1 2023 [North America, APAC, and Europe) (%)
  • Figure 4-5: IPO/FPO Amounts, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 4-3: Quarterly SPAC Funding Portion, Q1 2021-Q1 2023 ($M)
  • Figure 4-6: Quarterly SPAC Funding Portion Total and Average, Q1 2021-Q1 2023 ($M)
  • Table 4-4: IPO/FPO Deals, Q1 2023
  • Table 4-5: IPO/FPO Deals, Q4 2022
  • Table 4-6: IPO/FPO Deals, Q3 2022
  • Table 4-7: IPO/FPO Deals, Q2 2022
  • Table 4-8: IPO/FPO Deals, Q1 2022
  • Table 4-9: SPAC Portion, January 2021-Mar 2023 ($M)
  • Figure 4-7: SPAC Portion Amount, by Year, '21, '22, Q1 2023 ($M)

Chapter 5: Mergers & Acquisitions (M&A)

• Growing Numbers of M&A, Despite Lower Average Value
  • Figure 5-1: Total Number of Mergers and Acquisitions, By Month [Jan 2021-Mar 2023] (Total Count)
  • Figure 5-2: Average Merger/Acquisition Amount, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 5-1: Quarterly Merger and Acquisition Values, Counts, and Averages, Q1 2021-Q1 2023 ($M) (Total count)
  • Figure 5-3: Merger/ Acquisition Transactions Global Total, By Quarter [Q1 2022- Q1 2023] ($M)
  • Figure 5-4: Merger/ Acquisition Amounts, by Quarter [Q1 2021- Q1 2023] ($M)
  • Table 5-2: Mergers and Acquisitions Announcements, Q1 2023 ($M)
  • Table 5-3: Mergers and Acquisitions, Q4 2022 ($M)
  • Table 5-4: Mergers and Acquisitions, Q3 2022 ($M)
  • Table 5-5: Mergers and Acquisitions, Q2 2022 ($M)
  • Table 5-6: Mergers and Acquisitions, Q1 2022 ($M)
• Most Active Companies
  • Table 5-7: Most Active in Acquisition/Merger/Strategic Investment
  • Figure 5-5: Most Active in Acquisition/Merger/ Strategic Investment

Chapter 6: Technology/Research/Strategic Collaborations

• CGT Market Sees a Broad Variety of Collaborations
  • Figure 6-1: Total Number of Tech/ Research/ Strategic Collaborations, By Month [Jan 2021-Mar 2023] (Total count)
  • Figure 6-2: Total Number of Collaborations with Upfront and/or Milestone Payments, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 6-1: Collaboration Upfront and Future/ Milestone Payments, Counts, Averages, Q1 2021-Q1 2023 ($M) (Total count)
  • Figure 6-3: Average Collaboration Upfront Payment, By Quarter [Q1 2021-Q1 2023] ($M)
  • Figure 6-4: Total Collaboration Upfront Payments, By Quarter [Q1 2021-Q1 2023] ($M)
  • Figure 6-5: Average Collaboration Future/ Milestone Payments, By Quarter [Q1 2021-Q1 2023] ($M)
  • Figure 6-6: Total Collaboration Future/ Milestone Payments, By Quarter [Q1 2021-Q1 2023] ($M)
  • Table 6-2: Technology/Research/Strategic Collaboration Deals, January 2022-April 2023
• Most Active Companies
  • Table 6-3: Most Active in Research/Strategic Collaborations
  • Figure 6-7: Most Active in Research/Strategic Collaborations

Chapter 7: Licensing

• Stable Levels of Licensing in the Cell and Gene Therapy Market
  • Figure 7-1: Total Number of Licensing Deals, By Month [Jan 2021-Mar 2023] (Total count)
  • Table 7-1: Licensing Deals, January 2022-April 2023
• Most Active Companies
  • Table 7-2: Most Active Companies in Licensing Deals
  • Figure 7-2: Most Active Companies in Licensing Deals

Chapter 8: Manufacturing and Supply Chain

• Major Growth in Manufacturing and Supply Chain Management Activity in CGT
  • Figure 8-1: Total Number of Supply/ Manufacturing Deals, By Month [Jan 2021-Mar 2023] (Total count)
  • Table 8-1: Manufacturing and Supply Chain Deals, January 2022-March 2023
• Most Active Companies
  • Table 8-2: Most Active Companies in Manufacturing/Supply Deals
  • Figure 8-2: Most Active Companies in Manufacturing/Supply Deals

Chapter 9: Public Outreach, Education, & Philanthropy

• CGT Market Focusing Less on Public Outreach, Patient/ Consumer/ Trainee Education, and Philanthropy
  • Figure 9-1: Total Number of Outreach/ Philanthropy/ Education Deals, By Month [Jan 2021-Mar 2023] (Total count)
  • Table 9-1: Outreach, Education, & Philanthropy Deals, January 2022-Apr 2023

Chapter 10: Distribution & Co-Marketing

• A Look at CGT Distribution and Co-Marketing Deals
  • Figure 10-1: Total Number of Distribution/ Co-Marketing Deals, by Month [Jan 2021-Mar 2023] (Total count)
  • Table 10-1: Distribution & Co-Marketing Deals, January 2022-Mar 2023
• Most Active Companies
  • Table 10-2: Most Active Companies in Distribution/Co-Marketing Deals
  • Figure 10-2: Most Active Companies in Distribution/Co-Marketing Deals

Chapter 11: Other - JV, Restructuring, Termination, Spinoffs

• A Look at Other Types of Deals Impacting Cell and Gene Therapy
  • Figure 11-1: Total Number of JV, Restructuring, Termination, By Month [Jan 2021-Mar 2023] (Total count)
  • Table 11-1: Restructuring, JV, Termination, Spinoffs, January 2022-April 2023

Chapter 12: Other - New Facilities, Expansion; Real Estate

• Expansion, New Facilities and Related Announcements
  • Table 12-1: New Facilities, Expansion; Real Estate Deals, January 2022-April 2023

Appendix: Cell and Gene Therapy Market Assessment

• Market Outlook, 2022-2032
  • Table A-1: Cell and Gene Therapy Market Revenues by Product Type, 2022 and Projected 2027 and 2032 ($ millions)
  • Figure A-1: Cell and Gene Therapy Market Revenue Share, by Product Type [Cardiovascular-Blood, Dermatological, Musculoskeletal, Neurology, Oncology, Ophthalmic, Other Conditions] (%)
• Regional Market
  • Table A-2: Cell and Gene Therapy Market by Country/Region [Europe, United States, Other Countries], 2022 Projected 2027 and 2032 ($ millions)
• Products on the Market
  • Table A-3: Major Cell and Gene Therapy Product Approvals, FDA
• Top Companies in Cell and Gene Therapy
  • Figure A-2: Leading Companies in Cell and Gene Therapy, By Company [Amylan, Bristol Myers, Dendreon, Gilead, Novartis, Smith and Nephew, Others]