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Market Research Report

The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs)

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The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs)
Published: June 19, 2015 Content info: 204 Pages
Description

Circulating tumor cells (CTCs) have tremendous utility in cancer research, aiding researchers in deciphering the complex processes leading to cancer metastasis and in developing more effective cancer therapeutics. Besides the research applications, the detection and analysis of CTCs has enormous potential in the diagnosis and management of cancer, as current tools, such as tumor tissue biopsy or imaging technologies, have numerous limitations. Although their biology and characteristics are still not entirely elucidated, CTCs are believed to detach from primary or secondary tumors, enter the bloodstream, and travel to distant organs. The majority of CTCs die in the bloodstream due to the harsh environment; very few of them are able to metastasize, and even fewer - known as cancer stem cells (CSCs) - can form distant tumors. Nevertheless, this small percentage of CTCs - about 0.01% - is sufficient to initiate and continue the blood-borne metastasis process, which leads to the progression of the disease and death.

The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) is a detailed analysis of the potential opportunities for manufacturers of CTCs-based technologies, informing readers of the scientific basis of CTCs in an understandable fashion and constructing models of revenue opportunity based on several dimensions - application area, cancer type and region - that can assist with business planning efforts.

The report provides data on the following:

  • Industry Structure - Selected Competitors and Marketed Products, 2014
  • CellSearch System (IVD Use) Analysis, 2015
  • AdnaTest (IVD Use) Analysis, 2015
  • Significant Trends in the CTCs Market, 2015
  • Estimated Market Breakdown, 2014 (Research Segment, Diagnostics Segment)
  • Estimated Market Breakdown by Type of Cancer, 2014
  • Estimated Market Breakdown by Geographic Region, 2014
  • Global Revenues and Forecast for the CTCs Market by Application, 2013-2015 and 2019
  • Global Revenues for the CTCs Market by Geographic Region, 2013-2015 and 2019

The global market for technologies serving CTCs research and diagnostics is experiencing several notable trends that have a significant effect on its participants, as well as on the overall market growth. The report presents analysis of such trends, including:

  • Increasing Incorporation of CTCs Technologies in Clinical Trials to Accelerate Market Growth
  • The Quest for Personalized Medicine to Spur the Use of CTCs in Research & Development
  • Increasing Development of CTC-based Diagnostics Tests to Augment Market Revenues
  • Increasing Global Incidence of Cancer and Life Expectancy to Increase Testing Volumes
  • The Impact of Clinical Utility on Adoption of CTCs Tests in Clinical Practice
  • The Impact of New Technologies Approved by Regulatory Agencies on Market Growth
  • The Impact of Insurance Coverage on Utilization and Market Revenues

The report also covers notable industry events such as:

  • CTCs Enumeration by CellSearch Demonstrating Potential as an Efficacy-Response Surrogate
  • The Menarini Group Acquisition of Silicon Biosystems
  • Cynvenio Biosystems' Launch of the ClearID Breast Cancer Monitoring Test
  • Vitatex's Licensing of Cell Adhesion Matrix Technology to Noble Life Sciences
  • Janssen Diagnostics and Asuragen's Introduction of NGS technology for CellSearch

The global market for CTC detection, isolation and analysis devices is a heterogeneous and competitive market, constantly driven by technological innovation and demand for improved technologies. The market includes numerous competitors with different capabilities. These numerous specialized or research-based companies also develop and commercialize products for the detection, isolation and analysis of CTCs, and contribute considerably to the technological advancements in this field. As part of its extensive coverage, the report profiles several competitors in the market.

The following companies are profiled:

  • Janssen Diagnostics
  • AdnaGen AG (currently QIAGEN Hannover GmbH)
  • Acousys Biodevices, Inc.
  • Advanced Cell Diagnostics, Inc.
  • ApoCell, Inc.
  • BioCEP Ltd.
  • Biocept, Inc.
  • Biofluidica
  • BioView Ltd.
  • Clearbridge Biomedics Pte Ltd
  • Creatv MicroTech, Inc.
  • Cynvenio Biosystems
  • CytoTrack ApS
  • DeNovo Sciences Inc.
  • Epic Sciences
  • Fluidigm Corporation
  • Fluxion Biosciences
  • GILUPI GmbH
  • iCellate Medical AB
  • Ikonisys, Inc.
  • IVDiagnostics, LLC
  • Miltenyi Biotec GmbH
  • On-chip Biotechnologies
  • Oncolys Biopharma Inc.
  • Parsortix/ANGLE plc
  • QIAGEN N.V.
  • RareCells Diagnostics
  • RareCyte, Inc.
  • ScreenCell
  • Silicon Biosystems
  • SRI Biosciences
  • Vitatex Inc.
  • Vortex Biosciences
Table of Contents
Product Code: KLI5593376

Table of Contents

ONE: EXECUTIVE SUMMARY

  • Circulating Tumor Cells in Cancer
  • Current and Potential Clinical Applications of CTCs
  • CTCs Detection, Isolation and Analysis Technologies
  • Industry and Market Structure

TWO: CANCER OVERVIEW

  • Disease Overview
  • Risk Factors
  • Prevalence and Incidence of Cancer

THREE: CIRCULATING TUMOR CELLS OVERVIEW

  • Overview
  • CTCs Applications
  • Characteristics of CTCs
  • CTCs Isolation and Characterization Challenges
  • Current Markers for CTCs Identification and Analysis
  • Epithelial Cell Adhesion Molecule (EpCAM)
  • Ephrin Receptor B4 (EpB4)
  • Epidermal Growth Factor Receptor (EGFR)
  • Human Epidermal Growth Factor (HER2)
  • Mucin-1 (MUC-1)
  • Carcinoembryonic Antigen (CEA)
  • Cytokeratins
  • Other CTCs Markers Investigated for Clinical Applications
  • Cyclophilins
  • Plastin3 (PLS3)
  • Vimentin
  • Conclusions
  • Current and Potential Clinical Applications of CTCs
  • Prognostic Tool for Survival
  • Non-Invasive Early Diagnosis of Cancer
  • Predictors of Disease Evolution and Metastatic Potential
  • Therapy Guidance and Monitoring/ Predictor of Response to Therapy
  • Patient Stratification in Clinical Trials
  • Surrogate Endpoint in Clinical Trials
  • Drug Development - Selection of Drug Targets

FOUR: CTCs ISOLATION AND DETECTION TECHNOLOGIES

  • Overview
  • Enrichment Methods Based on Physical Properties
  • Size-based Methods
  • Density-based Methods
  • Electrophysiological-based Methods
  • Immuno-Mediated Capture Methods
  • Magnetic Platforms
  • Microfluidic Platforms
  • Conclusion
  • Optical Identification and Enumeration
  • Bioview's Duet Cell Imaging System (Israel)
  • CytoTrack's Optical Scanning Technology (Denmark)
  • Epic Sciences (San Diego, California, USA)
  • Ikonisys (New Haven, CT, USA)
  • Nucleic Acid-based CTC Detection Methods
  • RNAscope (Advanced Cell Diagnostics, USA)
  • Cytometric Detection and Enumeration Methods
  • FASTcell Cytometer (SRI Biosciences, USA)
  • On-chip Sort Cell Sorter (On-chip Biotechnologies, Japan)
  • Other CTCs Isolation and Detection Approaches
  • Virus Vectors Fluorescence
  • Selectin-Mediated Capture
  • Cell Adhesion Matrix
  • Other Combination Negative Depletion/ Positive Selection Methods
  • Rheology-based Methods
  • In Vivo Detection Methods

FIVE: INDUSTRY AND MARKET LANDSCAPE

  • Industry Structure
  • Competitive Factors
  • Products Analysis
  • CellSearch
  • AdnaTests
  • Significant Market Trends
  • Increasing Incorporation of CTCs Technologies in Clinical Trials to Accelerate
  • Market Growth
  • The Quest for Personalized Medicine to Spur the Use of CTCs in Research & Development
  • Increasing Development of CTC-based Diagnostics Tests to Augment Market Revenues
  • Increasing Global Incidence of Cancer and Life Expectancy to Increase Testing Volumes
  • The Impact of Clinical Utility on Adoption of CTCs Tests in Clinical Practice
  • The Impact of New Technologies Approved by Regulatory Agencies on Market Growth
  • The Impact of Insurance Coverage on Utilization and Market Revenues
  • Notable Industry Events
  • CTCs Enumeration by CellSearch Demonstrated Potential as Efficacy-Response Surrogate
  • The Menarini Group Acquired Silicon Biosystems
  • Cynvenio Biosystems Launched ClearID Breast Cancer Monitoring Test
  • Vitatex Licenses Cell Adhesion Matrix Technology to Noble Life Sciences
  • SWOG S0500 Clinical Trial Results Presented in December 2013
  • Parsorter PS1 Launched to Market in Europe
  • Clearbridge Biomedics Launched the ClearCell FX System for Capturing CTCs in Whole Blood Samples
  • Fluxion Biosciences Launched Next Generation Sequencing Assay Kits for IsoFlux System
  • Janssen Diagnostics and Asuragen Introduce NGS technology for CellSearch
  • Biocept Collaborates with Rosetta Genomics to Evaluate CTCs' microRNA
  • Biocept Launches Lung Cancer CTC Tests
  • Parsortix Collaborates with EKF Diagnostics and Undisclosed Pharmaceutical
  • Company to Develop “Liquid Biopsy” Applications
  • ThermoFisher Scientific Enters into Distribution Agreement with Cynvenio
  • Biosystems for LiquidBiopsy Platform
  • QIAGEN Acquired AdnaGen's CTC's Technology
  • Total Market Revenues and Forecast
  • Market Snapshot
  • Total Market Forecast

SIX: COMPANY PROFILES

  • Janssen Diagnostics
  • AdnaGen AG (currently QIAGEN Hannover GmbH)
  • Acousys Biodevices, Inc.
  • Advanced Cell Diagnostics, Inc.
  • ApoCell, Inc.
  • BioCEP Ltd.
  • Biocept, Inc.
  • Biofluidica
  • BioView Ltd.
  • Clearbridge Biomedics Pte Ltd
  • Creatv MicroTech, Inc.
  • Cynvenio Biosystems
  • CytoTrack ApS
  • DeNovo Sciences Inc.
  • Epic Sciences
  • Fluidigm Corporation
  • Fluxion Biosciences
  • GILUPI GmbH
  • iCellate Medical AB
  • Ikonisys, Inc.
  • IVDiagnostics, LLC
  • Miltenyi Biotec GmbH
  • On-chip Biotechnologies
  • Oncolys Biopharma Inc.
  • Parsortix/ANGLE plc
  • QIAGEN N.V.
  • RareCells Diagnostics
  • RareCyte, Inc.
  • ScreenCell
  • Silicon Biosystems
  • SRI Biosciences
  • Vitatex Inc.
  • Vortex Biosciences

LIST OF EXHIBITS

TWO: CANCER OVERVIEW

  • Table 2-1: Top Ten Causes of Death in the World by Geographic Region, 2012
  • Table 2-2: Top Ten Causes of Death in the World, 2012
  • Table 2-3: Projected Top Ten Causes of Death in the World, 2015
  • Table 2-4: Projected Top Ten Causes of Death in the World in High Income Countries, 2015
  • Table 2-5: Projected Top Ten Causes of Death in the World in Upper Middle Income Countries, 2015
  • Table 2-6: Global Incidence of Cancer by Geographic Region, 2012
  • Table 2-7: Global Incidence of the Five Most Common Types of Cancer in Men,2012
  • Table 2-8: Global Incidence of the Five Most Common Types of Cancer in Women, 2012
  • Table 2-9: Global Incidence of Most Common Types of Cancer in Both Genders,2012
  • Table 2-10: Projected Growth in Global Incidence of Cancer by Geographic Region, 2012-2030

THREE: CIRCULATING TUMOR CELLS OVERVIEW

  • Table 3-1: Typical Human Blood Cellular Composition
  • Table 3-2: Challenges in the Detection and Isolation of CTCs, 2015
  • Table 3-3: Selected Markers for CTCs Identification and Analysis
  • Table 3-4: Selected EpCAM-based Methods
  • Table 3-5: Current and Potential Clinical Uses of CTCs, 2015

FOUR: CTCs ISOLATION AND DETECTION TECHNOLOGIES

  • Table 4-1: Selected Size-Based CTCs Enrichment Methods
  • Table 4-2: Selected Density-Based CTCs Enrichment Methods
  • Table 4-3: Selected CTCs Detection and Isolation Methods Based on Electrophysiological Properties
  • Table 4-4: Selected CTCs Magnetic Platforms Based on Cell Surface Markers
  • Table 4-5: Selected CTCs Immunomagnetic Microfluidics Platforms
  • Table 4-6: Selected CTCs Optical Identification Methods
  • Table 4-7: Selected Nucleic Acid-based CTCs Detection Methods
  • Table 4-8: Comparison of Selected Cytometric CTCs Detection Methods
  • Table 4-9: Selected CTCs In Vivo Detection Platforms

FIVE: INDUSTRY AND MARKET LANDSCAPE

  • Table 5-1: Industry Structure - Selected Competitors and Marketed Products, 2014
  • Table 5-2: CellSearch System (IVD Use) Analysis, 2015
  • Table 5-3: AdnaTest (IVD Use) Analysis, 2015
  • Table 5-4: Significant Trends in the CTCs Market, 2015
  • Figure 5-1: Estimated Market Breakdown, 2014 (Research Segment, Diagnostics Segment)
  • Figure 5-2: Estimated Market Breakdown by Type of Cancer, 2014 (Breast, Prostate, Colorectal, Lung, Others)
  • Figure 5-3: Estimated Market Breakdown by Geographic Region, 2014 (US, EU, ROW)
  • Table 5-5: Global Revenues and Forecast for the CTCs Market by Application, 2013-2015 and 2019 (Diagnostics Segment, Research Segment, Total Market)
  • Figure 5-4: Global Revenues and Forecast for the CTCs Market, 2013-2015 and 2019 (Diagnostics Segment, Research Segment, Total Market)
  • Table 5-6: Global Revenues for the CTCs Market by Geographic Region, 2013-2015 and 2019 (US Market, EU Market, ROW Market, Total Market)
  • Figure 5-5: Global Revenues for the CTCs Market by Geographic Region, 2013- 2015 and 2019 (US Market, EU Market, ROW Market, Total Market)
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