Market Research Report
Gamma Secretase - Pipeline Review, H1 2020
|Published by||Global Markets Direct||Product code||363575|
|Published||Content info||77 Pages
Delivery time: 1-2 business days
|Gamma Secretase - Pipeline Review, H1 2020|
|Published: April 30, 2020||Content info: 77 Pages||
According to the recently published report 'Gamma Secretase (EC 3.4.23.) - Pipeline Review, H1 2020'; Gamma Secretase (EC 3.4.23.) pipeline Target constitutes close to 20 molecules. Out of which approximately 17 molecules are developed by companies and remaining by the universities/institutes.
Gamma Secretase (EC 3.4.23.) - Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. The most well-known substrate of gamma secretase is amyloid precursor protein, when cleaved by both gamma and beta secretase, produces a short 39-42 amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of the Notch protein.
The report 'Gamma Secretase (EC 3.4.23.) - Pipeline Review, H1 2020' outlays comprehensive information on the Gamma Secretase (EC 3.4.23.) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Gamma Secretase (EC 3.4.23.) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 3, 2, 10 and 1 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 2 molecules, respectively.
Report covers products from therapy areas Central Nervous System, Oncology, Ear Nose Throat Disorders, Non Malignant Disorders, Cardiovascular and Metabolic Disorders which include indications Alzheimer's Disease, Adenoid Cystic Carcinoma (ACC), Benign Tumor, Hearing Disorders, Metastatic Breast Cancer, Soft Tissue Sarcoma, T-Cell Acute Lymphocytic Leukemia (T-Cell Acute Lymphoblastic Leukaemia), Acute Sensorineural Hearing Loss, Bile Duct Cancer (Cholangiocarcinoma), Burkitt Lymphoma, Chronic Lymphocytic Leukemia (CLL), Colon Cancer, Congestive Heart Failure (Heart Failure), Gastrointestinal Stromal Tumor (GIST), Glioblastoma Multiforme (GBM), Leiomyosarcoma, Leukemia, Lymphoblastic Lymphoma, Metastatic Hepatocellular Carcinoma (HCC), Multiple Myeloma (Kahler Disease), Natural Killer Cell Lymphomas, Obesity, Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Solid Tumor, T-Cell Leukemia, T-Cell Lymphomas and Triple-Negative Breast Cancer (TNBC).
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.