Notice: Global Information Announces Listing on JASDAQ Standard Market of the Tokyo Stock Exchange

Cover Image
Market Research Report

Global Anaplastic Lymphoma Kinase ALK Inhibitors Market, Drug Sales, Price & Clinical Trials Insight 2026

Published by KuicK Research Product code 998804
Published Content info 190 Pages
Delivery time: 1-2 business days
Price
Back to Top
Global Anaplastic Lymphoma Kinase ALK Inhibitors Market, Drug Sales, Price & Clinical Trials Insight 2026
Published: April 7, 2021 Content info: 190 Pages
Description

“Global Anaplastic Lymphoma Kinase ALK Inhibitors Market & Clinical Trials Insight 2026” Report Highlights:

  • Global ALK Inhibitors Market Opportunity: > USD 5 Billion
  • US Dominates Global ALK Inhibitors Market Sales: >30%
  • Approved ALK Inhibitors: 5 Drugs
  • Global & Regional ALK Inhibitors Market Sales Insights (2017-2020)
  • Global & Regional ALK Inhibitors Market Opportunity (2021-2026)
  • Approved ALK Inhibitors Dosage, Patent, Price & Sales Insights
  • Global Clinical Trials Insight By Company, Indication & Phase

The progress made by science and technology in last few decades has led to identification of several potential targets which can be utilized in the drug development process. The characterization of anaplastic lymphoma kinase (ALK) gene and their role in the development and progression of ALK positive cancer has transformed the cancer therapeutics market. The extensive research activities by the researchers have led to the development of novel anaplastic lymphoma kinase inhibitors which belongs to the class of tyrosine receptor kinase and are used in the management of cancer.

Till now, multiple anaplastic lymphoma kinase inhibitors have been approved by the regulatory authorities and several others are present in clinical pipeline which are expected to enter the market in next few years. The advent of these drugs in the market has overcome the limitations of conventional therapies such as chemotherapy and radiotherapy. The high target ability and specificity of these inhibitors towards the cancer cells has enhanced the survival rates of cancer patients and also improved the quality of life of patients.

Since the approval of first generation anaplastic lymphoma kinase inhibitor in the management of non-small cell lung cancer, researchers have indulge in research activities for the development of next generation inhibitors which can overcome the limitations and can efficiently cross the blood brain barrier for enhanced efficacy. Apart from this, several clinical trials are ongoing to evaluate the efficacy of these drugs in combination with other chemotherapeutic drugs and immune checkpoint inhibitors. The combinational therapy will increase the efficacy of the drug which can better combat the complexity of the cancer.

The global anaplastic lymphoma kinase inhibitor market is going to witness high growth during the forecast period which is mainly attributed to the rise in prevalence of anaplastic lymphoma kinase positive cancers and high research and development activities in this sector. The rates at which conventional therapies are failing will further possess unmet need for the development of novel target therapies which will also drive the growth of the market. In addition to this, the robust clinical pipeline and their increasing application in different cancers will drive the market in coming years.

Despite several advantages of anaplastic lymphoma kinase inhibitors in management of cancer, there are several factors which restrains the growth of market. The resistance to the drugs during 1-2 year of the therapy is one of the limiting factors which will act as a barrier to the market. Moreover, the high cost associated with the drug will also limit the availability of the drug and increases the financial toxicity on the patient and their families.

Currently, US holds the top position in the global market and is expected to maintain its position over the forecast period mainly due to the presence of large pharmaceutical sector which actively invest in research and development activities as well as increasing funding by the government to promote research and development. Apart from this, other regions such Europe, Asia-Pacific and Japan are also expanding their markets to secure their position in the global market. The global anaplastic lymphoma kinase inhibitor market is going to witness high growth rate and is expected to double in next 5 years. Furthermore, the market will be flourished with next generation ALK inhibitors as well as several combintional therapies in wide range of cancers including neuroblastoma, lymphoma and colorectal cancer.

The report “Global Anaplastic Lymphoma Kinase ALK Inhibitors Market & Clinical Trials Insight 2026” includes information about the patent expiration, dosage, price, sales and mechanism of currently approved anaplastic lymphoma kinase inhibitors. In addition to this, several emerging ALK inhibitors along with their clinical trials are also provided in the report.

Table of Contents

Table of Contents

1. Introduction to Anaplastic Lymphoma Kinase (ALK) Inhibitors

  • 1.1. Overview
  • 1.2. History of Development

2. ALK Inhibitors as Cancer Therapeutics

  • 2.1. Need of ALK Inhibitors in Cancer Therapy
  • 2.2. ALK - Potential Target in Cancer Therapy
  • 2.3. Mechanism of Action

3. ALK Inhibitors in Lung Cancer

  • 3.1. Role of ALK Inhibitors in Lung Cancer
  • 3.2. On Going Research & Development

4. ALK Inhibitors in Neuroblastoma

  • 4.1. Role of ALK Inhibitor in Neuroblastoma
  • 4.2. On Going Clinical Research

5. ALK Inhibitors in Lymphoma

  • 5.1. Role of ALK in Lymphoma
  • 5.2. On Going Clinical Research

6. ALK Inhibitors in Other Cancers

  • 6.1. ALK Inhibitor in Colorectal Cancer
  • 6.2. ALK in Renal Cell Carcinoma
  • 6.3. ALK Inhibitor in Inflammatory Myofibroblastic Tumor

7. Crizotinib (Xalkori) - Clinical & Commercial Insight

  • 7.1. Overview
  • 7.2. Patents & Assignees
  • 7.3. Dosage & Price Analysis
  • 7.4. Sales Analysis

8. Certinib (Zykadia) - Clinical & Commercial Insight

  • 8.1. Overview
  • 8.2. Patents & Assignees
  • 8.3. Dosage & Price Analysis

9. Alectinib (Alecensa) - Clinical & Commercial Insight

  • 9.1. Overview
  • 9.2. Patents & Assignee
  • 9.3. Dosage & Price Analysis
  • 9.4. Sales Analysis

10. Brigatinib (Alunbrig) - Clinical & Commercial Insight

  • 10.1. Overview
  • 10.2. Patent Information
  • 10.3. Dosage & Price Analysis
  • 10.4. Sales Analysis

11. Lorlatinib (Lorbrena) - Clinical & Commercial Insight

  • 11.1. Overview
  • 11.2. Dosage, Patent & Price Analysis
  • 11.3. Sales Analysis

12. Emerging Novel ALK Inhibitors in Cancer

  • 12.1. Ensartinib
  • 12.2. Entrectinib (RXDX-101)
  • 12.3. TPX-0131
  • 12.4. TQ-B3139
  • 12.5. Belizatinib (TSR-011)
  • 12.6. CEP-37440
  • 12.7. Alkotinib

13. ALK Inhibitor Market Analysis - Clinical Trial Insight

  • 13.1. By Phase
  • 13.2. By Company
  • 13.3. By Country
  • 13.4. By Patient Segment

14. ALK Inhibitors Drug Market

  • 14.1. Current Market Scenario
  • 14.2. Global & Regional Market Analysis

15. ALK Inhibitor Drug Market by Product

  • 15.1. First Generation ALK Inhibitor
  • 15.2. Second Generation ALK Inhibitor
  • 15.3. Third Generation ALK Inhibitor

16. Anaplastic Lymphoma Kinase (ALK) Inhibitors Clinical Trials Insight

  • 16.1. Research
  • 16.2. Preclinical
  • 16.3. Phase-I
  • 16.4. Phase-I/II
  • 16.5. Phase-II
  • 16.6. Phase-III

17. Marketed Anaplastic Lymphoma Kinase (ALK) Inhibitors Clinical Insight

  • 17.1. ALUNBRIG
  • 17.2. Lorbrena/Lorviqua
  • 17.3. Alecensa
  • 17.4. Jikadia/ Zykadia
  • 17.5. Xalkori

18. ALK Inhibitor - On Going Research & Development

  • 18.1. Lorbrena Overcomes Xalkori as Front-Line Therapy in NSCLC
  • 18.2. Comparable Time to Treatment Deterioration of Lorlatinib & Crizotinib in Patients with NSCLC
  • 18.3. FDA Approved CDx Assay for Lorlatinib in ALK Positive NSCLC
  • 18.4. TPX-0131 Overcomes ALK Mutations in Preclinical Models

19. ALK Inhibitor Drug Market Future Prospects

  • 19.1. ALK Inhibitor Future Forecast
  • 19.2. Future Market Opportunity of ALK Inhibitor

20. ALK Inhibitor Drug Market Dynamics

  • 20.1. ALK Inhibitor Drug Market Favorable Parameters
  • 20.2. Barriers to ALK Inhibitor Drug Market

21. Competitive Landscape

  • 21.1. Astellas Pharma
  • 21.2. AstraZeneca
  • 21.3. Betta Pharmaceuticals
  • 21.4. GlaxoSmithKline
  • 21.5. Merck
  • 21.6. Novartis
  • 21.7. Pfizer
  • 21.8. Roche
  • 21.9. Takeda Pharmaceuticals
  • 21.10. Turning Point Therapeutics

List of Figures

  • Figure 1-1: History of Anaplastic Lymphoma Kinase Inhibitors
  • Figure 2-1: Frequency of ALK Rearrangements by Cancer
  • Figure 2-2: Structure of Anaplastic Lymphoma Kinase (ALK) Gene
  • Figure 2-3: ALK - Potential Target in Cancer Therapy
  • Figure 2-4: Anaplastic Lymphoma Kinase Signaling Pathway
  • Figure 2-5: Crizotinib - Mechanism of Action
  • Figure 2-6: Alectinib - Mechanism of Action
  • Figure 3-1: Role of ALK Inhibitors in NSCLC
  • Figure 3-2: Approved ALK Inhibitors for NSCLC
  • Figure 3-3: Ongoing Trials with Combination Therapy in ALK-Rearranged NSCLCs
  • Figure 4-1: ALK Protein Structure & Mutations Found in Neuroblastoma
  • Figure 4-2: Clinical trials Evaluating ALK Inhibitors in Neuroblastoma
  • Figure 5-1: Clinical trials Evaluating ALK Inhibitors in Lyphoma
  • Figure 6-1: ALK Fusions in Renal Cell Carcinoma
  • Figure 7-1: Xalkori - FDA Approval by Indication
  • Figure 7-2: Xalkori - FDA Approval by Region
  • Figure 7-3: US - Sugen's Xalkori Patent Issue & Expiration Year
  • Figure 7-4: US - Pfizer's Xalkori Patent Issue & Expiration Year
  • Figure 7-5: US - Agouron's Xalkori Patent Issue & Expiration Year
  • Figure 7-6: US - Price for 60 Capsule Supply & Price Per Unit of Xalkori Oral Capsule (US$), March'2021
  • Figure 7-7: UK - Price for 60 Capsule Supply & Price Per Unit of Xalkori Oral Capsule (US$/GBP), March'2021
  • Figure 7-8: Xalkori - Recommended & Reduced Daily Dose (mg)
  • Figure 7-9: Global - Xalkori Annual Sales (US$ Million), 2017 - 2020
  • Figure 7-10: US - Xalkori Annual Sales (US$ Million), 2017 - 2020
  • Figure 7-11: Global - Xalkori Annual Sales by Region (US$ Million), 2020
  • Figure 7-12: Global - Xalkori Annual Sales by Region (%), 2020
  • Figure 7-13: Global - Xalkori Quarterly Sales (US$ Million), 2019 & 2020
  • Figure 7-14: US - Xalkori Quarterly Sales (US$ Million), 2020
  • Figure 7-15: Europe - Xalkori Quarterly Sales (US$ Million), 2020
  • Figure 8-1: Zykadia - FDA Approval by Indication
  • Figure 8-2: Zykadia - FDA Approval Year by Region
  • Figure 8-3: US - Number of Zykadia Patents by Assignee
  • Figure 8-4: US - Novartis's Zykadia Patent Issue & Expiration Year
  • Figure 8-5: US - Rigel's Zykadia Patent Issue & Expiration Year
  • Figure 8-6: US - IRM's Zykadia Patent Issue & Expiration Year
  • Figure 8-7: US - Price for 84 Tablets Supply & Price Per Unit of Zykadia Oral Tablet (US$), Mrch'2021
  • Figure 8-8: UK - Price for 84 Tablets Supply & Price Per Unit of Zykadia Oral Tablet (US$/GBP), March'2021
  • Figure 8-9: Zykadia - Recommended & Reduced Dose for NSCLC Treatment (mg per day)
  • Figure 9-1: Alsensa - FDA Approval by Indication
  • Figure 9-2: Alsensa - FDA Approval by Region
  • Figure 9-3: US - Alecensa Patent Issue & Expiration Year
  • Figure 9-4: US - Price for 240 Tablet Supply & Price Per Unit of Alecensa Oral Tablet (US$), March'2021
  • Figure 9-5: UK - Price for 224 Tablet Supply & Price Per Unit of Alecensa Oral Tablet (US$/GBP), March'2021
  • Figure 9-6: Alecensa - Recommended & Reduced Dose for NSCLC Treatment (mg per day)
  • Figure 9-7: Global - Alecensa Annual Sales (US$/CHF Million), 2017 - 2020
  • Figure 9-8: US - Alecensa Annual Sales (US$/CHF Million), 2017 - 2020
  • Figure 9-9: Europe - Alecensa Annual Sales (US$/CHF Million), 2018 - 2020
  • Figure 9-10: Japan - Alecensa Annual Sales (US$/CHF Million), 2017 - 2020
  • Figure 9-11: Global - Alecensa Annual Sales by Region (US$/CHF Million), 2020
  • Figure 9-12: Global - Alecensa Annual Sales by Region (%), 2020
  • Figure 9-13: Global - Alecensa Quarterly Sales (US$/CHF Million), 2019
  • Figure 9-14: Global - Alecensa Quarterly Sales (US$/CHF Million), 2020
  • Figure 9-15: US - Alecensa Quarterly Sales (US$/CHF Million), 2020
  • Figure 9-16: Europe - Alecensa Quarterly Sales (US$/CHF Million), 2020
  • Figure 9-17: Japan - Alecensa Quarterly Sales (US$/CHF Million), 2020
  • Figure 10-1: Alunbrig - FDA Approval by Indication
  • Figure 10-2: Alunbrig - FDA Approval Year by Region
  • Figure 10-3: Alunbirg - Patent Issue & Expiration Year
  • Figure 10-4: US - Price for 30 Tablets & Price Per Unit of 30mg Alunbirg Tablet (US$), March'2021
  • Figure 10-5: US - Price for Various Supplies of 90 mg Alunbirg Tablet (US$), March'2021
  • Figure 10-6: US - Price for 30 Tablets & Price Per Unit of 180mg Alunbirg Tablet (US$), March'2021
  • Figure 10-7: US - Price for 30 Tablets & Price Per Unit of 90-180mg Alunbirg Tablet (US$), March'2021
  • Figure 10-8: UK - Price for Various Supplies of Alunbirg Oral Tablet of 30mg (US$/GBP), March'2021
  • Figure 10-9: UK - Price for Various Supplies of Alunbirg Oral Tablet of 90mg (US$/GBP), March'2021
  • Figure 10-10: UK - Price for 28 Tablets & Price Per Unit Tablet of Alunbirg 180mg (US$/GBP), March'2021
  • Figure 10-11: UK - Price for 28 Tablets & Price Per Unit Tablet of Alunbirg 90mg-180mg (US$/GBP), March'2021
  • Figure 10-12: Alunbirg - Recommended & Reduced Dose (mg)
  • Figure 10-13: Global - Alunbrig Annual Sales (US$/JPY Million), 2018 - 2020
  • Figure 10-14: Global - Alunbrig Quarterly Sales (US$/JPY Million), 2019
  • Figure 10-15: Global - Alunbrig Quarterly Sales (US$/JPY Million), 2020
  • Figure 10-16: Global - Alunbrig Annual Sales by Region (US$/JPY Million), 2020
  • Figure 10-17: Global - Alunbrig Annual Sales by Region (%), 2020
  • Figure 10-18: US - Alunbrig Quarterly Sales (US$/JPY Million), 2020
  • Figure 11-1: Lorbrena - FDA Approval by Indication
  • Figure 11-2: Lorbrena - FDA Approval Year by Region
  • Figure 11-3: US - Lorbrena Patent Issue & Expiration Year
  • Figure 11-4: US - Price for 30 Tablet Supply & Price Per Unit of 25mg Lorbrena Oral Tablet (US$), March'2021
  • Figure 11-5: US - Price for 30 Tablet Supply & Price Per Unit of 100 mg Lorbrena Oral Tablet (US$), March'2021
  • Figure 11-6: UK - Price for 90 Tablets Supply & Price Per Unit of Lorbrena Oral Tablet of 25mg (US$/GBP), March'2021
  • Figure 11-7: UK - Price for 120 Tablets Supply & Price Per Unit of Lorbrena Oral Tablet of 25mg (US$/GBP), March'2021
  • Figure 11-8: UK - Price for 30 Tablets Supply & Price Per Unit of Lorbrena Oral Tablet of 100mg (US$/GBP), March'2021
  • Figure 11-9: Lorbrena - Recommended & Reduced Dose for NSCLC Treatment (mg per day), March'2021
  • Figure 11-10: Global - Lorbrena Annual Sales (US$ Million), 2019 & 2020
  • Figure 11-11: US - Lorbrena Annual Sales (US$ Million), 2019 & 2020
  • Figure 11-12: Europe - Lorbrena Annual Sales (US$ Million), 2019 & 2020
  • Figure 11-13: ROW - Lorbrena Annual Sales (US$ Million), 2019 & 2020
  • Figure 11-14: Global - Lorbrena Annual Sales by Region (US$ Million), 2020
  • Figure 11-15: Global - Lorbrena Annual Sales by Region (US$ Million), 2020
  • Figure 12-1: Ensartinib - Mechanism of Action
  • Figure 12-2: Clinical Trials using Ensartinib
  • Figure 13-1: Global - ALK Inhibitor Clinical Trials by Phase (Number of Drugs), 2021 Till 2026
  • Figure 13-2: Global - ALK Inhibitor Clinical Trials by Company (Number of Drugs), 2021 Till 2026
  • Figure 13-3: Global - ALK Inhibitor Clinical Trials by Country (Number of Trials), 2021 Till 2026
  • Figure 13-4: Global - ALK Inhibitor Clinical Trials by Patient Segment (Number of Trials), 2021 Till 2026
  • Figure 13-5: ALK Inhibitor Clinical Trials by Region
  • Figure 13-6: North America - ALK Inhibitor Clinical Trial by Region
  • Figure 14-1: Lung Cancer Incidences by Region (Million), 2020 & 2040
  • Figure 14-2: Global - Anaplastic Lymphoma Kinase Inhibitors Market Size (US$ Billion), 2017-2020
  • Figure 14-3: Global - Anaplastic Lymphoma Kinase Inhibitors Market Size (US$ Billion), 2021-2026
  • Figure 14-4: US - Anaplastic Lymphoma Kinase Inhibitors Market Size (US$ Million), 2017-2020
  • Figure 14-5: US - Anaplastic Lymphoma Kinase Inhibitors Market Size (US$ Million), 2019-2026
  • Figure 14-6: Europe - Anaplastic Lymphoma Kinase Inhibitors Market Size (US$ Million), 2020-2026
  • Figure 15-1: Global - First Generation ALK Inhibitor Market Size (US$ Million), 2017-2020
  • Figure 15-2: Global - First Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-3: ALK Inhibitor Drug Market by Product (%), 2020
  • Figure 15-4: ALK Inhibitor Drug Market by Product (%), 2026
  • Figure 15-5: US - First Generation ALK Inhibitor Market Size (US$ Million), 2017 - 2020
  • Figure 15-6: US - First Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-7: Europe - First Generation ALK Inhibitor Market Size (US$ Million), 2017 - 2020
  • Figure 15-8: Europe - First Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-9: First Generation ALK Inhibitor - Market Size by Region (%), 2020
  • Figure 15-10: Global - Second Generation ALK Inhibitor Market Size (US$ Million), 2018-2020
  • Figure 15-11: Global - Second Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-12: Second Generation ALK Inhibitor - Market Size by Product (%), 2020
  • Figure 15-13: US - Second Generation ALK Inhibitor Market Size (US$ Million), 2018-2020
  • Figure 15-14: US - Second Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-15: Second Generation ALK Inhibitor - Market Size by Region (%), 2020
  • Figure 15-16: Second Generation ALK Inhibitor - Market Size by Region (%), 2026
  • Figure 15-17: US - Alecensa Market Size (US$ Million), 2017 - 2020
  • Figure 15-18: US - Alecensa Market Size (US$ Million), 2021 - 2026
  • Figure 15-19: Europe - Alecensa Market Size (US$ Million), 2018 - 2020
  • Figure 15-20: Europe - Alecensa Market Size (US$ Million), 2021 - 2026
  • Figure 15-21: Alecensa - Market Size by Region (%), 2020
  • Figure 15-22: Global - Lorlatinib Market Size (US$ Million), 2019 & 2020
  • Figure 15-23: Global - Third Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-24: ALK Inhibitor Drug Market by Product (%), 2020
  • Figure 15-25: US - Lorlatinib Market Size (US$ Million), 2019 & 2020
  • Figure 15-26: US - Third Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 15-27: Europe - Lorlatinib Market Size (US$ Million), 2019 & 2020
  • Figure 15-28: Europe - Third Generation ALK Inhibitor Market Size (US$ Million), 2021-2026
  • Figure 18-1: Lorbrena - Risk of Tumor Progression (%)
  • Figure 18-2: Risk of Tumor Progression by Product (%)
  • Figure 19-1: Global - Tyrosine Kinase Inhibitor Market Size (US$ Billion), 2017-2020
  • Figure 19-2: Global - Tyrosine Kinase Inhibitor Market Size (US$ Billion), 2021-2026
  • Figure 19-3: Global - Anaplastic Lymphoma Kinase Inhibitor Market Size (US$ Billion), 2017-2020
  • Figure 19-4: Tyrosine Kinase Inhibitor Market by Type (%), 2020
  • Figure 19-5: Global - ALK Inhibitor Market Opportunity by 15% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
  • Figure 19-6: Global - ALK Inhibitor Market Opportunity by 20% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
  • Figure 19-7: Global - ALK Inhibitor Market Opportunity by 25% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
  • Figure 19-8: Global - ALK Inhibitor Market Opportunity by 25% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
  • Figure 19-9: Global - Tagrisso Market Size (US$ Billion), 2017-2020
  • Figure 19-10: Global - Alectinib Market Size (US$ Billion), 2021-2026
  • Figure 20-1: ALK Inhibitors Drug Market Favorable Parameters
  • Figure 20-2: Cancer Incidences by Region (Million), 2020 & 2040
  • Figure 20-3: Cancer Deaths by Region (Million), 2020 & 2040
  • Figure 20-4: Alunbrig - Average Cost of Daily, Monthly & Annual Cost of Treatment (US$), March'2021
  • Figure 20-5: Lorbrena - Average Cost of Daily, Monthly & Annual Cost of Treatment (US$), March'2021
  • Figure 20-6: Barriers to ALK Inhibitor Drug Market
Back to Top